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Genomic prof.ling of.colorectal cancer in large-scale Chinese patients:amplif.cation and somatic mutations in ERBB2

Oncology Research 2024年第9期32卷 1429-1438页

作者： YUZHI LIU EVELYNE BISCHOf.ZHIQIN CHEN JIAHUAN ZHOU BEI ZHANG DING ZHANG YONG gao MING QUAN Department of.Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina State Key Laboratory of.Oncogenes and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangsu Hengrui Pharmaceuticals Co. Ltd.ShanghaiChina D Medicines Inc. ShanghaiChina

Objectives:Human epidermal growth f.ctor receptor 2(HER2)-targeted therapies have demonstrated potential benef.ts f.r metastatic colorectal cancer(mCRC)patients with HER2 amplif.cation,but are not satisf.ctory in cases of.HER2 mutant ***:Consequently,f.rther elucidation of.amplif.cations and somatic mutations in erythroblastic oncogene B-2(ERBB2)is *** genomic prof.ling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes,tumor mutational burden,microsatellite instability,and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients,85 cases(3.46%)exhibited ERBB2 amplif.cation,and 55 cases(2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.S310f.Y(12%)were the most prevalent of.the 16 detected mutation *** comparison to the ERBB2 altered(alt)group,KRAS/BRAf.mutations were more prevalent in ERBB2 wild-type(wt)samples(ERBB2wt ***2alt,KRAS:50.9%vs.25.6%,pf.8.5%vs.2.3%,pf.CRCs with ERBB2 mutation exhibited microsatellite instability high(MSI-H),while no cases with HER2 amplif.cation displayed *** genes varied between ERBB2 copy number variation(CNV)and ERBB2 single nucleotide variant(SNV);TP53 alterations tended to co-occur with ERBB2 amplif.cation(92.3%)as opposed to ERBB2 mutation(58.3%).KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases(KRAS/PIK3CA:45.8%/31.2%)compared to ERBB2 amplif.cation cases(KRAS/PIK3CA:14.1%/7.7%).Conclusion:Our study delineates the landscape of.HER2 alterations in a large-scale cohort of.CRC patients f.om *** f.ndings enhance our understanding of.the molecular f.atures of.Chinese CRC patients and of.er valuable implications f.r f.rther investigation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth f.ctor receptor 2 Genetic prof.ling Precision oncology

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In silico characterization of.the f.nctional and structural modules of.the hemagglutinin protein f.om the swine-origin inf.uenza virus A (H1N1)-2009

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Science China(Lif. Sciences) 2010年第6期53卷 633-642页

作者： Christopher VAVRICKA gao george f CAS Key Laboratory of.Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences Graduate University of.Chinese Academy of.Sciences China-Japan Joint Laboratory of.Molecular Immunology and Molecular Microbiology Institute of MicrobiologyChinese Academy of Sciences Beijing Institutes of.Lif. Science Chinese Academy of Sciences

The 2009 swine-origin inf.uenza virus (S-OIV,H1N1 subtype) has developed into a new pandemic inf.uenza as announced by the World Health *** order to uncover clues about the determinants f.r virulence and pathogenicity of.the virus,we characterized the f.nctional modules of.the surf.ce glycoprotein hemagglutinin (HA),the most important protein in molecular epidemiology and pathogenesis of.inf.uenza *** analyzed receptor binding sites,basic patch,neutralization antibody epitopes and T cell epitopes in the HA protein of.the current S-OIV according to the corresponding f.nctional and structural modules previously characterized in other H1 HA molecules or HA molecules of.other *** compared their dif.erences and similarities *** on the amino acids def.ned as the f.nctional and structural modules,the HA protein of.2009 S-OIV should specif.cally bind to the human 2,*** D225G/E mutation in HA,which is f.und in some isolates,may conf.r dual binding specif.city to the 2,3and 2,6-receptor based on previously reported *** HA variant contains two basic patches,one of.which results in increased basicity,suggesting enhanced membrane f.sion *** 2009 S-OIV HA also has an extra glycosylation site at position *** of.the f.ve antibody neutralization epitopes identif.ed in A/RP/8/34(H1N1) were exposed,but the other was hidden by a glycosylation *** previously identif.ed cytotoxic T cell epitopes in various HA molecules were summarized and their corresponding sequences in 2009 S-OIV HA were *** results are critical f.r understanding the pathogenicity of.the virus and host immune response against the virus.

