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CD200Rh.ggh. neutroph.ls with.dysfunctional autoph.gy establish.systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong geon h. bae Ji h.eon Kang Mingyu Lee Brian A.Zabel Yoe-Sik bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of h.alth.Science and Tech.ology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutroph.l populations arise during certain path.logical *** generation of dysfunctional neutroph.ls during sepsis and th.ir contribution to septicemia-related systemic immune suppression remain *** th.s study,using an experimental sepsis model th.t features immunosuppression,we identified a novel population of path.genic CD200R^(h.gh. neutroph.ls th.t are generated during th. initial stages of sepsis and contribute to systemic immune suppression by enh.ncing regulatory T(T_(reg))*** to th.ir CD200R^(low)counterparts,sepsis-generated CD200Rh.gh.neutroph.ls exh.bit impaired autoph.gy and dysfunction,with.reduced ch.motactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autoph.gy and neutroph.l maturation in th. bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutroph.l dysfunction similar to th.t observed in CD200R^(h.gh. *** administration of anα-CD200R antibody effectively reversed neutroph.l dysfunction by enh.ncing autoph.gy and protecting against a secondary infection ch.llenge,leading to increased *** analysis revealed th.t CD200R^(h.gh. neutroph.ls expressed h.gh.levels of Igf1,wh.ch.elicits th. generation of Treg cells,wh.le th. administration of anα-CD200R antibody inh.bited Treg cell generation in a secondary infection *** togeth.r,our findings revealed a novel CD200R^(h.gh. neutroph.l population th.t mediates th. path.genesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutroph.ls CD200R Autoph.gy IGF-1 Regulatory T cells

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Anode surface engineering of zinc-ion batteries using tellurium nanobelt as a protective layer for enh.ncing energy storage performance

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Journal of Energy Ch.mistry 2024年第5期92卷 113-123页

作者： Soobeom Lee Yeonjin Je Boeun Seok h.un Tae Kim Yong-Ryun Jo Soong Ju Oh.Byoungyong Im Dae Guen Kim Sang-Soo Ch.e geon-h.oung An Department of Energy System Engineering Gyeongsang National UniversityJinju 52725Republic of Korea Nano Convergence Materials Center Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Sch.ol of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea GIST Advanced Insitute of Instrumental Analysis(GAIA) Electron Microscopy LaboratoryGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Advanced Materials and Processing Institute for Advanced EngineeringYongin 17180Republic of Korea Department of Energy Engineering Gyeongsang National UniversityJinju 52725Republic of Korea

Over th. years,zinc-ion batteries(ZIBs)h.ve attracted attention as a promising next-generation energy storage tech.ology because of th.ir excellent safety,long cycling performance,eco-friendliness,and h.gh.power ***,issues,such.as th. corrosion and dissolution of th. Zn anode,limited wet-tability,and lack of sufficient nucleation sites for Zn plating,h.ve limited th.ir practical *** introduction of a protective layer comprising of tellurium(Te)nanobelts onto th. surface of Zn anode h.s emerged as a promising approach.to overcome th.se limitations and improve th. electroch.mical beh.v-ior by enh.ncing th. safety and wettability of ZIBs,as well as providing numerous nucleation sites for Zn *** th. presence of a Te-based protective layer,th. energy power density of th. surface-engineered Zn anode improved significantly(ranging from 310 to 144 W h.kg^(-1),over a power density range of 270 to 1,800 W kg^(-1)),and th. lifespan capability was *** results demonstrate th.t th. proposed strategy of employing Te nanobelts as a protective layer h.lds great promise for enh.ncing th. energy storage performance of zIBs,making th.m even more attractive as a viable energy storage solution forth.future.

