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Effect of phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin ligase Parkin mediated mitochondrial autophagy on chronic kidney disease myocardial injury and the intervention mechanism of Shenshuai recipe(肾衰方)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 934-943页

作者： ZHANG Gedi liu gengxin GUO Min LUO Fuli YAN Ziyou GE Wei School of Graduate Jiangxi University of Chinese MedicineNanchang 330000China Department of Nephrology Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000China Department of Anorectal Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000China

OBJECTIVE:To study whether Shenshuai recipe(肾衰方,SSR)can play a protective role on chronic kidney disease myocardial injury model through phosphatase and tensin homolog-induced putative kinase 1(PINK1)/E3 ubiquitin ligase Parkin(Parkin)mitochondrial autophagy ***:Forty-eight nephrectomized rats were randomly divided into six groups:sham-operated group,model group,Benazepril group,low,medium and highdose groups of *** rats were given the corresponding intervention for six weeks,then were *** was examined by enzyme linked immunosorbent assay(ELISA).Cardiac ultrasound was used to detect cardiac function in 5/6 nephrectomized *** tissue was examined by light and electron microscopy;PINK1,Parkin,microtubule-associated protein 1 light chain 3 II(LC3B),sequestosome 1(P62),BECN1(Beclin-1)and dynamin-related protein 1(Drp-1)were measured by real time polymerase chain reaction(RT-PCR),Western blot(WB)and immunohistochemistry(IHC).RESULTS:The expression levels of blood urea nitrogen(BUN)and creatinine(SCr)in the model group were significantly higher than those in the sham-operated group,indicating that modeling was *** can protect myocardium by reducing the relative expression of creatine kinase myocardial isoenzyme and hypersensitivity cardiac troponin I(P<0.05).SSR can improve cardiac function in rats after ultrasound *** can improve the pathological manifestations of myocardial tissue after Masson *** can increase the number of autophagosomes and autophagiclysosomes in 5/6 nephrectomized rats(P<0.05).Determined by RT-PCR,WB and IHC,SSR can increase the relative expression of PINK1,Parkin,and LC3B(P<0.05),and decrease the relative expression of P62,Beclin-1 and Drp-1(P<0.05).CONCLUSIONS:The PINK1/Parkin mitochondrial autophagy pathway in myocardial tissues in 5/6 nephrectomy CKD myocardial injury rats was *** can activate PINK1/Parkin mitochondrial autophagy to enhance mitochondrial autophagy,and p

关键词： renal insufficiency chronic PTEN phosphohydrolase ubiquitin-protein ligases myocardial injury mitochondrial autophagy Shenshuai recipe

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基于全局与局部特征对比的点云自监督学习

计算机辅助设计与图形学学报 2022年第9期34卷 1323-1333页

作者：刘耿欣胡瑞珍深圳大学可视计算研究中心深圳518061

传统的有监督学习依赖大量的标签数据,而收集标签数据通常是昂贵的.因此,提出一种通过对比点云的全局和局部特征的自监督学习算法,包括数据构造和对比学习2个阶段.在数据构造阶段,通过不同的局部视角和局部子结构生成全局物体的局部区域... 详细信息

传统的有监督学习依赖大量的标签数据,而收集标签数据通常是昂贵的.因此,提出一种通过对比点云的全局和局部特征的自监督学习算法,包括数据构造和对比学习2个阶段.在数据构造阶段,通过不同的局部视角和局部子结构生成全局物体的局部区域;在对比学习阶段,将全局物体和局部区域分别依次输入编码器、投影层和预测器得到全局和局部特征,使用基于对比学习的目标函数增强全局和局部特征相似.通过在2个公开数据集ModelNet40和ShapeNet上与Info3D等自监督学习算法对比,实验结果表明,所提算法在无监督点云分类和小样本学习任务上的分类准确率得到显著提升,并且在训练数据匮乏时比现有算法具有更强的鲁棒性.

关键词：点云分析自监督学习对比学习局部区域

Spherical Packing Superlattices in Self-Assembly of Homogenous Soft Matter:Progresses and Potentials

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Chinese Journal of Polymer Science 2023年第5期41卷 607-620,I0005页

作者： Yuchu liu Huanyu Lei Qing-Yun Guo Xianyou liu Xinghan Li Yuean Wu Weiyi Li Wei Zhang Geng Xin liu Xiao-Yun Yan Stephen Z.D.Cheng South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China School of Polymer Science and Polymer Engineering The University of AkronAkron OH 44325-3909USA State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Material Science and EngineeringDonghua UniversityShanghai 201620China