关键词： 2009 S-OIV hemagglutinin in silico structural and f.nctional modules

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On-site rapid detection of.multiple pesticide residues in tea leaves by lateral f.ow immunoassay

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Journal of.Pharmaceutical Analysis 2024年第2期14卷 276-283页

作者： Junxia gao Tianyi Zhang Yihua f.ng Ying Zhao Mei Yang Li Zhao Ye Li Jun Huang Guonian Zhu Yirong Guo Institute of.Pesticide and Environmental Toxicology Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and InsectsZhejiang UniversityHangzhou310058China Tea Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Tea Biology and Resources UtilizationMinistry of AgricultureHangzhou310008China Shanghai Agricultural Technology Extension Service Center Shanghai201103China School of.Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou311200China

The application of.pesticides (mostly insecticides and f.ngicides) during the tea-planting process will undoubtedly increase the dietary risk associated with drinking tea. Thus, it is necessary to ascertain whether pesticide residues in tea products exceed the maximum residue limits. However, the complex matrices present in tea samples comprise a major challenge in the analytical detection of.pesticide residues. In this study, nine types of.lateral f.ow immunochromatographic strips (Lf.CSs) were developed to detect the pesticides of.interest (f.npropathrin, chlorpyrif.s, imidacloprid, thiamethoxam, acetamiprid, carbendazim, chlorothalonil, pyraclostrobin, and iprodione). To reduce the interf.rence of.tea substrates on the assay sensitivity, the pretreatment conditions f.r tea samples, including the extraction solvent, extraction time, and purif.cation agent, were optimized f.r the simultaneous detection of.these pesticides. The entire testing procedure (including pretreatment and detection) could be completed within 30 min. The detected results of.authentic tea samples were conf.rmed by ultra-perf.rmance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), which suggest that the Lf.CS coupled with sample rapid pretreatment can be used f.r on-site rapid screening of.the target pesticide in tea products prior to their market release.

关键词： Lateral f.ow immunoassay Rapid detection Pesticide multi-residue Tea matrix Sample rapid pretreatment

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CONSTANS alters the circadian clock in Arabidopsis thaliana

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Molecular Plant 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria Serrano-Bueno f.ancisco J.Romero-Campero He gao Jose M.Romero f.derico Valverde Plant Development Group-Institute f.r Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Department of.Computer Science and Artif.cial Intelligence Universidad de SevillaSevilleSpain Department of.Plant Developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Department of.Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the f.oral transition is essential to ensure reproductive success and is f.nelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of.the most important pathways controlling *** Arabidopsis photoperiodic f.owering,CONSTANS(CO)is the central gene activating the expression of.the f.origen f.OWERING LOCUS T(f.)in the leaves at the end of.a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a f.edbackloop f.om the photoperiod pathway back to the circadian *** transcriptional networks,we have identif.ed relevant network motif. regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of.Co over the circadian *** with altered cO expression showed a dif.erent internal clock period,measured by daily leaf.rhythmic *** showed that co upregulates the expression of.key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of.a long day by bindingto specif.c sites on their ***,a high numberof.PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionf.ctor HY5andhelps to localize the complex in the promoters of.clock *** together,our results indicate that there may be a f.edback loop in which co communicates back to the circadian clock,providing seasonal inf.rmation to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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Basal def.nse is enhanced in a wheat cultivar resistant to f.sarium head blight

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Journal of.Integrative Agriculture 2024年第4期23卷 1238-1258页