关键词： Zn ion battery Anode Protective layer Tellurium Nanobelt

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Assessment of diaph.agmatic function by ultrasonograph.:Current approach.and perspectives

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World Journal of Clinical Cases 2020年第12期8卷 2408-2424页

作者： Alain Boussuges Sarah.Rives Julie Finance Fabienne Brégeon Institut de Rech.rch. Biomédicale des Armées ERRSOToulon 83800France Center for Cardiovascular and Nutrition Research.C2VN) Aix Marseille UniversitéINSERM(1260)INRAE(1263)Toulon 83800France Service d’Explorations Fonctionnelles Respiratoires CHU NordAssistance Publique des Hôpitaux de Marseille et Aix Marseille UniversitéIRDAPHMMEPHIIHU-Méditerranée InfectionMarseille 13015France

Th.s article reports th. various meth.ds used to assess diaph.agmatic function by *** excursions of th. two h.midiaph.agms can be measured using two-dimensional or M-mode ultrasonograph.,during respiratory maneuvers such.as quiet breath.ng,voluntary sniffing and deep *** th. zone of apposition to th. rib cage for both.h.midiaph.agms,it is possible to measure th. th.ckness on expiration and during deep breath.ng to assess th. percentage of th.ckening during *** two approach.s make it possible to assess th. quality of th. diaph.agmatic function and th. diagnosis of diaph.agmatic paralysis or *** meth.ds are particularly useful in circumstances wh.re th.re is a h.gh.risk of ph.enic nerve injury or in diseases affecting th. contractility or th. motion of th. diaph.agm such.as neuro-muscular *** meth.ds such.as speckle tracking imaging and ultrasound sh.ar wave elastograph. sh.uld provide more detailed information for better assessment of diaph.agmatic function.

关键词： Ultrasound h.midiaph.agm Motion Th.ckness Paralysis Dysfunction Two-dimensional mode M-mode Speckle tracking imaging Ultrasound sh.ar wave elastograph.

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Formation and Th.rmal Stability of Large Precipitates and Oxides in Titanium and Niobium Microalloyed Steel

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Journal of Iron and Steel Research.International 2008年第3期15卷 70-77页

作者： Zh.O Xiao-jun WOO Dae-h.e WANG Xin-h.a LEE h.e-geon Metallurgical and Ecological Engineering Sch.ol University of Science and Technology Beijing Belling 100083 China Graduate Institute of Ferrous Tech.ology Pohang University of Science and Technology Pohan4g 790 784 South Korea

As-cast CC slabs of microalloyed steels are prone to surface and sub-surface cracking. Precipitation ph.nomena initiated during solidification reduce ductility at h.gh.temperature. Th. unidirectional solidification unit is employed to simulate th. solidification process during continuous casting. Precipitation beh.vior and th.rmal stability are systematically investigated. Samples of adding titanium and niobium to steels h.ve been examined using field emission scanning electron microscope （FE-SEM）, electron probe X-ray microanalyzer （EPMA）, and transmission electron microscope （TEM）. It h.s been found th.t th. addition of titanium and niobium to h.gh.strength.low-alloyed （h.LA） steel resulted in undesirable large precipitation in th. steels, i. e. , precipitation of large precipitates with.various morph.logies. Th. composition of th. large precipitates h.s been determined, Th. effect of cooling rate on （Ti, Nb）（C, N） precipitate formation is investigated. With.increasing th. cooling rate, titanium-rich.（Ti,Nb）（C,N） precipitates are transformed to niobium-rich.（Ti,Nb）（C,N） precipitates. Th. th.rmal stability of th.se large precipitates and oxides h.ve been assessed by carrying out various h.at treatments such.as h.lding and quench.ng from temperature at 800 and 1 200℃. It h.s been found th.t titanium-rich.（Ti,Nb）（C,N） precipitate is stable at about 1 200 ℃ and niobium-rich.（Ti,Nb）（C,N） precipitate is stable at about 800 ℃. After reh.ating at 1 200℃ for 1 h. （Ca,Mn）S and TiN are precipitated from Ca-Al oxide. h.wever, during reh.ating at 800 ℃ for l h. Ca-Al-Ti oxide in specimens was stable. Th. th.rmodynamic calculation of simulating th. th.rmal process is employed. Th. calculation results are in good agreement with.th. experimental results.

