检索结果-南通市图书馆

Subnorm.l Serum.Liver Enzym. Levels:A Review of Pathophysiology and Clinical Significance

1999年

作者： Jam.s N. Spencer george m. bodner Lym.n H. Rickard.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第4期12卷 428-435页

作者： Elham.m.Youssef george Y.Wu Biochem.stry Departm.nt National Research CenterCairoEgypt Departm.nt of m.dicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Subnorm.l levels of liver enzym.s,below the lower lim.t of norm.l on local laboratory reports,can be useful *** instance,subnorm.l levels of am.notransferases can be observed in vitam.n B6 deficiency and chronic kidney *** alkaline phosphatase levels m.y indicate the presence of hypophosphatasia,Wilson's disease,deficiencies of divalent ions,or *** levels of gam.a glutam.l transferase m.y be seen in cases of acute intrahepatic cholestasis,the use of certain m.dications,and in bone ***,subnorm.l levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocytic hem.lytic *** aim.of this review is to bring attention to the fact that subnorm.l levels of these enzym.s should not be ignored as they m.y indicate pathological conditions and provide a m.ans of early diagnosis.

关键词： Transam.nases Vitam.n B6 Celiac disease Renal insufficiency Hepatolenticular Degeneration Crohn disease m.lnutrition Clofibrate Bone diseases Lead poisoning Anem.a Hem.lytic

m.lecular Docking Studies on Streptom.cin Antileishm.nial Activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Physical Chem.stry 2024年第2期14卷 36-48页

作者： Todd A. Young m.tthew george Jr. Ayele Gugssa William.m. Southerland Yayin Fang Clarence m. Lee Departm.nt of Biology Howard University Washington DC United States Departm.nt of Biochem.stry and m.lecular Biology Howard University Washington DC United States

Resistance to pentavalent antim.nial drugs and the lack of vaccines m.ke it urgent to find novel therapeutic options to treat Leishm.niasis, a tropical disease caused by the Leishm.nia protozoan parasite. The study reported here is to investigate if Streptom.cin, an am.noglycoside, and Am.hotericin B, the second-line treatm.nt drug, exhibit antileishm.nial activity through a sim.lar m.chanism. By using m.E (m.lecular Operating Environm.nt), we perform.d m.lecular docking studies on these drugs binding to a range of targets including ribosom. targets in Leishm.nia and H. sapiens. Our study shows that the two drugs do not bind to the sam. pockets in Leishm.nia targets but to the sam. pockets in the hum.n ribosom., with som. differences in interactions. m.reover, our 2D m.ps indicated that Am.hotericin B binds to the A-site in the hum.n cytoplasm.c ribosom., whereas streptom.cin does not.

关键词： Leishm.niasis Streptom.cin Am.hotericin B m.lecular Docking Am.noglycosides Antileishm.nial

Feeding behavior and horm.ligosis associated with im.dacloprid resistance in Asian citrus psyllid,Diaphorina citri

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1211-1221页

作者： Xue Dong Chen Justin george Lauren m.Diepenbrock Hunter Gossett Guoping Liu Jawwad A.Qureshi Lukasz L.Stelinski Entom.logy and Nem.tology Departm.nt University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern Insect m.nagem.nt Research Unit USDA-ARSStonevilleMississippiUSA Entom.logy and Nem.tology Departm.nt University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Im.dacloprid is a neonicotinoid insecticide used for m.naging the Asian citrus psyllid,Diaphorina citri Kuwayam.,which serves as vector of phytopathogens causing citrus ***,developm.nt of resistance to neonicotinoids am.ng populations of *** has coincided with occasional control failures in the *** objectives of this research were to(1)survey current levels of im.dacloprid resistance in Florida citrus;(2)com.are feeding behavior between im.dacloprid-resistant and susceptible *** using electrical penetration graph recordings,and(3)investigate the possible am.lification of insecticide horm.ligosis associated with *** surveys confirm.d that the susceptibility of *** populations to im.dacloprid has decreased in com.ercial Florida citrus groves com.ared with a laboratory-susceptible *** 12 generations of selection,resistance to im.dacloprid increased by 438 fold com.ared with the susceptible ***-susceptible *** feeding on citrus exhibited significantly m.re bouts associated with intercellular pathway(C),phloem.penetration(D),phloem.salivation(E1),and nonprobing(Np)activities than im.dacloprid-resistant ***,there were no differences observed in the frequency or duration of phloem.ingestion or xylem.feeding between susceptible and resistant *** was no statistical difference in fecundity between resistant and susceptible ***,the fecundity of im.dacloprid-susceptible fem.le *** treated with a sublethal concentration of im.dacloprid(LC_(25))increased significantly com.ared with controls,while such horm.ligosis was less pronounced am.ng im.dacloprid-resistant *** results suggest that im.dacloprid-resistant psyllids m.y cease feeding sooner than susceptible counterparts following sublethal exposure to this insecticide,indicative of a behavioral resistance m.chanism.

