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In-depth analysis of soil management and farmers’perceptions of related risks in two olive grove areas in southern Spain

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International Soil and Water Conservation Research 2021年第3期9卷 461-473页

作者： José A.Gòmez ana Sanchez Montero gema Guzman Marfa-Auxiliadora Soriano a Institute for Sustainable Agriculture CSICCordobaSpain Agronomy Department University of CordobaCordobaSpain

This manuscript presents a questionnaire-based study aimed to provide a detailed analysis on the different soil management carried out by olive farmers in two representative olive-growing areas in southern Spain(Cordoba and Estepa),their perceptions on cover crop use and the possible influence of the different types of farms and farmers’typologies on these *** results show a relatively large variability of soil management,with fourteen options,as a result of a combination of different alternatives for bare soil and cover crops with the use or not of pruning residues,but with a great similarity between both *** results indicate a high adoption of soil conservation measures in the two study areas,with 63%of farmers using cover crops and 80%a mulch of pruning residues,higher than that reported in previous studies in Southern Spain,and a trend of lower use of these techniques by less experienced and younger *** high penetration of soil conservation measures resulted in a significant reduction of soil erosion risk,as indicated by the relatively low values for the cover and management factor(C)of RUSLE,also calculated and presented in this study,but also the possibility of focusing further efforts on fanners with less *** results indicate the persistence of a minor,but relevant,percentage of farmers using bare soil management(37%)and no mulching(20%),with a moderate concern on the impact of soil erosion on soil degradation and provision of ecosystem *** suggests the need to concentrate efforts also on this cluster of farmers to enhance the success of what seems to be a remarkable expansion of the use of soil conservation measures in recent decades in Southern Spain,but also in similar areas in the Mediterranean basin.

关键词： Tillage Cover crops Olive yield Erosion risk Irrigation Questionnaire

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-Broto Francisco Segura ana Cavero Elvira Orduna-Hospital gema Insa-Sánchez ana Isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

EXTRACTING BEHAVIOURAL MODELS FROM 2010FIFA WORLD CUP

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Journal of Systems Science & Complexity 2013年第1期26卷 43-61页

作者： MENNDEZ Héctor BELLO-ORGAZ gema CAMACHO David Department of Computer Science Universidad Autnoma de Madrid

The FIFA World Cup^(TM) is the most profitable worldwide *** FIFA publishes global statistics of this competition which provide global data about the players and teams during the *** work is focused on the extraction of behavioural patterns for both,players and teams strategies,through the automated analysis of this *** knowledge and models extracted in this work could be applied to soccer leagues or even it could be oriented to sport ***,the main contribution is related to the study on several automatic knowledge extraction techniques,such as clustering methods,and how these techniques can be used to obtain useful behavioural models from a global statistics *** information provided by the clustering algorithms shows similar properties which have been combined to define the models,making the human interpretation of these statistics ***,the most successful teams strategies have been analysed and compared.

关键词： Behavioural patterns clustering FIFA World Cup football soccer web mining.

Responsible research and innovation training programmes:implementation and evaluation of the HEIRRI project

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Forensic Sciences Research 2021年第3期6卷 320-330页

作者： Ružica Tokalić Ivan Buljan Niels Mejlgaard Mar Carrió Alexander Lang gema Revuelta ana Marušić HEIRRI Consortium Department of research in Biomedicine and health University of split school of Medicinesplitcroatia Danish centre for studies in research and research Policy Department of Political scienceaarhus UniversityaarhusDenmark health sciences education research Group Department of experimental and health sciencesPompeu Fabra UniversityBarcelonaspain Techno-science&societal Transformation research Group institut für höhere studien-institute for advanced studies(i)Viennaaustria estudies centre on science communication and societyDepartment of experimental and health sciencesPompeu Fabra UniversityBarcelonaspain

Responsible research and innovation,or RRI,is a concept that aims to bring together society and science for a better *** are six key elements of RRI:public engagement,gender equality,science education,open access,ethics and *** Education Institutions and Responsible Research and Innovation(HEIRRI)project aimed to bring the concept of RRI into the educational *** state-of-the-art review of good practices,HEIRRI team developed 10 training programmes on RRI for different higher education institution educational levels,including a summer school and a massive open online course(MOOC).We conducted pilot of the trainings and evaluated participants’*** with HEIRRI training programmes on responsible research and innovation was high,both for participants and for the trainers,and trainings raised awareness of ***’feedback was used to identify areas that need improvement and provided for recommendations for final versions of the HEIRRI training *** order to equip researchers with skills to recognize and apply RRI values,RRI should be included in their *** training is suitable for a range of different disciplines,including forensic science,and is free to use and adjust for specific contexts(available from:https://***/heirri-training-programmes).

关键词： Research integrity research ethics responsible research and innovation responsibility societal inclusion higher education institutions RRI teaching

Tropical Cyclones in Nicaragua:Historical Impact and Contemporary Exposure to Disaster Risk

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International Journal of Disaster Risk Science 2024年第4期15卷 579-593页

作者： gema Velásquez‑Espinoza Irasema Alcántara‑Ayala Faculty of Sciences and Engineering National Autonomous University of Nicaragua14172 Unan-ManaguaNicaragua Postgraduate Programme in Geography National Autonomous University of Mexico(UNAM)04510 Mexico CityMexico Institute of Geography National Autonomous University of Mexico(UNAM)04510 Mexico CityMexico

