检索结果-南通市图书馆

Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： gema frühbeck Victoria Catalán Víctor Valentí Rafael Moncada Javier Gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa Javier Escalada Amaia Rodríguez Metabolic Research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain Department of Surgery Clínica Universidad de NavarraPamplonaSpain Department of Anesthesia Clínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND

EXTRACTING BEHAVIOURAL MODELS frOM 2010FIFA WORLD CUP

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2013年第1期26卷 43-61页

作者： MENNDEZ Héctor BELLO-ORGAZ gema CAMACHO David Department of Computer Science Universidad Autnoma de Madrid

The FIFA World Cup^(TM) is the most profitable worldwide *** FIFA publishes global statistics of this competition which provide global data about the players and teams during the *** work is focused on the extraction of behavioural patterns for both,players and teams strategies,through the automated analysis of this *** knowledge and models extracted in this work could be applied to soccer leagues or even it could be oriented to sport ***,the main contribution is related to the study on several automatic knowledge extraction techniques,such as clustering methods,and how these techniques can be used to obtain useful behavioural models from a global statistics *** information provided by the clustering algorithms shows similar properties which have been combined to define the models,making the human interpretation of these statistics ***,the most successful teams strategies have been analysed and compared.

关键词： Behavioural patterns clustering FIFA World Cup football soccer web mining.

Inhibition of p53 inhibitors:progress,challenges and perspectives

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2019年第7期11卷 586-599页

作者： gema Sanz Madhurendra Singh Sylvain Peuget Galina Selivanova Department of Microbiology Tumor and Cell BiologyBiomedicum 8CKarolinska InstituteSE17165Sweden

p53 is the major tumor suppressor and the most frequently inactivated gene in cancer.p53 could be disabled either by mutations or by upstream negative regulators,including,but not limited to MDM2 and MDMX.p53 activity is required for the prevention as well as for the eradication of *** of p53 activity in mouse models leads to the suppression of established tumors of different *** findings provide a strong support to the anti-cancer strategy aimed for p53 *** this review,we summarize recent progress in the development of small molecules,which restore the tumor suppressor function of wild-type p53 and discuss their clinical *** discuss different aspects of p53-mediated response,which contribute to suppression of tumors,including non-canonical p53 activities,such as regulation of immune *** targeting p53 inhibitors is a very promising approach,there are certain limitations and concerns that the intensive research and clinical evaluation of compounds will hopefully help to overcome.

关键词： p53 tumor suppression anti-cancer therapy targeted drugs transcription factor immune response

Tropical Cyclones in Nicaragua:Historical Impact and Contemporary Exposure to Disaster Risk

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2024年第4期15卷 579-593页

作者： gema Velásquez‑Espinoza Irasema Alcántara‑Ayala Faculty of Sciences and Engineering National Autonomous University of Nicaragua14172 Unan-ManaguaNicaragua Postgraduate Programme in Geography National Autonomous University of Mexico(UNAM)04510 Mexico CityMexico Institute of Geography National Autonomous University of Mexico(UNAM)04510 Mexico CityMexico

In tropical regions such as Nicaragua, the population's vulnerability to hazards has escalated in recent decades. This increase in vulnerability has led to a surge in disasters, particularly those triggered by intense hurricanes. The implications at the national level are still poorly understood. The aim of this article has, therefore, been two-fold. First, to present a historical review of the direct effects of tropical cyclones on society in Nicaragua from 1852 to 2020. Second, to analyze the statistical probabilities of future hurricane-spawned high winds over Nicaragua. Data on cyclones hitting Nicaragua's coasts were collected, including direct effects, wind speed, pressure, category, direction, and time of landfall. A database was created to classify intensity based on wind speed and frequency. Between 1852 and 2020, Nicaragua experienced 58 tropical cyclones with varying degrees of intensity between September and November. The trajectories of six past hurricanes were considered here regarding the areas that might have been under potential threat. Three zones of influence were delimited along each trajectory according to three wind intensities and the trajectory of these hurricanes. The consequent exposure of each Nicaraguan department and autonomous region was established. The findings are essential to delimitating priority areas for attention regarding the likely impact of tropical cyclones, mainly category 4 and 5 hurricanes. Public officials and the general public can use these data to identify the pressing need for enhanced strategies to mitigate disaster risk and avoid potential disasters.

关键词： Exposure Historical impact Hurricanes Nicaragua Tropical cyclones Vulnerability

Technical reports and theoretical studies about the structural behaviour of masonry domes in the 18th century

在线全文

学校读者我要写书评

暂无评论

frontiers of Architectural Research 2023年第1期12卷 42-66页

作者： gema M.Lopez-Manzanares Department of Architecture Universidad de AlcalaAlcala´de HenaresSpain

The development of the scientific theory on the stability of vaulted structures was driven mainly during the 18th century based on applying the laws of Mechanics and the knowledge of the properties of *** the specific case of structures such as domes,the development of the theory is closely related to the theory of arches and ***,the main contributions are made in technical reports on the construction,stability,and repair of domes,such as the dome of Saint Peter’s in Rome and Sainte-Genevie`ve or Pantheon in *** article,therefore,analyses the relationship between theory and practice and the development achieved in the specific subject of masonry domes during the 18th century from the point of view of the Limit Analysis of Masonry *** a more general sense,the objective of this research is to study in greater depth the theory of Limit Analysis itself,that is,to learn from the work carried out in the 18th century by mathematicians,architects,and engineers,who,although unaware of the existence of the theoretical framework of Limit Analysis as such,moved within it.

