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Flexofytol, a Purified Curcumin Extract, in Fibromyalgia and Gout: A Retrospective Study

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第2期3卷 104-107页

作者： Thierry appelboom Christian Mélot MsciBiost Emergency Department Erasme University Hospital Medical School University of Brussels Brussels Belgium Rheumatology Department Erasme University Hospital Medical School University of Brussels Brussels Belgium

Flexofytol is a recently-purified curcumin extract administered as a food supplement with the indication for being “able to improve musculoskeletal flexibility and preserve articular function”. It is now marketed in Belgium, frequently used with success in daily clinical practice according to pharmacists, and also prescribed by general practitioners and rheumatologists for various painful conditions. The objective of this retrospective study was to evaluate the potential efficacy of the compound in fibromyalgia and gout from our practice from 2011-2012. Accordingly, the medical files of 116 patients (83 with a follow-up of 1 to 12 months) with fibromyalgia or gout who were treated with Flexofytol were analysed to determine whether they had benefited from this therapy or had experienced undesirable effects. Flexofytol provided a benefit in acute gout crisis and fibromyalgia. Interestingly, the clinical improvement was rapid (within 24 - 48 h), with good efficacy in gout. The benefit of Flexofytol was on different manifestations of pain rather than on the sleep disorders of fibromyalgia. Except for some occasional difficulties with tablet swallowing and transient diarrhoea, the treatment was well tolerated. In conclusion, Flexofytol appears to be an alternative to conventional treatment for fibromyalgia and gout.

关键词： Curcumin Fibromyalgia Gout

Synofit Premium in Refractory Low Back Pain: A Retrospective Observational Study

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 120-127页

作者： Jiangan Qu Christian Mélot Thierry appelboom Dept. of Rheumatology and Physical Medicine Iris Sud Hospital Brussels Belgium Dept. of Emergency Erasme University Hospital Brussels Belgium

In this retrospective observational study, information about pain and quality of life was collected for analysis from medical records of 85 patients with chronic low back pain who were treated for 3 months with Synofit? Premium (2 - 3 capsules daily), a liquid mixture of green-lipped mussel from New Zealand, blackcurrant leaf, and curcuma extract. Within the first 6 weeks of therapy, a significant clinical benefit was observed for relief from pain, need for pain-relieving drugs, and the interference of pain with personal care and lifting. This benefit was more pronounced at 3 months. The mixture was well tolerated without significant side effects. Adherence was estimated to be “good” to “very good.” Patients assessed global improvement and efficacy as “sufficient” to “good.” Based on this study, the mode of action of Synofit? Premium appears mainly to be analgesic, as reported by patients, and allows them to reduce the consumption of other pain-relieving substances and improve their quality of life. In conclusion, Synofit? Premium holds potential as a promising candidate alternative therapy for relief of low back pain and likely other painful rheumatic conditions, with almost no or minor side effects.

关键词： Low Back Pain Synofit Osteoarthritis Curcumin Blackcurrant Leaf Perna canaliculus Curcuma longa Ribes nigrum

Short Report of a Preliminary Open Study of <i>Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract</i>in Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 113-117页

作者： Jiangang Qu Christian Mélot Thierry appelboom Department of Rheumatology Molière-Longchamp Hospital Brussels Belgium Department of Emergency Erasme University Hospital Brussels Belgium

To evaluate the potential benefit of Synofit—an association of Curcumin, Perna canaliculus green-mussels and blackcurrant leaf extracts, a real life open study was performed among 86 adult out patients suffering from Fibromyalgia (n = 22), low back pain (n = 33) or knee osteoarthritis (n = 31) who accepted to take 3 tablets a day during 1 week then 2 capsules of Synofit during 2 months in addition to their conventional therapy (mainly analgesics and anti-inflammatory) and then to report their evaluation of this complementary treatment. Statistical analysis included paired t test and when possible Wilcoxon signed rank test. Accordingly, the intermediate analysis showed that already within 4 weeks of treatment, an improvement quoted as “light” was statistically reported in patients with low back pain and knee osteoarthritis but not among those with fibromyalgia on pain, physical condition, global assessment of a benefit, quality of life but not on joint stiffness (although joint stiffness considered for the whole group was statistically improved). The limited number of patients and time duration of the study and the absence of double blind controlled study do not allow concluding on the efficacy but these preliminary analyses obtained from an intermediate analysis are encouraging for further studies.

关键词： Synofit Greenlipped Mussels Curcumin Blackcurrant Arthritis

Flexofytol^(■) (A Belgian Curcumin Extract)for the Treatment of Aged Patients with Osteoarthritis and Comorbidity

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第4期7卷 167-177页

作者： Sandra De Breucker Héloise Rouvière Christian Mélot Thierry appelboom Geriatrics Department Hopital ErasmeUniversité Libre de BruxellesBrusselsBelgium Emergency Department Hopital ErasmeUniversité Libre de BruxellesBrusselsBelgium Rheumatology Department Hôpital ErasmeUniversitéLibre de BruxellesBrusselsBelgium

Introduction: Currently, the therapeutic arsenal of osteoarthritis includes several extracts of Curcuma including Flexofytol®, a bio-optimized extract of Curcuma longa. However, in older patients, indications for treatment might be limited by comorbidity and polymedication. Therefore, we aimed to assess the benefits and risks of Flexofytol®, in an older population with comorbidities. Patients and Methods: This retrospective observational study included 31 patients over age 70 years (medianage: 77 years, range 71 - 81) that were treated with Flexofytol for painful osteoarthritis of the knee or lumbar spine. These patients were initially weakened by diabetes (48%) and/or renal insufficiency (71%), or they were taking anticoagulants (35%). The effects of Flexofytol®, were evaluated at 0, 6 and 12 weeks with visual analog scales for pain and disability and the SF-12 Quality of Life questionnaire. Adverse effects and drug interactions of Flexofytol®, were evaluated. In particular, we evaluated renal function, diabetes parameters and coagulation tests. The data were analyzed with Kruskal-Wallis and Wilcoxon-Mann-Withney non-parametric tests. Results: Patients with Flexofytol®, showed significant improvement: pain improved by 50% (p = 0.0002) and functional disability improved by 33% (p = 0.0075). A series of quality of life parameters improved within the first 6 weeks of treatment and up to 3 months of treatment without impacting renal function, metabolic parameters or coagulation tests. We observed no significant adverse effects. Conclusion: In conclusion, our results suggested that Flexofytol®, may be useful in the management of painful osteoarthritis, particularly in older patients that are fragile due to comorbidity and polymedication. These initial results must be confirmed in future studies.

关键词： Lumbar Arthrosis Knee Osteoarthritis Curcumin Flexofytol^(■) Geriatrics