检索结果-南通市图书馆

Bioactivity of mackerel peptides on obesity and insulin resistance,an in-vivo study

Food Bioscience 2022年第3期47卷 394-402页

作者： Soheila Abachi Hokmabadinazhad Jean-Philippe Songpadith Vanessa P.Houde geneviève pilon Ismail Fliss André Marette Laurent Bazinet Lucie Beaulieu Institute of Nutrition and Functional Foods (INAF) Université LavalQuebecQuebecCanada Department of Food Science Faculty of Agricultural and Food SciencesUniversité LavalQuebecQuebecCanada Department of Medicine Faculty of MedicineCardiology Axis of the Quebec Heart and Lung InstituteQuebecQuebecCanada

Of many metabolic irregularity risk factors,glucose intolerance,insulin resistance,and abdominal obesity are the main *** risk of vascular diseases and cancers is rather high in such individuals therefore its treatment and prevention are equally important for the health of *** including fish biopeptides have frequently shown to prevent and or ameliorate these risk *** our earlier studies,Atlantic mackerel hydrolysate and its fractions showed promising effects on immunity and ***,therefore,in the current study,aimed to examine the effects of mackerel hydrolysate along its cationic peptides,isolated at pH3 using electrodialysis with ultrafiltration membrane,on metabolic disorder factors in diet-induced insulin resistant obese *** were fed the chow and or the hypercaloric diet (high fat high sucrose) for the duration of *** the hypercaloric fed insulin resistant obese mice were gavaged daily either the vehicle and or the test material at the dosage of 208 mg of sample protein per kg mice body *** to our observations,mackerel peptides could not effectively modulate food intake,weight gain,adiposity,plasma glucose and insulin concentrations,hepatic cholesterol,and triglyceride ***,obesity and metabolic impairments could not be averted by the treatments in insulin resistant obese *** conclusion,anti-hypertensive,and immunomodulatory attributes of mackerel peptides at the tested concentrations do not seem to be correlated with its metabolic syndrome benefiting *** presume a general statement about the metabolic syndrome benefiting potency of Atlantic mackerel's biopeptides further research is warranted.

关键词： Atlantic mackerel Bioactivity Cationic peptides Diabetes Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of Caenorhabditis elegans pharynx,with emphasis on its nervous system

引用

Acta Pharmacologica Sinica 2005年第4期26卷 396-404页

作者： Marc pilon Catarina M RCK Lundberg Laboratory Chalmers University G teborg S-405 30 Sweden Lundberg Laboratory Chalmers University G teborg S-405 30 Sweden

The Caenorhabditis elegans pharynx is a neuromuscular tube of which the func-tion is to pump and crush bacteria,and inject them into the *** 80-cellpharynx develops via the morphogenesis and differentiation of the ceils that com-pose its semi-spherical primordiurn,and requires the activity of several evolution-arily conserved genes,such as pha-4 (the homolog to the Drosophilaforkheadand vertebrate FoxA),ceh-22 (the homolog to the Drosophila tinman and verte-brate Nkx2.5),and pha-2 (the homolog to the vertebrate Hex).There are 20 neu-rons in the pharynx,each with a reproducible unique *** analysis of axon guidance in the pharynx indicates that some axon trajec-tories are in part established without growth cones,whereas other parts necessi-tate growth cone function and *** we provide an overview of thedevelopmental genetics of the Caenorhabditis elegans pharynx,with an empha-sis on its nervous system.

关键词： Caenorhabditis elegans pharynx axon growth cones morphogenesis heart

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Lachesis Muta Muta: State of the Art

引用

Journal of Life Sciences 2021年第1期15卷 1-10页

作者： Grazielle Delaroli pilon Yoko Oshima-Franco Biomedicine Course University of Sorocaba(UNISO)Rodovia Raposo Tavares km 92.5SorocabaSP 18023-000Brazil Post-Graduate Program in Pharmaceutical Sciences University of Sorocaba(UNISO)Rodovia Raposo Tavares km 92.5SorocabaSP 18023-000Brazil