关键词： Structural analysis Masonry structures Limit analysis Technical reports Pathology Reinforcement Iron rings Domes

Spatial variability of soil organic carbon stock in an olive orchard at catchment scale in Southern Spain

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2023年第2期11卷 311-326页

作者： Jose A.Gòmez gema Guzmán Tom Vanwalleghem Karl Vanderlinden Institute for Sustainable Agriculture.Spanish National Research Council(IAS-CSIC) Alameda del Obispo S/N14004CordobaSpain Department of Agronomy University of CordobaCampus de Rabanales14071CordobaSpain Centro IFAPA Alameda del Obispo 14004CordobaSpain

Orchards have a high potential for carbon ***,little research is available on the spatial variability at catchment scale and on the difference between the tree area and the *** analyzed theik spatial variability of soil organic carbon stock,SOCstock at 90 cm depth in an 8-ha catchment in Southern Spain with olives on a vertic *** showed higher soil organic carbon concentration,SOC,in the tree area as compared to the lane up to 60 cm depth,but its impact on SOCstock was negligible since it was compensated by the higher soil bulk density in the *** at different depths was correlated with that in the top 0-5 *** overall SOCstock of the orchard was 4.14 kg m^(-2),ranging between 1.8 and 6.0 kg m^(-2).This SOCstock is in the mid-lower range of values reported for olive orchards,measured at smaller scale,and similar to those other intensive field crops and agroforestry under comparable rainfall *** spatial variability in SOCstock was correlated to several geomorphological variables:elevation,cumulative upstream area,topographic wetness index,sediment transport index,and tillage *** in SOC and SOCstock are driven by the sediment redis-tribution downslope,mainly by tillage erosion,and higher soil water availability in lower areas allowing higher biomass *** topographic indexes and the correlation between SOC in the topsoil and SOCstock up to 90 cm should be further explored in other typology of olive orchards for facilitating the mapping of SOC_(stock).

关键词： Carbon sequestration Mediterraneancrops Catchment Spatial variability Vertic soils

Gut passage of epigeous ectomycorrhizal fungi by two opportunistic mycophagous rodents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2011年第3期57卷 293-299页

作者： Citlalli CASTILLO-GUEVARAl Josette SIERRA gema GALINDO-FLORES Mariana CUAUTLE Carlos LARA Centro de Investigacion en Ciencias Biologicas Universidad Autonoma de Tlaxcala Km 10.5 Autopista Tlaxcala-San Martin Texmelucan San Felipe Ixtacuixtla Tlaxcala 90120 Mexico Departamento de Quimica y Biologfa Universidad de las Americas-Puebla Ex-hacienda Sta Catarina Martir s/n Cholula Puebla 72810 Mexico Centro Tlaxcala de Biologia de la Conducta Universidad Autdnoma de Tlaxcala-UNAM Carretera Tlaxcala-Puebla Km 1.5 s/n Tlaxcala Tlaxcala 90070 Mexico

Mycophagists can influence fungal diversity within their home ranges by ensuring the continued and effective dispersal of spores from one site to another. However, the passage of spores through the digestive tract of vertebrates can affect the activity and viability of the spores ingested. This phenomenon has been rarely documented in opportunistic mycophagists consuming epigeous fungi. Using laboratory experiments, we investigated the activity and viability of spores of two epigeous ectomycorrhizal fungal species （Laccaria trichodermophora and SuiUus tomentosus） after passage through the digestive tract of two opportunistic mycophagous small rodents, the volcano mouse Peromyscus alstoni and the deer mouse P maniculatus. We found that passage through the gut of either species of rodent had a significant effect on spore activity and viability for both fungal species. The proportion of active spores （0.37-0.40） of L. trichodermophora in the feces of both species of rodents was less than that recorded for the control （0.82）. However, the proportion of active spores （0.644）.73） of S. tomentosus in the feces of each species of rodent was higher than in the control （0.40）. On the other hand, the viability of spores was lower （0.26-0.30 in L. trichodermophora and 0.604）.69 in S. tomentosus） for both fungi when consumed by either rodent relative to the controls （0.90 in L. trichodermophora and 0.82 in S. tomentosus）. These findings suggest that these rodent species may be effective dispersers of both epigeous fungi [Current Zoology 57 （3）： 293-299, 2011].