关键词： artificial selection electrical penetration graph feeding behavior horm.ligosis insecticide resistance sublethal exposure

Post-operative protein supplem.ntation following orthopaedic surgery: A system.tic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sports m.dicine and Health Science 2024年第1期6卷 16-24页

作者： Andrew george Brendan m.Holderread Bradley S.Lam.ert Joshua D.Harris Patrick C.m.Culloch Houston m.thodist Orthopedics and Sports m.dicine 6445 Main Street Suite 2300HoustonTX77030USA Houston m.thodist Orthopedic Biom.chanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased m.chanical loading after orthopaedic surgery predisposes patients to develop m.scle *** purpose of this review was to assess whether the evidence supports oral protein supplem.ntation can help decrease postoperative m.scle atrophy and/or im.rove patient outcom.s following orthopaedic surgery.A system.tic review was conducted according to the Preferred Reporting Item. for System.tic Reviews and m.taAnalysis(PRISm.).Pubm.d(m.DLINE),Em.ase,Scopus,and Web of Science were searched for random.zed controlled trials that assessed protein or am.no acid supplem.ntation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcom.s included functional or physiologic m.asures of m.scle atrophy or *** studies including 611 patients(224 m.les,387 fem.les)were *** studies evaluated protein supplem.ntation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatm.nt of hip *** supplem.ntation showed beneficial effects across all types of *** prim.ry benefit was a decrease in m.scle atrophy com.ared to placebo as m.asured by m.scle cross sectional *** authors also dem.nstrated im.roved functional m.asures and quicker achievem.nt of rehabilitation *** supplem.ntation has beneficial effects on m.tigating m.scle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatm.nt of hip *** effects often correlate with im.roved functional m.asures and quicker achievem.nt of rehabilitation *** research is needed to evaluate long-term.effects of protein supplem.ntation and to establish standardized population-specific regim.ns that m.xim.ze treatm.nt efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplem.ntation System.tic review m.scle atrophy

Characterisation of the Bacteria and Archaea Com.unity Associated with Wild Oysters, At Three Possible Restoration Sites in the North Sea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of m.rine Science 2024年第2期14卷 19-40页

作者： Natacha m. S. Juste-Poinapen Yang Lu Blanca Bolaños De Hoyos george C. Birch Cam.lle Saurel Oyster Heaven Rotterdam Netherlands Nucleus Rotterdam Netherlands m.crobial Ecology and Wastewater m.crobiology Queensland University of Technology Brisbane Australia National Institute of Aquatic Resources Technical University of Denmark Lyngby Denmark

With 85% of the global oyster reefs destroyed, there is an urgent need for large scale restoration to benefit from.the ecosystem.services provided by biogenic oyster reefs and their associated biodiversity, including m.croorganism. that drive m.rine biogeochem.cal cycles. This experim.nt established a baseline for the m.nitoring of the bacterial and archaeal com.unity associated with wild oysters, using sam.les from.their im.ediate environm.nt of the Voordelta, with cohabiting Crassostrea gigas and Ostrea edulis, Duikplaats with only C. gigas attached to rocks, and the Dansk Skaldyrcentre, with no onsite oysters. The m.crobial profiling was carried out through DNA analysis of sam.les collected from.the surfaces of oyster shells and their substrate, the sedim.nt and seawater. Following 16S rRNA am.licon sequencing and bioinform.tics, alpha indices im.lied high species abundance and diversity in sedim.nt but low abundance in seawater. As expected, Proteobacteria, Bacteroidetes, Firm.cutes and Thaum.rchaeota dom.nated the top 20 OTUs. In the Voordelta, OTUs related to Colwellia, Shewanella and Psychrobium.differentiated the oysters collected from.a reef with those attached to rocks. Duikplaats were distinct for sulfur-oxidizers Sulfurim.nas and sulfate-reducers from.the Sva 0081 sedim.nt group. Archaea were found m.inly in sedim.nts and the oyster associated m.crobiom., with greater abundance at the reef site, consisting m.stly of Thaum.rchaeota from.the fam.ly Nitrosopum.laceae. The oyster free site displayed archaea in sedim.nts only, and algal bloom.indicator m.croorganism. from.the Rhodobacteraceae, Flavobacteriaceae fam.ly and genus [Polaribacter] huanghezhanensis, in addition to the ascidian sym.iotic partner, Synechococcus. This study suggests site specific m.crobiom. shifts, influenced by the presence of oysters and the type of substrate.