This article was carried out to gather a collection of data extracted from several studies about the snake Lachesis muta muta(surucucu),encompassing in this information from the effects and properties of its venom,case report,treatment and even *** was addressed throughout the study by referring mainly to their venom,which in isolated fractions,as LHFI,LHFII,LmTX-I,among others,present several activities,among which stand out are:coagulant,hemorrhagic,proteolytic and ***,other studies involving its diagnosis,treatment,cytotoxicity,edema,inflammation,genotoxicity and mutagenicity have also been carried *** bibliographic survey initially made,followed by the selection of collected data,was properly organized in the text using the narrative method,so that the findings could be chronologically distributed in a ***,it was possible to conclude that all these studies were and are of paramount importance to help understand the pathophysiology of envenoming by this snake,in addition to pointing out the Bothrops-Lachesis antivenom,opening a wide therapeutic window for numerous applications.

关键词： Lachesis muta muta snake venom state of the art

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贝叶斯方法

引用

作者： (加)Cameron Davidson-pilon

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats

引用

World Journal of Gastroenterology 2017年第38期23卷 6962-6972页

作者： Salim Hamdani Allan Thiolat Sina Naserian Cynthia Grondin Stéphane Moutereau Anne Hulin Julien Calderaro Philippe Grimbert JoséLaurent Cohen Daniel Azoulay Caroline pilon Université Paris-Est AP-HP Laboratoire de Biochimie Groupe Hospitalier Henri-Mondor Albert-Chenevier AP-HP Laboratoire de Pharmacologie-Toxicologie Biologiques Groupe Hospitalier Henri-Mondor Albert-Chenevier AP-HP Anatomie et Cytologie Pathologique Groupe Hospitalier Henri-Mondor Albert-Chenevier APHP Service de Chirurgie HPB et Trans-plantation Hépatique Groupe Hospitalier Henri-Mondor Albert-Chenevier Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation Henri Mondor Hospital

AIMTo test whether a delayed and short course of rapamycin would induce immunosuppressive effects following allogeneic orthotopic liver transplantation (OLT) in *** OLTs were performed using Dark Agouti livers transplanted into Lewis recipients, and syngeneic OLTs were performed using the Lewis rat strain. Rapamycin (1 mg/kg per day) was administered by gavage from day 4 to day 11 post-transplantation. Lymphocyte cellular compartments were analyzed by flow cytometry in draining lymph nodes, non-draining lymph nodes and the spleen at days 11 and 42 in rapamycin-treated rats, untreated control rats and syngeneic grafted rats. Skin grafts from Dark agouti or from F344 RT were performed at day 30 on liver grafted rats treated with *** 8-d course of rapamycin treatment initiated 4 d following transplantation resulted in the survival of grafted rats for more than 100 d. In contrast, untreated rats died of liver failure within 13 to 21 d. The analysis of the cellular compartment revealed an increase in two cellular subpopulations, specifically myeloid-derived suppressor cells (MDSCs) and CD8+CD45RClow T cells, without major modifications in the regulatory T cell (Treg) compartment in treated rats in the early stages after grafting. We evaluated the ability of treated rats to reject third-party allogeneic skin grafts to confirm their immune competence. In contrast, when skin was collected from rats syngeneic to the grafted liver, it was not *** results demonstrate that short and delayed rapamycin treatment allows for tolerance in allogeneic OLT. The results also allowed for the identification of the mechanisms of tolerance induced by rapamycin by identifying MDSCs and CD8+CD45RClow T cells as associated with the state of tolerance.

关键词： Myeloid-derived suppressor cells Liver transplantation Rapamycin Regulatory T cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endogenous Levels of Polyamines under Water-Deficit Stress during Cotton’s Reproductive Development

引用

American Journal of Plant Sciences 2015年第2期6卷 344-354页

作者： Dimitra A. Loka Derrick M. Oosterhuis Cristiane pilon Altheimer Laboratory Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA

