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XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer:a meta-analysis in 17 studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 875-883页

作者： Jian CHEN Qing-wei ZHAO gen-ming shi Lin-run WANG Department of Pharmacy the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Medical Oncology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： XRCCl polymorphism is a research hotpot in individual treatment for non-small cell lung cancer （NSCLC）. To obtain the association between XRCC1 polymorphism and clinical outcome of platinum-based treatment for NSCLC, a meta-analysis was conducted. Methods： Databases including PubMed, Embase, Cochrane, and Chi- nese National Knowledge Infrastructure （CNKI） were searched for publications that met the inclusion criteria. A fixed effect model was used to estimate pooled odds ratio （OR） and hazard ratio （HR） with 95% confidence interval （CI） for the association between XRCC1 Arg399GIn and response or survival of platinum-based treatment for advanced NSCLC. A chi-squared-based Q-test was used to test the heterogeneity hypothesis. Egger＇s test was used to check publication bias. Results： Seventeen published case-control studies that focus on the association between XRCC1 Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC in 2 256 subjects were included in this meta-analysis, of whom 522 were AA genotypes （23.2% frequency）, 916 AG genotypes （40.6% frequency）, and 818 GG genotypes （36.2% frequency）. The overall response rate （ORR） was 45.2% （110/243） for AA genotype pa- tients, 29.9% for AG genotype （73/244）, and 30.7% for GG genotype （124/403）. The heterogeneity test did not show any heterogeneity and the Egger＇s test did not reveal an obvious publication bias among the included studies. The meta-analysis indicated that AA genotype patients presented higher response rates toward platinum drug treatment compared with G model （GG＋GA） patients （GG vs. AA model： OR=0.489, 95% CI 0.266-0.900, P=0.021; AG vs. AA model： OR=0.608, 95% CI 0.392-0.941, P=0.026; GA＋AA vs. GG model： OR=1.259, 95% CI 0.931-1.701, P=-0.135; GG＋GA vs. AA model： OR=0.455, 95% CI 0.313-0.663, P=0.0001）. However, no evidence validates XRCC1 associates with the survival following platinum drug therapy. Conclusions： Our meta-analysis suggested that XRCC1 Arg399GIn is r

关键词： Meta-analysis XRCC1 Arg399Gln Non-small cell lung cancer (NSCLC) Response Survival

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Combination chemotherapy with paclitaxel,cisplatin and fluorouracil for patients with advanced and metastatic gastric or esophagogastric junction adenocarcinoma:a multicenter prospective study

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Chinese Journal of Cancer Research 2012年第4期24卷 291-298页

作者： Xiao-Dong Zhang Yong-Qian Shu Jun Liang Feng-Chun Zhang Xue-Zhen Ma Jian-Jin Huang Li Chen gen-ming shi Wei-Guo Cao Cheng-Ye Guo Lin Shen Mao-Lin Jin Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal Medical OncologyPeking University Cancer Hospital & Institute Department of Medical Oncology Jiangsu Province Hospital Department of Medical Oncology the Affiliated Hospital of Medical CollegeQingdao University Department of Medical Oncology Suzhou Kowloon HospitalShanghai Jiaotong University School of Medicine Department of Medical Oncology Qingdao Central Hospital Department of Medical Oncology Second Affiliated HospitalZhejiang University Department of Medical Oncology Shandong Tumor Hospital Department of Medical Oncology the First Affiliated Hospital of College of MedicineZhejiang University Department of Medical Oncology Ruijin Hospital ShanghaiShanghai Jiaotong University School of Medicine Department of Medical Oncology Qingdao Municipal Hospital

