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Investigation of Novel Plant Maerua Shrub (<i>Maerua subcordata</i>) for Cheap and Efficient Bioethanol Production in Kenya

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Journal of Agricultural Chemistry and Environment 2021年第3期10卷 305-313页

作者： Wesley Rerimoi Kangor Kiplagat Ayabei Samuel Lutta geoffrey maiyoh Department of chemistry and Biochemistry University of Eldoret Eldoret Kenya Department of Biochemistry and Clinical Chemistry School of Medicine Moi University Eldoret Kenya

Bioethanol is an attractive source of energy when compared to fossil fuel. It is renewable and environmentally friendly due to its low toxicity and biodegradability. The first generation bioethanol derived from is limited by the high cost of production of these crops and danger posed to food security. This study investigated the use of wild maerua shrub in production of bioethanol in comparison to cultivated food crops. Fermentation was done using Yeasts Y1, Y2 and Y3. Yeasts Y1 and Y2 were isolated from finger millet malt, while Y3 was the commercial yeast Saccharomyces cerevisiae. Fermented plant samples were distilled, oxidized and analysed at 595nm using UV-Visible spectrophotometer. Statgraphics centurion XVI.I was used for statistical analyses. The concentration (g/L) was obtained from a formula and converted to (g/L).The ethanol concentration (g/L) and productivity (g/L/h) were as follows;cassava (64.052 ± 0.098;1.334), maize (66.670 ± 0.227;1.389), sorghum (62.382 ± 2.148b;1.300) and maerua shrub (61.988 ± 0.160, 1.291) which were significantly higher compared to sugarcane molasses (49.978 g/L, 1.041) when fermented by Y2. Mean ethanol concentration (g/L) and productivity (g/L/h) for plants across all yeasts were comparable (p-value = 0.4239). Maerua Shrub should be used as an alternative sugar source for bioethanol production.

关键词： Maerua Shrub Bioethanol Biofuel Productivity Fermentation Feedstock

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Pharmacokinetic,Physicochemical and Medicinal Properties of N-glycoside Anti-cancer Agent More Potent than 2-Deoxy-D-Glucose in Lung Cancer Cells

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 165-176页

作者： Fidelis Toloyi Ndombera geoffrey K.K.maiyoh Vivian C.Tuei Covance Laboratories Inc.BioPharm CMC solutions Greenfield46140IndianaUSA Chemistry Department Wayne State UniversityDetroit48201MichiganUSA Department of Medical Biochemistry School of MedicineMoi University30100EldoretKenya Johannesburg Institute for Advanced Study An initiative of the University of Johannesburg and Nanyang Technological UniversitySingapore1 Tolip StreetWestdene 2092P.O Box 524Auckland Park 2006JohannesburgSouth Africa Department of Chemistry and Biochemistry School of ScienceUniversity of Eldoret30100EldoretKenya

Acetylated N-xyloside of 1-naphthylamine(K8A)has been shown to be more potent than 2-deoxy-D-glucose in lung cancer cells and has therapeutic potential for further drug *** this paper we evaluate and report cytotoxicity,pharmacokinetic,physicochemical and medicinal properties of this D-Xylose derivative(K8A)as a lead anticancer agent with greater therapeutic potential than 2-deoxy-D-glucose(2-DG).2-DG has been in clinical trials for treatment of solid tumors and other types of *** demonstrate using virtual tools that K8A has better“drug-likeness”than 2-DG and does not violate any Lipinski,Ghose,Veber,Egan or Muegge *** the other hand,2-DG violates Ghose and Muegge rules.A“BOILEDegg evaluation”,predicts that K8A has higher gastrointestinal absorption(HIA)than 2-DG and is not effluxed by P-glycoprotein(P-gp).Additionally,K8A does not penetrate the blood brain barrier(BBB)and is not a substrate of most Cytochrome P450(CYP)***,K8A did not show false positive alert from PAINS screening enabling us to narrow down and rule out false ***,K8A is more potent than 2-DG in H1299 and A549 lung cancer cells.

关键词： Anticancer agent N-glycoside 2-deoxy-D-glucose pharmacokinetics lung cancer

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