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Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution

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Bioactive Materials 2022年第3期7卷 183-197页

作者： Lili Bao geng dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an710032China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical EngineeringXi’an Jiao Tong UniversityXi’an710049China Department of Dermatology Tangdu HospitalThe Fourth Military Medical UniversityXi’an710038China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Digital DentistrySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China

Inflammatory response plays a critical role in myocardial infarction(MI)*** neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been ***,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI *** eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation *** in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac *** study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair.

关键词： Neutrophils Apoptotic bodies Engineering Inflammation Myocardial infarction

T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance

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Bioactive Materials 2021年第10期6卷 3150-3163页

作者： Xiaoshan Yang Fuxing Zhou Pingyun Yuan geng dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyFourth Military Medical UniversityXi’anShaanxi710032China Xijing Hospital of Digestive Diseases&State Key Laboratory of Cancer Biology Fourth Military Medical UniversityXi’anShaanxi710032China Department of Gynecology and Obstetrics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical EngineeringXi’an Jiao Tong UniversityXi’anShaanxi710049China Department of Dermatology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China

Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal *** chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell ***,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well ***,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)*** consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the *** showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in *** signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia ***,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 *** findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders.

关键词： Nanoparticles Activated T cell Immune tolerance Apoptotic extracellular vesicles Osteoporosis

高质量散布脉冲CELP算法的定点DSP实时实现

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北京工业大学学报 2006年第5期32卷 385-390页

作者：鲍长春白燕宁窦庚欣北京工业大学语音与音频信号处理研究室北京100022

为了将低比特率语音编码算法应用于实际的语音处理系统,开发了一种基于TMS320VC5410定点DSP 的实时低速率语音压缩系统．语音编码方法采用一种高质量的4 kb／s散布脉冲CELP算法．用汇编语言编写的定点DSP程序能在目标平台上实时完成语... 详细信息

为了将低比特率语音编码算法应用于实际的语音处理系统,开发了一种基于TMS320VC5410定点DSP 的实时低速率语音压缩系统．语音编码方法采用一种高质量的4 kb／s散布脉冲CELP算法．用汇编语言编写的定点DSP程序能在目标平台上实时完成语音数据的采集、处理和回放功能．整个系统大约占用31 K存储空间, 算法复杂度达到指令数为5．42×107条／s．客观质量测试结果显示,DSP定点程序处理后的语音质量非常接近于浮点C语言处理后的结果,表明该语音处理系统能满足实时语音压缩的需求．

关键词：语音编码码激励线性预测数字信号

双状态脉冲控制的一类食饵-捕食者模型阶1周期解的存在性

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西北大学学报（自然科学版） 2017年第5期47卷 643-648页

作者：耿妍窦霁虹李鹏西北大学数学学院陕西西安710127

研究一类具有HollingⅢ型功能反应函数的食饵-捕食者系统,在两种状态脉冲控制下周期解的存在性问题运用微分方程的几何理论和后继函数的方法,对食饵-捕食者模型中控制参数可能出现的五种情况进行了具体讨论,得到了该系统阶1周期解存在... 详细信息

研究一类具有HollingⅢ型功能反应函数的食饵-捕食者系统,在两种状态脉冲控制下周期解的存在性问题运用微分方程的几何理论和后继函数的方法,对食饵-捕食者模型中控制参数可能出现的五种情况进行了具体讨论,得到了该系统阶1周期解存在的条件。最后用数值模拟检验了结论的有效性,为现代病虫害治理提供了有效的方法。

关键词： HollingⅢ型食饵-捕食者模型双状态脉冲周期解后继函数

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ACELP语音编码器中增益码书的建立方法

北京工业大学学报 2007年第7期33卷 682-686页

作者：鲍长春窦庚欣范睿朱恒北京工业大学电子信息与控制工程学院北京100022

为提高ACELP语音编码器中激励增益的量化性能,基于广泛应用的代数码激励线性预测语音编码模型,提出了一种具有一般意义的激励增益码书的建立方法,该方法可应用于各种不同速率ACELP语音编码器中．实验结果表明,使用该方法建立的6b增益矢... 详细信息

为提高ACELP语音编码器中激励增益的量化性能,基于广泛应用的代数码激励线性预测语音编码模型,提出了一种具有一般意义的激励增益码书的建立方法,该方法可应用于各种不同速率ACELP语音编码器中．实验结果表明,使用该方法建立的6b增益矢量码书与8b标量增益码书的性能相当．

