检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

公路隧道施工过程中围岩变形规律分析

工程技术研究 2024年第14期9卷 8-10页

作者：耿利军盛兆旺宋立伟青岛地矿岩土工程有限公司山东青岛266000 青岛地质工程勘察院(青岛地质勘查开发局) 山东青岛266000

不良地质条件下隧洞围岩变形一直是相关领域研究的重难点。文章以某公路隧道开挖项目为例,通过数值模拟手段分析了隧道施工过程中不同土-岩界面位置工况下的围岩变形规律。结果表明:地表沉降曲线呈“盆”状,沉降峰值出现在隧道中线位置... 详细信息

不良地质条件下隧洞围岩变形一直是相关领域研究的重难点。文章以某公路隧道开挖项目为例,通过数值模拟手段分析了隧道施工过程中不同土-岩界面位置工况下的围岩变形规律。结果表明:地表沉降曲线呈“盆”状,沉降峰值出现在隧道中线位置处。不同土-岩界面位置工况下,地表沉降分布规律基本一致,主要差异为数值差异。

关键词：公路隧道围岩变形数值模拟衬砌结构

在线全文

学校读者我要写书评

暂无评论

钙在作物生长发育中的功能及应用

作物学报 2024年第4期50卷 793-807页

作者：王宇郜耿东葛萌萌常影谭静葛贤宏王晶汪波周广生傅廷栋华中农业大学植物科学技术学院湖北武汉430070

钙是作物必需的中量元素之一,广泛存在于根、茎、叶、花、果实、种子中,对作物的生长发育具有重要意义。钙属于再利用难的元素,其吸收、转运受制于蒸腾作用,因此农作物常发生生理性缺钙,从而导致抗逆性减弱,产量和品质降低。作物体内的... 详细信息

钙是作物必需的中量元素之一,广泛存在于根、茎、叶、花、果实、种子中,对作物的生长发育具有重要意义。钙属于再利用难的元素,其吸收、转运受制于蒸腾作用,因此农作物常发生生理性缺钙,从而导致抗逆性减弱,产量和品质降低。作物体内的钙具有双重功能,既参与细胞壁与细胞膜的构成,还可作为细胞内第二信使参与多种环境刺激和内部生长发育信号的响应。细胞中钙的吸收和转运对于维持细胞内钙离子稳态和钙信号精准传导至关重要。近年来,钙在作物生长与发育中的功能和在作物生产中的应用得到了广泛研究。本文阐述了作物体内钙元素的分布、吸收转运和需求状况,介绍了作物缺钙症状和原因,并综述了钙的营养结构功能和第二信使功能及钙信号产生、传导和解码机制,总结了钙在作物生长发育中的作用,包括对产量、品质和抗逆性等方面的影响,同时对其未来研究方向提出了展望。

关键词：作物缺钙钙吸收钙转运蛋白第二信使抗逆性

胰十二指肠切除术治疗十二指肠乳头癌—肿瘤大小和淋巴结转移影响术后长期生存

在线全文

学校读者我要写书评

暂无评论

中华普通外科杂志 2024年第9期39卷 686-691页

作者：崔笑郭子成薛鸿魏昇刘永凡耿小平黄艳侯辉安徽医科大学第二附属医院普外科合肥安徽医科大学第一附属医院普外科合肥安徽医科大学药学院合肥

目的探讨影响十二指肠乳头癌行胰十二指肠切除术后长期生存的临床病理因素。方法回顾性分析2015年1月至2021年12月在安徽医科大学第一附属医院和安徽医科大学第二附属医院接受胰十二指肠切除术治疗的十二指肠乳头癌患者的临床和病理资... 详细信息

目的探讨影响十二指肠乳头癌行胰十二指肠切除术后长期生存的临床病理因素。方法回顾性分析2015年1月至2021年12月在安徽医科大学第一附属医院和安徽医科大学第二附属医院接受胰十二指肠切除术治疗的十二指肠乳头癌患者的临床和病理资料。结果所有73例患者均获得术后随访, 中位随访时间60个月。COX比例风险模型多因素分析结果显示淋巴结转移阳性、肿瘤大小超过2.5 cm是影响总生存和无复发生存的共同独立危险因素。20例患者术后病理证实淋巴结转移, Logistic回归模型多因素分析结果显示吸烟、肿瘤突破浆膜层和肿瘤低分化是影响淋巴结转移的独立危险因素。结论肿瘤大小超过2.5 cm以及淋巴结转移阳性与十二指肠乳头癌较差的预后有关, 吸烟、肿瘤突破浆膜层和肿瘤低分化是淋巴结转移阳性的预测因素。

