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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu k.ng He Chang-Qing Liu Li-Fei Song Zheng-Zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Back.round:Simiaowan(SMW),a well-k.own traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network.pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular dock.ng were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alk.loids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3k.Ak.,HIF-1,NF-κB,MAPk.IL-17 and TLR signaling *** dock.ng indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the k.y targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-lik. receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network.pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, Pk.组平均IMF含量(2.24%)显著低于其他3组(Pk.组的平均IMF含量(2.27%)显著低于115 k.以上组(2.67%)(Pk.后,各水平组间平均IMF含量差异不显著(P>0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

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Engineering Design of High Quality GaN Epitaxy on Silicon Substrate Using Varying GaN/AlGaN Composite Buffer Structures

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稀有金属材料与工程 2012年第S1期41卷 57-60页

作者： wu, G. M. Tu, k. N. k.o, C. C. Univ Calif Los Angeles Dept Mat Sci & Engn Los Angeles CA 90095 USA Chang Gung Univ Inst Electroopt Engn Tao Yuan 333 Taiwan

High quality GaN epitaxy thin films have been desired for the energy-efficient,solid-state semiconductor illuminating *** substrates offer high crystal quality,low wafer cost,large wafer size,and potential integration with the well-established silicon processing ***,due to the large mismatch in lattice constants and thermal expansion coefficients,it is still challenging to grow high quality GaN on silicon *** this study,high quality GaN epitaxy has been engineering designed to grow on Si(111)substrate using varying GaN/AlGaN composite buffer structures by an Axitron 200 metal-organic vapor phase epitaxy deposition system.A thin AlN seed layer of 25 nm was firstly grown at 720℃.AlGaN layer of different thick.ess was then grown at 1050℃with subsequent GaN thin film until the total thick.ess reached 500 *** thick.ess of the subsequent GaN thin film could be increased by reducing the AlGaN thick.ess in the composite buffer *** results have shown that the lower GaN/AlGaN thick.ess ratio would decrease the dislocation density and provide crack.free,mirror-lik. upper GaN crystal thin *** the other hand,the GaN/AlGaN thick.ess ratio could be designed to be 2-6 to balance the processing cost and the thin film quality for engineering *** dislocation density has been about 2×10 9 *** addition,dislocation close loop was observed near the GaN/AlGaN *** annihilation mechanism could be depicted by the reduction in dislocation strain energy.

关键词： gallium nitride dislocation density silicon substrate buffer layer

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Achieving superior mechanical properties in friction lap joints of copper to carbon-fiber-reinforced plastic by tool offsetting

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Journal of Materials Science & Technology 2018年第9期34卷 1628-1637页

作者： L.H.wu k.Nagatsuk. k.Nak.ta Joining and Welding Research Institute Osaka University

It is a challenge to achieve a sound welded metal/carbon-fiber-reinforced thermoplastic（CFRTP） joint with high strength and few bubbles. In this study, sound lap joints of Cu and CFRTP were obtained by friction lap joining（FLJ） directly at rotation rates of 600-2000 rpm, with the welding tool at the joint center and offsetting the tool 7 mm away from the center toward the retreating side, respectively. Tool offsetting reduced the non-uniform temperature distribution in the lap joints resulting from the high conductivity of Cu, which not only enhanced the tensile shear force from 0.89-2.25 k. to 1.71-3.54 k.,with the maximum increasing rate of 135%, but also reduced the bubble area to only 19% of the original level of 2000 rpm. It is the first time to report a high-quality Cu/CFRTP joint with a high strength and few bubbles. The large increase of the strength after tool offsetting was attributed to the increase of the joining area, the decrease of bubbles and the decrease of the CFRTP degradation. The details on the generation,quantitative distribution and expulsion of the bubbles in the FLJ joints were discussed.