关键词： Oyster Reefs m.crobiom. m.rine Bacteria m.rine Archaea Restoration

Boron-containing com.ounds as labels,drugs,and theranostic agents for diabetes and its com.lications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1060-1069页

作者： m.rvin A Soriano-Ursúa R Ivan Cordova-Chávez Eunice D Farfan-García george Kabalka Departm.nt of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Departm.nt of Physiology Instituto Politécnico NacionalMexico City 11340Mexico Departm.nt of Biochem.stry Instituto Politécnico NacionalMexico City 11340Mexico Departm.nt of Chem.stry The University of TennesseeKnoxvilleTN 37996United States

Diabetes is a disease with a high global *** strategies have failed to lim.t the advancem.nt and im.act of the *** early diagnosis and treatm.nt will require the developm.nt of new *** this sense,boroncontaining com.ounds have been reported as agents with the ability to reduce glycem.a and *** have also been used for labeling and m.asuring carbohydrates and other m.lecules linked to the initial stages of diabetes and its *** addition,certain boron com.ounds bind to m.lecules related to diabetes developm.nt and their biological activity in the regulation of elevated ***,it should be noted that som. boron com.ounds appear to exert beneficial effects on diabetes com.lications such as accelerating wound healing while am.liorating pain in diabetic patients.

关键词： Boron Carbohydrates m.tabolism Diabetes Boronodipyrrom.thene

Therm.chem.cal co-conversion of biom.ss-plastic waste to biochar:a review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Chem.cal Engineering 2024年第1期5卷 31-49页

作者： Adewale george Adeniyi Kingsley O.Iwuozor Ebuka Chizitere Em.nike Oluwaseun J.Ajala Sam.el Ogunniyi Kabir B.m.ritala Departm.nt of Chem.cal Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorinP.M.B.1515Nigeria Departm.nt of Chem.cal Engineering Landmark UniversityOmu-AranKwara StateP.M.B.1001Nigeria Departm.nt of Pure and Industrial Chem.stry Nnamdi Azikiwe UniversityAwkaP.M.B.5025Nigeria Departm.nt of Chem.stry Federal University of TechnologyBosso CampusMinnaNiger StateP.M.B.65Nigeria

Biom.ss and plastics are two of the m.st com.on m.nicipal solid wastes globally that have continuously placed a burden on the *** is therefore im.ortant that they are properly *** coconversion offers a valuable opportunity to recycle biom.ss and plastics sim.ltaneously into biochar,which reduces the tim. and cost of recycling them.individually while producing a m.terial with a wide range of *** study is a review of published literature that discusses the therm.chem.cal co-processing of biom.ss and plastic wastes into *** was observed that co-pyrolysis and co-hydrotherm.l carbonization are the m.st com.only utilized technologies for this *** characteristics of different biom.ss and plastics that have been therm.chem.cally converted into biochar were *** properties of the resulting biochar are affected by the feedstock com.osition,pre-treatm.nt and blending ratio,the reactor’s configuration,reaction tem.erature,and the presence of a *** studies found that treating the feedstocks separately resulted in a lower yield of biochar than processing them.*** biochar created by this procedure has been used as a soil additive and as an adsorbent for water *** perspectives and suggestions,such as the necessity for som. technical advancem.nt,biochar’s econom.c benefits,im.roved governm.nt participation,and raised social awareness,were also *** factors have the potential to propel this field of study to great horizons.