关键词：胰十二指肠切除术预后十二指肠乳头癌淋巴结转移

在线全文

学校读者我要写书评

暂无评论

神经环路鉴定技术在中医药脑科学领域的应用

中国实验动物学报 2024年第8期32卷 1059-1064页

作者：崔雅茹高倩李自发胡明会张浩耿希文王新宇魏盛山东中医药大学中医药创新研究院济南250355 山东中医药大学中医药经典理论教育部重点实验室济南250355 国家中医药管理局高水平中医药重点学科中医基础理论学科济南250355 山东中医药大学中医药与脑科学交叉学科研究中心济南250355*神经环路鉴定技术在中医药脑科学领域的应用

神经环路是由不同神经元组成的复杂网络,是大脑功能实现的物质载体。神经环路鉴定技术通过对特定神经环路的结构追踪及其活动操纵,研究其对脑功能的充分性和必要性,对理解脑疾病发病机制尤为关键。作为神经科学与脑科学领域的高新技术手... 详细信息

神经环路是由不同神经元组成的复杂网络,是大脑功能实现的物质载体。神经环路鉴定技术通过对特定神经环路的结构追踪及其活动操纵,研究其对脑功能的充分性和必要性,对理解脑疾病发病机制尤为关键。作为神经科学与脑科学领域的高新技术手段,近年来已被逐渐引入中医药领域基础研究。本综述系统性梳理神经环路鉴定技术的原理及其在中医药脑科学领域的应用研究进展,指出该领域后期发展方向应立足中医药特色整体观念和辨证论治展开设计。开展中医药多样化手段干预疾病的神经环路机制研究有助于促进中医药与现代脑科学的深度融合。

关键词：神经环路鉴定技术中医药脑科学应用

同方期刊数据库

Cloning and Expression Profile of Deoxyhypusine Snyhtase Gene and Deoxyhypusine Hydroxylase Gene in Silkworm, Bombyx mori

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2009年第9期8卷 1120-1129页

作者： WANG geng-xian SIMA Yang-hu ZHANG sheng-xiang XU Shi-qing National Engineering Laboratory of Modern Silk College of Basic Medicine and Biological Sciences Soochow University Suzhou 215123. P.R. China Department of Biological Science Handan Collage Handan 056005 P.R.China College of Forestry Shandong Agricultural University Tai＇an 271018 P.R. China

Deoxyhypusine snyhtase （DHS） and deoxyhypusine hydroxylase （DOHH） are the two enzymes that catalyze the synthesis of hypusine within eukaryotic initiation factor 5A （eIF5A）. Synthesis of hypusine is essential for the function of eIF5A in eukaryotic cell proliferation and survival. Here we described the cloning and expression of two full-length cDNAs, encoding respectively DHS-like protein and DOHH-like protein from Bombyx mori by using the methods of bioinformatics, RACE, and RT-PCR technology, named as BmDHS and BmDOHH. Sequencing results indicate that they are 1 311 and 1 874 bp in length including complete open reading frame （ORF） 1 116 and 915 bp, which encode 371 amino acids （molecular weight is about 41.11 kD and isoelectric point is 5.84） and 304 amino acids （molecular weight is about 34.30 kD and isoelectric point is 4.86）, respectively. BmDHS contains only 1 exon, and BmDOHH contains 4 exons and 3 introns. The deduced amino acid sequence of BmDHS contains a deoxyhypusine synthase domain from 47 to 361 amino acid residues, and the deduced amino acid sequence of BmDOHH contains 6 E-Z type HEAT repeat domains （23-52, 54-83, 87-116, 177-206, 208-237, and 241- 270）. Compared to DHS and DOHH amino acid sequences from other species, such as Homo sapiens and Drosophila melanogaster, both silkworm DHS protein and DOHH protein have more than 55% identity. The conservative regions are very similar with each other. The phylogenetic tree analysis indicated that not only DHS but also DOHH from different species has genus-specific features. The expressions of BmDHS and BmDOHH are no tissue and stage specific in our tested samples.