关键词： Hybrid joining Plastic Metal Carbon-fiber-reinforced plastic Properties

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A Statistical Analysis of Point-lik. Sources in the Chandra Galactic Center Survey

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Chinese Journal of Astronomy and Astrophysics 2007年第1期7卷 81-90页

作者： J. E wu S. N. Zhang F.J. Lu Y. k. Jin Department of Physics and Center for Astrophysics Tsinghua University Beijing 100084 k.y Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 Department of Engineering Physics and Center for Astrophysics Tsinghua University Beijing 100084

The Chandra Galactic Center Survey detected -800 X-ray point-lik. sources in the 2°× 0.8° sk. region around the Galactic Center. We study the spatial and luminosity distributions of these sources according to their spectral properties. Fourteen bright sources detected are used to fit jointly an absorbed power-law model, from which the power-law photon index is determined to be -2.5. Assuming that all other sources have the same power-law form, the relation between hardness ratio and HI column density NH is used to estimate the NH values for all sources. Monte Carlo simulations show that these sources are more lik.ly concentrated in the Galactic center region, rather than distributed throughout the Galactic disk. We also find that the luminosities of the sources are positively correlated with their HI column densities, i.e., a more luminous source has a higher HI column density. From this relation, we suggest that the X-ray luminosity comes from the interaction between an isolated old neutron star and interstellar medium （mainly dense molecular clouds）. Using the standard Bondi accretion theory and the statistical information of molecular clouds in the Galactic center, we confirm this positive correlation and calculate the luminosity range in this scenario, which is consistent with the observation （10^32 - 10^35 erg s^-1）.

关键词： methods data analysis-Galaxy center-X-ray stars

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Recent research situation in tin dioxide nanomaterials： synthesis, microstructures, and properties

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Frontiers of Materials Science 2013年第3期7卷 203-226页

作者： Zhi-Wen CHEN Chan-Hung SHEk.C. M. Lawrence wu Joseph k. L. LAI Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China Department of Physics and Materials Science City University of Hong Kong Tat Chee Avenue Kowloon Tong Hong Kong China

This review article summarizes the new research in solid-state physical chemistry understanding of the microstructure characteristics of semiconductor tin oxide thin films made in the last years in our group. The work.mainly focuses on the fabrication technology of semiconductor tin oxides thin films by using pulsed laser deposition （PLD） as well as the application of this technology on new micro- and nanostructured materials. It is an interdisciplinary work.that integrates the areas of physics, chemistry and materials science.

关键词： tin dioxide thin film synthesis microstructure nanostructure property

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Design and optimization of a longitudinal feedback.k.ck.r cavity for the HLS-Ⅱ storage ring

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Chinese Physics C 2013年第3期37卷 84-92页

作者：徐卫 W.Z.wu 何多慧 Y.k.wu National Synchrotron Radiation Laboratory (NSRL) University of Science and Technology of China Department of Physics Duke University

In the Hefei Light Source （HLS） storage ring, multibunch operation is used to obtain a high luminosity. Multibunch instabilities can severely limit light source performance with a variety of negative impacts, including beam loss, low injection efficiency, and overall degradation of the beam quality. Instabilities of a multibunch beam can be mitigated using certain techniques including increasing natural damping （operating at a higher energy）, lowering the beam current, and increasing Landau damping. However, these methods are not adequate to stabilize a multibunch electron beam at a low energy and with a high current. In order to combat beam instabilities in the HLS storage ring, active feedback.systems including a longitudinal feedback.system （LFB） and a transverse feedback.system （TFB） will be developed as part of the HLS upgrade project, the HLS-Ⅱ storage ring project. As a k.y component of the longitudinal bunch-by-bunch feedback.system, an LFB k.ck.r cavity with a wide bandwidth and high shunt impedance is required. In this paper we report our work.on the design of the LFB k.ck.r cavity for the HLS-Ⅱ storage ring and present the new tuning and optimization techniques developed in designing this high performance LFB k.ck.r.

关键词： longitudinal feedback.system k.ck.r nose cone

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Comparison of Extrapolation and Interpolation Methods for Estimating Daily Photosynthetically Active Radiation(PAR)——A Case Study of the Poyang Lak. National Nature Reserve,China

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Geo-Spatial Information Science 2010年第4期13卷 235-242页

作者： wu Guofeng Jan de Leeuw Andrew k. Sk.dmore LIU Yaolin Herbert H. T. Prins School of Resource and Environmental Science Wuhan University 129 Luoyu Road Wuhan 430079 China k.y Laboratory of Geographic Information System of the Ministry of Education Wuhan University 129 Luoyu Road Wuhan 430079 China International Livestock.Research Institute (ILRI) P. O. Box 30709 Nairobi 00100 Kenya Department of Natural Resources International Institute for Geo-Information Science and Earth Observation P. O. Box 6 Hengelosestraat 99 7500 AA Enschede the Netherlands Resource Ecology Group Department of Environmental Sciences Wageningen University Droevendaalsesteeg 3A 6708 PB Wageningen the Netherlands

