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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas gema.roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María nuñez-negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades neurodegenerativas(CIBERnED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de neurología Hospital Virgen de las NievesGranadaSpain Departamento de neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa roldán Schilling Carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical *** Out of 1433 patients,453(31.6%)were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5±1.3vs.3.0±1.4;Pnd HAS-BLED scores(2.0±1.0vs.1.4±1.0;Pn was adequately prescribed in 83.4%of patients,but more frequently in the younger population(71.1%vs.89.1%;P=0.039).After a mean follow-up of 2.2±0.6 years,annual rates of stroke+systemic embolism+transient ische-mic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03%and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar com-pared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independ-ently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with and higher HAS-BLED score with major ***,Conclusions In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately pre-scribed in the majority of octogenarians.

关键词： patients atrial bleeding

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Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain: a prospective population-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Roure Sílvia Vallès Xavier Pérez-Quílez Olga López-Mu?oz Israel Chamorro Anna Abad Elena Valerio Lluís Soldevila Laura Espa?a Sergio Hegazy Alaa H. A. Fernández-Rivas gema Gorriz Ester Herena Dolores Oliveira Mário Miralles Maria Carme Conde Carmen Montero-Alia Juan José Fernández-Pedregal Elia Miranda-Sánchez Jose Llibre Josep M. Isnard Mar Bonet Josep Maria Estrada Oriol Prat núria Clotet Bonaventura The Schisto-Stop study group International Health Program (PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les Infeccions c/Can Ruti s/n Badalona Spain Infectious Diseases Department Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans Trias i Pujol Research Institute c/Can Ruti s/n Badalona Spain Microbiology Department Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Department of Genetics and Microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of Medicine University of Asyut El Fateh Assiut Governorate Egypt Department of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles Primary Health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Primary Health Care Unit Mataró-(Rocafonda-Palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona north Metropolitan Primary Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18–76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11–21] years. The most frequent country of origin was Senegal (n = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forSchistosoma. Parasite eggs were present in the urine of only 1.3%. nine genitourinary clinical items were significantly associated with positiveSchistosoma serology results: pelvic pain (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dyspareunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positiveSchistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant

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Spatial variability of soil organic carbon stock in an olive orchard at catchment scale in Southern Spain

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International Soil and Water Conservation Research 2023年第2期11卷 311-326页

作者： Jose A.Gòmez gema Guzmán Tom Vanwalleghem Karl Vanderlinden Institute for Sustainable Agriculture.Spanish national Research Council(IAS-CSIC) Alameda del Obispo S/N14004CordobaSpain Department of Agronomy University of CordobaCampus de Rabanales14071CordobaSpain Centro IFAPA Alameda del Obispo 14004CordobaSpain

Orchards have a high potential for carbon ***,little research is available on the spatial variability at catchment scale and on the difference between the tree area and the *** analyzed theik spatial variability of soil organic carbon stock,SOCstock at 90 cm depth in an 8-ha catchment in Southern Spain with olives on a vertic *** showed higher soil organic carbon concentration,SOC,in the tree area as compared to the lane up to 60 cm depth,but its impact on SOCstock was negligible since it was compensated by the higher soil bulk density in the *** at different depths was correlated with that in the top 0-5 *** overall SOCstock of the orchard was 4.14 kg m^(-2),ranging between 1.8 and 6.0 kg m^(-2).This SOCstock is in the mid-lower range of values reported for olive orchards,measured at smaller scale,and similar to those other intensive field crops and agroforestry under comparable rainfall *** spatial variability in SOCstock was correlated to several geomorphological variables:elevation,cumulative upstream area,topographic wetness index,sediment transport index,and tillage *** in SOC and SOCstock are driven by the sediment redis-tribution downslope,mainly by tillage erosion,and higher soil water availability in lower areas allowing higher biomass *** topographic indexes and the correlation between SOC in the topsoil and SOCstock up to 90 cm should be further explored in other typology of olive orchards for facilitating the mapping of SOC_(stock).