Polyamines, putrescine (PUT), spermidine (SPD) and spermine (SPM) are implicated in plants’ responses under conditions of abiotic stress. Previous research in other crops has indicated that polyamines and changes in their concentrations are associated with drought tolerance under conditions of water-deficit stress;however, no information exists on cotton (Gossypium hirsutum L.). Growth chamber experiments were conducted with two cotton cultivars differing in drought tolerance, ST5288B2F (drought-sensitive) and Siokra L23 (drought-tolerant) in order to investigate the distribution of free polyamines, the effect of water-deficit stress on the polyamine metabolism of cotton reproductive units and their subtending leaves as well as the possible relationship between polyamines and drought tolerance in cotton. Our results showed that cotton ovaries contained significantly higher levels of total free polyamines compared to their subtending leaves under both control and water stress conditions. Water-deficit stress significantly increased PUT concentrations in ST5288B2F, while SPM levels significantly decreased in Siokra L23. The results indicated that water-deficit stress significantly affected cotton polyamine metabolism in reproductive structures and their subtending leaves;however, no clear relationship between drought-tolerance and changes in polyamine accumulation was established. Further research is needed to elucidate the mechanism according to which water-deficit stress affects polyamine metabolism.

关键词： Cotton Gas Exchange Polyamine Levels Reproductive Units Water-Deficit Stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Copper Delivery by the Copper Chaperone for Chloroplast and Cytosolic Copper/Zinc- Superoxide Dismutases： Regulation and Unexpected Phenotypes in an Arabidopsis Mutant

引用

Molecular Plant 2009年第6期2卷 1336-1350页

作者： Christopher M. Cohu Salah E. Abdel-Ghany Kathryn A. Gogolin Reynolds Alexander M. Onofrio Jared R. Bodecker Jeffrey A. Kimbrel Krishna K. Niyogi Marinus pilon Biology Department Colorado State University Fort Collins CO 80523-1878 USA Department of Plant and Microbial Biology University of California Berkeley CA 94720-3102 USA

Copper （Cu） is an important mineral nutrient found in chloroplasts as a cofactor associated with plastocyanin and Cu/Zn superoxide dismutase （Cu/ZnSOD）. Superoxide dismutases are metallo-enzymes found in most oxygenic organisms with proposed roles in reducing oxidative stress. Several recent studies in Arabidopsis have shown that microRNAs and a SQUAMOSA promoter binding protein-like7 （SPL7） transcription factor function to down-regulate the expression of many Cu-proteins, including Cu/ZnSOD in both plastids and the cytosol, during growth on low Cu. Plants contain the Cu Chaperone for SOD （CCS） that delivers Cu to Cu/ZnSODs, and, in Arabidopsis, both cytosolic and plastidic CCS versions are encoded by one gene. In this study, we demonstrate that Arabiclopsis CCS transcript levels are regulated by Cu, mediated by microRNA 398 that was not previously predicted to target CCS. The microRNA target site is conserved in CCS of Oryza sativa. The data suggest that Cu-regulated microRNAs may have more mRNA targets than was previously predicted. A CCS null mutant has no measurable SOD activity in the chloroplast and cytosol, indicating an absolute requirement for CCS. When the CCS null mutant was grown on high Cu media, it lacked both Fe superoxide dismutase （FeSOD） and Cu/ZnSOD activity. However, this did not lead to a visual phenotype and no photosynthetic deficiencies were detected, even after high light stress. These results indicate that Cu/ZnSOD is not a pivotal component of the photosynthetic anti-oxidant system during growth in laboratory conditions.

关键词： Chloroplast photosynthesis copper homeostasis superoxide dismutase microRNA.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety and immunogenicity of a third dose of mRNA-1273 vaccine among cancer patients

引用

Cancer Communications 2023年第7期43卷 749-764页

作者： Anna Giuliano Barbara Kuter Shari pilon-Thomas Junmin Whiting Qianxing Mo Brett Leav Bradley Sirak Christopher Cubitt Christopher Dukes Kimberly Isaacs-Soriano Kayoko Kennedy Somedeb Ball Ning Dong Akriti Jain Patrick Hwu Jeffrey Lancet Department of Cancer Epidemiology Moffitt Cancer CenterTampaFloridaUSA Moderna CambridgeMassachusettsUSA Department of Immunology Moffitt Cancer CenterTampaFloridaUSA Department of Biostatistics and Bioinformatics Moffitt Cancer CenterTampaFloridaUSA Immune Monitoring Core Moffitt Cancer CenterTampaFloridaUSA Non-Therapeutic Research Office(NTRO) Moffitt Cancer CenterTampaFloridaUSA Department of Malignant Hematology Moffitt Cancer CenterTampaFloridaUSA