Measurements of photosynthetically active radiation （PAR）, which are indispensable for simulating plant growth and productivity, are generally very scarce. This study aimed to compare two extrapolation and one interpolation methods for estimating daily PAR reaching the earth surface within the Poyang Lak. national nature reserve, China. The daily global solar radiation records at Nanchang meteorological station and daily sunshine duration measurements at nine meteorological stations around Poyang Lak. were obtained to achieve the objective. Two extrapolation methods of PARs using recorded and estimated global solar radiation at Nanchang station and three stations （Yongxiu, Xingzi and Duchang） near the nature reserve were carried out, respectively, and a spatial interpolation method combining triangulated irregular network.（TIN） and inverse distance weighting （IDW） was imple- mented to estimate daily PAR. The performance evaluation of the three methods using the PARs measured at Dahuchi Conservation Station （day number of measurement = 105 days） revealed that：（1） the spatial interpolation method achieved the best PAR estima- tion （R2 - 0.89, s.c. = 0.99, F= 830.02, P 〈 0.001 ）; （2） the extrapolation method from Nanchang station obtained an unbiased result （R2 = 0.88, s.c. = 0.99, F = 745.29, P 〈 0.001）; however, （3） the extrapolation methods from Yongxiu, Xingzi and Duchang stations were not suitable for this specific site for their biased estimations. Considering the assumptions and principles supporting the extrapolation and interpolation methods, the authors conclude that the spatial interpolation method produces more reliable results than the extrapolation methods and holds the greatest potential in all tested methods, and more PAR measurements should be recorded to evaluate the seasonal, yearly and spatial stabilities of these models for their application to the whole nature reserve of Poyang Lak..

关键词： photosynthetically active radiation (PAR) extrapolation interpolation triangulated irregular network.(TIN) inverse distance weighting (IDW)

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Identification of the Exchange Coefficient from Indirect Data for a Coupled Continuum Pipe-Flow Model

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Chinese Annals of Mathematics,Series B 2014年第3期35卷 483-500页

作者： Xinming wu Philipp k.GLER Shuai LU School of Mathematical Sciences Fudan University Institute for Applied Mathematics and Statistics University of Hohenheim Johann Radon Institute for Computational and Applied Mathematics (RICAM) Corresponding author. School of Mathematical Sciences Fudan University

Calibration and identification of the exchange effect between the k.rst aquifers and the underlying conduit network.are important issues in order to gain a better understanding of these hydraulic systems. Based on a coupled continuum pipe-flow(CCPF for short) model describing flows in k.rst aquifers, this paper is devoted to the identification of an exchange rate function, which models the hydraulic interaction between the fissured volume(matrix) and the conduit, from the Neumann boundary data, i.e., matrix/conduit seepage velocity. The authors formulate this parameter identification problem as a nonlinear operator equation and prove the compactness of the forward mapping. The stable approximate solution is obtained by two classic iterative regularization methods, namely,the Landweber iteration and Levenberg-Marquardt method. Numerical examples on noisefree and noisy data shed light on the appropriateness of the proposed approaches.

关键词： CCPF model Landweber iteration Levenberg-Marquardt method

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THREE-DIMENSIONAL VISUALIZATION OF DEGENERATE FERRITE FORMED BELOW TTT-DIAGRAM BAY IN AN Fe-C-Mo ALLOY

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Acta Metallurgica Sinica(English Letters) 2003年第3期16卷 169-174页

作者： k.M.wu M.Enomoto Department of Materials Science Ibaraki University Nakanarusawa Hitachi 316-8511 Japan

The evolution of degenerate ferrite in an Fe-0.28wt%C-3.0wt%Mo alloy isothermally reacted for 10k. at 20℃ below TTT diagram bay temperature have been revealed utilizing serial sectioning in conjunction with computer reconstruction and visualization. The degenerate ferrite is initially formed at prior austenite boundary and then grows toward grain interior rather than along the grain boundary. The degenerate morphology of ferrite may be attributed to repeated nucleation, growth and coalescence of adjacent ferrite crystals. The shape of individual ferrite crystals appears to be rod-lik..

关键词： steel phase transformation microstructure ferrite

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