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Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats

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World Journal of Gastroenterology 2021年第16期27卷 1770-1784页

作者： Shan Tong Huan Wang Li-Sha A Ta-na bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai gen-na ba Sung-Bo Cho Ming-Hai Fu School of Mongolian Medicine Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Mongolian Medicine Surgery Department Affiliated Hospital of Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Traditional Mongolian Medicine Research Institute Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina

baCKGROUND Sulongga-4(SL-4)is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis,even though its pharmacological mechanism has not been well *** To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation(PL)in *** PL was performed to induce gastric and duodenal ulcers in rats,which were then treated with oral SL-4(1.3,2.6,or 3.9 g/kg per day)for 15 ***-induced gastroduodenal *** effects were characterized by pathological and histological evaluations and inflammatory indicators were analyzed by enzyme-linked immunosorbent *** analyses were conducted to identify gene expression profiles of gastroduodenal tissue in PL rats with or without SL-4 *** candidate target genes were selected and verified by quantitative reverse transcription polymerase chain reaction(qRT-PCR).RESULTS SL-4 decreased histopathological features in the PL-induced ulcerated ***-4 significantly (P nalysiswas used to identify a panel of candidate target genes for SL-4 acting on PLinducedulceration. genes included some complement and coagulation cascadeand retinol metabolism pathways that are closely associated with inflammatoryresponses and gastric mucosal protective mechanisms. qRT-PCR showed thataltered expression of the selected genes, such as CYP2b2, UGT2b1, A2m, andMASP1 was consistent with the microarray ***-4 exerts protective effects against PL-induced gastroduodenal ulcers viareducing inflammatory cytokines and elevating expression of gastric acidinhibitory factors. Downregulation of CYP2b2 and UGT2b1 genes in retinolmetabolism and upregulation of A2m and MASP1 ge

关键词： Sulongga-4 Peptic ulcer Pyloric ligation Microarray analysis Inflammatory reaction Retinol metabolism

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Lomatogonium rotatum extract alleviates diabetes mellitus induced by a high-fat,high-sugar diet and streptozotocin in rats

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World Journal of Diabetes 2023年第6期14卷 846-861页

作者： Li-Li Dai Sung-Bo Cho Hui-Fang Li Li-Sha A Xiao-Ping Ji Sirigunqiqige Pan Ming-Lan bao Laxinamujila bai gen-na ba Ming-Hai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsHainan Medical UniversityHaikou 571199Hainan ProvinceChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199Hainan ProvinceChina

baCKGROUND Lomatogonium rotatum(LR)is traditionally used in Mongolian folk medicine as a hypoglycemic agent,but its evidence-based pharmacological effects and mechanisms of action have not been fully *** To emphasize the hypoglycemic action mechanism of LR in a type 2 diabetic rat model and examine potential biomarkers to obtain mechanistic understanding regarding serum metabolite *** A high-fat,high-sugar diet and streptozotocin injection-induced type 2 diabetic rat model was *** chemical composition of the LR was identified by high performance liquid *** extract administrated as oral gavage at 0.5 g/kg,2.5 g/kg,and 5 g/kg for 4 ***-diabetic effects of LR extract were evaluated based on histopathological examination as well as the measurement of blood glucose,insulin,glucagon-like peptide 1(GLP-1),and lipid *** metabolites were analyzed using an untargeted metabolomics *** According to a chemical analysis,swertiamarin,sweroside,hesperetin,coumarin,1.7-dihydroxy-3,8-dimethoxyl xanthone,and 1-hydroxy-2,3,5 trimethoxanone are the principal active ingredients in *** anti-diabetic experiment revealed that the LR treatment significantly increased plasma insulin and GLP-1 levels while effectively lowering blood glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,and oral glucose tolerance test compared to the model ***,untargeted metabolomic analysis of serum samples detected 236 metabolites,among which 86 were differentially expressed between the model and the LR *** was also found that LR considerably altered the levels of metabolites such as vitamin B6,mevalonate-5P,Dproline,L-lysine,and taurine,which are involved in the regulation of the vitamin B6 metabolic pathway,selenium amino acid metabolic pathway,pyrimidine metabolic pathway,and arginine and proline metabolic *** These findings indicated that LR may have a hypoglycemic im

关键词： Mongolian medicine Lomatogonium rotatum Type 2 diabetes Metabolomics Swertiamarin Streptozotocin

