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Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C

World Journal of Hepatology 2023年第12期15卷 1315-1324页

作者： georg peschel Kilian Weigand Jonathan Grimm Martina Müller Christa Buechler Department of Internal Medicine I University Hospital RegensburgRegensburg 93053Germany Department of Internal Medicine Klinikum FürstenfeldbruckFürstenfeldbruck 82256Germany Department of Gastroenterology Gemeinschaftsklinikum MittelrheinKoblenz 56073Germany

BACKGROUND Patients with chronic hepatitis C virus(HCV)infection have increased serum ***-1 is an anti-inflammatory adipokine,and higher levels may be a direct effect of HCV *** elimination of HCV by direct acting antivirals almost normalized circulating levels of various molecules with a role in *** To evaluate the effect of HCV infection on serum omentin-1,serum omentin-1 levels of HCV patients were measured before therapy and at 12 wk after therapy *** of serum omentin-1 with parameters of inflammation and liver function were explored at both time *** omentin-1 levels of patients with and without liver cirrhosis,which was defined by ultrasound or the fibrosis-4(FIB-4)score,were *** Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay in 84 chronic HCV patients before therapy and at 12 wk after therapy end where sustained virological response 12(SVR12)was achieved in all *** omentin-1 of 14 non-infected controls was measured in *** In patients with chronic HCV,serum omentin-1 levels were not related to viral load or viral *** patients with liver steatosis and HCV patients with diabetes had serum omentin-1 levels comparable to patients not suffering from these *** omentin-1 levels at SVR12 were similar in comparison to pretreatment *** addition,serum levels did not differ between HCV-infected patients and non-infected *** omentin-1 levels did not correlate with leukocyte count or C-reactive *** correlations of serum omentin-1 with bilirubin and the model for end-stage liver disease score(MELD)were detected before therapy and at SVR12 in the whole *** and the MELD score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed liver cirrhosis before *** SVR12,serum omentin-1 levels of patients with liver cirrhosis negativel

关键词： Direct acting antivirals Hepatitis C Liver cirrhosis Adipokine

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