In tropical regions such as Nicaragua, the population's vulnerability to hazards has escalated in recent decades. This increase in vulnerability has led to a surge in disasters, particularly those triggered by intense hurricanes. The implications at the national level are still poorly understood. The aim of this article has, therefore, been two-fold. First, to present a historical review of the direct effects of tropical cyclones on society in Nicaragua from 1852 to 2020. Second, to analyze the statistical probabilities of future hurricane-spawned high winds over Nicaragua. Data on cyclones hitting Nicaragua's coasts were collected, including direct effects, wind speed, pressure, category, direction, and time of landfall. A database was created to classify intensity based on wind speed and frequency. Between 1852 and 2020, Nicaragua experienced 58 tropical cyclones with varying degrees of intensity between September and November. The trajectories of six past hurricanes were considered here regarding the areas that might have been under potential threat. Three zones of influence were delimited along each trajectory according to three wind intensities and the trajectory of these hurricanes. The consequent exposure of each Nicaraguan department and autonomous region was established. The findings are essential to delimitating priority areas for attention regarding the likely impact of tropical cyclones, mainly category 4 and 5 hurricanes. Public officials and the general public can use these data to identify the pressing need for enhanced strategies to mitigate disaster risk and avoid potential disasters.

关键词： Exposure Historical impact Hurricanes Nicaragua Tropical cyclones Vulnerability

Inhibition of p53 inhibitors:progress,challenges and perspectives

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Journal of Molecular Cell Biology 2019年第7期11卷 586-599页

作者： gema Sanz Madhurendra Singh Sylvain Peuget Galina Selivanova Department of microbiology Tumor and Cell BiologyBiomedicum 8CKarolinska InstituteSE17165Sweden

p53 is the major tumor suppressor and the most frequently inactivated gene in cancer.p53 could be disabled either by mutations or by upstream negative regulators,including,but not limited to MDM2 and MDMX.p53 activity is required for the prevention as well as for the eradication of *** of p53 activity in mouse models leads to the suppression of established tumors of different *** findings provide a strong support to the anti-cancer strategy aimed for p53 *** this review,we summarize recent progress in the development of small molecules,which restore the tumor suppressor function of wild-type p53 and discuss their clinical *** discuss different aspects of p53-mediated response,which contribute to suppression of tumors,including non-canonical p53 activities,such as regulation of immune *** targeting p53 inhibitors is a very promising approach,there are certain limitations and concerns that the intensive research and clinical evaluation of compounds will hopefully help to overcome.

关键词： p53 tumor suppression anti-cancer therapy targeted drugs transcription factor immune response

Technical reports and theoretical studies about the structural behaviour of masonry domes in the 18th century

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Frontiers of Architectural Research 2023年第1期12卷 42-66页

作者： gema M.Lopez-Manzanares Department of Architecture Universidad de AlcalaAlcala´de HenaresSpain

The development of the scientific theory on the stability of vaulted structures was driven mainly during the 18th century based on applying the laws of Mechanics and the knowledge of the properties of *** the specific case of structures such as domes,the development of the theory is closely related to the theory of arches and ***,the main contributions are made in technical reports on the construction,stability,and repair of domes,such as the dome of Saint Peter’s in Rome and Sainte-Genevie`ve or Pantheon in *** article,therefore,analyses the relationship between theory and practice and the development achieved in the specific subject of masonry domes during the 18th century from the point of view of the Limit analysis of Masonry *** a more general sense,the objective of this research is to study in greater depth the theory of Limit analysis itself,that is,to learn from the work carried out in the 18th century by mathematicians,architects,and engineers,who,although unaware of the existence of the theoretical framework of Limit analysis as such,moved within it.

关键词： Structural analysis Masonry structures Limit analysis Technical reports Pathology Reinforcement Iron rings Domes

Spatial variability of soil organic carbon stock in an olive orchard at catchment scale in Southern Spain

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International Soil and Water Conservation Research 2023年第2期11卷 311-326页

作者： Jose A.Gòmez gema Guzmán Tom Vanwalleghem Karl Vanderlinden Institute for Sustainable Agriculture.Spanish National Research Council(IAS-CSIC) Alameda del Obispo S/N14004CordobaSpain Department of Agronomy University of CordobaCampus de Rabanales14071CordobaSpain Centro IFAPA Alameda del Obispo 14004CordobaSpain

Orchards have a high potential for carbon ***,little research is available on the spatial variability at catchment scale and on the difference between the tree area and the *** analyzed theik spatial variability of soil organic carbon stock,SOCstock at 90 cm depth in an 8-ha catchment in Southern Spain with olives on a vertic *** showed higher soil organic carbon concentration,SOC,in the tree area as compared to the lane up to 60 cm depth,but its impact on SOCstock was negligible since it was compensated by the higher soil bulk density in the *** at different depths was correlated with that in the top 0-5 *** overall SOCstock of the orchard was 4.14 kg m^(-2),ranging between 1.8 and 6.0 kg m^(-2).This SOCstock is in the mid-lower range of values reported for olive orchards,measured at smaller scale,and similar to those other intensive field crops and agroforestry under comparable rainfall *** spatial variability in SOCstock was correlated to several geomorphological variables:elevation,cumulative upstream area,topographic wetness index,sediment transport index,and tillage *** in SOC and SOCstock are driven by the sediment redis-tribution downslope,mainly by tillage erosion,and higher soil water availability in lower areas allowing higher biomass *** topographic indexes and the correlation between SOC in the topsoil and SOCstock up to 90 cm should be further explored in other typology of olive orchards for facilitating the mapping of SOC_(stock).

关键词： Carbon sequestration Mediterraneancrops Catchment Spatial variability Vertic soils

VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura Gómez-Jaramillo Raquel Romero-García gema Jiménez-Gómez Lisa Riegle ana Belén Ramos-Amaya JoséAntonio Brieva Marie Kelly-Worden Antonio Campos-Caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins