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Management of primary retroperitoneal synovial sarcoma: A case report and review of literature

World Journal of Gastrointestinal Surgery 2019年第1期11卷 27-33页

作者： Aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou george bagias Nikolaos Machairas george Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Surgery National and Kapodistrian University of Athens Laikon Hospital Hannover Medical School Clinic for General Visceral and Transplant Surgery 3rd Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the ***, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our *** SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic *** RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low.

关键词： Retroperitoneal tumours Synovial sarcoma Case report Clinical presentation Diagnostic modalities Therapeutic management

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Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment

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World Journal of Gastroenterology 2018年第41期24卷 4635-4642页

作者： Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou george bagias Dimitrios Moris 1^st Department of Surgery Laikon General HospitalNational and Kapodistrian University of AthensAthens 11527Greece 4^th Department of Surgery Attikon University HospitalNational and Kapodistrian University of AthensAthens 12462Greece Laboratory of Experimental Surgery and Surgical Research National and Kapodistrian University of AthensAthens 11527Greece Department of General Visceral and Transplant SurgeryUniversity Hospital EssenEssen 45141Germany Department of Surgery Duke University Medical CenterDurhamNC 27710United States

Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular *** addition,HDACs have also been associated with increased chemotherapy *** on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free *** aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer.

关键词： Esophageal cancer Histone deacatylases Inhibitors Drugs

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Laparoscopic splenectomy:Current concepts

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World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 428-437页

作者： Evangelos P Misiakos george bagias Theodore Liakakos Anastasios Machairas 3rd Department of Surgery Attikon University HospitalUniversity of Athens School of Medicine Clinic for General Visceral and Transplant SurgeryHannover Medical School 1st Department of Surgery National and Kapodistrian University of AthensMedical SchoolLaikon General Hospital

Since early 1990's,when it was inaugurally introduced,laparoscopic splenectomy has been performed with excellent results in terms of intraoperative and postoperative *** laparoscopic splenectomy is the approach of choice for both benign and malignant diseases of the *** some contraindications still *** evolution of the technology has allowed though,cases which were considered to be absolute contraindications for performing a minimal invasive procedure to be treated with modified laparoscopic ***,the introduction of advanced laparoscopic tools for ligation resulted in less intraoperative ***,laparoscopic splenectomy is considered safe,with better outcomes in comparison to open splenectomy,and the increased experience of surgeons allows operative times comparable to those of an open *** this review we discuss the indications and the contraindications of laparoscopic *** we analyze the standard and modified surgical approaches,and we evaluate the short-term and long-term outcomes.

关键词： Laparoscopy Splenectomy Splenomegaly Hand-assisted-laparoscopic-splenectomy Lymphoma

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