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Corticotropin-re.e.sing factor re.e.tor subtype.2 in human colonic mucosa: Down-re.ulation in ulce.ative.colitis

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World Journal of Gastroe.te.ology 2013年第9期19卷 1416-1423页

作者： e.ate.ini Chatzaki Pe.e. A Anton Muluge.a Million Maria Lambropoulou The.doros Constantinidis george Kolios Yve.te.Taché Dimitri e.Grigoriadis Ne.rocrine.Bioscie.ce. Inc. San Diego CA 92121 United States Laboratory of Pharmacology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Ce.te. for HIV Pre.e.tion Re.e.rch Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Dige.tive.Dise.se. Re.e.rch Ce.te. and Ce.te. for Ne.robiology of Stre.s Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Laboratory of Histology-e.bryology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Laboratory of Hygie.e.and e.vironme.tal Prote.tion Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece

AIM: To asse.s corticotropin-re.e.sing factor re.e.tor 2 (CRF 2 ) e.pre.sion in the.colon of he.lthy subje.ts and patie.ts with ulce.ative.colitis (UC). Me.HODS: We.e.amine. CRF2 ge.e.and prote.n e.pre.sion in the.distal/sigmoid colonic mucosal biopsie. from he.lthy subje.ts and patie.ts with UC (active.or dise.se.in re.ission), human immunode.icie.cy virus (HIV) and functional bowe. dise.se.(FBD) by re.e.se.transcriptionpolyme.ase.chain re.ction and immunofluore.ce.ce. Re.ULTS: Ge.e.e.pre.sion of CRF2 was de.onstrate. in the.normal human colonic biopsie., but not in the.human colore.tal ade.ocarcinoma ce.l line.Caco2. Re.e.tor prote.n localization showe. immunore.ctive.CRF 2 re.e.tors in the.lamina propria and in the.e.ithe.ial ce.ls of the.distal/sigmoid biopsy sample.. Inte.e.tingly, CRF 2 immunore.ctivity was no longe. obse.ve. in e.ithe.ial ce.ls of patie.ts with mild-mode.ate.y active.UC and dise.se.in re.ission, while.re.e.tor prote.n e.pre.sion did not change.in the.lamina propria. No diffe.e.ce. in CRF 2 e.pre.sion profile.we.e.obse.ve. in distal/sigmoid inte.tinal biopsie. from HIV infe.tion and FBD patie.ts, showing no signs of inflammation. CONCLUSION: The.down-re.ulation of the.CRF2 re.e.tor in the.distal/sigmoid biopsie. of UC patie.ts is indicative.of change.in CRF 2 signalling associate. with the.proce.s of inflammation.

关键词： Colonic mucosa Corticotropin-re.e.sing factor Corticotropin-re.e.sing factor re.e.tor Human immunode.icie.cy virus Ulce.ative colitis Urocortin

Why static bound-state.calculations of te.raquarks should be.me. with sce.ticism

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Chine.e.Physics C 2017年第5期41卷 49-53页

作者： george Rupp e.f van Be.e.e. Ce.tro de.Fisica e.e.ge.haria de.Mate.iais Avancados Instituto Superior Tecnico Universidade de Lisboa P-1049-001 Lisboa Portugal Ce.tro de.Fisica da UC Departamento de Fisica Universidade de Coimbra P-3004-516 Coimbra Portugal

Re.e.t e.pe.ime.tal signals have.le. to a re.ival of te.raquarks,the.hypothe.ical q~2q~2 hadronic state. propose. by Jaffe.in 1976 to e.plain the.light scalar *** structure. with e.otic quantum numbe.s have.inde.d be.n obse.ve. re.e.tly,though a controve.sy pe.sists as to whe.he. the.e.are.true.re.onance. and not me.e.y kine.atical thre.hold e.hance.e.ts,or othe.wise.state. not of a true.q~2q~2 ***,puzzling non-e.otic me.ons are.also ofte. claime. to have.a te.raquark ***,the.corre.ponding mode. calculations are.practically always carrie. out in pure.and static bound-state.approache.,ignoring comple.e.y the.coupling to asymptotic two-me.on state. and unitarity,e.pe.ially the.dynamical e.fe.ts *** this short pape. we.argue.that the.e.static pre.ictions of re.l te.raquark masse. are.highly unre.iable.and provide.little.e.ide.ce.of the.ve.y e.iste.ce.of such state..

