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Effective anti-inflammatory phenolic compounds from dandelion:identification and mechanistic insights using UHPLC-ESi-MS/MS,fluorescence quenching and anisotropy,molecular docking and dynamics simulation

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Food Science and Human Wellness 2023年第6期12卷 2184-2194页

作者： Hui Zou Tingting Ben Ping Wu geoffrey i.n.waterhouse Yilun Chen College of Food Science and Engineering Shandong Agricultural UniversityKey Laboratory of Food Processing Technology and Quality Control in Shandong ProvinceTai’an 271018China School of Chemical Sciences University of AucklandAuckland 1142New Zealand

This novel study identifi es the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins(toll-like receptor 4,TLR4;co-receptor myeloid differentiation protein-2,MD-2)using UHPLC-ESi-MS/MS,lipopolysaccharide(LPS)-stimulated THP-1 cell line,fluorescence quenching and anisotropy,molecular docking(single ligand and multi-ligand docking)and molecular dynamics simulation.A 50%aqueous methanol extract had a greater anti-inflammatory effect and higher chicoric acid content,compared with the 100%water and 100%methanol *** acid,chlorogenic acid,methylophiopogonone A,caffeic acid,gallic acid monohydrate and 4’-O-demethylbroussonin A had relatively high binding energies and contents in all *** acid competed with chlorogenic acid,4’-O-demethylbroussonin A and quercetin for *** dandelion’s phenolics,chicoric acid most effectively hindered TLR4-MD-2 complex formation,with a quenching constant of 0.62×10^(6) L/mol for MD-2 or TLR4 at 320 K,and binding energies of-6.87 and-5.97 kcal/mol,respectively,for MD-2 and TLR4.

关键词： Dandelion extracts Phenolic compounds binding affinity TLR4-MD-2 antagonist Anti-inflammatory agent

Fermentation-enabled wellness foods:A fresh perspective

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Food Science and Human Wellness 2019年第3期8卷 203-243页

作者： Huan Xiang Dongxiao Sun-waterhouse geoffrey i.n.waterhouse Chun Cui Zheng Ruan South China University of Technology GuangzhouChina School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

Fermented foods represent an important segment of current food markets,especially traditional or ethnic food *** demand for efficient utilization of agrowastes,together with advancements in fermentation technologies(microbial-and enzyme-based processing),are stimulating rapid growth and innovation in the fermented food *** addition,the health-promoting benefits of fermented foods are attracting increasingly *** microorganisms contained in many common fermented foods can serve as“microfactories”to generate nutrients and bioactives with specific nutritional and health ***,recent research relating to the manufacture of fermented foods are critically reviewed,placing emphasis on the potential health benefits of fermentation-enabled wellness *** importance of the correct selection of microorganisms and raw materials and the need for precise control of fermentation processes are *** knowledge gaps and obstacles to fermented food production and market penetration are *** importance of integrating multidisciplinary knowledge,communicating with consumers,establishing regulatory frameworks specifically for fermentation-enabled wellness foods and functional fermented foods,are highlighted.

关键词： Fermented foods Microbial factories Bioactive Probiotics nutrients Processing technologies

A core-satellite self-assembled SERS aptasensor containing a“biological-silent region”Raman tag for the accurate and ultrasensitive detection of histamine

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Food Science and Human Wellness 2024年第2期13卷 1029-1039页

作者： Chen Chen Yingfang Zhang Ximo Wang Xuguang Qiao geoffrey i.n.waterhouse Zhixiang Xu Key Laboratory of Food Processing Technology and Quality Control in Shandong Province College of Food Science and EngineeringShandong Agricultural UniversityTai’an 271018China School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

Herein,a novel interference-free surface-enhanced Raman spectroscopy(SERS)strategy based on magnetic nanoparticles(MnPs)and aptamer-driven assemblies was proposed for the ultrasensitive detection of histamine.A core-satellite SERS aptasensor was constructed by combining aptamer-decorated Fe_(3)O_(4)@Au MnPs(as the recognize probe for histamine)and complementary DnA-modified silver nanoparticles carrying 4-mercaptobenzonitrile(4-MBn)(Ag@4-MBn@Ag-c-DnA)as the SERS signal probe for the indirect detection of *** an applied magnetic field in the absence of histamine,the assembly gave an intense Raman signal at“Raman biological-silent”region due to *** the presence of histamine,the Ag@4-MBn@Ag-c-DnA SERS-tag was released from the Fe_(3)O_(4)@Au MnPs,thus decreasing the SERS *** optimal conditions,an ultra-low limit of detection of 0.65×10^(-3)ng/mL and a linear range 10^(-2)-10^5 ng/mL on the SERS aptasensor were *** histamine content in four food samples were analyzed using the SERS aptasensor,with the results consistent with those determined by high performance liquid *** present work highlights the merits of indirect strategies for the ultrasensitive and highly selective SERS detection of small biological molecules in complex matrices.

