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Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： geonhee kim Won Hyuk Lee Seokin Kang Jung Rock Moon Yoon Suk Lee Jun Hyuk Son Nam-Hoon kim Jong Wook kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

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Chemical control of receptor kinase signaling by rapamycin-induced dimerization

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Molecular Plant 2021年第8期14卷 1379-1390页

作者： Sara kim Jeonghyang Park Byeong Wook Jeon geonhee Hwang Na Young Kang Yeim We Won-Young Park Eunkyoo Oh Jungmook kim Department of Life Sciences Korea UniversitySeoulKorea Department of Bioenergy Science and Technology Chonnam National UniversityGwangjuKorea Kumho Life Science Laboratory Chonnam National UniversityGwangjuKorea Department of Integrative Food Bioscienee and BiotechnologyChonnam National UniversityGwangjuKorea

Membrane-localized leucine-rich repeat receptor kinases(LRR-RKs)sense diverse extracellular signals,and coordinate and specify cellular functions in ***,functional understanding and identification of the cellular signaling of most LRR-RKs remain a major challenge owing to their genetic redundancy,the lack of ligand information,and subtle phenotypes of LRR-RK ***,we report an engineered rapamycin-inducible dimerization(RiD)receptor system that triggers a receptor-specific LRR-RK signaling independent of their cognate ligands or endogenous *** the RiD-receptors,we demonstrated that the rapamycin-mediated association of chimeric cytosolic kinase domains from the BRI1/BAK1 receptor/co-receptor,but not the BRI1/BRI1 or BAK1/BAK1 homodimer,is sufficient to activate downstream brassinosteroid signaling and physiological ***,we showed that the engineered RiD-FLS2/BAK1 could activate flagellin-22-mediated immune signaling and *** the RiD system,we also identified the potential function of an unkmown orphan receptor in immune signaling and revealed the differential activities of SERK co-receptors of *** results indicate that the RiD method can serve as a synthetic biology tool for precise temporal manipulation of LRR-RK signaling and for understanding LRR-RK biology.

关键词： leucine-rich repeat receptor kinase brassinosteroids BRI1 BAK1 FLS2

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