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Green Energy & Environment 2024年第3期9卷 544-555页

作者： Hengyuan Liu Xingjiang Wu Yuhao geng Xin Li jianhong Xu The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China

Electrocatalytic nitrogen reduction reaction(NRR)is considered as a promising candidate to achieve ammonia synthesis because of clean electric energy,moderate reaction condition,safe operating process and harmless ***,the chemical inertness of nitrogen and poor activated capacity on catalyst surface usually produce low ammonia yield and faradic ***,the microfluidic technology is proposed to efficiently fabricate enriched iridium nanodots/carbon *** to in-situ co-precipitation reaction and microfluidic manipulation,the iridium nanodots/carbon nanomaterials possess small average size,uniform dispersion,high conductivity and abundant active sites,producing good proton activation and rapid electrons transmission and moderate adsorption/desorption *** a result,the as-prepared iridium nanodots/carbon nanomaterials realize large ammonia yield of 28.73 μg h^(-1) cm^(-2) and faradic efficiency of 9.14%in KOH ***,the high ammonia yield of 11.21 μg h^(-1) cm^(-2) and faradic efficiency of 24.30%are also achieved in H_(2)SO_(4) *** microfluidic method provides a reference for large-scale fabrication of nano-sized catalyst materials,which may accelerate the progress of electrocatalytic NRR in industrialization field.

关键词： Iridium nanodots Carbon Microfluidic technology Efficient synthesis Electrocatalytic nitrogen fixation

Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy

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Chinese Medical Journal 2023年第5期136卷 571-577页

作者： Xiqin Fang Shan Qiao Ranran Zhang Tingting Yang Zhihao Wang Qingxia Kong Meihua Sun jianhong geng Chunyan Fang Yanxiu Chen Yanping Sun Dongmei Zhang Lixing Qu Wei Shang Jianguo Wang Xuewu Liu Department of Neurology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Institute of EpilepsyShandong UniversityJinanShandong 250000China Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China Department of Neurology Affiliated Hospital of Jining Medical CollegeJiningShandong 272000China Department of Neurology Tengzhou Central People’s HospitalJiningShandong 277599China Department of Neurology Affiliated Hospital of Weifang Medical CollegeWeifangShandong 261000China Department of Neurology Zhucheng People’s HospitalWeifangShandong 262200China Department of Neurology Liaocheng People’s HospitalLiaochengShandong 252000China Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of Neurology Linyi People’s HospitalLinyiShandong 276000China Department of Neurology Dezhou People’s HospitalDezhouShandong 253000China Department of Neurology Second Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Jinan Central HospitalJinanShandong 250000China.

Background:Given that seizures may be triggered by vaccination,this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy(PWE)after being vaccinated against coronavirus disease 2019(COVID-19).Methods:This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in *** divided the PWE into two groups as follows:(1)patients who developed seizures within 14 days of vaccination were assigned to the SAV(with seizures after vaccination)group;(2)patients who were seizure-free within 14 days of vaccination were assigned to the SFAV(seizure-free after vaccination)*** identify potential risk factors for seizure reccurence,the binary logistic regression analysis was ***,67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence,and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or ***:The study included a total of 407 patients;of which,48(11.8%)developed seizures within 14 days after vaccination(SAV group),whereas 359(88.2%)remained seizure-free(SFAV group).The binary logistic regression analysis revealed that duration of seizure freedom(P<0.001)and withdrawal from anti-seizure medications(ASMs)or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures(odds ratio=7.384,95%confidence interval=1.732–31.488,P=0.007).In addition,32 of 33 patients(97.0%)who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination.A total of 92(22.6%)patients experienced non-epileptic adverse reactions after *** logistic regression analysis results showed that vaccine did not significantly affect the recurrence

关键词： Coronavirus disease 2019 Electroencephalogram Seizure Vaccine

Lithium chloride alleviates MPTP-induced neurotoxicity in PD by activating the PI3K/Akt

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解剖学杂志 2021年第S1期44卷 129-130页

作者： Li Xuerwei Lyu E Pang Meng Li Jian geng jianhong Wang Yanqiang Weifang Medical University Weifang 261031China Department of Neurology II The Affiliated Hospital of Weifang Medical University

Dopamine replacement therapy is the most effective treatment to reduce motor symptoms in Parkinson's disease(PD).However,chronic L-Dopa treatment results in abnormal involuntary movements along with the prolongation of course of the disease and therapeutic *** studies have shown that lithium has the potential for the treatment of neurodegenerative *** tested whether lithium Chloride(LiCl)can reduce the progression of MPTP-induced damage by measuring weight and behavioral tests,further explored whether this is related to the PI3K/Akt signaling pathway using immunohistochemistry and *** results showed that lithium chloride significantly improved motor function and increased body weight and the expression of PI3K,p-Akt Ser473,and p-caspase 3 were significantly increased,Bax/Bcl-2 ratio and the level of p-caspase 3 were decreased.