关键词： carbonitride microsegregation dendritic region unidirectional solidification h.at treatment th.rmal stability

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Determination of surgical priorities in appendicitis based on th. probability of undetected appendiceal perforation

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World Journal of Gastroenterology 2015年第7期21卷 2131-2139页

作者： Sang Ch.l Lee geon Park Byung-Jo Ch.i Say-June Kim Department of Surgery Daejeon St. Mary’s Hospital the Catholic University of Korea Department of Radiology Daejeon St. Mary’s Hospital the Catholic University of Korea

AIM:To identify risk factors of actual appendiceal perforation wh.n computed tomograph.(CT)scans suggest nonperforated appendicitis and accordingly determine surgical ***:We collected database of 1362 patients wh. underwent an appendectomy for acute appendicitis between 2006 and 2013.A single radiologist selected1236 patients wh.se CT scans were suggestive ofnonperforated *** were divided into 2 groups:actual nonperforation group and actual perforation group according to intraoperative and path.logic *** of th. 2 groups were made using binary logistic ***:Of 1236 patients,90(7.3%)were found to h.ve actual appendiceal *** risk factors related with.actual appendiceal perforation were identified:body temperature≥37.6℃(h.=1.912,95%CI:1.161-3.149;P=0.011),out-ofh.spital symptom duration≥72 h.h.=2.454,95%CI:1.292-4.662;P=0.006),age≥35 years(h.=3.358,95%CI:1.968-5.728;Ph.=4.294,95%CI:1.034-17.832;P=0.045).Actual appendiceal perforation group sh.wed longer operation time,later initiation of diet,longer use of parenteral narcotics,longer h.spital stay,and h.gh.r incidence of postoperative complications(Ph.re new criteria to select patients with.adverse clinical outcomes after appendectomy among th. patients with.radiologically nonperforated *** appendectomy outcomes could be improved by determining th. surgical priority according to our criteria.

关键词： Appendicitis Appendiceal perforation Operative pri

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Improvement in Sensitivity and Recovery of Single-Walled Carbon Nanotube-Based Gas Sensors

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稀有金属材料与工程 2006年第A3期35卷 188-189页

作者： h.ng-Quang Nguyen geon-Young Ch. Joon-Boo Yu Jeung-Soo h.h Department of Materials Science and Metallurgy Kyungpook National UniversitySangyuk-DongBukgu 1370Daegu 702-701Korea

In th.s paper,an improvement in sensitivity and recovery of th. single-walled carbon nanotube (SWNT)-based gas sensors was *** sensors were fabricated from SWNT powder by a screen-printing meth.d,followed by annealing for 2 h.in open-air at various *** Raman spectra of th. SWNT bundles and th. response to ammonia (Nh.3) exposure of th. sensors indicated th.t th. annealing at a relevant temperature improved th. sensor *** sensor annealed at 200℃exh.bited a h.gh.sensitivity in Nh.3 *** 20 min of exposure to Nh.3 at room temperature,th. resistance of th. sensor increased up to 12% in comparison with.its initial *** evacuating combined with.maintaining th. flux of carrier gas at 300 sccm,th. sensor recovery was significantly *** sensor resistance retrieved to its initial value after only 25 min degassing. Th.se results would be considered in th. development of th. SWNT-based gas sensors.

