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Favipiravir and its potentials in COVID-19 pandemic:An update

Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 433-455页

作者： Dao Ngoc Hien Tam Ahmad T Qarawi Mai Ngoc Luu Morgan Turnage Linh Tran gehad Mohamed tawfik Le Huu Nhat Minh Nguyen Tien Huy Tatsuo Iiyama Kyoshi Kita Kenji Hirayama Online Research Club School of Tropical Medicine and Global HealthNagasaki UniversityNagasaki 852-8523Japan Asia Shine Trading&Service CO.LTD. Ho Chi Minh City 700000Vietnam Essen Healthcare BronxNew York 10461 USA Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh City 700000Vietnam American University of the Caribbean CupecoySint Maarten Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Natural Sciences Duy Tan UniversityDa Nang City 550000Vietnam Department of Otorhinolaryngology Faculty of MedicineAin Shams UniversityCairoEgypt Methodist Hospital MerrillvilleIndianaUnited States School of Tropical Medicine and Global Health Nagasaki University1-12-4 SakamotoNagasaki 852-8523Japan Department of International Trials Center of Clinical SciencesNational Center for Global Health and Medicine(NCGM)TokyoJapan

The COVID-19 pandemic has caused millions of deaths and hundreds of millions of confirmed infections *** pandemic has prompted researchers to produce medications or vaccines to reduce or stop the progression and spread of this disease.A variety of previously licensed and marketed medications are being tested for the treatment and recurrence of SARS-CoV2,including favipiravir(Avigan).Favipiravir was recognized as an influenza antiviral drug in Japan in 2014,and has been known to have a potential in vitro activity against SARS-CoV-2,in addition to its broad therapeutic safety *** was recently approved and officially used in many countries *** review provides insights and up-to-date knowledge of the current role of favipiravir in the treatment of COVID-19 infection,focusing on preclinical and ongoing clinical trials,evidence of its efficacy against SARS-CoV-2 in COVID-19,side effects,anti-viral mechanism,and the pharmacokinetic properties of the drug in the treatment of *** to its teratogenic effects,favipiravir cannot be offered to expectant or pregnant *** practical efficacy of such an intervention regimen will depend on its dose,treatment duration,and cost as well as difficulties in application.

关键词： Favipiravir Avigan COVID-19 SARS-CoV-2 Antiviral Review Efficacy

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Frozen Section in Postmenopausal Women Presented with Suspicious Ovarian Masses, Does It Have a Role?

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Journal of Cancer Therapy 2015年第14期6卷 1192-1195页

作者： Basel Refky Anas Gamal Emad Hamed Adel Fathi Mohammad Arafa Sameh Roshdy Khaled Gaballa Essam Attia Mohamed Abdelkhalek Mohamed T. Hafez Fayz Shahatto Shadi Awny Doaa Shokry gehad tawfik Surgical Oncology Unit Oncology Center Mansoura University Mansoura Egypt Gynecology Department Mansoura University Hospitals Mansoura Egypt Pathology Department Mansoura University Mansoura Egypt Public Health Department Mansoura Faculty of Medicine Mansoura Egypt Medical Intern Mansoura University Hospitals Mansoura Egypt

Background: Frozen section (FS) has a valuable role in the diagnosis of ovarian tumors. It is considered a pivotal point in guiding the surgical therapy, particularly in premenopausal women. In postmenopausal women, it may be required as well to avoid unnecessary surgical staging in benign ovarian tumors. Aim: This study aims to evaluate the accuracy of intraoperative frozen section in ovarian neoplasms in postmenopausal women. Materials and Methods: A retrospective analysis was done for intraoperative FS for suspected ovarian neoplasms. The study was conducted in Oncology Center, Mansoura University from March 2008 to December 2014. The frozen and paraffin section reports were compared, and overall accuracy, sensitivity, specificity, positive and negative predictive values were determined. Results: The study included 105 patients and the overall accuracy of FS in determining malignancy was 81.7%. The sensitivity for malignant tumors was 75.32% with specificity of 100%. For benign tumors, the sensitivity and specificity were 100% and 93%, respectively. Borderline tumors had the lowest sensitivity of 100% with specificity of 95.19%. Conclusion: The present study concurs that frozen section is an accurate test for diagnosis of benign and malignant tumors in postmenopausal women thus determining the extent of surgery done for them. On the other hand, accuracy rates for borderline tumors are low.

关键词： Frozen Section Ovarian Cancer Surgical Staging

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