The construction of complex superlattices using homogenous soft matter has great potential for the bottom-up fabrication of complex,nanoscale *** topic is not only interested in scientific exploring for new concepts of supramolecular crystals with nanometer in sizes,which is about thousand times larger in volumes than those of normal crystals,but also practically important to provide construction principles of metamaterials which are artificially structured materials for controlling and manipulating light,sound,and other physical *** systems have fast assembly kinetics and convenient processing procedures,making them ideal for large-scale superlattice *** this perspective,we focus on recent developments in the construction of complex spherical packing superlattices using homogenous soft *** discuss the general mechanism of those formations of supramolecular motifs and provide an overview of the spherical packing superlattices self-assembled by homogenous soft matters based on different volume ***,we outline the potentials of utilizing this approach in constructing novel superlattices as well as its future challenges.

关键词： Soft matter Self-assembly Spherical packing phases Superlattice Bottom-up construction

Self-healing materials enable free-standing seamless large-scale 3D printing

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Science China Materials 2021年第7期64卷 1791-1800页

作者： Han Zuo Zenghe liu Luzhi Zhang gengxin liu Xikai Ouyang Qingbao Guan Qilin Wu Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-Dimension Materials(Donghua University)College of Material Science and EngineeringDonghua UniversityShanghai 201620China Center for Advanced Low-Dimension Materials Donghua UniversityShanghai 201620China

Three-dimensional(3 D)printing has had a large impact on various fields,with fused deposition modeling(FDM)being the most versatile and cost-effective 3 D printing ***,FDM often requires sacrificial support structures,which significantly complicates the processing and increases the ***,poor layer-to-layer adhesion greatly affects the mechanical stability of 3D-printed ***,we present a new Print-Healing strategy to address the aforementioned challenges.A polymer ink(Cu-DOU-CPU)with synergetic triple dynamic bonds was developed to have excellent printability and room-temperature self-healing *** with various shapes were printed using a simple compact 3D printer,and readily assembled into large sophisticated architectures via *** dynamic bonds induce strong binding between ***,damaged printed objects can spontaneously heal,which significantly elongates their service *** work paves a simple and powerful way to solve the key bottlenecks in FDM 3D printing,and will have diverse applications.

关键词： dynamic bonds self-healing 3D printing support-free interlayer adhesion

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胆道闭锁诊断方法价值分析

中华肝胆外科杂志 2021年第3期27卷 232-235页

作者：刘更新詹江华天津医科大学研究生院 300070 天津市儿童医院普通外科 300134

胆道闭锁是以肝内外胆管进行性炎症和纤维化为特征的疾病,是导致婴儿持续性黄疸的重要原因,如未得到及时治疗,可迅速发展为肝硬化,患儿最终因肝功能衰竭而死亡,因此胆道闭锁的早期诊断显得尤为重要。胆道闭锁主要依靠术中胆道造影以及... 详细信息

胆道闭锁是以肝内外胆管进行性炎症和纤维化为特征的疾病,是导致婴儿持续性黄疸的重要原因,如未得到及时治疗,可迅速发展为肝硬化,患儿最终因肝功能衰竭而死亡,因此胆道闭锁的早期诊断显得尤为重要。胆道闭锁主要依靠术中胆道造影以及肝组织活检确诊,但其具有侵入性、操作复杂、并发症多等缺点,不利于胆道闭锁的早期诊断,相比较而言,一些无创性检查方法如实验室检查、影像学检查等具有明显优势。本文对各种胆道闭锁诊断方法的应用价值进行分析,为其早期诊断提供新思路。

关键词：胆道闭锁诊断早期方法

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国家审计服务国家治理:功能体系和实现路径

财经科学 2014年第6期 108-114页

作者：刘更新刘晓林中南财经政法大学会计学院重庆大学经管学院西南财经大学会计学院

本文首先分析了国家审计服务国家治理的历史性和必然性。在此基础上,从制度、组织主体和具体表征三个层面构建了国家审计服务国家治理的功能框架体系。最后,对国家审计服务国家治理的实现路径进行了探讨,提出应提高国家审计的信任度,开... 详细信息

本文首先分析了国家审计服务国家治理的历史性和必然性。在此基础上,从制度、组织主体和具体表征三个层面构建了国家审计服务国家治理的功能框架体系。最后,对国家审计服务国家治理的实现路径进行了探讨,提出应提高国家审计的信任度,开展审计治理诊断调查,提升国家审计适应性能力。

关键词：国家审计国家治理功能体系实现路径

基于meta分析和网络药理学理冲汤(丸)治疗癌症的疗效评价及作用机制研究

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Journal of Chinese Pharmaceutical Sciences 2023年第9期32卷 720-735页