Objective： To evaluate the efficacy and toxicity of the combination regimen of paclitaxel, cisplatin and 5-FU （PCF） as first-line or second-line therapy in patients with advanced gastric and esophagogastric junction （EGJ） adenocarcinoma in China. Methods： The patients were treated with paclitaxel 150 mg/m2 on dl; fractionated cisplatin 15 mg/m2 and continuous infusion 5-FU 600 mg/（mLd） intravenously on d 1-d5 of a 21-d cycle until disease progression or unacceptable toxicities. Results： Seventy-five patients have been enrolled, among which, 41 received PCF regimen as the first-line therapy （group A） and 34 received the regimen as the second-line therapy （group B） with the median age of 59 years old and Karnofsky performance status （KPS） score 〉80. Toxicities were analyzed in all 75 patients. Seventy-one patients were evaluable for efficacy. The median overall survival （mOS） was 12.0 months （95% CI： 7.9-16.2 months） in group A and 7.3 months （95% CI： 4.3-10.3 months） in group B, respectively. The median progression-free survival （mPFS） was 5.7 months （95% CI： 4.1-7.2 months） and 5.0 months （95% CI： 3.1-6.9 months）, respectively. The response rate （CR^PR） was 40% （16/40; 95% CI： 24.9-56.7%） in group A and 22.6% （7/31; 95% CI： 9.6-41.1%） in group B. Major grade 3 or 4 adverse events include neutropenia （41.3 %）, febrile neutropenia （9.3 %）, nausea/anorexia （10.7%）, and vomiting （5.3 %）. There was no treatment-related death. Conclusions： The combination chemotherapy with PCF is active and tolerable as first-line and second- line therapy in Chinese patients with advanced gastric and EGJ adenocarcinoma. The response and survival of PCF are same as those of DCF, but the tolerance is much better.

关键词： Advanced gastric cancer esophagogastric junction (EGJ) adenocarcinoma paclitaxel

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Emission of Intermediate-Mass Fragments From Hot-Nuclei Produced in the Reaction ^(40)Ar+^(nat)Ag at 25 MeV/u

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Chinese journal of nuclear physics 1995年第3期17卷 223-227页

作者： Jiang Dong-xing Qian Xing Qian Tao Hua Hui Lin Jun-song Department of Technical Physics,Peking University,Beijing 100871Wu En-jiu Zheng Ji-wen Jing gen-ming Yin shi-zhi Tan Ju-lian Jing Wei-yang Song ming-tao Li Zu-yu He Zhi-yong Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000 北京大学技术物理系北京中科院近代物理所甘肃兰州

Inclusive Intermediate-Mass Fragments（IMFs）are measured at seven angles for the40Ar+Ag reaction at 25 MeV/*** energy spectra of IMF from Li to F are obtained.A thermal mod-el with the same parameters well fits the energy spectra of all IMFs at backward *** IMFs areevaporated from hot nuclei formed in an incomplete fusion *** angular distribution and Z distri-bution are calculated with the statistical code GEMINI.

关键词： 40Ar+natAg reaction Intermediate-mass fragments Nuclear temperature Evaporation from hot nuclei

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XRCC1 Arg399GIn and clinical outcome of platinum-based treatment for ad- vanced non-small cell lung cancer： a meta-analysis in 17 studies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 215-215页

