检索结果-南通市图书馆

An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti george Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai wei Jacob george Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

矿物油对茶园小贯小绿叶蝉的控制效果和对茶叶感官品质的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境昆虫学报 2020年第4期42卷 1010-1018页

作者：徐长宝谢戈亮柯伟政王潇潇林雨晴 BEATTIE george A.C. 岑伊静华南农业大学园艺学院广州510642 华南农业大学昆虫生态研究室/广东省生物农药创制与应用重点实验室广州510642 School of Science Western Sydney UniversityPenrithNSW 2751Australia

小贯小绿叶蝉Empoasca(Matsumurasca)onukii Matsuda是东亚茶树的重要害虫之一,目前在我国主要采用化学防治。本文研究一种n C23园艺用矿物油、加德士的D-C-Tron NR对其产卵和取食行为的影响,以及对其田间种群的控制效果,为在茶园使用... 详细信息

小贯小绿叶蝉Empoasca(Matsumurasca)onukii Matsuda是东亚茶树的重要害虫之一,目前在我国主要采用化学防治。本文研究一种n C23园艺用矿物油、加德士的D-C-Tron NR对其产卵和取食行为的影响,以及对其田间种群的控制效果,为在茶园使用矿物油替代化学农药进行防治提供依据。室内选择性试验结果表明,用矿物油150倍液、200倍液处理茶树离体嫩梢对小贯小绿叶蝉成虫都有显著的拒食和产卵忌避效果,第3天的拒食率分别为85.59%、89.17%,产卵忌避率分别为70.22%、91.5%,200倍液处理对若虫也有显著的驱避和拒食效果,第2天驱避率为81.96%,第3天拒食率为85.86%。田间试验结果表明,矿物油100倍液、200倍液、300倍液处理都显著降低小贯小绿叶蝉田间种群的虫口密度,其中100倍液和200倍液的防治效果无显著差异,处理后5 d若虫的校正减退率分别达89.13%、87.63%,成虫分别达87.58%、84.22%,都显著高于300倍液的防效。田间试验结果还表明,矿物油3个浓度处理后茶梢上的卵量显著减少,其中100倍液处理第7天的产卵忌避率最高,达80.86%,而各处理茶园蜘蛛的数量与对照相比都没有显著差异。另外,用矿物油200倍液喷施茶树后5 d、10 d采摘的茶芽制成绿茶,经感官评审与对照没有差异,说明矿物油对小贯小绿叶蝉具有较好的防治效果,而且对茶园蜘蛛安全,对茶叶感官品质没有影响,可以在小绿叶蝉防治中推广应用。

关键词：矿物油小贯小绿叶蝉驱避取食产卵茶叶感官品质

Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne Lee Leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng george Pak-Heng Leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin Kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing ***,PCOS patients have decreased pregnancy rates and clomiphene citrate *** traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with ***,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been ***:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established *** serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was ***:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with *** serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ***,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated *** pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also cl

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

胰岛素眼液及其促吸收剂对兔血糖的影响

眼科新进展 2000年第4期20卷 262-264页

作者：周跃华李志辉安伟丽 george CHIOU 首都医科大学附属北京同仁医院眼科北京100730 美国德克萨斯A与M大学医学院眼科药物研究所

目的　本研究主要观察胰岛素眼液及其促吸收剂对兔血糖的影响。方法　不同浓度的胰岛素眼液及其促吸收剂滴入 30只 (30眼 )新西兰白兔眼内 ,然后 ,对其血糖及血浆胰岛素进行测量。结果　胰岛素眼液降低血糖的作用是剂量依赖性的 ,10 g·... 详细信息

目的　本研究主要观察胰岛素眼液及其促吸收剂对兔血糖的影响。方法　不同浓度的胰岛素眼液及其促吸收剂滴入 30只 (30眼 )新西兰白兔眼内 ,然后 ,对其血糖及血浆胰岛素进行测量。结果　胰岛素眼液降低血糖的作用是剂量依赖性的 ,10 g· L- 1的胰岛素降血糖作用与 2 .5 g· L- 1 和 5 g· L- 1 的胰岛素给药组比较 ,具有显著性差异 (P<0 .0 5 ) ;促吸收剂 Tween80可加速胰岛素的吸收 ,尤其是 10 g· L- 1 的 Tween80 ,其促进胰岛素吸收的能力与 5 g· L- 1的 Tween80比较 ,具有显著性的差异 (P<0 .0 5 )。结论　胰岛素眼液及其促吸收剂对于糖尿病病人的临床治疗具有一定的意义。