关键词： Surface-enhanced Raman spectroscopy Raman biological-silent region Aptamer Histamine detection Universal SERS-tag

Biomass-derived carbon dots with pharmacological activity for biomedicine:Recent advances and future perspectives

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Science Bulletin 2024年第19期69卷 3127-3149页

作者： Yue Liu Linlin Zhang Huijuan Cai Xiaoli Qu Junbiao Chang geoffrey i.n.waterhouse Siyu Lu College of Chemistry Pingyuan LaboratoryZhengzhou UniversityZhengzhou 450001China Erythrocyte Biology Laboratory School of Life SciencesZhengzhou UniversityZhengzhou 450001China School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

Carbon dots(CDs),a type of nanoparticle with excellent optical properties,good biocompatibility,and small size,are finding increasing application across the fields of biology and *** recent years,biomass-derived CDs with pharmacological activity(BP-CDs)derived from herbal medicines(HMs),HMs extracts and other natural products with demonstrated pharmaceutical activity have attracted particular ***,we review recent advances in the development of BP-CDs,covering the selection of biomass precursors,different methods used for the synthesis of BP-CDs from natural sources,and the purification of ***,we summarize the many remarkable properties of BP-CDs including optical properties,biocompatibility and pharmaceutical ***,the antibacterial,antiviral,anticancer,biosensing,bioimaging,and other applications of BP-CDs are ***,we discuss the advantages and disadvantages of BP-CDs and Western drug-derived CDs,highlighting the excellent performance of ***,based on the current state of research on BP-CDs,we suggest several aspects of BP-CDs that urgently need to be addressed and identify directions that should be pursued in the *** comprehensive review on BP-CDs is expected to guide the precise design,preparation,and future development of BP-CDs,thereby advancing the application of BP-CDs in biomedicine.

关键词： Carbon dots Biomass Pharmacological activity Synthesis Properties Biomedicine

Recent progress in high-loading single-atom catalysts and their applications

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Industrial Chemistry & Materials

industrial Chemistry & Materials 2023年第4期1卷 486-500页

作者： Jiahui Luo geoffrey i.n.waterhouse Lishan Peng Qingjun Chen Key Laboratory of Rare Earths Chinese Academy of SciencesGanjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China School of Rare Earths University of Science and Technology of ChinaHefei 230026P.R.China School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

Single-atom catalysts(SACs)attract significant attention owing to their high catalytic activity,high metal atom utilization efficiency,and well-defined and configurable active ***,achieving single-atom dispersion of active metals at high metal loadings remains challenging,limiting the performance of SACs in many practical ***,we provide a comprehensive review of recent methods developed for synthesizing high-loading SACs,critically exploring their advantages,limitations,and wider ***,we showcase the benefits of high-loading SACs in the oxygen reduction reaction(ORR),water electrolysis,photocatalytic hydrogen production and CO *** great recent progress has been made in the synthesis of high loading SACs,simple and universal routes that allowed the preprogrammed preparation of single metal and multi-metal SACs with specific metal coordination need to be discovered.

关键词： Single atom catalyst High-loading Synthesis methods ORR Water electrolysis CO oxidation

Towards human well-being through proper chewing and safe swallowing:multidisciplinary empowerment of food design

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Journal of Future Foods 2021年第1期1卷 1-24页

作者： Dongxiao Sun-waterhouse Wenyi Kang Changyang Ma geoffrey i.n.waterhouse national R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

This review article provides an overview of the physiology and biomechanics of food oral processing,with a wider view towards the development of wellness foods that facilitate proper chewing and safe *** complexity of food oral processing is well recognized,involving food-mouth-gut-brain *** process requires precise coordination of chewing,oro-sensing,neural control,saliva secretion,bolus formation,swallowing and respiration,involving central and peripheral nervous systems,sensors and muscles of the oral cavity,pharynx,larynx and *** processing of an ingested food leads to its fragmentation,hydration,breakdown,transformation and reconstruction,and provides simultaneous oro-sensory perception and preliminary food digestion via mechanical fracture and chemical/enzymatic *** exists a complex food structure-property-processing relationship from the first bite of a food through to bolus formation for *** maximal deformability of a bolus is a key criterion for successful swallow-aided food *** structure is the main variable affecting food breakdown,food sensory perception and bolus *** research is needed to better understand the food structure-oral processing relationship,which guides the tailoring of foods/diets for individuals with chewing and swallowing difficulties to achieve balanced nutrition and an enjoyable eating experience.