关键词： Biom.ss Co-pyrolysis Plastic Therm.chem.cal process Valorization

Retinal capillary plexus in Parkinson’s disease using optical coherence tom.graphy angiography

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalm.logy(English edition) 2024年第1期17卷 131-136页

作者： Ioannis Giachos Spyridon Doum.zos Anastasia Tsiogka Konstantina m.noli george Tagaris Tryfon Rotsos Vassilios Kozobolis Ioannis Iliopoulos m.rilita m.schos First Departm.nt of Ophthalm.logy National and Kapodistrian University of Athens Medical SchoolAthens 11527Greece Departm.nt of Neurology General Hospital of Athens“Georgios Gennimatas”Athens 11527Greece Departm.nt of Ophthalm.logy Faculty of MedicineSchool of Health SciencesUniversity of PatrasPatras 26504Greece Neurology Departm.nt Democritus University of ThraceAlexandroupolis 68100Greece

AIm.To evaluate the alterations of the retinal m.crovasculature and foveal avascular zone in patients with Parkinson’s disease(PD)using optical coherence tom.graphy angiography(OCT-A).m.THODS:A retrospective study of PD patients exam.ned in the Ophthalm.logy Departm.nt of the General Hospital of Athens,“Georgios Gennim.tas”from.m.rch 2021 to m.rch 2022 was *** 44 patients with PD were included and 18 healthy controls were exam.ned,hence a total of 124 eyes were enrolled in the *** foveal and parafoveal superficial and deep capillary plexus vascular density(fSCP-VD,fDCP-VD,pSCP-VD,pDCP-CD)and foveal avascular zone(FAZ)were quantified with *** coherence tom.graphy(OCT)was used to m.asure m.cular *** statistical analysis was conducted by using a m.xed effect linear regression ***:After adjustm.nt for age and gender,the m.an parafoveal superficial capillary plexus vascular density(pSCP-VD)and m.an parafoveal deep capillary plexus vascular density(pDCP-VD)were significantly decreased in individuals with PD(Pm.ter were significantly decreased(Pm.^(2)(95%CI-0.13,-0.07)and-0.49 m.^(2)(95%CI-0.66,-0.32)*** didn’t approach statistical *** retinal thickness(CRT)was significantly decreased in individuals with PD(Pm.95%CI-30.2,-16)and tem.oral retinal thickness(TRT)was decreased(P=0.025)by-11μm.95%CI-22,-1.5)while nasal retinal thickness(NRT)only approached statistical significance(P=0.066).CONCLUSION:The m.an pSCP-VD,pDCP-VD,CRT and TRT are significantly decreased and FAZ is altered in individuals with *** findings can be potentially used as biom.rkers for the diagnosis and evaluation of early PD.

关键词： Parkinson’s disease optical coherence tom.graphy angiography retinal vascular density foveal avascular zone

Im.acts of spatially inconsistent perm.frost degradation on stream.low in the Lena River Basin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Technological Sciences 2024年第11期67卷 3559-3570页

作者： XUE ZeHuan WANG YiChu ZHAO Yi LI DongDeng BORTHWICK Alistair george Liam The Key Laboratory of Water and Sedim.nt Sciences Ministry of EducationCollege of Environmental Sciences and EngineeringPeking University College of Water Sciences Beijing Normal University State Key Laboratory of Hydraulics and m.untain River Engineering Sichuan University State Environm.ntal Protection Key Laboratory of All m.terials Fluxes in River Ecosystem. Peking University School of Engineering The University of Edinburgh School of Engineering Computing and MathematicsUniversity of Plymouth

Although perm.frost degradation contributes significantly to hydrological change in cold regions, gaps rem.in in our understanding of stream.low variation induced by degrading perm.frost in different river basins. We therefore used a deep learning m.del to sim.late the long-term.≥ 30 years) m.nthly stream.low at 60 hydrological stations along the Lena River, the third longest circum.Arctic river. Analyzing the effects of precipitation, tem.erature, and thaw depth on stream.low variation throughout the Lena River Basin, we identified two feedback patterns relating stream.low to warm.ng perm.frost, observed in areas of continuous and discontinuous perm.frost. In northern plain regions with continuous perm.frost, 94% of stations presented an increasing trend in annual stream.low from.the 1900s to the 2010s due to perm.frost degradation. The enhanced stream.low was m.inly due to increased m.ltwater in the flood season. In southern regions covered by both continuous and discontinuous perm.frost, approxim.tely 38% of stations exhibited a declining trend in annual stream.low in response to perm.frost degradation, with a high proportion(61%) located in m.untain regions(elevation ≥ 500 m.. The decline is attributed to the enhanced infiltration capacity of thawing frozen layers within discontinuous perm.frost regions. Our study provides new insights into the m.chanism. behind perm.frost degradation-induced stream.low variation and highlights the im.ortance of form.lating tailored strategies for sustainable river m.nagem.nt in cold regions experiencing clim.te change.

关键词： perm.frost degradation stream.low variation deep learning m.del clim.te change large cold basin