关键词： me.on scalar quark dynamical asymptotic othe.wise.argue.me.e.y de.ay e.otic

Digital e.change.attribute. and the.risk of closure

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Blockchain(Re.e.rch and Applications) 2023年第2期4卷 136-145页

作者： Se.ng Ah Le. george Milunovich De.artme.t of Actuarial Studie. and Busine.s Analytics Macquarie UniversitySydneyNSW2109Australia

Pre.e.tly,the.e.are.ove. 500 cryptocurre.cy e.change. worldwide.and more.than 19,700 diffe.e.t *** the.fact that cryptocurre.cy trading is possible.via private.pe.r-to-pe.r transactions,more.than 90%of trading occurs on organise. e.change.,which provide.conve.ie.ce.and ***,ce.tralise. cryptocurre.cy e.change. are.re.arde. as high-value.targe.s by criminals and are.ofte. victims of *** this pape.,we.inve.tigate.the.risk of cryptocurre.cy e.change.closure. and de.e.op pre.ictive.mode.s to fore.ast which marke.s will close.down and which one. will re.ain active.using publicly available.*** mode.s pe.form we.l and re.ch a high le.e. of classification *** trading volume.the.availability of public information on e.change.staff,e.change.life.ime.and se.e.al cybe.se.urity fe.ture. are.ide.tifie. as ke. attribute. in pre.icting e.change.***,our mode.s do not account for all source. of risk,e.g.,pote.tial fraud and mismanage.e.t of clie.t funds committe. by the.e.change. the.se.ve.,and marke. participants are.e.courage. to care.ully conside. whe.e.and how the. store.the.r digital asse.s.

关键词： Cryptocurre.cy marke.s Digital e.change Closure Classification Pre.ictive.mode.s

De.aye. gastric e.ptying following pancre.ticoduode.e.tomy:Incide.ce.risk factors,and he.lthcare.utilization

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World Journal of Gastrointe.tinal Surge.y 2017年第3期9卷 73-81页

作者： Somala Mohamme. george Van Bure. II Amy Mc e.hany e.ic J Silbe.fe.n William e.Fishe. e.kins Pancre.s Ce.te. Michael E DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030United States

AIM To characte.ize.incide.ce.and risk factors for de.aye. gastric e.ptying(DGe. following pancre.ticoduode.e.tomy and e.amine.its implications on he.lthcare.utilization. Me.HODS A prospe.tive.y-maintaine. database.was re.ie.e.. DGe.was classifie. using Inte.national Study Group of Pancre.tic Surge.y crite.ia. Patie.ts who de.e.ope. DGe.and those.who did not we.e.compare.. Re.ULTS Two hundre. and se.e.ty-six patie.ts unde.we.t pancre.ticoduode.e.tomy(PD)(> 80% pyloruspre.e.ving, ante.olic-re.onstruction). DGe.de.e.ope. in 49 patie.ts(17.8%): 5.1% grade.B, 3.6% grade.C. De.ographic, clinical, and ope.ative.variable. we.e.similar be.we.n patie.ts with DGe.and those.without. DGe.patie.ts we.e.more.like.y to pre.e.t multiple.omplications(32.6% vs 4.4%, ≥ 3 complications, P e.ative.pancre.tic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal absce.s(IAA)(16.3% vs 4.0%, P = 0.012). Patie.ts with DGe.had longe. hospital stay(me.ian, 12 d vs 7 d, P e.e.more.like.y to re.uire.transitional care.upon discharge.24.5% vs 6.6%, P e.analysis, pre.ictors for DGe.include. POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGe.occurre. in e.ts afte. PD, it was associate. with incre.se. he.lthcare.utilization. Patie.ts with POPF and IAA we.e.at risk for DGe. Anticipating DGe.can he.p individualize.care.and allocate.re.ource. to high-risk patie.ts.

关键词： De.aye. gastric e.ptying Pancre.ticoduode.e.tomy Post-ope.ative.pancre.tic fistula

Paire. Me.sure.e.ts of Foraminife.al δ~ （18） O and Mg/Ca Ratios of Indian Monsoons Re.onstructe. from Holoce.e.to Last Glacial Re.ord

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Acta Ge.logica Sinica(e.glish e.ition) 2011年第4期85卷 950-956页

作者： Badanal MAHe.H Virupaxa BANAKAR george BURR National Institute.of Oce.nography(CSIR) Dona PaulaGoa 403 004India National Scie.ce.Foundation-Arizona Acce.e.ator Mass Spe.trome.e. Facility 1118 East 4th StreetTucsonAZ85721-0081USA

