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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 121-125页

作者： Solomon Habtemariam george kabakasseril varghese Pharmacognosy Research Laboratories&Herbal Analysis Services Medway School of ScienceUniversity of GreenwichChatham-MaritimeKent ME4 4TBUK Department of Botany St.Berchmans'CollegeChanganasseryKottayam 686101KeralaIndia

Objective: To investigate the antioxidant, anti-a-glucosidase and pancreatic b-cell protective potential of Ensete superbum(E. superbum) ***: A variety of in vitro assays including radical scavenging, reducing power potential, phenolic content determination, a-glucosidase assay and pancreatic b-cell(1.4E7 cells) viability were employed for assessing the effect of methanolic extract of E. superbum ***: The radical scavenging and reducing power effects comparable with the standard rutin were obtained while the enzyme inhibitory activity of the extract was 68-fold better than the standard antidiabetic drug, acarbose. The seed extract of E. superbum was packed-full of polyphenols with mean percentage gallic acid equivalent value of(38.2 ± 1.8)(n = 3). The protection of pancreatic cells from massive onslaught of hydrogen peroxide was far superior to that obtained for ***: The reputed antidiabetic therapeutic uses of the seeds extract of E. superbum may be justified on the basis of inhibition of carbohydrate enzymes, antioxidant effects and pancreatic b-cell protection.

关键词： Ensete superbum Musaceae Seeds Antioxidant Pancreatic beta-cell protection Alpha-glucosidase inhibition

Effect of post-thermal annealing on the structural and optical properties of ZnO thin films prepared from a polymer precursor

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Chinese Physics B 2012年第7期21卷 551-558页

作者： Jijoy.P.Mathew george varghese Jacob Mathew Thin Film Research Laboratory Department of PhysicsSt.Berchmans CollegeChanganasseryKerala 686101India Department of Physics Calicut UniversityThenjippalamKeralaIndia

ZnO thin films were synthesised by a new method which uses polyvinyl alcohol （PVA） as the polymer precursor. The films are annealed at different temperatures and for different annealing times. The structural parameters, like grain size, lattice constants, optical band gap, and Urbach energy, depend on the annealing temperature and time. All the films possess tensile strain, which relaxes as the annealing temperature and time increase. The photoluminescence （PL） spectra contain only ultraviolet （UV） peaks at low temperature, but as the annealing temperature and time increase, we observe peaks at the blue and green regions with a variation in the intensities of these peaks with annealing temperature and time.

关键词： stress, band gap, Urbach energy photoluminescence

Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics

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Genes & Diseases 2023年第3期10卷 960-989页

作者： Hafiza Padinharayil Jinsu varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi Renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex george Jubilee Centre for Medical Research Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India PG&Research Department of Zoology St.Thomas CollegeKozhencheryPathanamthittaKerala 689641India Department of Medical Oncology Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India School of Biotechnology National Institute of TechnologyCalicutKerala 673601India Canterbury Christ Church University Natural Applied SciencesLife Sciences Industry Liaison LabDiscovery ParkSandwich CT139FFUnited Kingdom Centre of Molecular Medicine and Diagnostics(COMManD) Department of BiochemistrySaveetha Dental College&HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil Nadu 600077India Department of Pharmaceutical Technology Jadavpur UniversityKolkataWest Bengal 700032India Department of Botany Bhairab Ganguly CollegeFeeder RoadBelghoriaKolkataWest Bengal 700056India Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biomedical Sciences School of Bio-Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance.

关键词： Biomarker Clinical trial Epidemiology Histology Liquid biopsy NSCLC Targeted therapy

Delayed inflammatory pulmonary syndrome: A distinct clinical entity in the spectrum of inflammatory syndromes in COVID-19 infection?

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世界重症医学杂志 2023年第4期12卷 226-235页

作者： Prithviraj Bose Binila Chacko Ashwin Oliver Arul Leena Robinson Vimala Balamugesh Thangakunam george M varghese Mohan Jambugulam Audrin Lenin John Victor Peter Department of Medical Intensive Care Christian Medical CollegeVellore 632004Tamil NaduIndia Department of Radiodiagnosis Christian Medical CollegeVellore 632004Tamil NaduIndia Department of Pulmonary Medicine Christian Medical CollegeVellore 632004Tamil NaduIndia Department of Infectious Disease Christian Medical CollegeVellore 632004Tamil NaduIndia Department of Medicine Christian Medical CollegeVellore 632004Tamil NaduIndia

