检索结果-南通市图书馆

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： Tong Zhang Martina schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(Zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Machine learning guided high-throughput search of non-oxide garnets

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 1717-1725页

作者： Jonathan schmidt Hai-Chen Wang georg schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany

Garnets have found important applications in modern technologies including magnetorestriction,spintronics,lithium batteries,*** overwhelming majority of experimentally known garnets are oxides,while explorations(experimental or theoretical)for the rest of the chemical space have been limited in scope.A key issue is that the garnet structure has a large primitive unit cell,requiring a substantial amount of computational *** perform a comprehensive search of the complete chemical space for new garnets,we combine recent progress in graph neural networks with high-throughput *** apply the machine learning model to identify the potentially(meta-)stable garnet systems before performing systematic density-functional calculations to validate the *** discover more than 600 ternary garnets with distances to the convex hull below 100 meV⋅atom−*** includes sulfide,nitride,and halide *** analyze their electronic structure and discuss the connection between the value of the electronic band gap and charge balance.

关键词： structure sulfide oxides

Recent advances in microvascular autologous breast reconstruction after ablative tumor surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2016年第1期7卷 114-121页

作者： Michael S Pollhammer Dominik Duscher Manfred schmidt georg M Huemer Section of Plastic Aesthetic and Reconstru-ctive Surgery Department of General Surgery Kepler University Hospital Linz MAZ - Microsurgical Training and Research Center

breast cancer is a ubiquitous disease and one of the leading causes of death in women in western societies. With overall increasing survival rates, the number of patients who need post-mastectomy reconstruction is on the rise. Especially since its psychological benefits have been broadly recognized, breast reconstruction has become a key component of breast cancer treatment. Evolving from the early beginnings of breast reconstruction with synthetic implants in the 1960 s, microsurgical tissue transfer is on the way to become the gold standard for post oncology restoration of the breast. Particularly since the advent of perforator based free flap surgery, free tissue transfer has become as safe option for breast reconstruction with low morbidity. The lower abdominal skin and subcutaneous fat tissue typically offer enough volume to create an aesthetically satisfying breast mound. Nowadays, the most commonly used flap from this donor site is the deep inferior epigastric artery perforator flap. If the lower abdomen is not available as a donor site, the gluteal area and thigh provide a number of flaps suitable for breast recon-struction. If the required breast volume is small, and there is enough tissue available on the upper medial thigh, then a transverse upper gracilis flap may be a practicable method to reconstruct the breast. In case of a higher amount of required volume, a gluteal artery perforator flap is the best choice. However, what is crucial in addition to selecting the best flap option for the individual patient is the timing of the operation. In patients with confirmed post-mastectomy radiation therapy, it is advisable to perform microvascular breast reconstruction only in a delayed fashion.

关键词： breast cancer Microsurgery Autologous tissue transfer breast reconstruction Flap Transverse musculocutaneous gracilis Fasciocutaneous infragluteal Deep inferior epigastric perforator

CO_2 mitigation potential in farmland of China by altering current organic matter amendment pattern

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2010年第9期53卷 1351-1357,1407-1417页

作者： CADISCH georg Institute of Plant Production and Agroecology in the Tropics and Subtropics University of Hohenheim

The estimation of the global warming mitigation potential in terrestrial ecosystems is of great importance for decision makers to adopt measures to increase soil organic carbon (SOC) as well as to reduce greenhouse gas (GHGs) emissions. In this paper, we compiled data published in peer-reviewed journals, and conducted a holistic analysis of the effects of organic matter amendment on soil organic carbon sequestration, methane (CH4) and nitrous oxide (N2O) emissions in paddy and upland systems. Results showed that organic matter amendment increased soil organic carbon content, and apparent conversion rate of organic matter carbon to soil organic carbon in paddies was constant, while that in uplands decreased along with amendment years at 25 years time scale. Organic matter amendment during the rice season led to large CH4-C emissions, e.g on average 99.5 g CH4-C per kg organic carbon input under intermittent flood conditions, and 191.7 g CH4-C per kg organic carbon input under continuous flood conditions, respectively. by alteration of organic matter amendment from rice season to off-rice upland crop season, estimated CH4-C emissions in China could be cut by 3.5 Tg yr-1, accounting for 63% of current CH4-C emissions (5.5 Tg). If organic matter amendment percentage was increased from current 30% to future 50% of organic matter production and by alteration of organic matter amendment from rice season to off-rice upland crop season, the equivalent CO2-C mitigation potential in farmland of China would be 49.2 Tg yr-1 at the 10th year organic matter amendment and 36.0 Tg yr-1 at the 30th year amendment. These findings are important not only for China but also for the other rice production countries to increase farmland global warming mitigation.

