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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： Di Wu yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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A Survey of Voltage-Controlled-Oscillator-Based ?∑ ADCs

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Tsinghua Science and Technology 2022年第3期27卷 472-480页

作者： yi Zhong Nan sun Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Department of Electrical and Computer Engineering The University of Texas at AustinAustinTX 78712USA

The benefits of technology scaling have fueled interest in realizing time-domain oversampling(?∑) of Analog-to-Digital Converters(ADCs). Voltage-Controlled Oscillators(VCO) are increasingly used to design ?∑ADCs because of their simplicity, high digitization, and low-voltage tolerance, making them a promising candidate to replace the classical Operational Transconductance Amplifier(OTA) in ?∑ ADC design. This work aims to provide a summary of the fully VCO-based ?∑ ADCs that are highly digital and scaling-friendly. This work presents a review of first-order and high-order VCO-based ?∑ ADCs with several techniques and architectures to mitigate the nonidealities introduced by VCO, achieving outstanding power efficiency. The contributions and drawbacks of these techniques and architectures are also discussed.

关键词： Voltage-Controlled Oscillator(VCO) Analog-to-Digital Converter(ADC) oversampling(?∑)ADC time-domain signal processing VCO-based?∑ADC

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Buchstaber Invariants of Universal Complexes

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1335-1344页

作者： yi sun School of Mathematical Sciences Fudan UniversityShanghai 200433China.

Davis and Januszkiewicz introduced(real and complex) universal complexes to give an equivalent definition of characteristic maps of simple polytopes, which now can be seen as "colorings". The author derives an equivalent definition of Buchstaber invariants of a simplicial complex K, then interprets the difference of the real and complex Buchstaber invariants of K as the obstruction to liftings of nondegenerate simplicial maps from K to the real universal complex or the complex universal complex. It was proved by Ayzenberg that real universal complexes can not be nondegenerately mapped into complex universal complexes when dimension is 3. This paper presents that there is a nondegenerate map from 3-dimensional real universal complex to 4-dimensional complex universal complex.

关键词： Buchstaber invariant Universal complex Lifting problem

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Optimization of equimolar reverse constant-temperature mass-diffusion process for minimum entransy dissipation

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Science China(Technological Sciences) 2016年第12期59卷 1867-1873页

作者： XIA Shao Jun CHEN Lin gen sun Feng Rui Institute of Thermal Science and Power Engineering Naval University of Engineering Military Key Laboratory for Naval Ship Power Engineering Naval University of Engineering College of Power Engineering Naval University of Engineering

The mass entransy describes the mass-diffusion ability of the solution system, and the mass-diffusion process with the finite concentration difference always leads to the mass-entransy dissipation. This paper studies the equimolar reverse constant-temperature mass-diffusion process with Fick's law( g∝Δ(c)). The optimal concentration paths for the MED(Minimum Entransy Dissipation) are derived and compared with those for the MEG(Minimum Entropy generation) and CCR(Constant Concentration Ratio) operations. It is indicated that the strategy of the MED is equivalent to that of the CCD(Constant Concentration Difference) of the same component; whether the MED or the MEG is selected as the optimization objective, the strategy of the CCD is much better than that of the CCR.

关键词： mass entransy finite time thermodynamics equimolar reverse mass-diffusion Fick's mass-diffusion law optimal concentration path generalized thermodynamic optimization

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Exploring three-dimensional biological tissues with new chemical labels

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Chinese Chemical Letters 2023年第12期34卷 7-8页

作者： Qiu-yi Duan Fu-gen Wu State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Three-dimensional(3D)histology has exhibited tremendous potential in fundamental research and clini-cal disease grading,but compatible labeling techniques are still *** in Science Advances,Pac et *** a new histological technique termed 3DNFC,which realizes 3D fluorescence imaging of thick tissues via citrate-based in situ fluorophore formation.