Background:Compared to the general population,cancer patients are at higher risk of morbidity and mortality following SARS-CoV-2 *** immune response to a two-dose regimen ofmRNA vaccines in cancer patients is generally lower than in immunocompetent *** doses may meaningfully augment immune response in this *** conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three(100μg)of mRNA-1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 ***:The mRNA-1273 vaccine was administered~7 to 9 months after administering two vaccine doses(i.e.,the primary series).Immune responses(enzyme-linked immunosorbent assay[ELISA])were assessed 28 days post-dose *** events were collected at days 14(±5)and 28(+5)post-dose *** exact or X^(2)tests were used to compare SARS-CoV-2 antibody positivity rates,and paired t-tests were used to compare SARS-CoV-2 antibody geometric mean titers(GMTs)across different time ***:Among 284 adults diagnosed with solid tumors or hematologic malignancies,dose three of mRNA-1273 increased the percentage of patients seropositive for SARS-CoV-2 antibody from 81.7%pre-dose three to 94.4%28 days post-dose *** increased 19.0-fold(15.8-22.8).Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post-dose three,*** responses after dose three were reduced among those who received anti-CD20 antibody treatment,had lower total lymphocyte counts and received anticancer therapy within 3 *** patients seronegative for SARS-CoV-2 antibody pre-dose three,69.2%seroconverted after dose three.A majority(70.4%)experienced mostly mild,transient adverse reactions within 14 days of dose three,whereas severe treatment-emergent events within 28 days were very rare(<2%).Conclusion:Dose three of the mRNA-1273 vaccine was well-tolerated and augmented SAR

关键词： Cancer Coronavirus disease 2019 Immunogenicity Observational study Vaccination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

怎样清理性搔扰的烂摊子

引用

商业周刊（中文版） 2019年第2期 60-63页

作者： MARY pilon JERSEAN GOLATT(摄) 不详

2018年9月的媒体日,达拉斯独行侠队(Dallas Mavericks)首席执行官辛西娅·“辛特”·马歇尔(Cynthia “Cynt”Marshall)来到办公室时手机还在响个不停。

关键词：理性首席执行官达拉斯马歇尔办公室

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interaction of Seedling Germination, Planting Date, and Flumioxazin on Peanut Physiology under Irrigated Conditions

引用

American Journal of Plant Sciences 2020年第12期11卷 2012-2030页

作者： Nicholas L. Hurdle Timothy L. Grey Cristiane pilon W. Scott Monfort Donn G. Shilling Department of Crop and Soil Sciences University of Georgia Tifton GA USA

Diclosulam and flumioxazin applied preemergent (PRE) results in direct peanut exposure to these herbicides prior to seedling emergence. Flumioxazin has been reported to induce injury in adverse weather (i.e. cool-wet soil conditions) at crop emergence. Research at Ty Ty and Plains, Georgia evaluated the physiological effects of PRE herbicides to emerging peanut in 2018 and 2019. Peanut seed with variable germination and different planting dates were evaluated as additional factors. Peanut plant physiological measurements included electron transport (ETR), net assimilation rate (Anet), quantum yield of PSII (ΦPSII), and stomatal conductance to water vapor (GSW). Data were obtained from V3 to R1 peanut growth stages using a LiCOR 6800, along with stand counts and plant width measures. In 2018, diclosulam reduced peanut ETR when measured across multiple growing degree days (GDD) after planting, compared to the nontreated control (NTC). Flumioxazin reduced peanut ETR compared to the NTC, at several sample timings for each planting date. In 2018 and 2019 at both locations, flumioxazin impacted Anet less than ETR, but was consistently similar to/or greater than the NTC. Peanut ΦPSII responded similarly as Anet at each location and yr. GSW was variable in both years<

关键词： Diclosulam Flumioxazin Peanut Arachis hypogaea L. Photosynthesis Electron Transport

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：