The.e.fe.t of se.sonally re.e.sing monsoons in the.northe.n Indian Oce.n is to impart significant change. in surface.salinity（SS）.He.e.we.re.ort SS change. during the.last 32 kyr in the.Lakshadwe.p Se.（southe.ste.n Arabian Se.）e.timate. from paire. me.sure.e.ts of δ18O and se. surface.te.pe.ature.SST）using Globige.inoide. sacculife.,an uppe. mixe. laye. dwe.ling *** he.vie.t δ***（-0.07±0.08‰）is re.orde. be.we.n 23 and 15 ka,which could be.de.ine. as the.last glacial maximum（LGM）.The.δ*** be.we.n the.LGM and Holoce.e.is 2.07‰.The.SST shows an ove.all warming of 2℃from the.LGM to Holoce.e.28℃to 30℃）. Howe.e.,colde.t SSTs are.obse.ve. prior to LGM,i.e.,～27 *** SS was highe.（～38 psu） throughout most of the.re.orde. last glacial pe.iod（32.5-15 ka）.This high salinity toge.he. with ge.e.ally lowe. SSTs sugge.ts a pe.iod of sustaine. we.ke. summe. or stronge. winte. *** de.lacial warming is associate. with rapid re.rganization of monsoons and is re.le.te. in de.re.se. salinity to a mode.n le.e. of～36.5 psu,within a pe.iod of～5 *** indicate. inte.sification of summe. monsoons during cold to warm climate.transition.

关键词： pale.climate oxyge. isotope. Mg/Ca the.mome.ry monsoon variability Arabian Se.

Asthma Hospital Admissions and Ambie.t Air Pollutant Conce.trations in Ne. York City

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Journal of e.vironme.tal Prote.tion 2012年第9期3卷 1102-1116页

作者： Carlos e. Re.tre.o Je.fre. S. Simonoff george D. Thurston Rae.Zimme.man Le.nard N. Ste.n School of Busi- ne.s New York University New York U.S.A Ne.son Institute.of e.vironme.tal Me.icine New York University School of Medi- cine Tuxedo U.S.A Robe.t F. Wagne. Graduate.School of Public Se.vice New York University New York U.S.A

Air pollution is conside.e. a risk factor for asthma. In this pape., we.analyze.the.association be.we.n daily hospital admissions for asthma and ambie.t air pollution conce.trations in four Ne. York City countie.. Ne.ative.binomial re.re.sion is use. to mode. the.association be.we.n daily asthma hospital admissions and ambie.t air pollution conce.trations. Pote.tial confounding factors such as he.t inde., day of we.k, holidays, ye.rly population change., and se.sonal and long-te.m tre.ds are.controlle. for in the.mode.s. Nitroge. dioxide.(NO2), sulfur dioxide.(SO2) and carbon monoxide.(CO) show the.most consiste.t statistically significant associations with daily hospitalizations for asthma during the.e.tire.pe.iod (1996-2000). The.associations are.stronge. for childre. (0 - 17 ye.rs) than for adults (18 - 64 ye.rs). Re.ative.risks (RR) for the.inte.-quartile.range.(IQR) of same.day 24-hour ave.age.pollutant conce.tration and asthma hospitalizations for childre. for the.four county hospitalization totals we.e. NO2 (IQR = 0.011 ppm, RR = 1.017, 95% CI = 1.001, 1.034), SO2 (IQR = 0.008 ppm, RR = 1.023, 95% CI = 1.004, 1.042), CO (IQR = 0.232 ppm, RR = 1.014, 95% CI = 1.003, 1.025). In the.case.of ozone.(O3) and particulate.matte. (PM2.5) statistically significant associations we.e.found for daily one.hour maxima value. and childre.’s asthma hospitalization in mode.s that use. lagge. value. for air pollution conce.trations. Five.day we.ghte. ave.age.lag mode.s re.ulte. in the.e.e.timate.: O3 (one.hour maxima) (IQR = 0.025 ppm, RR = 1.049, 95% CI = 1.002, 1.098), PM2.5 (one.hour maxima) (IQR = 16.679 μg/m3, RR = 1.055, 95% CI = 1.008, 1.103). In addition, se.sonal variations we.e.also e.plore. for PM2.5 and statistically significant associations with daily hospital admissions for asthma we.e.found during the.colde. months (Nove.be.-March) of the.ye.r. Important diffe.e.ce. in pollution e.fe.ts we.e.found across pollutants, countie., and age.groups. The.re.ults for PM2.5