关键词： Three-dimensional histology Fluorescence staining In situfluorophoreformation 3Dimagingof organs Citrate

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Sparse recovery in probability via l_q-minimization with Weibull random matrices for 0 < q ≤ 1

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Applied Mathematics(A Journal of Chinese Universities) 2018年第1期33卷 1-24页

作者： GAO yi PENG Ji-gen YUE Shi-gang School of Mathematics and Statistics Xi'an Jiaotong University School of Mathematics and Information Science North Minzu University School of Mathematics and Information Science Guangzhou University School of Computer Science University of Lincoln

Although Gaussian random matrices play an important role of measurement matrices in compressed sensing, one hopes that there exist other random matrices which can also be used to serve as the measurement matrices. Hence, Weibull random matrices induce extensive interest. In this paper, we first propose the lrobust null space property that can weaken the D-RIP, and show that Weibull random matrices satisfy the lrobust null space property with high probability. Besides, we prove that Weibull random matrices also possess the lquotient property with high probability. Finally, with the combination of the above mentioned properties,we give two important approximation characteristics of the solutions to the l-minimization with Weibull random matrices, one is on the stability estimate when the measurement noise e ∈ R~n needs a priori ‖e‖≤ε, the other is on the robustness estimate without needing to estimate the bound of ‖e‖. The results indicate that the performance of Weibull random matrices is similar to that of Gaussian random matrices in sparse recovery.

关键词： compressed sensing l_q-minimization Weibull matrices null space property quotient property

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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu yifei Yang yike Jing Zhen Zeng Xuesong yi Wei sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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Variable Selection in the Partially Linear Errors-in-Variables Models for Longitudinal Data

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 769-780页

作者： yi-ping YANG Liu-gen XUE Wei-hu CHENG College of Mathematics and Statistics Chongqing Technology and Business University Department of Applied Mathematics Beijing University of Technology

This paper proposes a new approach for variable selection in partially linear errors-in-variables （EV） models for longitudinal data by penalizing appropriate estimating functions. We apply the SCAD penalty to simultaneously select significant variables and estimate unknown parameters. The rate of convergence and the asymptotic normality of the resulting estimators are established. Furthermore, with proper choice of regularization parameters, we show that the proposed estimators perform as well as the oracle procedure. A new algorithm is proposed for solving penalized estimating equation. The asymptotic results are augmented by a simulation study.

关键词： errors-in-variables variable selection estimating function oracle SCAD

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Tracking the atomic pathways of Pt3Ni-Ni(OH)2 core-shell structures at the gas-liquid interface by in-situ liquid cell TEM

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Science China Chemistry 2020年第4期63卷 513-518页

作者： Junyu Zhang gen Li Hong-Gang Liao Shi-Gang sun State Key Lab of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Using the in-situ liquid cell transmission electron microscopy, the three-stage growth of Pt3Ni-Ni(OH)2 core-shell structures at the gas-liquid interfaces was clearly observed, which consists of(1) a thermodynamically driven Pt3Ni alloy core by the monomer attachment,(2) a nickel(Ni) shell formation due to the depletion of the Pt salt precursor, and(3) the oxidation and of the Ni shell into Ni(OH)2 flakes. We also further observed the nucleation and growth of the Ni(OH)2 flakes on an existing layer either at the middle part or at the step edge. More interestingly, the dynamic transformation among a Pt3Ni alloy, Ni clusters and Ni(OH)2 flakes was also imaged even at a high electron dose rate.

关键词： Pt3Ni-Ni(OH)2 core-shell structure liquid cell electron microscopy gas-liquid interface dynamic transformation

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On Global and Local Properties of the Trajectories of Gaussian Random Fields——A Look Through the Set of Limit Points

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Acta Mathematica Sinica,English Series 2020年第2期36卷 137-152页

作者： Wen Sheng WANG Zhong gen SU yi Min XIAO School of Economics Hangzhou Dianzi UniversityHangzhou 310018P.R.China School of Mathematical Sciences Zhejiang UniversityHangzhou 310027P.R.China Department of Statistics and Probability Michigan State UniversityMI 48824USA

This paper studies the global and local properties of the trajectories of Gaussian random fields with stationary increments and proves sufficient conditions for Strassen's functional laws of the iterated logarithm at zero and infinity *** sets of limit points of those Gaussian random fields are *** main results are applied to fractional Riesz-Bessel processes and the sets of limit points of this field are obtained.

关键词： Fractional Riesz-Bessel processes functional law of the iterated logarithm Gaussian random fields large deviation principle

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