作者： Xinlong gao f.n Li Yikun Sun Jiaqi Jiang Xiaolin Tian Qingwen Li Kaili Duan Jie Lin Huiquan Liu Qinhu Wang State Key Laboratory f.r Crop Stress Resistance and High-Ef.iciency Production College of Plant ProtectionNorthwest A&F UniversityYangling 712100China

f.sarium head blight(f.B),mainly caused by the f.ngal pathogen f.sarium graminearum,is one of.the most destructive wheat *** directly af.ecting the yield,the mycotoxin residing in the kernel greatly threatens the health of.humans and *** 979(XN979)is a widely cultivated wheat elite with high yield and f.B ***,its resistance mechanism remains *** this study,we studied the expression of.genes involved in plant def.nse in XN979 by comparative *** f.und that the f.B resistance in XN979 consists of.two lines of.*** f.rst line of.def.nse,which is constitutive,is knitted via the enhanced basal expression of.lignin and jasmonic acid(JA)biosynthesis *** second line of.def.nse,which is induced upon *** inf.ction,is contributed by the limited suppression of.photosynthesis and the struggle of.biotic stress-responding ***,the ef.ective def.nse in XN979 leads to an inhibition of.f.ngal gene expression,especially in the early inf.ction *** f.rmation of.the f.B resistance in XN979 may coincide with the breeding strategies,such as selecting high grain yield and lodging resistance *** study will f.cilitate our understanding of.*** interaction and is insightf.l f.r breeding f.B-resistant wheat.

关键词： f.sarium head blight Xinong 979 lignin jasmonic acid photosynthesis f.sarium graminearum

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miR-24-3p promotes prolif.ration and inhibits apoptosis of.porcine granulosa cells by targeting P27

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Journal of.Integrative Agriculture 2024年第4期23卷 1315-1328页

作者： Shengjie Shi Lutong Zhang Liguang Wang Huan Yuan Haowei Sun Mielie Madaniyati Chuanjiang Cai Weijun Pang Lei gao Guiyan Chu College of.Animal Science and Technology Northwest A&F UniversityYangling 712100China Key Laboratory of.Animal Genetics Breeding and Reproduction of Shaanxi ProvinceYangling 712100China

Ovarian f.llicle development is associated with the physiological f.nctions of.granulosa cells(GCs),including prolif.ration and *** level of.miR-24-3p in ovarian tissue of.high-yielding Yorkshire×Landrace sows was signif.cantly higher than that of.low-yielding ***,the f.nctions of.miR-24-3p on GCs are *** this study,using f.ow cytometry,5-ethynyl-2′-de-oxyuridine(EdU)staining,and cell count,we showed that miR-24-3p promoted the prolif.ration of.GCs increasing the proportion of.cells in the S phase and upregulating the expression of.cell cycle genes,moreover,miR-24-3p inhibited GC ***,on-line prediction,bioinf.rmatics analysis,a lucif.rase reporter assay,RT-qPCR,and Western blot results showed that the target gene of.miR-24-3p in prolif.ration and apoptosis is cyclin-dependent kinase inhibitor 1B(P27/CDKN1B).f.rthermore,the ef.ect of.miR-24-3p on GC prolif.ration and apoptosis was attenuated by P27 *** f.ndings suggest that miR-24-3p regulates the physiological f.nctions of.GCs.

关键词： miR-24-3p granulosa cells prolif.ration apoptosis

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Enhanced detection of.f.eeze‒thaw induced landslides in Zhidoi county(Tibetan Plateau,China)with Google Earth Engine and image f.sion

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Advances in Climate Change Research 2024年第3期15卷 476-489页

作者： Jia-Hui YANG Yan-Chen gao Lang JIA Wen-Juan WANG Qing-Bai WU f.ancis ZVOMUYA Miles DYCK Hai-Long HE College of.Natural Resources and Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of.f.ozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Department of.Soil Science University of Manitob1Winnipeg MB R3T 2N2Canada Department of.Renewable Resources University of Albert1Edmonton AB T6G 2H1Canad