关键词： climate change global warming radiative forcing SOC GHGs CH4 N2O

Dynamic knee valgus kinematics and their relationship to pain in women with patellofemoral pain compared to women with chronic hip joint pain

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2019年第5期8卷 486-493页

作者： Eric schmidt Marcie Harris-Hayes Gretchen b.Salsich Program in Physical Therapy Washington University School of MedicineSt.LouisMO 63108USA Program in Physical Therapy Department of Physical Therapy and Athletic TrainingSaint Louis UniversitySt.LouisMO 63104USA Department of Orthopaedic Surgery Washington University School of MedicineSt.LouisMO 63108USA

background:Dynamic knee valgus(DKV)is an abnormal movement pattern visually characterized by excessive medial movement of the lower extremity during weight *** in hip and knee kinematic components of DKV may explain the emergence of different pain problems in people who exhibit the same observed movement *** a secondary analysis of exiting data sets,we sought to determine whether hip and knee frontal and transverse plane angles during a functional task differed between women with patellofemoral pain and women with chronic hip joint pain and the relationship between joint-specific kinematics and pain in these 2 pain ***:In the original studies,3-dimensional hip and knee kinematics during a single-limb squat were obtained in 20 women with patellofemoral pain and 14 women with chronic hip joint pain who demonstrated visually classified *** intensity during the squat was assessed in both *** the secondary analysis,kinematic data were compared between pain groups using their respective control groups as a *** each pain group,correlation coefficients were used to determine the relationship between kinematics and pain during the ***:Hip adduction and contralateral pelvic drop were greater in those with chronic hip joint pain compared to those with patellofemoral pain(effect sizes ≥0.40).Greater knee external rotation(r= 0.47,p= 0.04)was correlated with greater knee pain in those with patellofemoral pain,while greater hip adduction(r = 0.53,p = 0.05)and greater hip internal rotation(r = 0.55,p = 0.04)were correlated with greater hip pain in those with chronic hip joint ***:Hip frontal plane motion was greater in those with chronic hip joint pain compared to those with patellofemoral *** both groups,greater abnormal movement at the respective joint(e.g.,knee external rotation in the patellofemoral pain group and hip adduction and internal rotation in the chronic hip joint pain gro

关键词： Anterior knee pain syndrome Femoroacetabular impingement Hip joint Kinematics Knee joint Single-limb squat

Ultrafast imaging of terahertz electric waveforms using quantum dots

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第1期11卷 63-68页

作者： Moritz b.Heindl Nicholas Kirkwood Tobias Lauster Julia A.Lang Markus Retsch Paul Mulvaney georg Herink Experimental Physics VIII-Ultrafast Dynamics University of BayreuthBayreuthGermany ARC Centre of Excellence in Exciton Science School of ChemistryUniversity of MelbourneMelbourneAustralia Physical Chemistry I University of BayreuthBayreuthGermany

Microscopic electric fields govern the majority of elementary excitations in condensed matter and drive electronics at frequencies approaching the Terahertz(THz)***,only few imaging schemes are able to resolve sub-wavelength fields in the THz range,such as scanning-probe techniques,electro-optic sampling,and ultrafast electron ***,intrinsic constraints on sample geometry,acquisition speed and field strength limit their ***,we harness the quantum-confined Stark-effect to encode ultrafast electric near-fields into colloidal quantum dot *** approach,termed Quantum-probe Field Microscopy(QFIM),combines far-field imaging of visible photons with phase-resolved sampling of electric *** capturing ultrafast movies,we spatio-temporally resolve a Terahertz resonance inside a bowtie antenna and unveil the propagation of a Terahertz waveguide excitation deeply in the sub-wavelength *** demonstrated QFIM approach is compatible with strong-field excitation and sub-micrometer resolution—introducing a direct route towards ultrafast field imaging of complex nanodevices inoperando.