作者： Jian CHEN Qing-wei ZHAO gen-ming shi Lin-run WANG

Objective： XRCC1 polymorphism is a research hotpot in individual treatment for non-small cell lung cancer （NSCLC）. To obtain the association between XRCC1 polymorphism and clinical outcome of platinum-based treatment for NSCLC, a meta-analysis was conducted. Methods： Databases including PubMed, Embase, Cochrane, and Chinese National Knowledge Infrastructure （CNKI） were searched for publications that met the inclusion criteria. A fixed effect model was used to estimate pooled odds ratio （OR） and hazard ratio （HR） with 95% confidence interval （CI） for the association between XRCCI Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC. A chi-squared-based Q-test was used to test the heterogeneity hypothesis. Egger＇s test was used to check publication bias. Results： Seventeen published case-control studies that focus on the association between XRCCI Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC in 2 256 subjects were included in this meta-analysis, of whom 522 were AA genotypes （23.2% frequency）, 916 AG genotypes （40.6% frequency）, and 818 GG genotypes （36.2% frequency）. The overall response rate （ORR） was 45.2% （110/243） for AA genotype patients, 29.9% for AG genotype （73/244）, and 30.7% for GG genotype （124/403）. The heterogeneity test did not show any heterogeneity and the Egger＇s test did not reveal an obvious publication bias among the included studies. The meta-analysis indicated that AA genotype patients presented higher response rates toward platinum drug treatment compared with G model （GG＋GA） patients （GG vs. AA model： OR=0.489, 95% CI 0.266-0.900, P=0.021; AG vs. AA model： OR=0.608, 95% CI 0.392 0.941, P=0.026; GA＋AA vs. GG model： OR=1.259, 95% CI 0.931 1.701, P=0.135; GG＋GA vs. AA model： OR=0.455, 95% CI 0.313 0.663, P=-0.0001）. However, no evidence validates XRCC1 associates with the survival following platinum drug therapy. Conclusions： Our meta-analysis suggested that XRCC1 Arg399Gln is relat

关键词：非小细胞肺癌基础设施工程药物治疗晚期临床固定效应模型铂基因多态性

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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-ming Yuan Guo-Da Zhang Chao Wang Shu-Juan Sun Peng-Fei shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan shi Yun-Hao Xu ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Contact theory and algorithm

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Science China(Technological Sciences) 2021年第8期64卷 1775-1790页

作者： shi gen-Hua University of Chinese Academy of Sciences Beijing100049China DDA-NMM Company Beijing100026China School of Qilu Transportation Shandong UniversityJinan250100China

In discontinuous computations,contacts between two general blocks A and B are common and represent a fundamental *** paper presents a mathematically proven theory and algorithm to address this *** the proposed approach,a reference point a0 is selected from block A,and the contacts between blocks A and B are transferred to the contact of the reference point a0 and the entrance block E(A,B).Discontinuity related computations DEM,DDA,and FEM can use this mathematically proven theory and algorithm directly.

关键词： contact discontinuity entrance block computational geometry

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1-吡啶甲酰基-4-烯丙基氨基硫脲的合成与结构表征

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山西大学学报(自然科学版) 2007年第1期30卷 64-67页

作者：赵明根石玉芳赵江瑜吕海斌张婷婷忻州师范学院化学系忻州师范学院化学系山西忻州034000

报道了1-吡啶甲酰基-4-烯丙基氨基硫脲的合成.以3-溴丙烯和硫氰酸铵制得异硫氰酸烯丙酯(1);将2-吡啶甲酸,3-吡啶甲酸和4-吡啶甲酸酯化;由酯化反应所得(3a-3c)经肼解得吡啶甲酰肼(4a-4c);最后将化合物(1)分别和4a,4b,4c反应,合成了1-吡... 详细信息

报道了1-吡啶甲酰基-4-烯丙基氨基硫脲的合成.以3-溴丙烯和硫氰酸铵制得异硫氰酸烯丙酯(1);将2-吡啶甲酸,3-吡啶甲酸和4-吡啶甲酸酯化;由酯化反应所得(3a-3c)经肼解得吡啶甲酰肼(4a-4c);最后将化合物(1)分别和4a,4b,4c反应,合成了1-吡啶甲酰基-4-烯丙基氨基硫脲类化合物(5a-5c),其结构经红外光谱、氢核磁共振谱、元素分析表征.

关键词： 1-吡啶甲酰基-4-烯丙基氨基硫脲烯丙基氨基硫脲合成

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Influences of shale microstructure on mechanical properties and bedding fractures distribution

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Petroleum Science 2024年第3期21卷 1944-1954页

作者： ming-Zhe Gu Mao Sheng shi-Zhong Cheng Fan-Hao Gong gen-Sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

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