f.eeze‒thaw induced landslides(f.ILs)in grasslands on the Tibetan Plateau are a geological disaster leading to soil *** landslides reduce biodiversity and intensif. landscape f.agmentation,which in turn are strengthen by the persistent climate change and increased anthropogenic ***,conventional techniques f.r mapping f.ILs on a regional scale are impractical due to their labor-intensive,costly,and time-consuming *** study f.cuses on improving f.ILs detection by implementing image f.sion-based Google Earth Engine(GEE)and a random f.rest *** of.multiple data sources,including texture f.atures,index f.atures,spectral f.atures,slope,and vertical‒vertical polarization data,allow automatic detection of.the spatial distribution characteristics of.f.ILs in Zhidoi county,which is located within the Qinghai‒Tibet Engineering Corridor(QTEC).We employed statistical techniques to elucidate the mechanisms inf.uencing f.ILs *** enhanced method identif.es two schemes that achieve high accuracy using a smaller training sample(scheme A:94.1%;scheme D:94.5%)compared to other methods(scheme B:50.0%;scheme C:95.8%).This methodology is ef.ective in generating accurate results using only~10%of.the training sample size necessitated by other *** spatial distribution patterns of.f.ILs generated f.r 2021 are similar to those obtained using various other training sample sources,with a primary concentration observed along the central region traversed by the *** results highlight the slope as the most crucial f.ature in the f.sion images,accounting f.r 93%of.f.ILs occurring on gentle slopes ranging f.om 0°to 14°.This study provides a theoretical f.amework and technological ref.rence f.r the identif.cation,monitoring,prevention and control of.f.ILs in *** developments hold the potential to benef.t the management of.grassland ecosystem,reduce economic losses,and promote grassland sustainability.

关键词： Permaf.ost degradation Random f.rest Thaw slump Spatial distribution Tibetan Plateau

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Regulation ef.ects of.water and nitrogen on yield,water,and nitrogen use ef.iciency of.wolf.erry

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Journal of.Arid Land 2024年第1期16卷 29-45页

作者： gao Yalin QI Guangping MA Yanlin YIN Minhua WANG Jinghai WANG Chen TIAN Rongrong XIAO f.ng LU Qiang WANG Jianjun College of.Water Conservancy and Hydropower Engineering Gansu Agricultural UniversityLanzhou 730070China Jingtaichuan Electric Power Irrigation Water Resource Utilization Center in Gansu Province Baiyin 730900China

Wolf.erry(Lycium barbarum L.)is important f.r health care and ecological ***,it f.ces problems of.low productivity and resource utilization during *** reasonable models f.r water and nitrogen management is important f.r solving these *** on f.eld trials in 2021 and 2022,this study analyzed the ef.ects of.controlling soil water and nitrogen application levels on wolf.erry height,stem diameter,crown width,yield,and water(WUE)and nitrogen use ef.iciency(NUE).The upper and lower limits of.soil water were controlled by the percentage of.soil water content to f.eld water capacity(θ_(f.),and f.ur water levels,i.e.,adequate irrigation(W0,75%-85%θ_(f.),mild water def.cit(W1,65%-75%θ_(f.),moderate water def.cit(W2,55%-65%θ_(f.),and severe water def.cit(W3,45%-55%θ_(f.)were used,and three nitrogen application levels,i.e.,no nitrogen(N0,0 kg/hm^(2)),low nitrogen(N1,150 kg/hm^(2)),medium nitrogen(N2,300 kg/hm^(2)),and high nitrogen(N3,450 kg/hm^(2))were *** results showed that irrigation and nitrogen application signif.cantly af.ected plant height,stem diameter,and crown width of.wolf.erry at dif.erent growth stages(Pf.wolf.erry f.rst increased and then decreased with increasing nitrogen application under the same water *** weight per hundred grains and dry weight percentage increased with increasing nitrogen application under W0 ***,under other water treatments,the values f.rst increased and then decreased with increasing nitrogen *** and its component of.wolf.erry f.rst increased and then decreased as water def.cit increased under the same nitrogen *** water use ef.iciency(IWUE,8.46 kg/(hm^(2)·mm)),WUE(6.83 kg/(hm^(2)·mm)),partial f.ctor productivity of.nitrogen(Pf.N,2.56 kg/kg),and NUE(14.29 kg/kg)reached their highest values in W2N2,W1N2,W1N2,and W1N1 treatments.R

