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Current knowledge for the risk factors of early permanent pacemaker implantation following transcatheter aortic valve replacement and what is next for the primary prevention?

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World Journal of Cardiology 2024年第2期16卷 54-57页

作者： gen-min lin Wei-Chun Huang Chih-Lu Han Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan Cardiovascular Center Kaohsiung Veterans General HospitalKaohsiung 81346Taiwan Department of Medicine Taipei Veterans General HospitalTaipei 112Taiwan

In this editorial,we comprehensively summarized the preoperative risk factors of early permanent pacemaker implantation after transcatheter aortic valve replacement(TAVR)among patients with severe aortic stenosis from several renowned clinical studies and focused on the primary prevention of managing the modifiable factors,e.g.,paroxysmal atrial fibrillation before the TAVR.

关键词： Permanent pacemaker implantation Transcatheter aortic valve replacement Interventricular conduction delay Diabetes Supraventricular arrhythmia

High risk for obstructive sleep apnea and risk of hypertension in military personnel: The CHIEF sleep study

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World Journal of Clinical Cases 2023年第30期11卷 7309-7317页

作者： Wei-Nung Liu Ko-Huan lin Kun-Zhe Tsai Chen-Chih Chu Yun-Chen Chang Younghoon Kwon gen-min lin Department of Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Psychiatry Hualien Tzu Chi HospitalHualien City 970TaiwanChina Department of Stomatology of Periodontology Mackay Memorial HospitalTaipei 104TaiwanChina School of Nursing and Graduate Institute of Nursing China Medical UniversityTaichung 406TaiwanChina Department of Medicine University of WashingtonSeattle98104-2499United States Department of Medicine Hualien Armed Forces General HospitalHualien City 970TaiwanChina

BACKGROUND Epidemiological studies have revealed an association between obstructive sleep apnea(OSA)and hypertension in the general population,while the association in military personnel was rarely *** To examine the association between high risk for OSA and hypertension by phenotypes in military young *** A total of 746 military personnel,aged 27.9 years,were included in the cardiorespiratory fitness and health in armed forces(CHIEF)-sleep study in Taiwan in *** medications were not used by the *** risk for OSA was assessed using the Berlin *** was defined using the 7th Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure(JNC 7)and the 2017 American College of Cardiology(ACC)/American Heart Association(AHA)*** cutoff levels of systolic and diastolic blood pressure(SBP and DBP)for the 2017 ACC/AHA-and JNC 7-based guidelines were 130/140 mmHg and 80/90 mmHg,*** phenotypes included isolated systolic and diastolic hypertension(ISH,high SBP only and IDH,high DBP only)and combined hypertension(both high SBP and DBP).Multivariable logistic regression analysis with adjustment for demographics,lifestyle and metabolic *** The prevalence of high risk for OSA,JNC 7-based hypertension and 2017 ACC/AHA-based hypertension were 8.0%,5.2%and 22.0%,*** with a high risk for OSA had a higher probability of JNC 7-based overall and combined hypertension(odds ratios(ORs))and 95%confidence intervals:2.82(1.07-7.42)and 7.54(1.10-51.54),although the probabilities of ISH and IDH were unaffected by a high risk for OSA(ORs:1.96 and 2.35,respectively,both P>0.05).In contrast,no associations for any hypertension phenotypes were found according to the 2017 ACC/AHA *** A high risk for OSA was associated with severe hypertension and combined hypertension among Asian military young adults.

关键词： Asian young adults Berlin questionnaire Hypertension phenotypes Military Sleep apnea

Cancer risk among patients with hereditary muscular dystrophies:a population-based study in Taiwan,1997-2009

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Chinese Journal of Cancer 2014年第5期33卷 256-258页

作者： gen-min lin Yi-Hwei Li Department of Public Health Tzu-Chi University Department of Medicine Hualien Armed Forces General Hospital

Muscular dystrophies(MD) comprise a heterogeneous group of hereditary myopathic *** this group,myotonic MD is associated with an increased cancer ***,the cancer risk in other types of MD is *** address this gap in knowledge,we assessed data obtained from the Taiwan Health Insurance Program database.A total of 1,272 patients with MD diagnosed between 1997 and 2009 were *** were followed up for cancer during the same period by record linkage with the cancer certification in ***-and sex-standardized incidence ratios(SIRs) of overall and site-specific cancers were *** congenital and progressive hereditary MD,there were 685 and 505 cases(males:69.5% and 80.6%),the median ages at diagnosis were 16 and 13 years,and the mean follow-up durations were 7.12 and 5.06 years,*** addition,cancers were developed in 10 patients with congenital MD and 3 patients with progressive hereditary *** MD patients exhibited an increased cancer risk,yielding an SIR of 3.37 [95% confidence interval(CI) = 1.38-8.25] in congenital MD and 2.95(95% CI = 0.95-9.19) in hereditary progressive ***-specific cancer SIRs were not powered to be significantly *** conclusion,genetic defects in hereditary MD may increase cancer risks in females and a sex difference should be further investigated.

