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Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats

Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 403-410页

作者： Farouk K.El-Baz gehad a.abdel jaleel Dalia O.Saleh Rehab A.Hussein Plant Biochemistry Department National Research Centre (NRC) Pharmacology Department National Research Centre (NRC) Pharmacognosy Department National Research Centre (NRC)

Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina(D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose(D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL(200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass(250 mg/kg), its carotenoid(250 μg/kg) and polar(250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31%. salina carotenoid fraction as well as the total biomass amelior β-carotene. Conclusions: Date D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β-carotene.

关键词： Aging Cardiac dysfunction Dunaliella salina Rats

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Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 44-49页

作者： gehad abdel Raheem abdel jaleel Heba Mohammed Ibrahim Abdallah Nawal E.L.Sayed Gomaa Pharmacology Department National Research Centre

Objective:To investigate some pharmacological effects including gastroprotective,antiinflammatory,analgesic,antipyretic and in vitro antioxidant effects of Artemisia herbaalba extract in different experimental ***:Inflammation was induced in rat paw by subcutaneous injection of 1%(v/v)carrageenan *** was induced in mice by intraperitoneal injection of 0.6%(v/v) acetic acid *** was induced using Brewer's yeast *** lesion was induced in rats by oral administration of 99% *** anti-inflammatory,analgesic,antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated *** vitro antioxidant effect was investigated using DPPH free ***:The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats,analgesic effect against acetic acid-induced writhing,and antipyretic activity in Brewer's yeast model of ***,it was shown to be a gastroprotective agent against ethanol-induced gastric *** plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using ***:The results validate the use of the investigated plant in traditional medicine for different ailments.

关键词： Artemisia herba-alba Gastric ulcer Inflammation Antioxidant Rats Mice

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Geochemistry and spectrometric prospection of younger granites and granitic pegmatites bearing uranium mineralization at *** El Rakeb area, Central Eastern Desert, Egypt

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Acta Geochimica 2021年第4期40卷 575-601页

作者： gehad M.Saleh Bahaa M.Emad Ibrahim B.abdel Kader Nuclear Materials Authority El MaadiP.O.Box 530CairoEgypt

The present study deals with the detailed field geology,mineralogy,geochemistry,and spectrometric prospection of rare metals and radioactive minerals associated with granitic pegmatites in the Gabal Um LassafAbu Dob-Um Atelia-Kadabora-Kab El Rakeb area(LDAKK),which are situated in the central Eastern Desert of *** study area is composed of granodiorites and *** latter is dissected by granitic pegmatites with a discriminatory distribution of economically important mineralization(rare-metals and U-Th minerals).The granitic pegmatites display a zoning structure composed of feldspar-rich zones enveloping pockets of mica(mostly muscovite) and all zoning internal quartz ***,the monzogranite and granitic pegmatites are composed of potash-feldspar,albite,and quartz with a small amount of biotite and *** mineralogical investigation of the highly radioactive zones in the granitic pegmatite shows enrichment in kasolite,uranothorite,thorite,xenotime,columbite,zircon,bismuth,and ***,the granitic pegmatites are enriched with high field strength elements(HFSE;Zr,Nb,Th,and U) and ion lithophilic elements(LILE;Rb,and Pb) and depleted in Ba,Sr,and *** are strongly peralkaline to metalumainous except for two samples,which are *** are formed by partial melting of metagreywackes at *** studied granitic pegmatites could belong to the NYF family(Niobium-Yttrium-Fluorine family) according to the geochemistry of the trace *** studied granitic pegmatites show deep negative Eu anomaly and display a strong M-type tetrad effect of rare earth *** field spectroscopy measurements showed the localization of the radiometric anomalous associated with the granitic pegmatites,which are intruded in the granitic host *** eU and eTh contents reached up to 316 and 1367 ppm,*** and thorium occurrences in the investigated granitic pegmatites are related to magmatic(syngenetic)ori

关键词： Geochemistry Gabal Um Lassaf-Abu Dob-Um Atelia-Kadabora-Kab El Rakeb area(LDAKK) Uranium REE Egypt

