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Microglandular hyperplasia-like mucinous adenocarcinoma of the endometrium: A rare case report

World Journal of Obstetrics and Gynecology 2022年第2期11卷 8-16页

作者： Helen J Trihia Efthymia Souka george galanopoulos Kitty Pavlakis Loukas Karelis Alexandros Fotiou Ioannis Provatas Department of Pathology ‘Metaxas’Memorial Cancer HospitalPiraeus 18537Greece Department of Pathology National&Kapodistrian University of AthensAthens 11527Greece Department of Pathology ‘IASO’General Maternity&Gynecological ClinicMaroussiAthens 15123Greece Department of Gynaecologic Oncology ‘Metaxas’Memorial Cancer HospitalPiraeus 18537Greece Department of Pathology Evangelismos District General HospitalAthens 10676Greece

BACKGROUND Microglandular hyperplasia(MGH)is a proliferation of endocervical glands,related to estrogen stimulation,mainly occurring in the reproductive age *** differential diagnosis includes endometrial adenocarcinoma with MGH-like pattern(MGA),a distinction that may be particularly problematic in curettage *** SUMMARY A 57-year-old,postmenopausal woman was admitted in our hospital for surgical *** had been diagnosed with a uterine leiomyoma,after complaints of irregular vaginal *** underwent dilatation and curettage(D&C)and subsequent total abdominal hysterectomy with bilateral salpingo-oophorectomy.D&C were compatible with ***,a proliferation of small glands,without intervening stroma,with mucin production,accumulation of neutrophils in the gland lumen and stroma,mild nuclear atypia and rare mitoses,were *** the hysterectomy specimen,the endometrium was thickened,but without apparent tumor *** microscopic examination,a residual similar adenocarcinoma was seen in the isthmus and more conventional-of endometrioid and mucinous type,in the rest of the *** MGH-like proliferation with mild cytologic atypia,detected in the endometrial curettage specimen of a postmenopausal woman,should alert pathologists for MGA of the ***,p16,PAX-2,CD10 and CD34 may help in the differential diagnosis.

关键词： Microglandular hyperplasia-like Microglandular-like adenocarcinoma Endometrium Curettage Pitfall

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