关键词：肌营养不良遗传性癌症风险台湾地区患者基础人口

Pros and cons of continuous glucose monitoring in the intensive care unit

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World Journal of Clinical Cases 2021年第29期9卷 8666-8670页

作者： ming-Tsung Sun I-Cheng Li Wei-Shiang lin gen-min lin Department of Medicine Hualien Armed Forces General HospitalHualien 971Taiwan Department of Medicine Tri-Service General HospitalTaipei 114Taiwan

Diabetes mellitus affects people worldwide,and management of its acute complications or treatment-related adverse events is particularly important in critically ill *** reports have confirmed that hyperglycemia can increase the risk of mortality in patients cared in the intensive care unit(ICU).In addition,severe and multiple hypoglycemia increases the risk of mortality when using insulin or intensive antidiabetic *** innovation of continuous glucose monitoring(CGM)may help to alert medical caregivers with regard to the development of hyperglycemia and hypoglycemia,which may decrease the potential complications in patients in the *** major limitation of CGM is the measurement of interstitial glucose levels rather than real-time blood glucose levels;thus,there will be a delay in the treatment of hyperglycemia and hypoglycemia in ***,the European Union approved a state-of-art artificial intelligence directed loop system coordinated by CGM and a continuous insulin pump for diabetes control,which may provide a practical way to prevent acute adverse glycemic events related to antidiabetic therapy in critically ill *** this mini-review paper,we describe the application of CGM to patients in the ICU and summarize the pros and cons of CGM.

关键词： Continuous glucose monitor Diabetes Insulin Intensive care unit Hypoglycemia

generating diverse clothed 3D human animations via a generative model

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Computational Visual Media 2024年第2期10卷 261-277页

作者： min Shi Wenke Feng lin Gao Dengming Zhu School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Data-driven garment animation is a current topic of interest in the computer graphics *** approaches generally establish the mapping between a single human pose or a temporal pose sequence,and garment deformation,but it is difficult to quickly generate diverse clothed human *** address this problem with a method to automatically synthesize dressed human animations with temporal consistency from a specified human motion *** the heart of our method is a twostage ***,we first learn a latent space encoding the sequence-level distribution of human motions utilizing a transformer-based conditional variational autoencoder(Transformer-CVAE).Then a garment simulator synthesizes dynamic garment shapes using a transformer encoder-decoder *** the learned latent space comes from varied human motions,our method can generate a variety of styles of motions given a specific motion *** means of a novel beginning of sequence(BOS)learning strategy and a self-supervised refinement procedure,our garment simulator is capable of efficiently synthesizing garment deformation sequences corresponding to the generated human motions while maintaining temporal and spatial *** verify our ideas *** is the first generative model that directly dresses human animation.

关键词： Transformer garment animation conditional variational autoencoder(CVAE) computer graphics

Hydrothermal hydrogenation/deoxygenation of palmitic acid to alkanes over Ni/activated carbon catalyst

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Chinese Journal of Chemical Engineering 2024年第2期66卷 8-18页

作者： min lin Yuhao Yan Xiaoxian Li Rui Li Yulong Wu MOE Engineering Center of Forestry Biomass Materials and Bioenergy Beijing Forestry UniversityBeijing 100083China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Key Laboratory of Advanced Reactor Engineering and Safety of ministry of Education Tsinghua UniversityBeijing 100084China

To produce paraffin from hydrogenation/deoxygenation of palmitic acid,model compound of bio-oil obtained by hydrothermal liquefaction(HTL)of microalgae has been an attractive focus in recent *** order to avoid energy-intensive separation process of water and bio-oil,it is of importance that deoxygenation upgrading of fatty acids under hydrothermal conditions similar to HTL ***,it is the first time to explore the application of activated carbon(AC)-supported non-noble-metal catalysts,such as Ni,Co,and Mo,and so on,in the hydrothermal hydrogenation/deoxygenation of long-chain fatty acids,and the obtained Ni/AC-H(the Ni/AC was further H_(2)pre-reduced)is one of the best *** addition,it is found that the catalytic activity can be further improved by H_(2)pre-reduction of *** results that are more low valences of nickel and oxygen vacancy can be obtained after H_(2)pre-reduction,thus significant promoting the deoxygenation especially the decarbonylation pathway of fatty *** total alkanes yield can reaches 95.9%at optimal conditions(280℃,360 min).This work confirmed that the low-priced AC-supported non-noble-metal catalysts have great potential compared with the noble-metal catalyst,in hydrothermal upgrading of bio-oil.

