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Effectiveness of royal jelly supplementation in glycemic regulation:A systematic review

World Journal of Diabetes 2019年第2期10卷 96-113页

作者： Kamel Omer Maxwell J Gelkopf genevieve newton Department of Human Health and Nutritional Sciences University of Guelph

BACKGROUND Royal jelly(RJ)has been observed to have therapeutic properties in diabetic individuals,including the reduction of high blood *** systematic review synthesized existing evidence to investigate the effectiveness of RJ supplementation in managing measures of blood *** To determine the effectiveness of RJ supplementation on glycemic responses in healthy and non-insulin dependent diabetic adults,as well as animal models of *** This was a systematic review employing the PRISMA ***-reviewed,published articles were extracted from several databases using key words related to target population,intervention and outcome and hand-selected for *** articles proceeded to data extraction phase,where information on target parameters and effectiveness of treatment was *** this,the risk of bias for each included study was ***,the long-term and immediate effectiveness of RJ supplementation in glycemic control were assessed using the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)tool,which rates the quality of *** Of 168 articles extracted from database searching,eighteen were included for analysis in this systematic *** the studies,studied populations,intervention styles and outcome measures were largely *** this,the results in studies indicate a general trend of positive effect of RJ in glycemic regulation in vitro and in ***,some dose-dependent glycemic effects were observed,along with some large effect *** risk of bias for human and animal studies is generally low-unclear risk,although lack of blinding is a serious concern in both ***,as per the GRADE tool,the quality of evidence is low,and very low for long-term and immediate effectiveness of RJ,respectively.A major limitation affecting evidence quality is the heterogeneity among included *** blood glucose and glucose clearance a

关键词： Royal jelly Type 2 diabetes Dietary supplement Glycemic control 10-hydroxy-trans-2-decenoic acid Hyperglycemia Adults Animals

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