关键词： Gut passage Epigeous ectomycorrhizal fungi Mexico Spore activity and viability Peromyscus

Does wetland watershed land use influence amphibian larval development? A relevant effect of agriculture on biota

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2019年第1期37卷 160-168页

作者： GARCíA-MU?OZ Enrique GUERRERO francisco ARECHAGA Garbi?e PARRA gema Departamento de Biología Animal Biología Vegetal y Ecología Campus de las Lagunillas Centro de Estudios Avanzados en Ciencias de la Tierra Campus de las Lagunillas Departamento de Ciencias de la Salud Campus de las Lagunillas

Agriculture practices have been widely proposed as the major cause of amphibian population decline. However, the majority of these results have been based on laboratory experiments. The present study was conducted to test the repercussion of wetland sediment provenance on amphibian larval *** bufo larvae were used in two dif ferent treatments in an outdoor experiment, the ?rst one using sediment from one wetland surrounded by intensive agricultural practices, and the second using sediment with no record of agrochemical uses. A negative ef fect was observed in the agricultural treatment, from subcellular to individual level. The results showed that the sediment from agricultural practices watershed generates a reduction in survival. Furthermore, individuals that developed under this treatment showed a lower total length and a delay in the time necessary to complete metamorphosis; these features are connected with recruitment success. In the same way, biochemical analysis showed high values of lipid peroxidation in metamorphs developing in sediments from an agricultural area. Finally, the results obtained highlight the importance of considering the sediments, not only the water, as origin treatment, allowing us to understand the consequences on amphibian populations that inhabit areas af fected by intensive agriculture.

关键词： amphibian decline Bufo bufo survival ecotoxicology agricultural practices

In-depth analysis of soil management and farmers’perceptions of related risks in two olive grove areas in southern Spain

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2021年第3期9卷 461-473页

作者： José A.Gòmez Ana Sanchez Montero gema Guzman Marfa-Auxiliadora Soriano a Institute for Sustainable Agriculture CSICCordobaSpain Agronomy Department University of CordobaCordobaSpain

This manuscript presents a questionnaire-based study aimed to provide a detailed analysis on the different soil management carried out by olive farmers in two representative olive-growing areas in southern Spain(Cordoba and Estepa),their perceptions on cover crop use and the possible influence of the different types of farms and farmers’typologies on these *** results show a relatively large variability of soil management,with fourteen options,as a result of a combination of different alternatives for bare soil and cover crops with the use or not of pruning residues,but with a great similarity between both *** results indicate a high adoption of soil conservation measures in the two study areas,with 63%of farmers using cover crops and 80%a mulch of pruning residues,higher than that reported in previous studies in Southern Spain,and a trend of lower use of these techniques by less experienced and younger *** high penetration of soil conservation measures resulted in a significant reduction of soil erosion risk,as indicated by the relatively low values for the cover and management factor(C)of RUSLE,also calculated and presented in this study,but also the possibility of focusing further efforts on fanners with less *** results indicate the persistence of a minor,but relevant,percentage of farmers using bare soil management(37%)and no mulching(20%),with a moderate concern on the impact of soil erosion on soil degradation and provision of ecosystem *** suggests the need to concentrate efforts also on this cluster of farmers to enhance the success of what seems to be a remarkable expansion of the use of soil conservation measures in recent decades in Southern Spain,but also in similar areas in the Mediterranean basin.

关键词： Tillage Cover crops Olive yield Erosion risk Irrigation Questionnaire

Farm-scale evaluation of the impact of CrylAb Bt maize on canopy nontarget arthropods： a 3-year study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2018年第1期25卷 87-98页

作者： Maria Arias-Martin Matias Garcia Pedro Castanera Felix Ortego gema P. Farinos Centro de Investigaciones Biologicas CSIC Departamento de Biologia Medioambiental Grupo de Interaccion Planta-lnsecto Ramiro deMaeztu 9 28040 Madrid Spain

The cultivation of CrylAb-expressing genetically modified MON810 （Bt maize） has led to public concern in Europe, regarding its impact on nontarget arthro- pods （NTAs）. We have assessed the potential effects of DKC 6451 YG （MON810） maize on canopy NTAs in a farm-scale study performed in Central Spain during 3 years. The study focused on hemipteran herbivores （leafhoppers and planthoppers） and hymenopteran parasitic wasps （mymarids） collected by yellow sticky traps, which accounted for 72% of the total number of insects studied. The dynamics and abundance of these groups varied among years, but no significant differences were found between Bt and non-Bt maize, indicating that Bt maize had no negative effect on these taxa. Nonetheless, the CrylAb toxin was detected in 2 different arthropods collected from Bt maize foliage, the cicadellids Zyginidia scutellaris and Empoasca spp. A retrospective power analysis on the arthropod abundance data for our field trials has determined that Z. scutellaris and the family My- maridae have high capacity to detect differences between the Bt maize and its isogenic counterpart. The use of these canopy NTAs as surrogates for assessing environmental impacts of Bt maize is discussed.

关键词： Cicadellidae MON810 Mymaridae risk assessment surrogate species Zyginidia scutellaris