关键词： Chewing Swallowing Food structure nutrition Health Eating experience

Dual sensitivity of spiropyran-functionalized carbon dots for full color conversions

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Science China Chemistry 2022年第11期65卷 2274-2282页

作者： Lin Ai Huimin Liu Rui Liu Haoqiang Song Ziqi Song Mingjun nie geoffrey i.n.waterhouse Siyu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450000China College of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China School of Chemical Sciences The University of AucklandAuckland 142New Zealand

Multicolor phosphors that respond rapidly to external stimuli are highly desirable for many applications, including lighting,optical displays and sensors. Herein, spiropyran(SP)-functionalized carbon dots(CDs) were synthesized with a broad-spectrum output that were responsive to both ultraviolet(UV)/visible light and pH. The SP-CDs possessed strong ester linkages between the UV-absorbing/blue-emitting CDs and blue-absorbing/red-emitting surface SP groups, allowing efficient F?rster resonance energy transfer(FRET) between the donor and acceptor. UV irradiation or acid addition cause the SP ring opening to merocyanine(MC) or protonated MCH+forms, respectively, together with the formation of sheet-like aggregates. These processes enhanced the red emissions by the SP groups and attenuated blue emissions from the CDs. These changes were fully reversible under visible light or basic conditions, respectively, allowing dynamic regulation of the fluorescence properties(emission colors from blue to red, photoluminescence(PL) intensity) under photoirradiation on the timescale of minutes. As proof-of concept, we demonstrate that the emission properties of the SP-CDs can be used to construct UV and pH sensing materials as well as light emitting diode(LED) with different colors.

关键词： carbon dots dual-sensitivity full color emission spiropyran F?rster resonance energy transfer

Cross-linking enhanced room-temperature phosphorescence of carbon dots

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SmartMat 2022年第2期3卷 337-348页

作者： Boyang Wang Zhen Sun Jingkun Yu geoffrey i.n.waterhouse Siyu Lu Bai Yang Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhouChina School of Chemical Sciences The University of AucklandAucklandNew Zealand State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunChina

Currently,there is a strong drive to discover alternative materials that exhibit room-temperature phosphorescence(RTP)for displays,bioimaging,and data ***,these materials should be nontoxic,cheap,and possess controllable photoluminescent *** dots(CDs)possess each of these characteristics,but to date,less attention has been paid to their RTP ***,we synthesized a series of CDs by self-crosslinking and carbonization of *** resultant CDs were luminescent and exhibited a bright,micro-second afterglow *** increase the RTP,a second microwave processing step was used to coat the CDs with polyvinyl alcohol(PVA),polyacrylamide(PAM),or tetraethyl orthosilicate(TEOS),producing CDs@PVA,CDs@PAM,and CDs@TEOS *** core-shell structure acted to enhance crosslinking at the surface of the CDs to boost the RTP,creating abundant energy levels for intersystem *** situ X-ray photoelectron spectroscopy verified electron transfer during ***,we present a design rule that can be used to tune the quantum yields and RTP lifetime of CDs,based on the effective stabilization of triplet excited states through the extent and strength of *** simple strategy provides a flexible route for guiding the further development of CDs with tailored RTP properties for various applications.

关键词： carbon dots crosslink-enhanced emission effect phosphorescence mechanism polymers room-temperature phosphorescence

Disulfide Crosslinking-induced Aggregation:Towards Solid-State Fluorescent Carbon Dots with Vastly Different Emission Colors

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Chinese Journal of Chemistry 2023年第9期41卷 1007-1014页

作者： Rui Fu Haoqiang Song Xingjiang Liu Yongqiang Zhang Guanjun Xiao Bo Zou geoffrey i.n.waterhouse Siyu Lu Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450000China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchunJilin 130012China School of Chemical Sciences The University of AucklandAuckland 1142New Zealand

Solid-state fluorescent multi-color carbon dots(SFM-CDs),prepared using the same precursor(s)without the need for dispersion in a solid matrix,are highly demanded for a wide range of ***,we report a microwave-assisted strategy for the prepara-tion of SFM-CDs with blue,yellow and red emissions within 5 min from the same *** as-prepared B-CDs,Y-CDs,and R-CDs possessed bright fluorescence at 425 nm,550 nm,and 640 nm,and photoluminescence quantum yields(PLQYs)of 54.68%,17.93%,and 2.88%,*** structure of SFM-CDs consisted of 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-7-carboxylic acid(TPCA)immobilized on the surface of a carbon core,with the size of the carbon core and degree of disulfide crosslinking between CDs both increasing on going from the B-CDs to the R-CDs,as verified by mechanochromic *** excellent solid-state fluorescence performance of the SFM-CDs allowed their utilization as the fluorescent converter layer in multi-color LEDs and white LEDs with a high color rendering index.

关键词： Solid-state fluorescence Multicolor Cross-linked aggregation Disulfide bond Carbon dots