关键词： PI3K/Akt lithium Dopamine

Lithium chloride alleviates MPTP-induced neurotoxicity in PD by activating the PI3K/Akt

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Lithium chloride alleviates MPTP-induced neurotoxicity in PD...

遗传性压迫易感性神经病临床、病理及遗传学研究（附11例报道）

中国解剖学会2021年年会

作者： Li Xuewei Lyu E Pang Meng Li Jian geng jianhong Wang Yanqiang Weifang Medical University Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical University

Dopamine replacement therapy is the most effective treatment to reduce motor symptoms in Parkinson’s disease (PD).However,chronic L-Dopa treatment results in abnormal involuntary movements along with the prolongation of course of the disease and therapeutic *** studies have shown that lithium has the potential for the treatment of neurodegenerative disorders.

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中华神经医学杂志 2016年第5期15卷 490-493页

作者：耿建红詹淑琴王黎首都医科大学宣武医院神经内科北京100053

目的通过研究遗传性压迫易感性神经病（HNPP）患者的临床、电生理、病理及基因突变特点，以提高对本病的认识及诊断水平。方法选取自1999年3月至2014年12月首都医科大学宣武医院神经内科收治的11例HNPP患者进行临床和体征资料采集、神... 详细信息

目的通过研究遗传性压迫易感性神经病（HNPP）患者的临床、电生理、病理及基因突变特点，以提高对本病的认识及诊断水平。方法选取自1999年3月至2014年12月首都医科大学宣武医院神经内科收治的11例HNPP患者进行临床和体征资料采集、神经电生理检查、腓肠神经活检、家系资料收集，并对先证者进行HNPP相关基因检测。结果本组11例患者中8例患者来自2个家系，家系1及家系2分别各有4例，符合常染色体显性遗传模式；另3例患者为散发病例。大部分患者在青少年发病，临床特征表现为局灶性单神经病，多于数天至数月内自行缓解。神经电生理检查有四肢广泛的运动及感觉神经传导速度减慢，于易嵌压部位神经传导速度减慢更明显。4例腓肠神经活检髓鞘染色均显示部分有髓纤维髓鞘脱失，轴索多正常，部分有髓纤维髓鞘增厚，形成＂洋葱球样＂改变，单神经剥离呈腊肠样。2例经基因检测存在17P11.2的周围神经髓鞘蛋白22（PMP22）基因区域连续性缺失突变。结论HNPP临床所表现的反复发生的与压迫有关的单神经麻痹很具有特征性，多呈典型的常染色体显性遗传，神经电生理检查在无症状的肢体也能检测到不同程度的神经传导速度减慢，周围神经活检可见髓鞘增生，基因检测发现特异位点的基因突变可确定诊断。

关键词：遗传性压迫易感性神经病神经电生理基因突变

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卵圆孔未闭致颈内动脉反常性栓塞一例

中国脑血管病杂志 2022年第7期19卷 501-503页

作者：张佳庞萌张术词贾帅王炎强耿建红潍坊医学院临床医学院 261053 潍坊医学院附属医院神经内二科

卵圆孔未闭(PFO)与隐源性卒中关系紧密,发病机制多为反常性栓塞。针对反常性栓塞进行病因排查十分重要。作者报道了1例卵圆孔未闭致颈内动脉反常性栓塞的青年卒中患者的临床资料及诊治过程,以提高临床医师对该类疾病的认识。

关键词：血管内治疗卵圆孔,未闭反常性栓塞

预测颈动脉粥样硬化易损斑块的新型生物标志物研究进展

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中国动脉硬化杂志 2022年第8期30卷 714-718页

作者：李梦馨庞萌李健耿建红王炎强潍坊医学院研究生院山东省潍坊市261031 潍坊医学院附属医院神经内二科山东省潍坊市261031

易损斑块是指动脉壁内稳定性差的斑块,其易破裂、脱落,导致原位血栓或多发微栓子形成。颈动脉粥样硬化易损斑块是缺血性脑卒中的主要致病机制,颈动脉斑块易损性增加脑缺血事件的发生。因此,早期鉴别易损斑块,对干预脑卒中高危因素、改... 详细信息