关键词： Carbon sequestration Mediterraneancrops Catchment Spatial variability Vertic soils

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Technical reports and theoretical studies about the structural behaviour of masonry domes in the 18th century

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Frontiers of Architectural Research 2023年第1期12卷 42-66页

作者： gema M.Lopez-Manzanares Department of Architecture Universidad de AlcalaAlcala´de HenaresSpain

The development of the scientific theory on the stability of vaulted structures was driven mainly during the 18th century based on applying the laws of Mechanics and the knowledge of the properties of *** the specific case of structures such as domes,the development of the theory is closely related to the theory of arches and ***,the main contributions are made in technical reports on the construction,stability,and repair of domes,such as the dome of Saint Peter’s in Rome and Sainte-Genevie`ve or Pantheon in *** article,therefore,analyses the relationship between theory and practice and the development achieved in the specific subject of masonry domes during the 18th century from the point of view of the Limit Analysis of Masonry *** a more general sense,the objective of this research is to study in greater depth the theory of Limit Analysis itself,that is,to learn from the work carried out in the 18th century by mathematicians,architects,and engineers,who,although unaware of the existence of the theoretical framework of Limit Analysis as such,moved within it.

关键词： Structural analysis Masonry structures Limit analysis Technical reports Pathology Reinforcement Iron rings Domes

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Hybrid low salinity water and surfactant process for enhancing heavy oil recovery

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Petroleum Exploration and Development 2023年第6期50卷 1466-1477页

作者： roldÁn-CARRILLO Teresa CASTOREnA-CORTES Gladys SALAZAR CASTILLO Rodrigo Orlando HERnÁnDEZ-ESCOBEDO Luis OLGUÍn-LORA Patricia GACHUZ-MURO Herón Instituto Mexicano del Petróleo Mexico City 07730Mexico Petroleos Mexicanos PEMEXVillahermosaMexico

Combining low salinity water (LSW) with surfactants has an enormous potential for enhancing oil recovery processes. However, there is no consensus about the mechanisms involved, in addition to the fact that several studies have been conducted in model systems, while experiments with rocks and reservoir fluids are scarce. This study presents a core-flooding experiment of LSW injection, with and without surfactant, using the core and heavy oil samples obtained from a sandstone reservoir in southeastern Mexico. The effluents and the crude oil obtained at each stage were analyzed. The study was complemented by tomographic analysis. The results revealed that LSW injection and hybrid process with surfactants obtained an increase of 11.4 percentage points in recovery factor. Various phenomena were caused by LSW flooding, such as changes in wettability and pH, ion exchange, mineral dissolution, detachment of fines and modification of the hydrocarbon profile. In the surfactant flooding, the reduction of interfacial tension and alteration of wettability were the main mechanisms involved. The findings of this work also showed that the conditions believed to be necessary for enhanced oil recovery with LSW, such as the presence of kaolinite or high acid number oil, are not relevant.

关键词： low salinity water flooding surfactant flooding hybrid processes enhanced oil recovery tomography

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Litter decomposition in fragile ecosystems:A review

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Research in Cold and Arid Regions 2022年第3期14卷 151-161页

作者： Hao Qu XueYong Zhao XiaoAn Zuo ShaoKun Wang XuJun Ma Xia Tang XinYuan Wang Eduardo Medina-roldán Urat Desert-grassland Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China naiman Desertification Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Ecological Environmental Supervision and Administration Bureau of Gansu Province LanzhouGansu 730020China Institute of BioEconomy−national Research Council(IBE-CnR) Sesto Fiorentino 50019Italy

As a linkage between plants and soil,litter decomposition and its effect on nutrient recirculation have an important ecolog‐ical significance as they contribute to soil structure improvement and the restoration of degraded *** eco‐systems in arid regions(both hot and cold)are depleted in soil organic matter,and as a result of various factors their circu‐lation of material and energy is *** we discuss how litter decomposition is necessary to maintain the stability of fragile *** reviewed research on litter decomposition carried out in arid *** objective in this review is to outline how litter decomposition,and the subsequent buildup of organic matter in soil,is a key process determining the stability of fragile *** review shows that existing studies have focused on the influence of single ecologi‐cal factors on litter decomposition and nutrient cycling,and highlights how the exploration of interactions among factors determining litter decomposition is still *** interaction is a key aspect,since in the real world,decomposition and nutrient return to soil of litter products is affected by multiple *** propose a network setup on a cross-regional scale using standardized methods(e.g.,the tea bag method)to understand litter decomposition and nutrient return in frag‐ile *** a unique network could contribute to establish predictive models suitable for litter decomposition and nutrient return in these areas,and thus could provide theoretical and practical support for regional ecological protec‐tion and high-quality development.

