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Towards a global One Health index: a potential assessment tool for One Health performance

Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song geoff simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai Legislative Research Institute ShanghaiPeople’s Republic of China Zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases

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Scientists Provide A New Option for Anti-Leukemia Therapy

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Bulletin of the Chinese Academy of Sciences 2019年第2期33卷 117-118页

作者： simm simm

RNA epitranscriptomics, the study of chemical modifications to RNA or the transcriptome (the entirety of RNA in a cell), represents a recently identified layer of regulation of genetic information. As the most abundant internal mRNA modification, N6- methyladenosine (or m6 A, adenosine tagged along with an additional methyl group) is critical for the regulation of mRNA metabolisms and impacts various biological and pathological processes.

关键词： study RNA processes

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采用COREX设备生产低成本优质钢

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钢铁 1999年第9期34卷 26-28,41页

作者： WPirklbauerRsimm 奥钢联工程技术公司

由于废钢数量因炼钢和加工收得率的提高而不断减少，因此，质量优、价格低的废钢将会发生短缺，对优质废钢的需求不断增长。针对上述情况，介绍了一种适用于短流程钢厂的极为经济的优质钢生产方案，即生产能力为３０～４０万ｔ／ａ的 ... 详细信息

由于废钢数量因炼钢和加工收得率的提高而不断减少，因此，质量优、价格低的废钢将会发生短缺，对优质废钢的需求不断增长。针对上述情况，介绍了一种适用于短流程钢厂的极为经济的优质钢生产方案，即生产能力为３０～４０万ｔ／ａ的ＣＯＲＥＸＣ１０００技术。

关键词： COREX 短流程低成本优质钢炼钢生产方案

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植物育种中的家系选择

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国外作物育种 1997年第1期16卷 1-4页

作者： simm.,NW 向平

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ASDEX托卡马克欧姆放电整体能量约束时间的统计学分析

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国外核聚变与等离子体应用 1997年第1期 17-28页

作者： simm.,EE 李芳

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Pekeris‘—维电阻率解释方法的再评价

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石油物探快讯 1991年第1期8卷 72-79页

作者： simm.,JE 臧怀仕

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花生密芳对水分供需的影响

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国外农学（农业气象） 1990年第2期 26-27页

作者： simm.,LP 李玉娥

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Multi-substituted Quinolines:Design,Synthesis and RTK Inhibitory Activities

Multi-substituted Quinolines:Design,Synthesis and RTK Inhibi...

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2011年全国药物化学学术会议——药物的源头创新

作者： Ao Zhang Synthetic Organic & Medicinal Chemistry Laboratory(SOMCL),Shanghai Institute of Materia Medica(simm),Chinese Academy of Sciences(CAS),Shanghai,China 201203.

＜正＞Natural products,as the whole structures or their druglike fragments,have served as the most important starting-point for current drug design and ***,compared to the large number of nature-born cytotoxic drugs,natural products with a major molecular target to exert their therapeutic actions are ***,molecular editing and structural evolution play

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Au（111）电极上砷沉积的电化学反应机理（英文）

Au（111）电极上砷沉积的电化学反应机理（英文）

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第十三次全国电化学会议

作者：贾铮 Andrew O．simm Richard G．Compton 哈尔滨工业大学应用化学系牛津大学物理和理论化学实验室牛津大学物理和理论化学实验室

＜正＞The arsenic contamination of groundwater and soil in various parts of the world has been well reported. In Bangladesh alone, an estimated SO million people are at risk in the threat which WHO calls the world’s worst mass human poisoning disaster. The electrochemical methods have been effectively applied in arsenic removal and quantitative analysis of arsenic. Especially, many researches have revealed that anodic stripping voltammetry （ASV） on different forms of gold electrodes provided a low-cost, rapid and portable detection of arsenic for routine in-field monitoring of large numbers of samples. Therefore, the study of electrochemical

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Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines:Key precursors to potent RTK inhibitors

Expeditious one-pot synthesis of C3-piperazinyl-substituted ...

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2011年全国药物化学学术会议——药物的源头创新

作者： Yuanxiang Wang,Jing Ai,Gang Liu,Meiyu Geng,Ao Zhang~* Synthetic Organic & Medicinal Chemistry Laboratory,Shanghai Institute of Materia Medica(simm), Chinese Academy of Sciences,Shanghai,China 201203.

We have developed a highly effective one-pot synthetic strategy to access quinolines bearing diverse C3-piperazinyl functions by using a modified Friedlander’s *** the newly developed method,our early reported RTK inhibitor 10 was readily prepared on a large scale(100 g,scheme 1). With the key precursor 5-bromo-3-aminoquinolines in hand,we then designed a series of new RTK

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