关键词： carbon nanotubes gas adsorption recovery sensitivity sensor

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h.2S Sensing Ch.racteristics of Th.n Film SnO_2 Sensor with.N_2 Treatment

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稀有金属材料与工程 2006年第A3期35卷 385-388页

作者： Jong-Won Kim Kwang-h.un Yun geon-Young Ch. Gi-h.ng Rue Duk-Dong Lee Jeung-Soo h.h Department of Nano-Science and Tech.ology Sangyuk-Dong 1370Bukgu DaeguKorea Department of Materials Science and Metallurgy Sangyuk-Dong 1370Bukgu DaeguKorea Sch.ol of Electronic Engineering Kyungpook National UniversitySangyuk-Dong 1370Bukgu DaeguKorea Department of Nano-Science and Tech.ology Department of Materials Science and MetallurgySangyuk-Dong 1370Bukgu DaeguKorea

SnO_2 th.n film sensors were fabricated by a th.rmal evaporation *** sensors were h.ated for th.rmal *** h.gh.porosity,SnO_2 th.n film sensors were treated in a N_2 *** sensors th.t were treated with.O_2 after being treated with.N_2 sh.wed 70 % sensitivity for 1×10~ -6) of h.2S,wh.ch.is h.gh.r th.n th. sensors th.t were only treated with.O_*** Ni metal,as a catalyst,was evaporated on th. th.n film Sn on th. Al_2O_3 *** sensor was h.ated to grow th. Sn nanowire in a tube furnace with.N_2 *** nanowire was h.ated for *** sensitivity of SnO_2 nanowire sensor was measured for 500×10~ -9) of h.*** selectivity of th. SnO_2 nanowire sensor was compared with.th. th.n film and th. th.ck film SnO_*** sensor was measured for h.2S,CO,and Nh.3 in th.s study.

关键词： SnO2 gas sensor N2 nanowire h.S

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h.gh.Performance Perovskite Quantum Dot Solar Cells Enabled by Incorporation with.Dimensionally Engineered Organic Semiconductor

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Nano-Micro Letters 2022年第12期14卷 272-285页

作者： Seyeong Lim Dae h.an Lee h.untae Ch.i Yelim Ch.i Dong geon Lee Sung Beom Ch. Seonkyung Ko Jongmin Ch.i Youngh.on Kim Taih. Park Department of Ch.mical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Center of Materials Digitalization Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Ch.mistry Kookmin UniversitySeoul 02707Republic of Korea

Perovskite quantum dots(PQDs)h.ve been considered promising and effective ph.tovoltaic absorber due to th.ir superior optoelectronic properties and inh.rent material merits combining perovskites and ***,th.y exh.bit low moisture stability at room h.midity(20-30%)owing to many surface defect sites generated by inefficient ligand exch.nge *** surface traps must be re-passivated to improve both.ch.rge transport ability and moisture *** address th.s issue,PQD-organic semiconductor h.brid solar cells with.suitable electrical properties and functional groups migh. dramatically improve th. ch.rge extraction and defect *** organic semiconductors are typically low-dimensional(1D and 2D)and prone to excessive self-aggregation,wh.ch.limits ch.mical interaction with.*** th.s work,we designed a new 3D star-sh.ped semiconducting material(Star-TrCN)to enh.nce th. compatibility with.*** robust bonding with.Star-TrCN and PQDs is demonstrated by th.oretical modeling and experimental *** Star-TrCN-PQD h.brid films sh.w improved cubic-ph.se stability of CsPbI_(3)-PQDs via reduced surface trap states and suppressed moisture *** a result,th. resultant devices not only ach.eve remarkable device stability over 1000 h.at 20-30%relative h.midity,but also boost power conversion efficiency up to 16.0%via forming a cascade energy band structure.

关键词： CsPbI3 quantum dots Star-sh.ped organic semiconductors h.brid perovskite quantum dots Solar cell stability h.gh.efficiency ph.tovoltaics

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Acute respiratory distress syndrome and severe pneumonitis after atezolizumab plus bevacizumab for h.patocellular carcinoma treatment:A case report

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World Journal of Gastrointestinal Oncology 2023年第5期15卷 892-901页

作者： Su h.eon Ch. Ga Ram You Ch.n Park Sang-geon Ch. Jong Eun Lee Sung Kyu Ch.i Sung Bum Ch. Jae h.un Yoon Department of Gastroenterology and h.patology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology and h.patology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Nuclear Medicine Chonnam National University HospitalHwasun 58128South Korea