关键词： Bio-oil Fatty acids Deoxygenation Hydrothermal upgrading

In-situ thermal Raman mapping and stress analysis of CNT/CF/epoxy interfaces

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新型炭材料（中英文） 2024年第4期39卷 703-714页

作者： HE Jing-zong CHEN Shi MA Zheng-kun LU Yong-gen WU Qi-lin State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

A study of the interfacial behavior and internal thermal stress distribution in fiber-reinforced composites is essential to assess their performance and ***/carbon fiber(CF)hybrid fibers were constructed using electrophoretic *** interfacial properties of CF/epoxy and CNT/CF/epoxy composites were statistically investigated and compared using in-situ thermal Raman mapping by dispersing CNTs as a Raman sensing medium(CNT_(R))in a *** associated local thermal stress changes can be simulated by capturing the G'band position distribution of CNT_(R) in the epoxy at different *** was found that the G'band shifted to lower positions with increasing temperature,reaching a maximum difference of 2.43 cm^(−1) at 100℃.The interfacial bonding between CNT/CF and the matrix and the stress distribution and changes during heat treatment(20-100℃)were investig-ated in *** work is important for studying thermal stress in fiber-reinforced composites by in-situ thermal Raman mapping technology.

关键词： Thermal Raman mapping Stress distribution Carbon fiber Carbon nanotube Interface

Distributions of Visual Receptive Fields from Retinotopic to Craniotopic Coordinates in the Lateral Intraparietal Area and Frontal Eye Fields of the Macaque

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Neuroscience Bulletin 2024年第2期40卷 171-181页

作者： lin Yang min Jin Cong Zhang Ning Qian mingsha Zhang Key Laboratory of Cognitive Neuroscience and Learning Division of PsychologyBeijing Normal UniversityBeijing 100875China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Neuroscience and Zuckerman Institute Columbia UniversityNew York 10027USA

Even though retinal images of objects change their locations following each eye movement,we perceive a stable and continuous *** possible mechanism by which the brain achieves such visual stability is to construct a craniotopic coordinate by integrating retinal and extraretinal *** have been several proposals on how this may be done,including eye-position modulation(gain fields)of retinotopic receptive fields(RFs)and craniotopic *** the present study,we investigated coordinate systems used by RFs in the lateral intraparietal(LIP)cortex and frontal eye fields(FEF)and compared the two *** mapped the two-dimensional RFs of neurons in detail under two eye fixations and analyzed how the RF of a given neuron changes with eye position to determine its coordinate *** same recording and analysis procedures were applied to the two brain *** found that,in both areas,RFs were distributed from retinotopic to craniotopic *** was no significant difference between the distributions in the LIP and *** a small fraction of neurons was fully craniotopic,whereas most neurons were between the retinotopic and craniotopic *** distributions were strongly biased toward the retinotopic side but with significant craniotopic *** results suggest that there is only weak evidence for craniotopic RFs in the LIP and FEF,and that transformation from retinotopic to craniotopic coordinates in these areas must rely on other factors such as gain fields.

关键词： Reference frames Eye-centered Headcentered Visual stability

Psychological stress and long-term blood pressure variability of military young males:The cardiorespiratory fitness and hospitalization events in armed forces study

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World Journal of Cardiology 2020年第12期12卷 626-633页

作者： Yen-Po lin Chia-Hao Fan Kun-Zhe Tsai Ko-Hwan lin Chih-Lu Han gen-min lin Department of Critical Care Medicine Yonghe Cardinal Tien HospitalYonghe 234Taiwan Department of Nursing Hualien Armed Forces General HospitalHualien 97144Taiwan Department of Dentistry Hualien Armed Forces General HospitalHualien 971Taiwan Department of Psychiatry Hualien Armed Forces General HospitalHualien 97144Taiwan Department of Medicine Taipei Veterans General HospitalTaipei 112Taiwan Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan

BACKGROUND Acute stress might increase short-term heart rate variability and blood pressure variability(BPV);however,chronic stress would not alter short-term BPV in animal *** To examine the association of psychological stress with long-term BPV in young male *** We prospectively examined the association of chronic psychological stress with long-term BPV in 1112 healthy military males,averaged 32.2 years from the cardiorespiratory fitness and hospitalization events in armed forces study in *** stress was quantitatively evaluated with the Brief Symptom Rating Scale(BSRS-5),from the least symptom of 0 to the most severe of 20,and the five components of anxiety,insomnia,depression,interpersonal sensitivity,and hostility(the severity score in each component from 0 to 4).Longterm BPV was assessed by standard deviation(SD)for systolic and diastolic blood pressure(SBP and DBP),and average real variability(ARV),defined as the average absolute difference between successive measurements of SBP or DBP,across four visits in the study period from 2012 to 2018(2012-14,2014-15,2015-16,and 2016-18).RESULTS The results of multivariable linear regressions showed that there were no correlations of the BSRS-5 score with SDSBP,SDDBP,ARVSBP,and ARVDBP after adjusting for all the covariates[β(SE):-0.022(0.024),-0.023(0.026),-0.001(0.018),and 0.001(0.020),respectively;P>0.05 for all].In addition,there were also no correlations between each component of the BSRS score and the long-term BPV *** Our findings suggest that chronic psychological stress might not be associated with long-term BPV in military young male humans.

关键词： Long-term blood pressure variability Military Psychological stress Young males Brief Symptom Rating Scale Average real variability