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Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance:Results of a Pilot Study

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Infectious Microbes & Diseases 2022年第1期4卷 26-33页

作者： Merlin Moni Thushara Madathil Dipu T.Sathyapalan Veena Menon Georg Gutjahr Fabia Edathadathil Deepthi Sureshkumar Preetha Prasanna Soumya Jose Roshni Jerome Ajai Krishnan Indulekha C.L.Pillai geetha kumar Bipin Nair Victor Nizet Aveek Jayant Department of Medicine Division of Infectious DiseasesAmrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Department of Cardiac Anaesthesiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Clinical Virology Laboratory Amrita Institute of Medical SciencesAmrita Vishwa VidyapeethamKochiKeralaIndia Center for Research in Analytics and Technologies for Education(CREATE) Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Department of Infection Control and Epidemiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Medicine Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Biotechnology Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Skaggs School of Pharmacy and Pharmaceutical Sciences University of CaliforniaSan DiegoLa JollaCaliforniaUSA Department of Pediatrics University of CaliforniaSan DiegoLa JollaCaliforniaUSA

Hypoxic patients with coronavirus disease 2019(COVID-19)are at high risk of adverse *** nitric oxide(iNO)has shown anti-viral and immunomodulatory effects in ***,in vivo evidence of efficacy in hypoxic COVID-19 is *** open label feasibility study was conducted at a single referral center in South India and evaluated the effectiveness of repurposed iNO in improving clinical outcomes in COVID-19 and its correlation with viral *** recruited hypoxemic COVID-19 patients and allocated them into treatment(iNO)and control groups(1:1).Viral clearance on day 5 favored the treatment group(100%vs 72%,P<0.01).The speed of viral clearance as adjudged by normalized longitudinal cycle threshold(Ct)values was positively impacted in the treatment *** proportion of patients who attained clinical improvement,defined as a≥2-point change on the World Health Organization ordinal scale,was higher in the iNO cohort(n=11,79%)as compared to the control group(n=4,36%)(odds ratio 6.42,95%confidence interval 1.09–37.73,P=0.032).The proportion of patients progressing to mechanical ventilation in the control group(4/11)was significantly higher than in the treatment group(0/14).The all-cause 28-day mortality was significantly different among the study arms,with 36%(4/11)of the patients dying in the control group while none died in the treatment *** numbers needed to treat to prevent an additional poor outcome of death was estimated to be *** study demonstrates the putative role of repurposed iNO in hypoxemic COVID-19 patients and calls for extended validation.

关键词： nitric oxide COVID-19 antiviral activity WHO ordinal scale

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Effect of Stress-Adaptation on Antibiotic Sensitivity Profiles of <i>Campylobacter jejuni</i>

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Advances in Microbiology 2013年第1期3卷 76-82页

作者： geetha S. kumar-Phillips Irene Hanning Michael Slavik Department of Food Science and Technology University of Tennessee Knoxville USA Department of Poultry Science University of Arkansas Fayetteville USA

Campylobacter jejuni is one of the leading causes of human gastroenteritis. Campylobacter jejuni requires special conditions and media in the laboratory for its growth. In nature, however, this organism is able to survive in very diverse and hostile environments and produce disease in humans and animals. The different mechanisms by which C. jejuni survives stressful conditions in the environment still remain unclear. Stress-adaptation may be one of the factors helping this organism to survive stresses. Some C. jejuni strains have been found to have increased antibiotic resistance in last several years. To determine the effect of acid adaptation on the antibiotic sensitivity profile of C. jejuni, 4 different isolates of C. jejuni (a human isolate and 3 poultry isolates) were exposed to an acid pH of 5.5 and then rechallenged with different stresses. The antibiotic sensitivity profiles of C. jejuni after stress-adaptation were compared with antibiotic sensitivity profiles of non-stressed C. jejuni using the Kirby Bauer agar disc diffusion assay. The antibiotic sensitivity profiles of the C. jejuni isolates used in this study were found to change when the acidadapted bacteria were subjected to further stresses such as an acidic pH of 4.5, aerobic atmosphere and starvation. In the majority of the cases, antibiotic-resistant C. jejuni isolates were found to be more sensitive to antibiotics after stress-adaptation, but in a few cases C. jejuni showed increased resistance. These results indicate that increasing various stresses in a sequential pattern may, in some cases, reduce antibiotic resistance of C. jejuni isolates.

关键词： Campylobacter jejuni Stress Stress-Adaptation Antibiotic Resistance Antibiotics

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Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions

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World Journal of Hepatology 2024年第1期16卷 17-32页

作者： Yash R Shah Hassam Ali Angad Tiwari David Guevara-Lazo Natalia Nombera-Aznaran Bhanu Siva Mohan Pinnam Manesh kumar Gangwani Harishankar Gopakumar Amir H Sohail SriLakshmiDevi Kanumilli Ernesto Calderon-Martinez geetha Krishnamoorthy Nimish Thakral Dushyant Singh Dahiya Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Maharani Laxmi Bai Medical CollegeJhansi 284001India Faculty of Medicine Universidad Peruana Cayetano HerediaLima 15102Peru Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology University of Illinois College of Medicine at PeoriaPeoriaIL 61605United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine GSL Medical CollegeRajamahendravaram 533296India Department of Internal Medicine Universidad Nacional Autonoma de MexicoCiudad De Mexico 04510Mexico Department of Digestive Diseases and Nutrition University of KentuckyLexingtonKY 40536United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States