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The possible source of uranium mineralization in felsic volcanic rocks,Eastern Desert,Egypt of the Arabian-Nubian Shield:Constraints from whole-rock geochemistry and spectrometric prospection

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Acta Geochimica 2021年第5期40卷 819-845页

作者： gehad.M.Saleh Bahaa.M.Emad Ibrahim.B.abdel Kader Rania.M.Sakr Nuclear Materials Authority El MaadiP.O.Box 530CairoEgypt

The present work deals with the detailed geology,mineralogy,geochemistry,and spectrometric prospection of the felsic volcanic rocks at the Eastern Desert,Egypt of the Arabian-Nubian *** volcanic rocks are an essential source for rare earth elements(REEs)and uranium occurrences in this *** are compositionally uniform with tholeiitic to calc-alkaline affinities,peraluminous and belong to the series of rhyolite with high-K *** exhibit more enrichment in high field strength elements(HFSE,***,Ta,Nd,Th,and U)and large-ion lithophile elements(LILE,*** and Rb)compared to the country rocks of the studied area,with REE ranging from 188.20 to 442.70 ppm and strong depletion in Ti,Sr,P with deep negative Eu *** felsic volcanic rocks were mostly generated from the partial melting of quartz-amphibolite facies accreted during the *** oddities of Zr-U-Th for the felsic volcanic rocks determine the involvement of crustal *** volcanic rocks are found in A-type suites of magma and represent highly fractionated rocks derived from rhyolitic magma,with insignificant interaction with continental crust in the low-pressure environment and during fractional *** volcanic rocks have higher values of radioactivity in which eU range from 0.5 to 121 ppm and eTh from 1.0 to 415.10 *** high values of eU and eTh can be ascribed to the mineralization of uranium and the presence of accessory minerals of radiogenic nature such as uranophane,uranothorite,zircon,and *** is considered as the mineral with most enriched uranium contents in the studied felsic volcanic rocks in which(UO2=87.30 wt%).Also,they are enriched with REE-bearing accessory minerals comprising allanite,titanite,and *** geological investigations of the felsic volcanic rocks in the studied areas are inappropriate to clear the feasible economic potentialities of rare earth elements and U occurrences;itemized and invaluable

关键词： Felsic volcanic rocks Geochemistry REE Uranium mineralization Egypt Arabian-Nubian Shield

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Evaluation of Reticulocyte Hemoglobin Content and Serum Neutrophil Gelatinase-Associated Lipocalin as Predictive Biomarkers of Anemia in Children on Hemodialysis

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Open Journal of Nephrology 2021年第4期11卷 523-537页

作者： Heba Ahmed Donia Manal abdel El-Salam gehad Nabil Mohammed Doaa Aly Abd Elfattah Pediatrics Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Clinical Pathology Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Background: Diagnosis of iron deficiency anemia with currently available tests is rendered difficult in hemodialysis patients. The aim: To investigate the role of reticulocyte Hemoglobin Content (CHr) in the diagnosis of iron deficiency anemia in hemodialysis children in comparison to the used traditional markers and assess the impressiveness and the utility of Neutrophil Gelatinase Associated Lipocalin (NGAL) as a novel biomarker of iron status in those patients. Methods: This study investigated CHr in addition to NGAL serum level in the same line with traditional markers for anemia, including: CBC, serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT%). Results: It is more significant that CHr content in hemodialysis children is lower than their controls as they are (27.06 ± 2.90) pg and (32.86 ± 3.59) pg, respectively, p = 0.01. There is no significant difference regarding NGAL between the study groups. Significant negative correlation between CHr with ferritin, urea, creatinine, and positively correlated with iron and RBCS. CHr showed a sensitivity of 90% and specificity of 86.67% to detect iron-deficiency anemia with a cut-off value of 27 pg. Conclusion: CHr is superior to ferritin and TSAT % for the early diagnosis of iron deficiency anemia in hemodialysis children;our results do not support NGAL as a marker of anemia in hemodialysis patients.

关键词： Children Hemodialysis Reticulocyte Hemoglobin Content Neutrophil Gelatinase-Associated Lipocalin

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