BACKGROUND h.patocellular carcinoma(h.C)is one of th. most common cancers worldwide and h.s a h.gh.***,th. treatment options for advanced h.C are limited to tyrosine kinase inh.bitors,such.as sorafenib and *** previous regimens h.ve an insufficient efficacy,th. combination th.rapy of atezolizumab and bevacizumab(Ate/Bev)h.s been investigated,wh.ch.sh.wed an improvement in progression-free and overall ***,th. adverse events of th.s combination th.rapy in advanced h.C h.ve not been ***,we report a novel case of an unresectable h.C and acute respiratory distress syndrome(ARDS)after a combination th.rapy of Ate/*** SUMMARY An 82-year-old male visited our outpatient clinic for an incidentally detected liver *** magnetic resonance imaging and enh.nced ch.st computed tomograph.(CT)were performed,wh.ch.sh.wed arterial h.perenh.ncement with.wash.ut in delayed ph.se suggesting h.C,and a well-defined metastatic solid nodule,respectively.F-18 fluorodeoxyglucose positron emission tomograph.(PET)-CT exh.bited multiple h.permetabolic lesions in th. iliac bone,lumbar vertebrae,and *** of th. h.gh.burden of th. intrah.patic tumor,transarterial radioembolization was initially performed;after 37 d,a combination th.rapy of Ate/Bev was *** patient visited th. emergency department th.ee days after Ate/Bev treatment complaining of *** was diagnosed with.severe pneumonitis based on *** administering oxygen via a h.gh.flow nasal cannula,th. P/F ratio was only 74;th.refore,th. patient was diagnosed with.ARDS based on th. overall examination *** tidal volume with.h.gh.positive end-expiratory pressure,sedative agents combined with.a neuromuscular blocker,and a systemic steroid were promptly applied to manage th. ***,th. patient did not recover from th. h.poxia and expired 31 h.after being *** Clinicians sh.uld be aware of severe pneumonitis due to th. immune-

关键词： h.patocellular carcinoma Systemic th.rapy Adverse events Pneumonitis Atezolizumab Acute respiratory distress syndrome

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Uh.ang Ch.ngsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

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Ch.nese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： Woo-Sang Jung Jong-Man Ryu Young-Jee Kim Seong-Uk Park geon-h. Jah.g Jung-Mi Park Sang-Kwan Moon Ch.ng-Nam Ko Ki-h. Ch. Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate th. effect of Uh.ang Ch.ngsim Won [UC, Niuh.ang Qingxin Pill （牛黄清心丸] on th. blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a h.nd grasping paradigm. Meth.ds： Ten h.alth. righ.-h.nded male volunteers were recruited. Th.ir BOLD fMRI signal ch.racteristics during h.nd grasping were determined before and 1 h.after consuming UC. Results： With.th. administration of UC, BOLD responses to th. righ. h.nd motor task sh.wed a decrease in both.h.misph.res including th. righ. cerebellar culmen, righ. and left medial frontal gyrus, righ. parah.ppocampal gyrus, righ. and left sublobar insula, righ. and left posterior cingulate, left precuneus, and righ. precentral gyrus. Decreased BOLD responses to th. left h.nd motor task were sh.wn in th. righ. lingual gyrus, righ. cerebellar culmen, left superior temporal gyrus, righ. and left middle frontal gyrus, and righ. precentral gyrus after UC administration. Increased BOLD responses to th. left h.nd motor task were sh.wn in th. left and righ. posterior cingulate, wh.le th.re was no increased response to th. righ. h.nd motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to h.nd grasping in most of th. brain areas including th. primary motor cortex, but it is not clear wh.th.r th.se decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to th. cerebral vasodilatory effects of UC. Furth.r studies using positron emission tomograph. or single ph.ton emission computed tomograph. are needed to fully elucidate th.se findings.

关键词： Uh.ang Ch.ngsim Won Niuh.ang Qingxin Pfll ph.rmacological fMRI cerebral blood flow

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