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Psychological effects of colorectal cancer screening: Participants vs individuals not invited

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World Journal of Gastroenterology 2016年第43期22卷 9631-9641页

作者： Benedicte Kirk?en Paula Berstad Edoardo Botteri Linn Bernklev Badboni El-Safadi geir hoff Thomas de Lange Tomm Bernklev Department of bowel cancer screening Cancer Registry of Norway Institute of Clinical Medicine University of Oslo Department of Internal Medicine Vestre Viken Hospital Trust B?rum Hospital Department of Gastroenterology ?stfold Hospital Trust Department of Research and Development Telemark Hospital Trust Department of Health Management and Health Economics Institute of Health and Society University of Oslo

AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in *** In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the *** Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group.

关键词： Colorectal cancer screening Flexible sigmoidoscopy Fecal immunochemical test Anxiety Health-related quality of life Control group

Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia

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World Journal of Gastroenterology 2016年第27期22卷 6276-6286页

作者： Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen geir hoff Tomm Bernklev Anette Hjartaker Paula Berstad Department of bowel cancer screening Cancer Registry of Norway Majorstuen 0304 Oslo Norway Department of Research and Development Telemark Hospital 3710 Skien Norway Department of Nutrition Institute of Basic Medical Sciences University of Oslo 0317 Oslo Norway Department of Medicine aerum Hospital Vestre Viken Hospital Trust 3004 Drammen Norway Division of Epidemiology and Biostatistics European Institute of Oncology 20141 Milan Italy Department of Gastroenterology фstfold Hospital Trust 1714 Gralum Norway Department of Health Management and Health Economics Institute of Health and Society University of Oslo 0317 Oslo Norway Institute of Clinical Medicine University of Oslo Blindern P.O. Box 1171 0318 Oslo Norway

AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) ***: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ***: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) ***: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening.

关键词： Screening Colorectal neoplasia Lifestyle Prevention Health recommendations

Acceptance of American society for gastrointestinal endoscopy’s guidelines for endoscopy reports

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Open Journal of Gastroenterology 2012年第4期2卷 209-214页

作者： Thomas de Lange Michael Bretthauer Lars Aabakken geir hoff Department of Internal Medicine Section of Gastroenterology Barum Hospital Sandvika Norway Department of Internal Medicine Section of Gastroenterology Oslo University Hospital Oslo Norway Department of Internal Medicine Section of Gastroenterology Telemark Hospital Skien Norway

Background: Several studies indicate that endoscopy reports lack uniform content and terminology. Thus ASGE, ESGE, and WEO have prepared guidelines to improve the quality of endoscopy reports. However, the acceptance of such recommendations in the community of endoscopists has not been assessed. Objective: The aim of the present study was to determine Non-US endoscopists’ agreement to current ASGE guidelines for endoscopy reporting and ESGE recommendations for image documentation. Design: 137 endoscopists were invited to participate in this internet survey, covering 34 items regarding the content of the endoscopy reports. Non-responders received three e-mail reminders before the study was closed. Settings: A web-based survey tool developed at the University of Oslo was used to perform this study (https://***/as/WebObjects/***). Results: Eighty (60%) of the 137 endoscopists responded, to the survey. Their agreement to the various items of the ASGE guidelines for text content ranged from 21% - 100%. Only 8.9% (95% CI, 4.4% - 17.2%) considered it necessary to perform routine image documentation according to the ESGE guidelines. Limitations: The response rate of 68%, is on the lower limit of acceptable. Conclusions: The cohort of endoscopists agrees partially to the ASGE guidelines. However, they do not consider systematic image documentation

关键词： Quality Assurance Guideline Adherence Gastrointestinal Endoscopy

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癌症筛检项目效果比较研究

英国医学杂志中文版 2012年第5期15卷 301-304页

作者： Michael Bretthauer geir hoff 许群(译) 乌正赉(校) University of Oslo.Oslo Norway Oslo University Hospital Oslo Cancer Registry of Norway Oslo Department of Research Telemark Hospital Skjen Norway 中国医学科学院基础医学研究所北京协和医学院基础学院流行病学与卫生统计学系

癌症大规模筛检项目在获得新证据或对新证据作出应答方面，往往经不起考验。为了克服筛检项目的这些缺点，本文作者根据筛检效果的比较研究概述了在挪威实施的一种新的筛检方法？

关键词：筛检项目癌症筛检方法新证据

Acceptance of American Society for Gastrointestinal Endoscopy's Guidelines for Endoscopy Reports

