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Implementation experience of a 12-month intervention to introduce intermittent kangaroo mother care to eight Chinese neonatal intensive care units

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World Journal of Pediatrics 2022年第12期18卷 849-853页

作者： Xin liu Xiao-Hui Chen Zhan-Kui li Bei Cao Shao-Jie Yue Qiong-Yu liu Chuan-Zhong Yang Chang-Yi Yang Ying-Xi zhao geng-li zhao Qi Feng Neonatal Intensive Care Unit Department of PediatricsPeking University First HospitalBeijing 100034China Department of Neonatology Nanjing Maternity and Child Health Care HospitalNanjingChina Department of Neonatology Northwest Women’s and Children’s HospitalXi’anChina Department of Neonatology The Maternal and Child Health Care Hospital of Hunan ProvinceChangshaChina Department of Neonatology Xiangya Hospital Central South UniversityChangshaChina Department of Neonatology Women&Children’s Health Care Hospital of LinyiLinyiChina Department of Neonatology Shenzhen Maternity&Child Healthcare HospitalShenzhenChina Department of Neonatology Fujian Provincial Maternity and Children’s HospitalFuzhouChina Nuffield Department of Medicine University of OxfordOxfordUK Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina

Kangaroo mother care(KMC)is recommended by the World Health Organization for the care of preterm and low-birth-weight *** has been shown to increase survival rates and the quality of life of preterm and low-birth-weight infants,including improved clinical outcomes,weight gain and thermoregulation when compared to conventional care[1,2,3].More recent research focused on KMC in high-risk preterm,critically ill newborns and newborns requiring special care,which suggested that KMC helped to stabilize the vital signs of preterm infants[4,5].KMC is well accepted and promoted by medical associations and professional organizations around the world[6,7].In November 2015 with support from the National Health Commission of China,participants from ten hospitals based in different areas of China received theoretical and practical training on *** a four-year period,health professionals from these hospitals participated in theoretical and practical training,which included two operation training from foreign experts,two academic lectures,and three study tours to hospitals in the UK,Sweden and the *** this period,the KMC Operational Manual for Premature Infants in China was developed,and a 12-month prospective multicenter study of KMC for preterm infants was conducted in the eight *** the present study,we further examine whether KMC was sustained as a practice during a 12-month period from April 2018 to March 2019 and the characteristics of preterm infants that received KMC.

关键词： mother sustained promoted

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CRISPR/Cas9系统中引导RNA的研究进展

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生物技术通报 2019年第4期35卷 108-115页

作者：李江耿立召许建平先正达生物科技(中国)有限公司北京102206

CRISPR/Cas9系统作为重要的一种基因编辑工具,自产生以来广泛应用于各种生物体基因组序列的精确编辑,可在特定位点产生核苷酸的删除、插入或替换,从而改变编码基因的功能。以CRISPR/Cas9为代表的基因编辑技术将应用于包括生物育种在内... 详细信息

CRISPR/Cas9系统作为重要的一种基因编辑工具,自产生以来广泛应用于各种生物体基因组序列的精确编辑,可在特定位点产生核苷酸的删除、插入或替换,从而改变编码基因的功能。以CRISPR/Cas9为代表的基因编辑技术将应用于包括生物育种在内的各项生物技术领域,产生新一代生物技术产品。目前关于CRISPR/Cas9的研究报道多集中于Cas9蛋白的结构功能,以及CRISPR/Cas9系统的工作原理。引导RNA(Guide RNA)作为CRISPR/Cas9系统的重要组分之一,也是基因编辑技术领域的研究热点,近来有多篇文章报道通过改良引导RNA从而提高CRISPR/Cas9的编辑效率和精确性。对CRISPR/Cas9系统中的引导RNA研究进展进行了综述,围绕引导RNA的序列组成、结构特征以及转录产生方式这3方面内容,有助于全面了解CRISPR/Cas9系统的结构特征,讨论了引导RNA对CRISPR/Cas9基因编辑效率的影响,有利于CRISPR/Cas9系统的使用。最后,展望引导RNA今后的研究发展趋势,旨在解决CRISPR/Cas9目前存在的相关问题,优化出效率更高、精度更高的基因编辑技术。

关键词：基因编辑 CRISPR/Cas9 引导RNA

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Fuzzy Ranking Approach for Conceptual Design Evaluation

Fuzzy Ranking Approach for Conceptual Design Evaluation

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第二十七届中国控制会议

作者： geng liqing,zhao li,Hu Shan,li Hongwei Automation Engineering Department,Tianjin University of Technology and Education,Tianjin 300222,P.R.China

Schemes evaluation is one of the most important stages in conceptual design.A fuzzy ranking approach based on fuzzy preference relations,considering both customer preference and technical capability of design scheme,is *** terms are employed to denote the performance of intangible criteria while information content is applied to determining the fuzzy performances of tangible criteria;with the fuzzy performances,A partial preference relation of design schemes is got by constructing fuzzy preference relations on single-criteria ***,global preference relation is achieved by aggregating the partial preference relation on level of every *** orders of design schemes and the optimal scheme can thus be derived.A case study of high-speed chain stitch sewing machine is described to illustrate the effectiveness of the proposed approach.