关键词： Bombyx mori deoxyhypusine snyhtase deoxyhypusine hydroxylase gene cloning gene expression

Apparent Molar Volumes and Solvation Coefficients in Ternary-pseudo-binary Mixtures [(Styrene+Ethyl Acetate or Benzene)+(N-Methyl-2-pyrrolidone+Ethyl Acetate or Benzene)]

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第2期26卷 309-317页

作者： HOU Hai-yun PENG San-jun WANG sheng-ze geng Xing-peng College of Environmental and Chemical Engineering Xi ＇an Polytechnic University Xi＇an 710048 P. R. China College of Chemistry and Biological Engineering Changsha University of Science and Technology Changsha 410004 P. R. China

Over the full range of compositions, in the ternary-pseudo-binary mixtures of x[（1-y）C6H5CH=CH2＋ yCH3COOC2H5（or C6H6）]＋（1-x）[（1-y）NMP＋yCH3COOC2Hs（or C6H6）], the apparent molar volumes of each pseudo-pure component at different y values were calculated from the density data at 298.15 K and atmospheric pressure. The results show that the four parameters cubic polynomial can correlate the apparent molar volume with the molar fraction well over the full molar fraction range. The limiting partial molar volumes and the molar volumes of each pseudo-pure component were evaluated with different methods. Based on the limiting partial molar volume and molar volume at a certain y value, a new universal coefficient termed as solvation coefficient γ was defined to describe quantitatively the solvation degree of pseudo-pure solute and the interactions of solute-solvent molecules from the macroscopical thermodynamics viewpoint. The results demonstrate the solvation coefficients decrease with the amount of the third component increasing for each pseudo-pure solute, irrespective of the pseudo-pure solvent. Then the solvation degrees of each pseudo-pure component, the specific interactions between the solute molecule and the solvent one were discussed in terms of the solvation coefficient.

关键词： Apparent molar volume Ternary-pseudo-binary mixture Solvation coefficient

Renormalizability of leading order covariant chiral nucleon-nucleon interaction

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第5期45卷 113-121页

作者： Chun-Xuan Wang Li-sheng geng Bingwei Long School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data-based Precision Medicine Beihang UniversityBejing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China College of Physics Sichuan UniversitySichuan 610065China

In this work,we study the renormalization group invariance of the recently proposed covariant power counting in the case of nucleon-nucleon scattering[***.C 42(2018)014103]at leading *** show that unlike the Weinberg scheme,renormalizaion group invariance is satisfied in the^(3)P0 *** interesting feature is that the^(1)S0 and^(3)P1 channels are *** the relevant low energy constants by ftting to the^(1)S0 phase shiftsat T_(lab)=10 and 25 MeV with cutoff values∧=400-650 MeV,one can describe the 3 P1 phase shifts relatively *** the limit of∧→∞,the^(1)S0 phase shifts become cutoff-independent,whereas the 3P1 phase shifts do *** is consistent with the Wigner bound and previous observations that the 3P1 channel is best treated *** for the^(2)P1 and^(3)S1-^(3)D1 channels,renormalization group invariance is satisfied.

关键词： nucleon-nucleon interaction chiral effective field theory renormalization group invariance

Study of spatial distribution for the active ingredient in ibuprofen tablet based on near-infrared micro-imaging technology

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第11期22卷 1335-1338页

作者： Dong Wang Yun sheng Ding Jin Li Cao Yue He sheng Feng Ye Shun geng Min College of Science China Agricultural University Beijing 100193 China Yunnan Tobacco Company Dali Branch Dali 671000 China Beijing Research Center for Information Technology in Agriculture Beijing 100097 China

The NIR micro-images of ibuprofen tablets were collected in this *** correlation imaging and principal component analysis（PC A） with histogram were applied to acquire the spatial distribution of ibuprofen *** result indicated that a similar distribution trend can be acquired by both of the two methods mentioned above;the information of PC2 results from ibuprofen mainly since the correlation coefficient between PC2 loading vector and the NIR spectrum of ibuprofen is *** result of PCA indicated that the information of PC2 results from ibuprofen mainly for both the low and the high content of ibuprofen in the *** correlation coefficient between the data of the two PC2 loading vectors of the low and the high content of ibuprofen in the tablets is 0.9998,which indicates that the result of PCA is stable and reliable.

关键词： Near-infrared micro-imaging Compare correlation imaging Principal component analysis Ibuprofen Spatial distribution

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction