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Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance

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Chinese Journal of Natural Medicines 2024年第4期22卷 341-355页

作者： WANG Hao geng Xiaolong AI Fangbin YU Zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang YUE Bei dou Wei The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia MedicaShanghai University of Traditional Chinese Medicine(SHUTCM)Shanghai 201203China

Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective ***,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains *** study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase ***,nuciferine significantly reduced the migration and invasion capabilities of MH7A *** therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory *** also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA *** results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats.

关键词： Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance Nuciferine

Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution

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Bioactive Materials 2022年第3期7卷 183-197页

作者： Lili Bao geng dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an710032China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical EngineeringXi’an Jiao Tong UniversityXi’an710049China Department of Dermatology Tangdu HospitalThe Fourth Military Medical UniversityXi’an710038China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Digital DentistrySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China

Inflammatory response plays a critical role in myocardial infarction(MI)*** neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been ***,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI *** eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation *** in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac *** study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair.

关键词： Neutrophils Apoptotic bodies Engineering Inflammation Myocardial infarction

Chromosomal-level genome and metabolome analyses of highly heterozygous allohexaploid Dendrocalamus brandisii elucidate shoot quality and developmental characteristics

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Journal of Integrative Plant Biology 2024年第6期66卷 1087-1105页

作者： Jutang Jiang Zeyu Zhang Yucong Bai Xiaojing Wang Yuping dou Ruiman geng Chongyang Wu Hangxiao Zhang Cunfu Lu Lianfeng Gu Jian Gao Key Laboratory of National Forestry and Grassland Administration Beijing for Bamboo&Rattan Science and TechnologyInstitute of Gene Science and Industrialization for Bamboo and Rattan ResourcesInternational Center for Bamboo and RattanBeijing 100102China College of Forestry Basic Forestry and Proteomics Research CenterFujian Agriculture and Forestry UniversityFuzhou 350002China School of Life Science Peking UniversityBeijing 100871China College of Biological Sciences and Biotechnology Beijing Forestry UniversityBeijing 100083China

Dendrocalamus brandisii(Munro)Kurz is a sympodial bamboo species with inimitable taste and flavorful *** rapid growth and use as high-quality material make this bamboo species highly valued for both food processing and wood ***,genome information for *** is lacking,primarily due to its polyploidy and large genome ***,we assembled a high-quality genome for hexaploid ***,which comprises 70chromosomes with a total size of 2,756 Mb,using long-read Hi Fi ***,we accurately separated the genome into its three constituent *** used Oxford Nanopore Technologies long reads to construct a transcriptomic dataset covering 15 tissues for gene annotation to complement our genome assembly,revealing differential gene expression and post-transcriptional *** integrating metabolome analysis,we unveiled that well-balanced lignin formation,as well as abundant flavonoid and fructose contents,contribute to the superior quality of *** *** genomic,transcriptomic,and metabolomic datasets provided a solid foundation for enhancing bamboo shoot quality and developing efficient gene-editing *** study should facilitate research on *** and enhance its use as a food source and wood material by providing crucial genomic resources.

关键词： bamboo shoots Dendrocalamus brandisii(Munro)Kurz flavonoid genome lignin

T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance

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Bioactive Materials 2021年第10期6卷 3150-3163页

作者： Xiaoshan Yang Fuxing Zhou Pingyun Yuan geng dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyFourth Military Medical UniversityXi’anShaanxi710032China Xijing Hospital of Digestive Diseases&State Key Laboratory of Cancer Biology Fourth Military Medical UniversityXi’anShaanxi710032China Department of Gynecology and Obstetrics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical EngineeringXi’an Jiao Tong UniversityXi’anShaanxi710049China Department of Dermatology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China

Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal *** chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell ***,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well ***,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)*** consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the *** showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in *** signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia ***,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 *** findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders.

关键词： Nanoparticles Activated T cell Immune tolerance Apoptotic extracellular vesicles Osteoporosis

高质量散布脉冲CELP算法的定点DSP实时实现

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北京工业大学学报 2006年第5期32卷 385-390页

作者：鲍长春白燕宁窦庚欣北京工业大学语音与音频信号处理研究室北京100022

为了将低比特率语音编码算法应用于实际的语音处理系统,开发了一种基于TMS320VC5410定点DSP 的实时低速率语音压缩系统．语音编码方法采用一种高质量的4 kb／s散布脉冲CELP算法．用汇编语言编写的定点DSP程序能在目标平台上实时完成语... 详细信息