易损斑块是指动脉壁内稳定性差的斑块,其易破裂、脱落,导致原位血栓或多发微栓子形成。颈动脉粥样硬化易损斑块是缺血性脑卒中的主要致病机制,颈动脉斑块易损性增加脑缺血事件的发生。因此,早期鉴别易损斑块,对干预脑卒中高危因素、改善脑卒中预后具有重要意义。除各类影像技术外,循环生物标志物为识别颈动脉易损斑块提供了辅助手段。本综述回顾以往研究,讨论能够识别颈动脉易损斑块的新型生物标志物。

关键词：颈动脉粥样硬化易损斑块生物标志物缺血性脑卒中

乙肝清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化临床研究

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河北中医 2009年第10期31卷 1508-1510页

作者：徐菁黄桂芹耿建洪河北省沧州市传染病医院感染二科河北沧州061001 河北省沧州市传染病医院医务科河北沧州061001 河北省沧州市传染病医院感染一科河北沧州061001

目的观察乙型肝炎清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化的临床疗效。方法将乙型肝炎病毒DNA(HBV-DNA)、乙型肝炎表面抗原(HBsAg)阳性,中医辨证为肝胆湿热型的活动型肝炎肝硬化患者173例随机分为2组。治疗组102例予乙型肝炎清... 详细信息

目的观察乙型肝炎清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化的临床疗效。方法将乙型肝炎病毒DNA(HBV-DNA)、乙型肝炎表面抗原(HBsAg)阳性,中医辨证为肝胆湿热型的活动型肝炎肝硬化患者173例随机分为2组。治疗组102例予乙型肝炎清热解毒胶囊,每次6粒,每日3次口服;同时予拉米夫定,每次100 mg,每日1次口服,疗程1年。对照组71例予拉米夫定,每次100 mg,每日1次口服,疗程1年。观察2组血清HBV-DNA、HBsAg、乙型肝炎e抗原(HBeAg)阴转率和肝功能变化。结果治疗组HBsAg阴转率为5.9%,对照组阴转率为7.0%,2组比较差异无统计学意义(P>0.05);治疗组HBV-DNA阴转率67.6%、HBeAg阴转率32.4%,对照组HBV-DNA阴转率42.3%、HBeAg阴转率12.2%,2组比较差异均有统计学意义(P<0.05);肝功能指标改善及Child-Pugh评分下降治疗组较对照组明显(P<0.01)。结论乙型肝炎清热解毒胶囊联合拉米夫定对肝胆湿热型的活动性肝炎肝硬化疗效理想,能有效抑制HBV复制。

关键词：肝炎,慢性并发症肝硬化中西医结合疗法

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多驱动带式输送机功率的平衡

水泥技术 2020年第1期 48-50页

作者：周湖川毛文才耿建宏四川峨胜水泥集团股份有限公司原料分厂

分析了多驱动带式输送机传动滚筒磨损后产生功率不平衡的问题。通过采用冷包胶修复工艺,调整了各驱动滚筒直径和周长,平衡了驱动功率,多驱动带式输送机运行恢复正常。

关键词：多驱动带式输送机传动滚筒

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COLQ基因突变致先天性肌无力综合征1例

中国神经精神疾病杂志 2022年第10期48卷 624-628页

作者：张术词张佳刘振兴祝新莉耿建红王炎强潍坊医学院附属医院(临床医学院) 潍坊261000 潍坊医学院附属医院电生理室潍坊医学院附属医院神经内二科

患者男,10岁,从1岁时开始出现波动性进展的运动后肢体无力,神经系统查体:双下肢近端肌力4级,双下肢平举小于5 s下落,单下肢平举小于10 s下落,髂腰肌肌力3级,肌张力减低。重复神经电刺激(repetitive nerve stimulation,RNS)示:低频刺激... 详细信息

患者男,10岁,从1岁时开始出现波动性进展的运动后肢体无力,神经系统查体:双下肢近端肌力4级,双下肢平举小于5 s下落,单下肢平举小于10 s下落,髂腰肌肌力3级,肌张力减低。重复神经电刺激(repetitive nerve stimulation,RNS)示:低频刺激时波幅递减,四肢运动神经传导(motor conduction velocity,MCV)检查可见重复复合肌肉动作电位(repetitive compound muscle action potential,R-CMAP)。基因检测结果示COLQ基因存在c.393+1G>A和c.655G>A的杂合变异,经Sanger测序验证变异分别来自其父母,诊断为先天性肌无力综合征(congenital myasthenic syndrome,CMS)。予以沙丁胺醇治疗后,患者运动耐力较前增加。报告本例旨在增强临床医生对此疾病的认识,拓宽“肌无力”患者的诊断思路。c.655G>A错义变异既往无报告,可能是CMS的新致病位点。

关键词：先天性肌无力综合征重复神经电刺激低频递减重复复合肌肉动作电位 COLQ基因终板乙酰胆碱酯酶缺乏鉴别诊断