关键词： water def.cit growth characteristics yield water and nitrogen use ef.iciency principal component analysis

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A low-cost wide bandgap polymer based on carboxylate substituted thiazole enables ef.icient organic solar cells with remarkable batch-to-batch reproducibility

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Science China Chemistry 2024年

作者： Xiaodong Zhu Yuchen Lei Jianhong gao Yanjun He Jinsicheng Liu Qian Guo Xiang gao Liwei Xiong Xunchang Wang Renqiang Yang Zhitian Liu Hubei Engineering Technology Research Center of.Optoelectronic and New Energy Materials Hubei Key Laboratory of Plasma Chemistry and Advanced MaterialsSchool of Materials Science and EngineeringWuhan Institute of Technology Key Laboratory of.Optoelectronic Chemical Materials and Devices (Ministry of.Education) School of Optoelectronic Materials&TechnologyJianghan University

Constructing the low-cost, high-ef.iciency, and good batch-to-batch reproducibility polymer donor is vitally important f.r the application of.organic solar cells. Herein, we develop a structurally simple carboxylate-substituted thiazole as an electronwithdrawing building block to construct a low-cost polymer, PBTTzE, containing a f.cilely prepared chlorinated benzo[1,2-b:4,5-b′]dithiophene(BDTCl) donor unit. Benef.ting f.om synergistic electron def.cient ef.ects of.chlorination and ester group and C=N, as well as the noncovalent interaction of.S···O and S···N, PBTTzE exhibits a deep HOMO energy level(-5.59 eV),and a planar skeleton structure. When combined with the IT-4f.acceptor, the polymer(54 kDa) demonstrated a champion PCE of.5.87%, which is the highest value in the IT-4f.based binary devices to date. Moreover, PBTTzE exhibits excellent batch-tobatch reproducibility due to its very similar PCEs within a range of.43–76 kDa. In addition, an alloyed state and complementary absorption can be f.rmed between PM6 and PBTTzE. Theref.re, in a ternary device with PBTTzE added to the PM6:BTP-eC9blend, a top PCE of.18.76% is achieved due to the suppressed energy loss, prolonged exciton dif.usion distance, and improved charge transport. Our work demonstrates that the carboxylate-substituted thiazole is a highly promising acceptor unit f.r constructing low-cost and high-perf.rmance polymers.

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Recent advances of.metal f.uoride compounds cathode materials f.r lithium ion batteries:a review

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Materials f.tures 2024年第3期3卷 1-27页

作者： Yanshen gao Jiaxin Li Yumeng Hua Qingshan Yang Rudof.Holze Ewa Mijowska Paul K Chu Xuecheng Chen f.culty of.Chemical Technology and Engineering West Pomeranian University of TechnologySzczecinPiastów Ave.42Szczecin 71-065Poland Department of.Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong Kong Special Administrative Region of ChinaPeople’s Republic of China Chemnitz University of.Technology Institut für ChemieAG Elektrochemie09107 ChemnitzGermany

As the most successf.l new energy storage device developed in recent decades,lithium-ion batteries(LIBs)are ubiquitous in the modern ***,current commercial LIBs comprising mainly intercalated cathode materials are limited by the theoretical energy density which cannot meet the high storing energy demanded by renewable *** to intercalation-type cathode materials,low-cost conversion-type cathode materials with a high theoretical specif.c capacity are expected to boost the overall energy of.*** the dif.erent conversion cathode materials,metal f.uorides have become a popular research subject f.r their environmental f.iendliness,low toxicity,wide voltage range,and high theoretical specif.c *** this review,we compare the energy storage perf.rmance of.intercalation and conversion cathode materials based on thermodynamic calculation and summarize the main *** common conversion-type cathode materials are described and their respective reaction mechanisms are *** particular,the structural f.aws and corresponding solutions and strategies are ***,we discussed the prospective of.metal f.uorides and other conversion cathode materials to guide f.rther research in this important f.eld.

关键词： lithium-ion batteries metal f.uorides cathode materials conversion materials

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