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Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias

Open Journal of Gastroenterology 2012年第4期

作者： Thomas de Lange Michael Bretthauer Lars Aabakken geir hoff

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Journal of Integrative Medicine 2017年第4期15卷 255-264页

作者： Salvatore Chirumbolo geir Bj?rklund Department of Neurological and Movement Sciences University of Verona Council for Nutritional and Environmental Medicine

Marzotto et al. showed that homeopathic preparations of Amica montana L. acted directly on gene expression of Tamm-Horsfall protein- 1 （THP-1） monocyte/macrophage cell lines activated with phorbol 12-mydstate 13- acetate and interleukin-4 （IL-4）. A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4- treated monocyte/macrophage THP-I. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry, used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models.

关键词： Arnica homeopathy bias statistics gene expression Tamm-Horsfall protein cell line

Gas electrodes with nickel based current collectors for molten carbonate electrolyte thermo-electrochemical cells

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Journal of Energy Chemistry 2020年第2期29卷 34-42页

作者： Sathiyaraj Kandhasamy geir Martin Haarberg Signe Kjelstrup Asbjorn Solheim Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)TrondheimNorway PoreLab Department of ChemistryNTNUTrondheimNorway Metal Production and Processing SINTEF IndustrySINTEFTrondheimNorway

Thermo-electrochemical cells with inexpensive molten carbonate electrolyte and(CO2|O2) gas electrodes allow the possible conversion of high temperature waste heat from industrial processes into *** cell containing eutectic(Li,Na)2CO3 electrolyte with solid Mg O dispersion delivers a large Seebeck coefficient of-1.7 m V/K. At present, the(CO2|O2) gas electrodes use metallic gold as current collectors in order to avoid the formation of interfering oxide layers during operation. For further reduction in energy generation cost, the gold current collectors should be replaced with an inexpensive and stable *** this study, the suitability of the(molten carbonate fuel cell) MCFC’s nickel-based cathodes to operate the molten-carbonate thermo-electrochemical cell, was investigated. Ni current collectors were examined in two different states, as Ni O and as lithiated Ni O(LixNi1-xO). The Ni O phase shows higher stability than the LixNi1-xO while the Seebeck coefficient remains above-1.2 m V/K.

关键词： High-temperature thermo-electrochemical cell Molten carbonate NiO Lithiated NiO

Electrochemical Behavior of Dissolved Fe_2O_3 in Molten CaCl_2-KF

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Journal of Iron and Steel Research International 2008年第6期15卷 48-51页

作者： WANG Shu-lan geir Martin Haarberg Eirin Kvalheim Department of Chemistry Northeastern University Shenyang 110004 Liaoning China Department of Materials Science and Engineering NTNU Trondheim 7429 Norway

The electrochemical behavior of dissolved Fe2O2 in 82.5CaCl2-17.5KF （mole percent, %） was studied using cy clic voltammetry, chronoamperometry, and galvanostatic electrolysis at 827 ℃, and the deposits were characterized by XRD and SEM. Pure iron was deposited on a rotating cylinder （210 r/min） with a cell voltage less than -- 1.0 V. Deposition rate was controlled by diffusion on a molybdenum electrode. The diffusion coefficient of iron species Fe（ Ⅲ ） in the melt at 827 ℃ was found to be 9.7×10^-5 cm^2/s.

关键词： iron electrolysis electrochemistry molten salt

Bioinformatics—Mining the genome for information

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Frontiers of Electrical and Electronic Engineering in China 2010年第3期5卷 391-404页

作者： Runsheng CHEN geir SKOGERBØ National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China

Since the launching of the human genome sequencing project in the 1990s,genomic research has already achieved definite *** the beginning of the present century,the complete genomes of several model organisms have already been sequenced,including a number of prokaryote microorganisms and the eukaryotes yeast(Saccharomyces cerevisiae),nematode(***),fruit fly(Drosophila melanogaster)and thale cress(Arabidopsis thaliana)as well as the major part of the human *** achievements signified that a new era of data mining and analysis on the human genome had *** language of human genetics would gradually be read and understood,and the genetic information underlying metabolism,development,differentiation and evolution would progressively become known to *** amounts of data are already accumulating,but at present many of the rules that should guide the understanding of this information are yet *** research is thus not only becoming more important,but is also faced with severe challenges as well as great opportunities.

关键词： bioinformatics genome algorithm noncoding RNA biological network