关键词： Schemes evaluation Fuzzy ranking Fuzzy preference relation Information content Uncertainty

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中国四城市医院未婚人流女青年生殖道感染状况研究

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生殖与避孕 2005年第3期25卷 163-168页

作者：周敏张小松赵更力王临虹吴久玲北京大学第一医院妇产科妇儿保健中心北京100034 中国疾病预防控制中心妇幼保健中心北京100013

目的:了解未婚人流女青年生殖道感染/性传播疾病(RTIs/STIs)的患病率、性暴力的发生率及其相关的影响因素;了解未婚人流女青年性和生殖健康知识、态度、行为和生殖健康保健需求。方法:2002.10-2003.02期间,广东省深圳市、广西省南宁市... 详细信息

目的:了解未婚人流女青年生殖道感染/性传播疾病(RTIs/STIs)的患病率、性暴力的发生率及其相关的影响因素;了解未婚人流女青年性和生殖健康知识、态度、行为和生殖健康保健需求。方法:2002.10-2003.02期间,广东省深圳市、广西省南宁市、北京市、河南省郑州市的市级医院妇产科对2002名年龄<24岁来院要求人工流产的未婚女青年进行妇科检查和实验室检查及自填式问卷调查。结果:调查对象平均年龄为22.0±1.7岁,流动人口占61.0%。在调查中生殖道感染的患病率为57.1%,性传播疾病的患病率是9.8%。与生殖道感染有关的影响因素包括非流动人口、首次性行为年龄≤19岁、未使用避孕方法、既往有患RTIs病史、清洁外阴间隔时间≥2d。调查对象性暴力的发生率是11.7%。首次性行为的平均年龄为20.3±1.9岁。平均拥有性伴侣数为1.2±0.9个。生殖健康知识总分平均为4.2±2.3分(总分9分)。调查对象对生殖健康保健知识的需求依次为避孕知识、人工流产危害、性生理知识、性传播疾病的危害与预防等。结论:未婚人流女青年有关性和生殖健康知识贫乏;首次性行为平均年龄提前;RTIs/STIs是未婚人流女青年生殖健康的主要问题;未婚人流女青年中的性暴力现状不容忽视。

关键词：生殖健康生殖道感染性暴力未婚人流女青年

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao liang Xingping Quan Xiaorui geng Yujing Huang Yonghua zhao Lei Xi Zhen Yuan Ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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基于混合反向学习策略的鲸鱼优化算法

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计算机工程与科学 2022年第2期44卷 355-363页

作者：耿召里李目曹淑睿刘昶忻湖南科技大学信息与电气工程学院湖南湘潭411201

针对鲸鱼优化算法(WOA)在解决高维复杂问题时存在收敛速度慢、全局搜索能力不足的问题,提出一种最优最差个体混合反向学习的WOA(MWOA)。首先,引入一种自适应惯性权重,用于调节寻优前期的步长和寻优后期的种群多样性;其次,提出一种混合... 详细信息

针对鲸鱼优化算法(WOA)在解决高维复杂问题时存在收敛速度慢、全局搜索能力不足的问题,提出一种最优最差个体混合反向学习的WOA(MWOA)。首先,引入一种自适应惯性权重,用于调节寻优前期的步长和寻优后期的种群多样性;其次,提出一种混合反向学习策略并将其融入WOA,以提高算法的收敛精度;最后,引入一种参数非线性衰减策略,以提高其在高维度以及复杂问题上的探索开发能力和收敛速度。将MWOA与WOA、MS-WOA、IWOA对10个基准函数的优化效果进行比较,结果表明MWOA在收敛速度、优化精度上相较对比算法均有所提升。另外,将MWOA与CODE、CPSO、EGWO和DIHS进行比较,结果表明MWOA具有较好的收敛精度。

关键词：鲸鱼优化算法混合反向学习非线性收敛因子自适应权重

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao li zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Construction of Ni single-atom coordinated with doped N and S elements for mild hydrogenation of methyl acrylate to methyl propionate

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Nano Research 2025年第1期18卷 217-224页

作者： Taolue Sun Chen Jian Gang Wang Hui zhao Guoliang Zhang Zengxi li Chunshan li State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Huizhou Institute of Green Energy and Advanced Materials Huizhou 516081China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516081China

Although the nickel-based catalyst is able toexhibit comparative catalytic activity to noble metal formethyl acrylate hydrogenation,it requires strict reactioncondition,which can be improved by regulation ofcoordination *** this study,we constructed akind of Ni single-atom coordinated with N and S(Ni-NSC)through the pyrolysis of organic Ni-based precursors at600℃.The existence and fine structure of Ni single-atom were confirmed by the spherical electron microscopicobservation in combination with the X-ray absorption spectroscopy(XAS)*** addition,the catalytichydrogenation assessment suggested that the as-prepared Ni-NSC catalyst exhibited higher activity and stability than theNi/NSC supported catalyst prepared by incipient wetness impregnation *** remarkable catalytic activity was dueto the high dispersion and density of Ni single-atom and weak adsorption energy of intermediates on these Ni sites.

关键词： methyl acrylate mild hydrogenation Ni single-atom coordination environment adsorption energy

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