关键词： litter mass loss fragile ecosystems arid semi-arid hot-deserts cold-deserts

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CECRE:Supervision and Control of Spanish Renewable Energies in the Last 15 years

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 269-276页

作者： gema Garcia Platero Mayte Garcia Casado Marta Perez Garcia Paula Junco Madero David Alvira Baeza the Red Electrica de Espafia MaridSpain

From its commissioning in 2006 to the present,the Spanish Control Centre for Renewable Energies(CECRE)has been a worldwide pioneer and reference centre in the integration of renewable energies in the electrical *** the last 15 years,CECRE has allowed a high penetration of renewable energies in Spanish electrical system by means of the supervision and control of renewable facilities,while ensuring the power supply *** paper defines the bases of renewable en-ergy operation in CECRE and introduces forecasting systems for renewable ***,this paper describes the participation of renewable energies in balancing services and congestion ***,new challenges for Spanish transmission system operator(TSO)are presented for the integration of renewable energies along with the energy transition and decarbonization.

关键词： Balancing services controllability forecasting system observability Control Centre for Renewable Energies(CECRE) renewable energy photovoltaic(PV) wind.

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Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1162-1174页

作者： Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina roldán MÁngeles Cerón nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero Department of Surgical Pathology Hospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyComplutense University of MadridMadrid 28040Spain Department of Surgical Pathology Hospital Rey Juan CarlosMadrid 28933Spain Department of Basic Medical Sciences Rey Juan Carlos UniversityMadrid 28933Spain

BACKGROUnD In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these *** recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical ***,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in *** To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type *** Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were *** specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was *** tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and *** analyses were performed and prognostic scores were developed based on hazard *** Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic *** tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer *** lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier *** depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén ***,intestinal and diffuse GC were asso

关键词： Gastric cancer Clinicopathological Score Prognosis Laurén Molecular

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低矿化度水与表面活性剂混注提高稠油采收率机理

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石油勘探与开发 2023年第6期50卷 1278-1288页

作者： roldÁn-CARRILLO Teresa GLADYS-CASTOREnA Cortés SALAZARCASTILLO Rodrigo Orlando HERnÁnDEZ-ESCOBEDO Luis OLGUÍnLORA Patricia GACHUZ-MURO Herón 墨西哥石油研究院墨西哥墨西哥城07730 墨西哥国家石油公司墨西哥墨西哥城07730

针对低矿化度水与表面活性剂混注工艺提高原油采收率机理不清的问题,采用墨西哥东南部砂岩油藏储集层岩心和稠油样品,开展了加入表面活性剂和未加入表面活性剂条件下的低矿化度水岩心驱替实验,并结合层析分析方法,研究驱替过程中岩心内... 详细信息

针对低矿化度水与表面活性剂混注工艺提高原油采收率机理不清的问题,采用墨西哥东南部砂岩油藏储集层岩心和稠油样品,开展了加入表面活性剂和未加入表面活性剂条件下的低矿化度水岩心驱替实验,并结合层析分析方法,研究驱替过程中岩心内部的变化。结果显示,低矿化度水和表面活性剂混注工艺能够提高采收率,实验中低矿化度水驱与混注工艺提高岩心采收率11.4个百分点。低矿化度水驱使得岩心中产生多种现象,例如润湿性改变、pH值变化、离子交换、矿物溶解、微粒运移和原油组分变化等。在表面活性剂驱替过程中,界面张力降低和润湿性改变是提高采收率的主要机理。以往研究认为低矿化度水驱提高原油采收率需要储集层中存在高岭石或原油为高酸值原油,但驱替实验结果表明这两点并非必要条件。

关键词：低矿化度水驱表面活性剂驱混注工艺提高采收率层析分析

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