作者：张格第刘庚鑫晏子友江西中医药大学江西南昌330000 江西中医药大学附属医院江西南昌330000

理冲汤(丸)是一种具有显著抗肿瘤功效的中医处方。本研究基于meta分析和网络药理学的方法,对理冲汤治疗癌症的疗效评价和作用机制进行了研究。首先,采用循证医学的研究方法,收集尽可能多的理冲汤(丸)治疗肿瘤的临床研究报告,然后进行荟... 详细信息

理冲汤(丸)是一种具有显著抗肿瘤功效的中医处方。本研究基于meta分析和网络药理学的方法,对理冲汤治疗癌症的疗效评价和作用机制进行了研究。首先,采用循证医学的研究方法,收集尽可能多的理冲汤(丸)治疗肿瘤的临床研究报告,然后进行荟萃分析,以确认理冲汤(丸)治疗肿瘤的疗效和安全性;接下来,利用网络药理学的方法预测了理冲汤(丸)对肿瘤的干预机制。Meta分析显示,理冲汤(丸)的总有效率和安全性显著高于对照组,具有统计学意义(P <0.01)。理冲汤(丸)共筛选出化合物111个;与癌症的交集靶点共339个;由PPI网络图可知,其核心靶点是:AKT1、TP53、TNF、IL6、JUN、VEGFA、MYC、ESR1、EGFR、CASP3;进行GO分析,富集基因数量最多的是protein binding, cytosol, nucleus,分别分布了291, 179, 166个基因;KEGG分析共富集通路1894条。分子对接结果显示,槲皮素、木犀草素、山奈酚能够很好地与AKT1、TNF、VEGFA、EGFR对接,木犀草素-AKT1和槲皮素-AKT1结合程度最佳。发现,理冲汤(丸)在癌症治疗中保持其疗效性和安全性;理冲汤(丸)的有效中药成分可能通过上述多个靶点和通路,发挥出多种生物活性来抑制癌症;目前理冲汤(丸)治疗非妇科癌症的类型主要集中在肝细胞癌上。

关键词：理冲汤(丸) 中医癌症 Meta分析网络药理学数据挖掘

Identification of metabolitesand their distribution of modified Wu-Zi-Yan-Zong prescription(MWP) in rats after oral administration by high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry

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Identification of metabolitesand their distribution of modif...

第十一届全国博士生学术年会

作者：王琳琳 Caisheng Wu Jinlan Zhang 王学美 Yixiang Song Fangjiao Song gengxin liu Hong Fu Institute of Integrated of Traditional Chinese Medicin and Western Medicine Peking University First Hospital Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical Colledge

Modified Wu-Zi-Yan-Zong prescription(MWP) is a polyherbal formula derived from traditional Chinese kidney-nourishing medicine Wu-Zi-Yan-Zong Pill that has been deeply studied in the mechanism of neuroprotective effects on mild cognitive impairment(MCI) and Alzheimer's Disease(AD).In this paper, high-performance liquid chromatography couples with Fourier transform ion cyclotron resonance mass spectrometry(HPLC/FTICR-MS) was developed to identify the metabolites and their distribution of modified Wu-Zi-Yan-Zong prescription(MWP) in rats after oral administration,using parent mass list triggered data-dependent multiple-stage mass analysis at a resolving power of 100 000 in the external calibration *** mass accuracies obtained for full-scan MS were within 3 ppm(

关键词： metabolites modified Wu-Zi-Yan-Zong prescription(MWP) HPLC/FTICR-MS

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个人医疗健康信息合理使用初探

特区经济 2024年第9期 136-139页

作者：刘庚鑫西北大学法学院陕西西安710127

使用个人医疗健康信息虽然会造成利益冲突,但也能满足防治公共卫生危机、助推智慧医疗企业发展以及发展医学研究的现实需求。又因为合理使用制度本身具有调和利益冲突、促进信息流通的作用,且个人医疗健康信息具有特殊性,所以个人医疗... 详细信息

使用个人医疗健康信息虽然会造成利益冲突,但也能满足防治公共卫生危机、助推智慧医疗企业发展以及发展医学研究的现实需求。又因为合理使用制度本身具有调和利益冲突、促进信息流通的作用,且个人医疗健康信息具有特殊性,所以个人医疗健康信息的合理使用具有一定的正当性。应当通过细化《个人信息保护法》中个人医疗健康信息合理使用制度的规定、严格解释合理使用个人医疗健康信息的情形、用比例原则审查使用的“合理性”来完善个人医疗健康信息合理使用制度。

关键词：个人医疗健康信息合理使用敏感个人信息利益冲突《个人信息保护法》