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Botanical,chemical,and pharmacological characteristics of Lomatogonium rotatum:A review

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World Journal of Pharmacology 2022年第2期11卷 6-15页

作者： Li-Li Dai Rong-Gui Eni Ming-Hai Fu gen-na ba School of Mongolian Medicine Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina

Lomatogonium rotatum(***)Fries ex Nym,a dry whole grass belonging to the family gentianaceae,is widely used to treat liver diseases in Mongolian *** Mongolian medicine,*** Fries ex Nym,also known as Digeda,is a rare medicinal herb with low yield and widespread clinical ***,it is included in over 25 traditional Mongolian medicine prescriptions that help reduce heat,dispel xieri,enhance stomach function,and heal *** studies have shown that *** Fries ex Nym contains a variety of metabolites,including flavonoids,xanthone compounds,terpenoids,organic acids,steroids,and *** addition,its anti-hepatitis B,anti-inflammatory,anti-acute liver injury,and anti-obesity effects have been proven by pharmacological *** this review,we summarize the ecological resources,traditional pharmacodynamics,chemical constituents,and pharmacological actions of *** Fries ex Nym,with an aim to provide a theoretical basis for future applied research and new product development.

关键词： Mongolian medicine Lomatogonium rotatum Chemical composition Pharmacological action Research progress

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History, philosophy and modern research of traditional Mongolian medicine

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History & Philosophy of Medicine 2022年第4期4卷 1-10页

作者： Xi-Ye-Le Mu Lan Feng na Ta Li bai Ru-Re A gen-na ba Ming-Hai Fu NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) School of Mongolian MedicineInner Mongolia Minzu UniversityTongliao 028000China Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199China

The Mongolian nationality is a legendary ethnic group with a long *** the long history process,Mongolians have developed broad,profound and gorgeous cultural patterns in many aspects,such as living,diet,clothing,language,writing,dance,art,medicine and health,which has accumulated tremendous achievements and formed its unique *** Mongolian medicine(TMM)is one of the most important ethnic medicines with systematic theories that has been developed over thousands of years among Mongolian *** study of TMM has the potential to aid in the prevention and treatment of a wide range of diseases,as well as the provision of more effective medical services across the *** paper reviews the key literature concerned with the origin and history,main theoretical philosophies and the modern research status of *** provides a reference for the study of traditional medicine.

关键词： traditional Mongolian medicine developmental history theoretical system modernization research

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Bitter components related to alleviating intestinal obstruction in traditional Mongolian medicine

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TMR Theory and Hypothesis 2020年第2期3卷 337-347页

作者： Hong-Zhen Yu Li-Sha A Xiao-Ping Ji Sung-Bo Cho gen-na ba Peng-Fei Han Ming-Hai Fu School of Mongolian Medicine Inner Mongolia University for NationalitiesTongliaoChina Faculty of Psychology Southwest UniversityChongqingChina.

Intestinal obstruction is a blockage that keeps digesta from passing through upper or lower *** Mongolian medicine(TMM)has been proven to be efficacious in the clinical treatment of intestinal ***,the mechanism of its treatment has not been *** bitter taste receptors(T2Rs)are highly expressed in the extra-oral digestive system,such as gastrointestinal tract,which can regulate gastrointestinal peristalsis and contraction of gastrointestinal smooth *** the respiratory system,T2Rs can relax the airway smooth muscle and effectively alleviate asthma *** this review,the theory and clinical applications of bitter herbs in TMM were discussed and the functional expression of T2Rs and bitter taste signal transduction pathway were analyzed to investigate whether bitter Mongolian medicine may play an effective role in promoting gastrointestinal ***,the scientific connotation of the theory of bitter medicinal property of TMM was interpreted by combining T2Rs research and application of modern *** new research approach may enrich and improve the basic theory and accelerate the modernization of TMM.