关键词：语音编码矢量量化误差分析码激励线性预测

Research on Intelligent Vehicle Following Technology Based on UWB

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ACELP语音编码中代数码书的快速搜索算法

第三十九届中国控制会议

作者： Jing-run Pan Yi-geng dou Xu-dong Huang Jian-hua Xu Jia-bin Chen Ling Xie School of Automation Beijing Institute of Technology

Considering the communication interference and occlusion for close following, this paper proposes an intelligent vehicle following method based on Ultra-Wideband（UWB）. Based on the characteristics of UWB ranging, we proposed four ranging schemes by combining different base station placement methods and positioning algorithms. We obtained the best method by collecting a large number of distance data from vehicle to beacon and angle data away from the front of the vehicle. Taking the characteristics of vehicle following into account, the deviation between the distance from the vehicle to the beacon and the safety distance is used to control the linear velocity, the angle away from the front of the vehicle is used to control the angular velocity. Finally, in order to test the following method, we carried out tracking experiment, and it is verified that it has good tracing effect under linear, V-shaped and S-shaped tracks.

关键词： UWB Positioning ROS Fuzzy control

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北京工业大学学报 2007年第8期33卷 823-827页

作者：鲍长春窦庚欣范睿刘泽新北京工业大学电子信息与控制工程学院北京100022

为降低ACELP语音编码中代数码书搜索的复杂度,提出了一种基于代数多子码书结构的多路径快速搜索算法.实验结果表明,在不降低编码质量的条件下,这种搜索算法的复杂度仅为全搜索算法的1/128.

关键词：语音编码算法计算复杂度

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神泉油田气井水合物防治研究与应用

化工设计通讯 2017年第5期43卷 144-145页

作者：杨辛更窦睿中国石油吐哈油田吐鲁番采油厂新疆吐鲁番838200

神泉油田纵向上发育五个油气藏,分别是中侏罗统三间房油藏(J2s)、下白垩统吐谷鲁群组油藏(K1tg)和古新统鄯善群组油藏(Esh),其中鄯善群组油藏从上到下又分为Esh上、Esh中、Esh下三个油藏。2013年1月葡北工区共有气井21口,工区日产气61万... 详细信息

神泉油田纵向上发育五个油气藏,分别是中侏罗统三间房油藏(J2s)、下白垩统吐谷鲁群组油藏(K1tg)和古新统鄯善群组油藏(Esh),其中鄯善群组油藏从上到下又分为Esh上、Esh中、Esh下三个油藏。2013年1月葡北工区共有气井21口,工区日产气61万方,其中9口高压气井时常发生冻堵,冻堵位置主要为油嘴、连接油嘴的地面管线和汇管,气井冻堵严重影响了油气的正常生产,需要重点解决。

关键词：油田气井水合物研究

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高频超声联合低频超声诊断肠套叠的临床价值

中国肛肠病杂志 2024年第4期44卷 34-37页

作者：蔡晓军茹燕耿豆豆河南省平顶山市第二人民医院湛河分院彩超室河南平顶山467000 平顶山市第二人民医院彩超室河南平顶山467000 平顶山市第二人民医院湛河分院内科河南平顶山467000

目的:研究高频超声(HFUS)联合低频超声(LFUS)诊断肠套叠的临床价值。方法:将2019年1月至2023年3月于我院诊断疑似肠套叠的62例患者纳入研究参与者,分别采用HFUS、LFUS以及二者联合诊断。将X光钡灌肠检查结果作为“金标准”,对比不同诊... 详细信息

目的:研究高频超声(HFUS)联合低频超声(LFUS)诊断肠套叠的临床价值。方法:将2019年1月至2023年3月于我院诊断疑似肠套叠的62例患者纳入研究参与者,分别采用HFUS、LFUS以及二者联合诊断。将X光钡灌肠检查结果作为“金标准”,对比不同诊断方式的诊断结果、诊断效能、诊断符合率和典型征象检出率。结果:3种检查方式的检查结果具有显著性差异,HFUS联合LFUS诊断结果、诊断效能均优于HFUS、LFUS单独诊断(P<0.05);联合检查肠套叠类型的诊断符合率分别为96.15%、90.00%和100.00%,均高于HFUS、LFUS单独检查(P<0.05);联合检查肠套叠典型征象的诊断率分别为100.00%、95.16%和98.39%,均高于HFUS、LFUS单独检查(P<0.05)。结论:HFUS联合LFUS诊断肠套叠的临床价值较高,可有效提高诊断符合率与诊断结果准确度,具有较高的诊断效能。

关键词：肠套叠高频超声低频超声诊断