为了将低比特率语音编码算法应用于实际的语音处理系统,开发了一种基于TMS320VC5410定点DSP 的实时低速率语音压缩系统．语音编码方法采用一种高质量的4 kb／s散布脉冲CELP算法．用汇编语言编写的定点DSP程序能在目标平台上实时完成语音数据的采集、处理和回放功能．整个系统大约占用31 K存储空间, 算法复杂度达到指令数为5．42×107条／s．客观质量测试结果显示,DSP定点程序处理后的语音质量非常接近于浮点C语言处理后的结果,表明该语音处理系统能满足实时语音压缩的需求．

关键词：语音编码码激励线性预测数字信号

双状态脉冲控制的一类食饵-捕食者模型阶1周期解的存在性

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西北大学学报（自然科学版） 2017年第5期47卷 643-648页

作者：耿妍窦霁虹李鹏西北大学数学学院陕西西安710127

研究一类具有HollingⅢ型功能反应函数的食饵-捕食者系统,在两种状态脉冲控制下周期解的存在性问题运用微分方程的几何理论和后继函数的方法,对食饵-捕食者模型中控制参数可能出现的五种情况进行了具体讨论,得到了该系统阶1周期解存在... 详细信息

研究一类具有HollingⅢ型功能反应函数的食饵-捕食者系统,在两种状态脉冲控制下周期解的存在性问题运用微分方程的几何理论和后继函数的方法,对食饵-捕食者模型中控制参数可能出现的五种情况进行了具体讨论,得到了该系统阶1周期解存在的条件。最后用数值模拟检验了结论的有效性,为现代病虫害治理提供了有效的方法。

关键词： HollingⅢ型食饵-捕食者模型双状态脉冲周期解后继函数

关于非线性鞍点问题的一个新的非线性不精确Uzawa算法

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应用数学 2024年第2期37卷 489-495页

作者：豆铨煜耿宏瑞关宏波郑州轻工业大学数学与信息科学学院河南郑州450002

本文针对非线性鞍点问题,借助于一个非线性映射,构造了一个新的非线性不精确Uzawa算法,该算法避免了传统Uzawa方法所必需的求逆运算.并通过精细分析得到了该算法在能量范数意义下收敛的充分条件,最后给出的数值实验验证了该方法的有效性.

关键词：非线性鞍点问题非线性不精确Uzawa算法收敛性分析

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ACELP语音编码器中增益码书的建立方法

北京工业大学学报 2007年第7期33卷 682-686页

作者：鲍长春窦庚欣范睿朱恒北京工业大学电子信息与控制工程学院北京100022

为提高ACELP语音编码器中激励增益的量化性能,基于广泛应用的代数码激励线性预测语音编码模型,提出了一种具有一般意义的激励增益码书的建立方法,该方法可应用于各种不同速率ACELP语音编码器中．实验结果表明,使用该方法建立的6b增益矢... 详细信息

为提高ACELP语音编码器中激励增益的量化性能,基于广泛应用的代数码激励线性预测语音编码模型,提出了一种具有一般意义的激励增益码书的建立方法,该方法可应用于各种不同速率ACELP语音编码器中．实验结果表明,使用该方法建立的6b增益矢量码书与8b标量增益码书的性能相当．

关键词：语音编码矢量量化误差分析码激励线性预测

计及成本和价值的长周期负荷侧调节能力投入策略

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全球能源互联网 2024年第1期7卷 37-45页

作者：高志远耿建李峰周竞陈鹏窦迅田颖中国电力科学研究院(南京) 江苏省南京市210003 南瑞集团有限公司(国网电力科学研究院有限公司) 江苏省南京市211106 南京工业大学电气工程与控制科学学院江苏省南京市211816 四川中电启明星信息技术有限公司四川省成都市610067

随着新型电力系统的发展,负荷侧调节能力建设日益受到关注,对于负荷侧调节能力成本、价值及其投入策略的研究,具有重要意义。基于近10 a来中国电力工业发展的基础数据,结合新型电力系统发展态势,分析了负荷侧调节能力需求的背景,通过对... 详细信息

随着新型电力系统的发展,负荷侧调节能力建设日益受到关注,对于负荷侧调节能力成本、价值及其投入策略的研究,具有重要意义。基于近10 a来中国电力工业发展的基础数据,结合新型电力系统发展态势,分析了负荷侧调节能力需求的背景,通过对发用电两侧调节能力特点的比较,从电力系统整体角度梳理了负荷侧调节能力的投入所带来的增量价值,分析了负荷侧调节能力的应用价值盈余,进一步结合具体需求提出了3种长周期下负荷侧调节能力投入的优化策略模型,并进行了算例分析。结果显示:负荷侧调节能力的投入有利于降低电力系统的总成本、增加系统调节能力,但是由于其成本曲线的变化以及“非持久特性”等因素,其投入策略需要综合长周期市场发展需求和发用电两侧成本因素进行权衡,所提出的3种优化模型各有其适用场景。

关键词：新型电力系统可调节负荷需求响应容量市场