关键词： Intestinal obstruction Mongolian medicine Bitter taste receptors Signal transduction pathway

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Multi-Step Clustering of Smart Meters Time Series:Application to Demand Flexibility Characterization of SME Customers

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 869-907页

作者： Santiago bañales Raquel Dormido natividad Duro Department of Computer Sciences and Automatic Control Universidad Nacional de Educación a Distancia(UNED)Madrid28040Spain Iberdrola Innovation Middle East Doha210177Qatar

Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens’participation in the energy *** study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time *** meter data is split between daily and hourly normalized time series to assess monthly,weekly,daily,and hourly seasonality patterns *** dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series *** intraday clustering procedure sequentially identifies representative hourly day-unit profiles for each customer and the entire *** the first time,a step function approach is applied to reduce time series *** attributes embedded in surveys are employed to build external clustering validation metrics using Cramer’s V correlation factors and to identify statistically significant determinants of load-shape in energy *** addition,a time series features engineering approach is used to extract 16 relevant demand flexibility indicators that characterize customers and corresponding clusters along four different axes:available Energy(E),Temporal patterns(T),Consistency(C),and Variability(V).The methodology is implemented on a real-world electricity consumption dataset of 325 Small and Medium-sized Enterprise(SME)customers,identifying 4 daily and 6 hourly easy-to-interpret,well-defined *** application of the methodology includes selecting key parameters via grid search and a thorough comparison of clustering distances and methods to ensure the robustness of the *** research can test the scalability of the methodology to larger datasets from various customer segments(households and large commercial)and locations with different weather and socioeconomic conditio

关键词： Electric load clustering load profiling smart meters machine learning data mining demand flexibility demand response

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Two new xanthones from Lomatogonium carinthiacum

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Chinese Journal of natural Medicines 2014年第9期12卷 693-696页

作者： ba-gen-na CHEN Yu-Lan baderihu TONG Yu-Feng Ye-ri-gui WANG Qing-Hu College of Traditional Mongolian Medicine Inner Mongolia University for Nationalities

AIM: To study the chemical constituents of Lomatogonium carinthiacum(Wulfen) Rchb. METHOD: The CHCl3-soluble fraction was separated by chromatography and the structures of the new compounds were elucidated by spectral experiments. RESULTS: Two new xanthones, 1, 8-dihydroxy-4, 5-dimethoxy-6, 7-methylenedioxyxanthone(1), 1, 4, 8-trimethoxyxanthone-6-O-β-D-glucoronyl-(1→6)O-β-D-glucoside(2) were isolated from the whole plant of Lomatogonium carinthiacum. CONCLUSION: Compounds 1 and 2 are new natural products.

关键词： dihydroxy dimethoxy glucoside elucidated separated methoxyl silica spectroscopic elucidation gentianaceae

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Multiplicity and Uniqueness of Positive Solutions for Nonhomogeneous Semilinear Elliptic Equation with Critical Exponent

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 81-94页

作者： na ba Yan-yan WANG Lie ZHENG School of Science Hubei University of Technology Department of Mathematics Zhoukou Normal University

In this paper,we consider the following problem {-Δu（x）＋u（x）=λ（u^p（x）＋h（x））,x∈R^N,u（x）∈h^1（R^N）,u（x）〉0,x∈R^N,（＊）where λ 〉 0 is a parameter,p =（N＋2）/（N—2）.We will prove that there exists a positive constant 0 〈 A＊〈＋00such that（＊） has a minimal positive solution for λ∈（0,λ＊）,no solution for λ 〉 λ＊,a unique solution for λ = λ＊.Furthermore,（＊） possesses at least two positive solutions when λ∈（0,λ＊） and 3 ≤ N ≤ *** N ≥ 6,under some monotonicity conditions of h we show that there exists a constant 0 〈λ＊＊〈 λ＊ such that problem（＊）possesses a unique solution for λ∈（0,λ＊＊）.

关键词： nonhomogeneous semilinear elliptic problems multiplicity uniqueness

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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi gen ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

baCKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

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Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu Lin-na Wu Yuan Zhang Te ba Xiao-feng Zhao Acupuncture and Moxibustion Department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China national Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

background:Electroacupuncture is often used to treat ***:To evaluate the efficacy and safety of electroacupuncture for *** strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China national Knowledge Infrastructure,Wanfang Data and VIP Fulltext e-Journals Database were searched up to January 15,*** criteria:Randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,publication year,diagnostic criteria,sample size,population characteristics,interventions and *** above steps were performed independently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was reported when the same scale was *** dichotomous variables (clinical response rate and adverse events),a meta-analysis was performed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacupuncture was more effective in improving insomnia compared with the control group (sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];P<0.001).There was no significant difference in the incidence of adverse events between the EA and control groups (sham acupuncture and no treatment or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addition,the regression results revealed t

关键词： Electroacupuncture Insomnia Systematic review Meta-analysis

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