BACKGROUND During the second wave of the coronavirus disease 2019(COVID-19)pandemic,a subset of critically ill patients developed delayed respiratory deterioration in the absence of new infection,fluid overload or extra-pulmonary organ *** To describe the clinical and laboratory characteristics,outcomes,and management of these patients,and to contrast this entity with other post COVID-19 immune dysregulation related inflammatory *** This was a retrospective observational study of adult patients admitted to the medical intensive care unit of a 2200-bed university affiliated teaching hospital,between May and August 2021,who fulfilled clearly defined inclusion and exclusion *** was assessed by a change in PaO_(2)/FiO_(2) ratio and levels of inflammatory markers before and after immunomodulation,duration of mechanical ventilation after starting treatment,and survival to *** Five patients developed delayed respiratory deterioration in the absence of new infection,fluid overload or extrapulmonary organ dysfunction at a median interquartile range(IQR)duration of 32(23-35)d after the onset of *** patients had elevated inflammatory markers,required mechanical ventilation for 13(IQR 10-23)d,and responded to glucocorticoids and/or intravenous *** patient died(20%).CONCLUSION This delayed respiratory worsening with elevated inflammatory markers and clinical response to immunomodulation appears to contrast the well described Multisystem Inflammatory Syndrome–Adults by the paucity of extrapulmonary organ *** diagnosis can be considered in patients presenting with delayed respiratory worsening,that is not attributable to cardiac dysfunction,fluid overload or ongoing infections,and associated with an increase in systemic inflammatory markers like C-reactive protein,inteleukin-6 and ferritin.A good response to immunomodulation can be *** delayed inflammatory pulmonary syndrome may re

关键词： COVID-19 ARDS Multisystem Inflammatory Syndrome in Adults Long COVID Organizing pneumonia

Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus

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四川生理科学杂志 2023年第3期45卷 536-536页

作者： george M varghese 不详

Background:The appropriate antibiotic treatment for severe scrub typhus,a neglected but widespread reemerging zoonotic infection,is ***:In this multicenter,double-blind,randomized,controlled trial,we compared the efficacy of intravenous doxycycline,azithromycin,or a combination of both in treating severe scrub *** who were 15 years of age or older with severe scrub typhus with at least one organ involvement were *** patients were assigned to receive a 7-day course of intravenous doxycycline,azithromycin,or both(combination therapy).The primary outcome was a composite of death from any cause at day 28,persistent complications at day 7,and persistent fever at day 5.

关键词： involvement intravenous Intravenous

Assesment of diabetes related quality of life and the impact of pharmaceutical care in its improvement

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Journal of Coastal Life Medicine 2016年第8期4卷 649-651页

作者： Ruksana Faizal Lincy george Panayappan Lakshmanan Treesa P.varghese Department of Pharmacy Practice St.James College of Pharmaceutical SciencesKeralaIndia Department of Pharmacy Practice JSS College of PharmacyOotyTamil NaduIndia

Objective:To assess the role of pharmaceutical care in improving quality of life in type II diabetes mellitus patients in a tertiary care ***:A prospective observational survey study was carried out for a period of 9 months in the General Medicine Department of the hospital.A total of 106 patients were enrolled and were randomly allocated to the control and intervention groups with 53 patients in each ***-19 of audit on diabetes-dependent quality of life questionnaire were provided to the patients,at the time of admission and during *** the time of admission the intervention group was provided with counseling for diabetes and with patient information leaflets on the disease.A data entry format comprising the socio-demographic details of the patients,their medical and medication history,laboratory results,*** used to note down the patient *** prescribing patterns of different oral hypoglycemic agents were ***:A total of 106 patients were recruited,51%being *** ranged from 32 to 80 years with a mean age of 60.210±*** duration since diagnosis was 5-10 years for most of the participants(67%),10-20 years for 29%and>20 years for the *** the time of study,17.9%of participants were received insulin treatment,and 82.1%on oral hypoglycemic *** average weighted impact of intervention group which improved from-1.7526±0.5630 to-1.668800±0.048013 was found to be statistically *** the study showed that pharmaceutical care has a positive impact on the quality of life of diabetes ***:Quality of life is worsened in diabetes mellitus patients,particularly for the'freedom to eat'domain,indicating that an intervention to improve dietary freedom might be a good way of improving quality of *** study also showed that patient counseling played an important role in improving quality of life of diabetes patients.

关键词： Quality of life Health related quality of life Diabetes mellitus Audit on diabetes-dependent quality of life Average weighted impact

印度3个区域恙虫病患者东方立克次体分子流行病学和遗传多样性

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中国人兽共患病学报 2015年第3期 293-294页

作者： george M.varghese Jeshina Janardhanan Sanjay K.Mahajan 赵琳福建省疾病预防控制中心

恙虫病是一种在亚太地区广泛流行的急性发热性疾病,其病原体为东方立克次体,其抗原高度变异。我们调查了印度南部、北部以及东北部3个恙虫病地方性流行区域的病原体,以确定流行的基因型。于2010年9月—2012年8月间,从恙虫病患者身上收... 详细信息

恙虫病是一种在亚太地区广泛流行的急性发热性疾病,其病原体为东方立克次体,其抗原高度变异。我们调查了印度南部、北部以及东北部3个恙虫病地方性流行区域的病原体,以确定流行的基因型。于2010年9月—2012年8月间,从恙虫病患者身上收集的焦痂标本进行56kDa的型特异性PCR和测序以确定其基因型。以Kato样菌株为主

