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Update on the laboratory diagnosis and monitoring of HIV infection

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Cell Research 2005年第Z1期15卷 870-876页

作者： Niel T CONSTANTINE William kabat Richard Y ZHAO Department of Pathology University of Maryland School of Medicine BaltimoreMD 21201-1192 USAInstitute of Human Virology Baltimore MD 21201-1192 USA Children’s Memorial Hospital Chicago IL 60614-3363 USA Department of Pathology University of Maryland School of Medicine BaltimoreMD 21201-1192 USADepartment of Microbiology and ImmunologyUniversity of Maryland School of Medicine BaltimoreMD 21201-1192 USAInstitute of Human Virology Baltimore MD 21201-1192 USA

In China, the estimated number of HIV infected cases is approaching one million. Although public education has been initiated for awareness and behavioral modification for this devastating infection, better diagnostic methods are needed to identify infected persons and manage infection. Simple and more accurate diagnostic tools have become available, particularly for early detection and to monitor treatment in those who receive anti-retroviral treatment. In this short review, we summarize some of the common and new methodologies that can be used in clinical laboratories, in the field, or in private laboratories. These range from simple antibody tests to more sophistical methods that are used to monitor disease progression and identify drug resistance. These tools can assist physicians, medical practitioners, and laboratory personnel to select suitable diagnostic tools for the diagnosis, blood screening, monitoring of disease progression, and for detection of drug resistance to anti-retroviral therapies.

关键词： HIV diagnosis viral load drug resistance.

A Heuristic Algorithm for Core Selection in Multicast Routing

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Journal of Computer Science & Technology 2011年第6期26卷 954-961页

作者： Manas Ranjan kabat Manoj Kumar Patel Chita Ranjan Tripathy Department of Computer Science and Engineering Veer Surendra Sai University of Technology

With the development of network multimedia technology, more and more real-time multimedia applications need to transmit information using multicast. The basis of multicast data transmission is to construct a multicast tree. The main problem concerning the construction of a shared multicast tree is selection of a root of the shared tree or the core point. In this paper, we propose a heuristic algorithm for core selection in multicast routing. The proposed algorithm selects core point by considering both delay and inter-destination delay variation. The simulation results show that the proposed algorithm performs better than the existing algorithms in terms of delay variation subject to the end-to-end delay bound. The mathematical time complexity and the execution time of the proposed algorithm are comparable to those of the existing algorithms.

关键词： QoS routing multicast routing delay-variation end-to-end delay

Hybrid IWD-DE:A Novel Approach to Model Cooperative Navigation Planning for Multi-robot in Unknown Dynamic Environment

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Journal of Bionic Engineering 2019年第2期16卷 235-252页

作者： Degal Chandrasekhar Rao Manas Ranjan kabat Pradipta Kumar Das Prabir Kumar Jena Department of Information Technology VSSUTBurlaOdisha 768018India Department of Computer Science&Engineerings VSSUT、Burla Odisha 76801&India Department of Mechanical Engineering VSSUTBurlaOdisha 76801&India

The current study emphasizes inadequacies of earlier research findings on multi-robot navigation and offers a robust approach to guide the robots in an unknown dynamic *** attain the objective,the Intelligent Water Drop(IWD)algorithm is combined with Differential Evolution(DE)in a new conceptual fashion to optimize the navigation path of multiple mobile *** hybrid IWD-DE,basic IWD and DE algorithms are then explored for multi-robot navigation in a dynamic workspace through *** simulation outcomes demonstrate the competency of the proposed method to guide the robot in predicting the nature of the obstacle and to generate an optimal and safe trajectory in a dynamic *** potency of the proposed algorithm is further validated through experimentation with fire bird robot in a real *** outcomes of the simulation and experimentation,by employing IWD-DE algorithm are compared with those of basic IWD and DE *** error estimated for Average Navigation Path Travelled(ANPT),Aggregate Navigation Path Deviation(ANPD)and number of turns between simulation and experimental results by employing IWD-DE is 8.96,9.09,and 11.13,respectively while reaching 16.43,28.61,29.15 for IWD,and 6.66,10.20,14.28 for *** efficiency of the proposed approach is further verified with the state-of-the-art in a dynamic *** outcomes reveal the efficiency and flexibility of the proposed approach in resolving the multi-robot navigation problem as compared to the state-of-the-art in a dynamic workspace.