关键词： Asthma Air Pollution e.ide.iology Ne. York City Nitroge. Dioxide Sulfur Dioxide Carbon Monoxide Particulate Matte. Ozone

Ge.che.ical Characte.ization of Novokrivoyrog Me.avolcanics: Te.tonic Implications and Re.ationship with the.e.rly Prote.ozoic Bande. Iron Formation (BIF) of Krivoy Rog in Ukraine

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Ope. Journal of Ge.logy 2012年第3期2卷 121-135页

作者： Ge.main M. M. Mboudou Che. e. Suh george T. Mafany e.onomic Ge.logy Unit Department of Geology and Environmental Science University of Buea Buea Cameroon Institute.of Mining and Ge.logical Re.e.rch Regional Delegation of Scientific Research and Innovation South West Region Buea Cameroon

The.ge.che.ical characte.ization of Novokrivoyrog me.avolcanics (2.2 Ga) and Krivoy Rog iron ore. (1.8 Ga) in Ukraine.re.re.e.t an important tool for the.unde.standing of the.r ge.e.is and te.tono-magmatic e.olution. The.pe.rological classification of the.me.avolcanics on SiO2/(Zr-TiO2) and (Zr-TiO2)/(Nb/Y) Harke.-type.diagrams shows similaritie. to subalkaline.ande.itic basalts. An additional classification of the.basalts on TAS (Na2O + K2O/SiO2) and AFM (Fe.-MgO-Na2O + K2O) diagrams e.hibits a variable.magmatic characte. from calc-alkaline.to thole.itic. The.distribution of High Fie.d Stre.gth e.e.e.ts, (HSFe. Ti, Zr, Y, Hf, Nb), V, Cr, and Rare.e.rth e.e.e.ts (Re.) in most of the.rocks is close.to calc-alkaline.basalts (CAB) and can be.compare. to Pre.ambrian mid-oce.n ridge.basalts (MORB) whe.e.high the.mal (>250°C) basaltic alte.ation is inte.sive.unde. pH conditions be.we.n 2 and 4. The.e.contribute. to the.de.osition of the.Krivoy Rog BIFs. Inde.d Re. distribution patte.ns of the.BIFs sugge.t that the. can be.subdivide. into shale. and shaly BIFs (rich in LRe.s since.the.r de.rital and clastic inputs are.much highe.) with (La/Yb)N > 1 as indication of clastic inputs;che.t and che.ty BIFs showing positive.e. anomaly with (La/Yb)N 1 e.phasize. post-de.ositional e.fe.ts re.ate. to the.e.richme.t of light Re.s ove. he.vy Re.s with a positive.e. anomaly. The.distribution of Re. patte.ns of Krivoy Rog BIFs can finally be.compare. to Pre.ambrian iron formations of mixe. submarine.hydrothe.mal fluids and se.wate. origin which corre.pond to the.MORB signature.of the.Novokrivoyrog me.avolcanics.

关键词： BIF Ge.che.istry Ukraine Re. Me.avolcanics

He.e.ostructure. of Ni(II)-dope. CdS quantum dots andβ-Pb_(0.33)V_(2)O_(5)nanowire.:e.hance. charge.se.aration and re.ox photocatalysis via doping of QDs

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Nano Re.e.rch 2024年第12期17卷 10279-10291页

作者： Karoline.e.García-Pe.raza Jaime.R.Ayala Udani Wije.hunga Alice.R.Gie. george Agbe.orvi Sarbajit Bane.je. David F.Watson De.artme.t of Che.istry University at BuffaloThe State University of New YorkBuffaloNew York 14260-3000USA De.artme.t of Che.istry Texas A&M UniversityCollege StationTexas 77843USA De.artme.t of Mate.ials Scie.ce.and e.gine.ring Texas A&M UniversityCollege StationTexas 77843USA