关键词：恙虫病立克次氏体病立克次体遗传多样性患者印度南亚

A Model Study on Accelerated Consolidation of Coir Reinforced Lateritic Lithomarge Soil Blends with Vertical Sand Drains for Pavement Foundations

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Open Journal of Soil Science 2012年第3期2卷 320-332页

作者： george varghese Hegde Ramakrishna A.G. Nirmal Kumar L. Durga Prashanth G. Santosh Department of Civil Engineering National Institute of Technology India

Sub-grade soils of lateritic origin encountered in the construction of highway embankments in various regions of India, often comprise intrusions of soft lithomargic soils that result in large settlements during constructions, and differential settlements at later stages. This necessitates the use of appropriate soil improvement techniques to improve the load-carrying capacity of pavements. This work deals with accelerated consolidation of un-reinforced and coir-rein- forced lateritic lithomargic soil blends, provided with three vertical sand drains. The load-settlement characteristics were studied for various preloads ranging from 50 kg (0.0013 N/mm2) to 500 kg (0.013N/mm2) on soil specimens prepared in circular ferro-cement moulds. It was observed that at lower preloads up to 200kg, across the blends, the relative increase in consolidation (Rct) for randomly reinforced soil with vertical drains was sig-nificantly higher than that of un-reinforced soil without vertical drains, with an average value of 124.8%. Also, the Rct for un-reinforced soil with vertical drains was quite higher than that of un-reinforced soil without vertical drains, with an average value of 103.9%. In the case of higher preloads, the Rct values for randomly reinforced soil with vertical drains were moderate with an average value of 30.88%, while the same for un-reinforced soil with vertical drains was about 20.4%. The aspect-ratio of coir fibers used was 1:275.

关键词： Vertical Sand Drains Accelerated Consolidation Settlement Coir Reinforcement Laterite Shedi Lithomarge

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让妇女和女孩远离烟酒营销

英国医学杂志中文版 2022年第4期25卷 196-200页

作者： Emma Feeny Katie Dain Cherian varghese george A Atiim Dag Rekve Hebe N Gouda 张樱子(译) 周红霞(校) The george Institute for Global Health United Kingdom NCD Alliance Switzerland World Health Organization Switzerland United Nations University-International Institute for Global Health Malaysia School of Public Health University of Queensland 广西医科大学外国语学院广西医科大学外国语学院公共卫生学院

Emma Feeny及其同事认为,改变性别不平等性的措施可以控制烟酒业向中、低收入国家扩张,遏制慢性病的疾病负担,促进性别平等。因为社会和文化的规范污名化了女性吸烟、饮酒的行为,所以一直以来,男性是烟酒的主要消费人群,特别是在中、低... 详细信息

Emma Feeny及其同事认为,改变性别不平等性的措施可以控制烟酒业向中、低收入国家扩张,遏制慢性病的疾病负担,促进性别平等。因为社会和文化的规范污名化了女性吸烟、饮酒的行为,所以一直以来,男性是烟酒的主要消费人群,特别是在中、低收入国家更是如此。然而,在中、低收入国家,性别规范不断变化,行业营销越发激进,人口数量持续增长。这意味着如果不采取紧急行动,吸烟和饮酒的妇女和女孩人数可能在未来几年大幅增加。

关键词：低收入国家持续增长行业营销性别不平等疾病负担人口数量性别规范污名化

Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection

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World Journal of Critical Care Medicine 2018年第1期7卷 16-23页

作者： Gunasekaran Karthik Thomas Isaiah Sudarsan John Victor Peter Thambu Sudarsanam george M varghese Paul Kundavaram Sowmya Sathyendra Ramya Iyyadurai Kishore Pichamuthu Department of Medicine Christian Medical College Medical Intensive Care Unit Christian Medical College Department of Infectious Diseases Christian Medical College

AIM To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to *** Demographic data, electrocardiographic(ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio(OR) with 95%*** The cohort(n = 81; 35 males) aged 49.4 ± 16.1 years(mean, SD) presented 8.1 ± 3.1 d after symptom onset. The APACHE-Ⅱ score was 15.7 ± 7.0. Fortyeight (59%) patients were ventilated, and 46 (56%) required vasoactive agents. Mortality was 9.9%. ECG changes were non-specific; sinus tachycardia was the most common finding. Myocardial injury was evident in 61.7% of patients and LV systolic dysfunction in 30.9%. A diagnosis of myocarditis was made in 12.3%. In addition, seven patients with regional wall motion abnormalities had LV systolic dysfunction and elevated cardiac enzymes. Mild diastolic dysfunction was observed in 18 (22%) patients. Mild to moderate pericardial effusion was seen in 51%. On multivariate logistic regression analysis, patients with myocarditis tended to be older (OR = 1.04, 95%CI: 0.99-1.09), had shorter symptom duration (OR = 0.69, 95%CI: 0.49-0.98), and tended to stay longer in hospital(OR = 1.17, 95%CI: 0.98-1.40). Myocarditis was not associated with increased *** In scrub typhus infection, cardiac manifestations are frequent and associated with increased morbidity but not mortality.

关键词： Scrub typhus Myocarditis Outcome