关键词： multi-robot dynamic environment intelligent water drop differential evolution navigation planning waypoints fire bird robot

National Identity as a Useful Tool for Setting Limits to European Integration

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International Relations and Diplomacy 2018年第3期6卷 143-151页

作者： Danuta kabat-Rudnicka University of Economics CracowPoland

The European Union law,a new order of international law,permeates the legal orders of the Member States,binding not only states but also ***,this permeation of the European Union law into the constitutional orders of the Member States is not *** of the limits is the national identity,understood as the constitutional *** legal terms,the concept of national identity is narrower than the one,characteristic for the national *** it is the constitutional identity that shapes the relationship between the European Union and the Member *** purpose of this study is to show the relationship between the European Union legal order and legal(constitutional)orders of the Member *** will focus on such aspects as:national and constitutional identity,the concept of national identity shaped by the case law of the European Court of Justice and the significance of constitutional identity in the jurisprudence of constitutional courts.

关键词： national identity constitutional identity constitutional courts Court of Justice EU

一株人抗人A—血型物质单克隆抗体特异性的研究

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生物化学杂志 1991年第1期7卷 110-116页

作者：陈华堂 Larrick J kabat E.A 安徽医科大学生化教研室 Cetus lmmune Corporation Palo Alto CA94303 Departments of Microbiology Genetics and Development and Neurology College of Physicians and Snrgeona Columbia University New Yolk N. Y. 10032. U. S. A.

本文对一株人抗人A-血型物质单克隆抗体,用定量免疫沉淀法以及ELISA研究其与多种单糖、双糖及寡糖的反应性,从而确定了其结合部位的结构特异性。实验发现其结合部位互补于含有双分子岩藻糖残基的A-t糖:这一研究进一步强调了含有双分子... 详细信息

本文对一株人抗人A-血型物质单克隆抗体,用定量免疫沉淀法以及ELISA研究其与多种单糖、双糖及寡糖的反应性,从而确定了其结合部位的结构特异性。实验发现其结合部位互补于含有双分子岩藻糖残基的A-t糖:这一研究进一步强调了含有双分子岩藻糖残基的A血型抗原决定簇的重要性。

关键词：单克隆抗体结合部位抗原决定基

The Mindful Way through Depression: Freeing Yourself from Chronic Unhappiness First Printing

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2007年

作者： Mark Williams John Teasdale Zindel Segal Jon kabat-Zinn

ISBN: (数字)9781593851286

ISBN: (纸本)9781593851286

If you’ve ever struggled with depression, take heart. Mindfulness, a simple yet powerful way of paying attention to your most difficult emotions and life experiences, can help you break the cycle of chronic unhappiness once and for all. In The Mindful Way through Depression , four uniquely qualified experts explain why our usual attempts to think” our way out of a bad mood or just snap out of it”

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木菠萝凝集素结合部位糖的特异性

生物化学杂志 1991年第2期7卷 164-170页

作者：陈华堂 Liao J kabat E.A 安徽医科大学生物化学教研室 Departments of Microbiology Genetics and Developmentand NeurologyCollege of Physicians and Surgeons Columbia University New York 10032 U.S.A.