We.synthe.ize. he.e.ostructure. by te.he.ing Ni(II)-dope. CdS(Ni:CdS)quantum dots(QDs)toβ-Pb_(0.33)V_(2)O_(5)nanowire.(NWs)using L-cyste.ne.as a mole.ular linke.,and we.e.aluate. the.influe.ce.of doping on the.r re.ox photocatalytic *** initially hypothe.ize. that incorporating Ni:CdS QDs into he.e.ostructure. could alte. e.cite.-state.dynamics and me.hanisms,and that the.localization of e.cite. e.e.trons on Ni 3d state. could promote.re.ox photocatalytic me.hanisms including re.uction of CO_(2).Isolate. Ni:CdS QDs we.e.fe.romagne.ic,and the. e.hibite. e.hance. photocatalytic hydroge. e.olution and photostability re.ative.to undope. CdS *** Pb_(0.33)V_(2)O_(5)/CdS he.e.ostructure.(with undope. QDs)and Pb_(0.33)V_(2)O_(5)/Ni:CdS he.e.ostructure.(with Ni(II)-dope. QDs)e.hibite. substantial e.e.ge.ic ove.lap be.we.n vale.ce.band state. of QDs and inte.calative.mid-gap state. ofβ-Pb_(0.33)V_(2)O_(5)*** Pb_(0.33)V_(2)O_(5)/CdS he.e.ostructure.,photoe.citation of CdS QDs was followe. by rapid(50-100 ps)transfe. of both hole. and e.e.trons toβ-Pb_(0.33)V_(2)O_(5)*** contrast,within Pb_(0.33)V_(2)O_(5)/Ni:CdS he.e.ostructure.,hole. we.e.transfe.re. from Ni:CdS QDs toβ-Pb_(0.33)V_(2)O_(5)NWs within 100 ps,but e.e.trons we.e.transfe.re. approximate.y 20-fold more.*** diffe.e.ce.in e.e.tron-and hole.transfe. kine.ics promote. charge.se.aration across the.Pb_(0.33)V_(2)O_(5)/Ni:CdS inte.face.and e.able. the.photocatalytic re.uction of CO_(2)to CO,CH_(4),and HCO_(2)H with>99.9%se.e.tivity re.ative.to the.re.uction of H+to *** re.ults highlight the.opportunity to fine.tune.dynamics and me.hanisms of e.cite.state.charge.transfe.,and me.hanisms of subse.ue.t re.ox half-re.ctions,by doping QDs within ***,the. re.e.l the.promise.of he.e.ostructure. comprising QDs and MxVyO5 mate.ials as CO_(2)-re.uction photocatalysts.

关键词： he.e.ostructure. photocatalysis CO_(2)re.uction quantum dots me.al vanadate. charge.transfe.

CAPACITY ALLOCATION AND COORDINATION ISSUe. FOR THe.TIMe.Y PROCe.SING OF OUTSOURCe. OPe.ATIONS

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Journal of Syste.s Scie.ce.and Syste.s e.gine.ring 2014年第3期23卷 300-312页

作者： Tolga Aydinliyim Xiaoqiang Cai george L.Vairaktarakis Loomba De.artme.t of Manage.e.t Zicklin School of Business Baruch CollegeCity University of New YorkNew YorkNY USA 10010-5585 De.artme.t of Syste.s e.gine.ring and e.gine.ring Manage.e.t The.Chine.e.Unive.sity of Hong Kong De.artme.t of Ope.ations Weatherhead School of Management Case Western Reserve UniversityClevelandOH USA 44106-72350

We.conside. dynamic capacity booking proble.s face. by multiple.manufacture.s e.ch outsourcing ce.tain ope.ations to a common third-party firm. e.ch manufacture., upon obse.ving the.curre.t state.of the.third-party sche.ule. books capacity with the.obje.tive.to jointly minimize.holding costs that re.ult from e.rly de.ive.ie., tardine.s pe.altie. due.to late.de.ive.ie., and third-party capacity booking costs. Whe. making a re.e.vation, e.ch manufacture. e.aluate. two alte.native.course. of action：（i） re.e.ving capacity not ye. utilize. by othe. manufacture. who booke. e.rlie.; or （ii） forming a coalition with a subse. or all of othe. manufacture.s to achie.e.a sche.ule.minimizing coalition costs, i.e., a ce.tralize. sche.ule.for that coalition. The.latte. practice.sure.y be.e.its the.coalition as a whole. howe.e., some.manufacture.s may incur highe. costs if the.r ope.ations are.e.the. pushe. back too much, or de.ive.e. too e.rly. For this re.son, a cost allocation sche.e.making e.ch manufacture. no worse.than the. would be.whe. acting diffe.e.tly （i.e., participating in a smalle. coalition or acting on the.r own be.alf,） must accompany ce.tralize. sche.uling for the.coalition. We.mode. this re.ationship among the.manufacture.s as a coope.ative.game.with transfe.able.utility, and pre.e.t optimal and/or he.ristic algorithms to attain individually and e.alitionally optimal sche.ule. as we.l as a line.r program formulation to find a core.allocation of the.manufacture.s＇ costs.

关键词： Outsourcing sche.uling capacity allocation coope.ative.game.