关键词：兔血糖糖尿病胰岛素眼液促吸收剂

Effects of notoginosides on proliferation and upregulation of GR nuclear transcription factor in hematopoietic cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第5期28卷 703-711页

作者： Rui-lan GAO~(2,4),Xiao-hong CHEN~2,Xiao-jie LIN~2,Xu-dai QIAN~2,wei-hong XU~2,Beng Hock CHONG~3~2 Hematology Institution,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China ~3 Department ofMedicine,St george Hospital,University of New South Wales,Sydney,New South Wales,Australia HematologyInstitution TheFirstAffiliatedHospitalofZhejiangChineseMedicalUniversityHangzhou310006China DepartmentofMedicine StGeorgeHospitalUniversityofNewSouthWalesSydneyNewSouthWalesAustralia

Aim:To investigate the effects of panax notoginosides （PNS） on the proliferationof human hematopoietic stem/progenitor cells,and to explore the signaling path-way of the nuclear transcription factor of the glucocorticoid receptor （GR-NTF）initiated by PNS related with the ***:The human CD34+cellsand bone marrow nuclear cells were exposed to PNS at a concentration of 0,10,25,50,and 100 mg/L,respectively,in semi-solid culture system to observe colonyforming unite of all lineages,granulocyte,erythrocyte,and megakaryocyte （CFU-GEMM,CFU-GM,CFU-E,and CFU-MK）.Three lineages of human hematopoieticcell lines,including granulocytic HL-60,erythrocytic K562,megakaryocytic CHRF-288,and Meg-01 cells were incubated with PNS at 20 mg/L for 14 ***,dexamethasone （Dex） was used as a positive *** nuclear protein of thecells was analyzed by Western blotting with monoclonal antibodies against theamino or carboxyl terminus of *** mobility shift assay per-formed by using the32p-radiolabeled GR-NTF consensus ***:PNS promoted the proliferation of CD34+cells and significantly raised the colonynumbers of CFU-GEMM by 34.7%±16.0% over the non-PNS control （P<0.01）.PNS also enhanced the proliferation of CFU-GM,CFU-E,and CFU-MK by 39.3%±5.7%,33.3%±7.3%,and 26.2%±3.2%,***-NTF protein levels ofeither the amino or carboxyl terminus in K562,CHRF-288,and Meg-01 treated byPNS increased by 2.4-2.8 fold and 1.3-3.9 fold over the untreated ***-NTFbinding activity,initiated by either PNS or Dex,was apparently elevated to formthe complex of GR-NTF with DNA as higher density bands in K562 and CHRF-288cells,and some activity appeared as a band in HL-60 cells induced by ***:PNS displayed the action of hematopoietic growth factor-like or syn-ergistic efficacy to promote proliferation of human progenitor cells,may play arole in the upregulation of gene expression related to proliferation of hematopoi-etic cells thro

关键词： panax notoginosides hematopoietic stem/progenitor cells proliferation GR-NTF

年龄相关性黄斑变性(AMD)实验模型的研究进展(英文)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际眼科杂志 2007年第3期7卷 585-589页

作者：江伟邱春亿美国德克萨斯A&M大学医学院眼科药理研究所

本文回顾了近年来各种不同的年龄相关性黄斑变性(AMD)的实验模型。其中应用最广泛的是激光诱导脉络膜新生血管的形成(CNV),即渗出性AMD的晚期阶段。其它模型有的以本病不同病理表现为基础,如地图样萎缩,drusen形成;有的以引起病变的不... 详细信息

本文回顾了近年来各种不同的年龄相关性黄斑变性(AMD)的实验模型。其中应用最广泛的是激光诱导脉络膜新生血管的形成(CNV),即渗出性AMD的晚期阶段。其它模型有的以本病不同病理表现为基础,如地图样萎缩,drusen形成;有的以引起病变的不同影响因素为基础,如年龄,光线,高脂饮食等。我们希望这篇综述能为研究者们选择合适的AMD模型起到一定参考作用。

关键词：年龄相关性黄斑变性模型

胼酞嗪对眼血流和激光诱导的脉络膜新生血管及体外培养的内皮细胞的影响(英文)

在线全文

学校读者我要写书评

暂无评论

国际眼科杂志 2008年第12期8卷 2359-2363页

作者：江伟邱春亿美国德州大学城德州农工大学健康科学中心医学院眼科药理研究所

目的:研究胼酞嗪对兔脉络膜血流和激光诱导的鼠脉络膜新生血管及人脐静脉内皮细胞管状结构形成的影响。方法:雌性新西兰白兔左眼眼内压升高至40mmHg后,滴入10g/L胼酞嗪滴眼液,采用彩色微球技术测量眼血流变化。用Nd:YAG激光诱导雄性Brow... 详细信息