关键词： antenna waveguide quantum

The quest for conditional independence in prospectivity modeling： weights-of-evidence, boost weights-of-evidence, and logistic regression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2016年第3期10卷 389-408页

作者： Helmut SCHAEbEN georg SEMMLER Department of Geophysics and Geoinformatics TU Bergakademie Freiberg Freiberg 09596 Germany

The objective of prospectivity modeling is prediction of the conditional probability of the presence T = 1 or absence T = 0 of a target T given favorable or prohibitive predictors b, or construction of a two classes {0,1} classification of T. A special case of logistic regression called weights-of-evidence （WofE） is geolo- gists＇ favorite method of prospectivity modeling due to its apparent simplicity. However, the numerical simplicity is deceiving as it is implied by the severe mathematical modeling assumption of joint conditional independence of all predictors given the target. General weights of evidence are explicitly introduced which are as simple to estimate as conventional weights, i.e., by counting, but do not require conditional independence. Complementary to the regres- sion view is the classification view on prospectivity modeling. boosting is the construction of a strong classifier from a set of weak classifiers. From the regression point of view it is closely related to logistic regression. boost weights-of-evidence （boostWofE） was introduced into prospectivity modeling to counterbalance violations of the assumption of conditional independence even though relaxation of modeling assumptions with respect to weak classifiers was not the （initial） purpose of boosting. In the original publication of boostWofE a fabricated dataset was used to ＂validate＂ this approach. Using the same fabricated dataset it is shown that boostWofE cannot generally compensate lacking condi- tional independence whatever the consecutively proces- sing order of predictors. Thus the alleged features of boostWofE are disproved by way of counterexamples, while theoretical findings are confirmed that logistic regression including interaction terms can exactly com- pensate violations of joint conditional independence if the predictors are indicators.

关键词： general weights of evidence joint conditionalindependence naive bayes model Hammersley-Cliffordtheorem interaction terms statistical significance

On a Fast Integral Equation Method for Diffraction Gratings

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2006年第6期1卷 984-1009页

作者： A.Rathsfeld G.schmidt b.H.Kleemann Weierstrass Institute for Applied Analysis and Stochastics Mohrenstr.3910117 BerlinGermany Carl Zeiss AG Corporate Research and TechnologyOptical Design73446 OberkochenGermany

The integral equation method for the simulation of the diffraction by optical gratings is an efficient numerical tool if profile gratings determined by simple crosssection curves are *** method in its recent version is capable to tackle profile curves with corners,gratings with thin coated layers,and diffraction scenarios with unfavorably large ratio period over *** discuss special implementational issues including the efficient evaluation of the quasi-periodic Green kernels,the quadrature algorithm,and the iterative solution of the arising systems of linear ***,as an example we present the simulation of echelle gratings which demonstrates the efficency of our approach.

关键词： Diffraction gratings integral equation method preconditioning

Genomic landscape of pancreatic neuroendocrine tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第46期20卷 17498-17506页

作者： Niklas Gebauer Christian schmidt-Werthern Veronica bernard Alfred C Feller Tobias Keck Nehara begum Dirk Rades Hendrik Lehnert georg brabant Christoph Thorns Department of Pathology University Hospital of Schleswig-Holstein23538 LuebeckGermany Department of Surgery University Hospital of Schleswig-Holstein23538 LuebeckGermany Department of Radiation Oncology University Hospital of Schleswig-Holstein 23538 LuebeckGermany Department of Internal Medicine I University Hospital of Schleswig-Holstein23538 LuebeckGermany

AIM: To investigate the prognostic role of genomic stability and copy number alterations (CNAs) pancreatic neuroendocrine tumors (PanNETs).

关键词： Array comparative genomic hybridization Copy number alterations Chromosomal aberrations Pancreatic neuroendocrine tumors Prognosis