用定量免疫沉淀法和定量免疫沉淀抑制法研究了从木菠萝(Arthrocarpus integrifolia)种子提取的凝集素(jacalin)结合部位糖的特异性。Jacalin最强烈地沉淀含有DGalβ1→3DGalNAc结构的无活性抗冻糖蛋白,不同程度非特异地沉淀各种血型物... 详细信息

用定量免疫沉淀法和定量免疫沉淀抑制法研究了从木菠萝(Arthrocarpus integrifolia)种子提取的凝集素(jacalin)结合部位糖的特异性。Jacalin最强烈地沉淀含有DGalβ1→3DGalNAc结构的无活性抗冻糖蛋白,不同程度非特异地沉淀各种血型物质。研究发现凝集素结合部位对DGalβ→3DGalNAc有最高特异性。最强抑制剂是DGalβ1→3DGalNAcal→φNO_2,其抑制活性分别比DGalNAc和DGal高380倍和1000倍。对于各种甲基化或对硝基酚化的糖苷以及寡糖,除methylaDGalNAc_f外,仅α-构型表现出抑制活性,所有β-构型的糖苷均无抑制活性,jacalin结合部位对糖的结合是构型依赖性的。

关键词：糖特异性凝集素结合部位

HIV-1蛋白酶和逆转录酶抗药基因变异检测方法的建立及临床应用

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中华实验和临床病毒学杂志 2000年第4期14卷 325-329页

作者：俞敏 William kabat 王健伟洪涛 Ram Yogev 赵玉琪美国西北大学附属儿童医院美国西北大学儿科系美国西北大学免疫及微生物系中国预防医学科学病毒学研究所病毒形态学研究室

目的　应用现有DNA序列分析技术对人类免疫缺陷病毒 1型 (HIV 1)的蛋白酶 (PR)和逆转录酶 (RT)基因进行简便、快速、准确的序列分析 ,在临床上为HIV 1患者治疗方案的确定提供可靠依据。方法　从HIV 1感染者血清中提取RNA ,用套式逆转录... 详细信息

目的　应用现有DNA序列分析技术对人类免疫缺陷病毒 1型 (HIV 1)的蛋白酶 (PR)和逆转录酶 (RT)基因进行简便、快速、准确的序列分析 ,在临床上为HIV 1患者治疗方案的确定提供可靠依据。方法　从HIV 1感染者血清中提取RNA ,用套式逆转录聚合酶链反应 (RT PCR)扩增HIV 1的PR和RT基因片段 ,并对此片段进行核苷酸序列分析。结果　本方法对血清中HIV 1RNA含量约 2 0 0 0拷贝 ml以上的样品都能有效扩增。在序列分析时背景干扰少 ,对 2 5 %左右的混合序列均能准确反映。通过对临床治疗病人进行动态序列分析观察 ,发现在药物治疗过程中 ,病人血浆中HIV 1RNA含量变化与PR和RT基因抗药性变异具有很大相关性。结论　PR和RT基因序列分析方法能够及时、准确地反映HIV 1患者在抗病毒药物治疗过程中病毒的变异情况。该方法的建立能在临床上能为不同患者治疗方案的确定提供直接。

关键词： HIV-1 蛋白酶逆转录酶序列分析耐药性

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非吸烟者肺癌

国外医学(肿瘤学分册) 1984年第6期11卷 365-366页

作者： kabat Wynder 王允惠

在1971和1980年之间调查了近期诊断的2668例肺癌,非吸烟者为134例。男性占总数的1.9%,女性占总数的13.0%,男女之比为1:2.6。与全部肺癌相比,非吸烟者病例,特别是女性,KreybergⅡ型(腺癌为主)居多。相等数量病例,其年龄、性别、种族及非... 详细信息

在1971和1980年之间调查了近期诊断的2668例肺癌,非吸烟者为134例。男性占总数的1.9%,女性占总数的13.0%,男女之比为1:2.6。与全部肺癌相比,非吸烟者病例,特别是女性,KreybergⅡ型(腺癌为主)居多。相等数量病例,其年龄、性别、种族及非吸烟者住院配对对照,宗教、出生国籍、婚姻状况、居住(城、乡)、饮酒或Quetelet’s 指数均无差异。男性病例比对照组受教育多,有职

关键词：肺癌腺癌肺肿瘤腺瘤吸烟者男性病例