目的:研究胼酞嗪对兔脉络膜血流和激光诱导的鼠脉络膜新生血管及人脐静脉内皮细胞管状结构形成的影响。方法:雌性新西兰白兔左眼眼内压升高至40mmHg后,滴入10g/L胼酞嗪滴眼液,采用彩色微球技术测量眼血流变化。用Nd:YAG激光诱导雄性Brown Norway大鼠至Bruch膜破裂,而后分别予生理盐水或5,10和20g/L胼酞嗪滴眼液点眼,3次/d,连续4wk。采用眼底荧光血管造影和脉络膜平片测量新生血管的面积。此外亦用不同浓度的胼酞嗪作用于培养之人脐静脉内皮细胞并探讨对其管状结构形成的影响。结果:10g/L胼酞嗪滴眼液滴入眼内压为40mmHg的兔眼30,60min后,脉络膜血流明显增加。眼底荧光血管造影和脉络膜平片测量均显示,经过4wk药物治疗,5,10,20g/L胼酞嗪滴眼液均明显抑制了鼠眼CNV的形成。3～30mg/L胼酞嗪对在基质凝胶中培养了48h的人脐静脉内皮细胞的管状结构的形成有抑制作用。结论:胼酞嗪可以抑制体内脉络膜新生血管及体外培养的人脐静脉内皮细胞管状结构的形成,并增强缺血后的兔脉络膜血流。胼酞嗪有望成为治疗年龄相关性黄斑变性的药物。

关键词：胼酞嗪脉络膜新生血管人脐静脉内皮细胞年龄相关性黄斑变性

Rethinking phonons:The issue of disorder

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2017年第1期3卷 44-51页

作者： Hamid Reza Seyf Luke Yates Thomas L.Bougher Samuel Graham Baratunde A.Cola Theeradetch Detchprohm Mi-Hee Ji Jeomoh Kim Russell Dupuis wei Lv Asegun Henry george W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGAUSA Heat Lab Georgia Institute of TechnologyAtlantaGAUSA School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA School of Electrical Engineering and Computer Science Georgia Institute of TechnologyAtlantaGAUSA

Current understanding of phonons treats them as plane waves/quasi-particles of atomic vibration that propagate and *** problem is that conceptually,when any level of disorder is introduced,whether compositional or structural,the character of vibrational modes in solids changes,yet nearly all theoretical treatments continue to assume phonons are still *** example,the phonon contributions to alloy thermal conductivity(TC)rely on this assumption and are most often computed from the virtual crystal approximation(VCA).Good agreement is obtained in some cases,but there are many instances where it fails—both quantitatively and ***,we show that the conventional theory and understanding of phonons requires revision,because the critical assumption that all phonons/normal modes resemble plane waves with well-defined velocities is no longer valid when disorder is *** we show,surprisingly,that the character of phonons changes dramatically within the first few percent of impurity concentration,beyond which phonons more closely resemble the modes found in amorphous *** then utilize a different theory that can treat modes with any character and experimentally confirm its new insights.

关键词： alloy character utilize

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南药巴戟天化学成分

中南民族大学学报（自然科学版） 2010年第4期29卷 53-56页

作者：李竣张华林蒋林杨得坡马伟 Li george Q 中南民族大学药学院武汉430074 中山大学药学院天然药物与中药研究所广州510006 广州国际医药港有限公司广州510500 悉尼大学传统药研究教育中心

为研究巴戟天药材的化学成分.通过硅胶柱色谱和ODS柱色谱等方法对其分离纯化,根据理化性质和光谱数据进行了结构鉴定.从巴戟天药材的乙醇提取物中分离得到了7个化合物,分别为1,2-二氧乙烯蒽醌(1)、1,3-二羟基-2-丁酰基蒽醌(2)、1,2-二... 详细信息

为研究巴戟天药材的化学成分.通过硅胶柱色谱和ODS柱色谱等方法对其分离纯化,根据理化性质和光谱数据进行了结构鉴定.从巴戟天药材的乙醇提取物中分离得到了7个化合物,分别为1,2-二氧乙烯蒽醌(1)、1,3-二羟基-2-丁酰基蒽醌(2)、1,2-二羟基蒽醌(3)、β-谷甾醇(4)、3β,20(R),丁基-5-烯基-胆甾醇(5)、3β,5-烯基螺旋甾(6)、水晶兰苷(7),其中化合物1、2、5、6属于首次从该植物中分离得到.

关键词：巴戟天蒽醌甾体环烯醚萜苷