Fecal microbiota transplantation(FMT)offers a potential treatment avenue for hepatic encephalopathy(HE)by leveraging beneficial bacterial displacement to restore a balanced gut *** prevalence of HE varies with liver disease severity and *** pathogenesis involves ammonia toxicity,gut-brain communication disruption,and *** aims to restore gut microbiota balance,addressing these ***'s efficacy has been explored in various conditions,including *** suggest that FMT can modulate gut microbiota,reduce ammonia levels,and alleviate *** has shown promise in alcohol-associated,hepatitis B and C-associated,and non-alcoholic fatty liver *** include improved liver function,cognitive function,and the slowing of disease ***,larger,controlled studies are needed to validate its effectiveness in these *** have shown cognitive improvements through FMT,with potential benefits in cirrhotic ***,trials have demonstrated reduced serious adverse events and cognitive enhancements in FMT arms compared to the standard of *** evidence is promising,challenges remain:Limited patient numbers,varied dosages,administration routes,and donor *** large-scale,controlled trials are essential to establish standardized guidelines and ensure FMT's clinical applications and *** FMT holds potential for HE management,ongoing research is needed to address these challenges,optimize protocols,and expand its availability as a therapeutic option for diverse hepatic conditions.

关键词： Hepatic encephalopathy Fecal microbiota transplant Cognitive impairment Liver cirrhosis Chronic liver disease

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A framework for the sustainability implications of 3D bioprinting through nature-inspired materials and structures

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Bio-Design and Manufacturing 2022年第2期5卷 412-423页

作者： Ruban Whenish Seeram Ramakrishna Amit kumar Jaiswal geetha Manivasagam Center for Biomaterials Cellular and Molecular TheranosticsVellore Institute of TechnologyVelloreTamilnadu 632014India Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1119260Singapore

Introduction The climax of the industrial revolution was marked by the rapid growth of industry,and advancement in technologies have further fueled this industrial expansion,leading to a surge in economic *** technolo... 详细信息

关键词： printing advancement revolution

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Recognizing Ancient South Indian Language Using Opposition Based Grey Wolf Optimization

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Intelligent Automation & Soft Computing 2023年第3期35卷 2619-2637页

作者： A.Naresh kumar G.geetha Department of CSE Anna UniversityChennai600025TamilnaduIndia Department of CSE Agni College of TechnologyChennai600130TamilnaduIndia

Recognizing signs and fonts of prehistoric language is a fairly difﬁcult job that requires special *** stipulation make the dispensation period over-riding,difﬁcult and tiresome to *** paper present a technique for recognizing ancient south Indian languages by applying Artiﬁcial Neural Network(ANN)associated with Opposition based Grey Wolf Optimization Algorithm(OGWA).It identiﬁes the prehistoric language,signs and *** is an apparent from the ANN system that arbitrarily produced weights or neurons linking various layers play a signiﬁcant role in its *** adaptively determining these weights,this paper applies various optimization algorithms such as Opposition based Grey Wolf Optimization,Particle Swarm Optimization and Grey Wolf Opti-mization to the ANN *** results are illustrated that the proposed ANN-OGWO technique achieves superior accuracy over the other *** test case 1,the accuracy value of OGWO is 94.89%and in test case 2,the accu-racy value of OGWO is 92.34%,on average,the accuracy of OGWO achieves 5.8%greater accuracy than ANN-GWO,10.1%greater accuracy than ANN-PSO and 22.1%greater accuracy over conventional ANN technique.

关键词： Ancient language symbols characters artiﬁcial neural network opposition based grey wolf optimization

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Twitter Data Analysis Using Hadoop and‘R’and Emotional Analysis Using Optimized SVNN

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Computer Systems Science & Engineering 2023年第1期44卷 485-499页

作者： K.Sailaja kumar H.K.Manoj D.Evangelin geetha Department of CA M S Ramaiah Institute of Technology560054BangaloreIndia

Standalone systems cannot handle the giant traffic loads generated by Twitter due to memory constraints.A parallel computational environment pro-vided by Apache Hadoop can distribute and process the data over different desti-nation *** this paper,the Hadoop cluster with four nodes integrated with RHadoop,Flume,and Hive is created to analyze the tweets gathered from the Twitter *** stream data is collected relevant to an event/topic like IPL-2015,cricket,Royal Challengers Bangalore,Kohli,Modi,from May 24 to 30,2016 using *** is used as a data warehouse to store the streamed *** analytics like maximum number of tweets by users,the average number of followers,and maximum number of friends are obtained using *** network graph is constructed with the user’s unique screen name and men-tions using‘R’.A timeline graph of individual users is generated using‘R’.Also,the proposed solution analyses the emotions of cricket fans by classifying their Twitter messages into appropriate emotional categories using the optimized sup-port vector neural network(OSVNN)classification *** attain better classi-fication accuracy,the performance of SVNN is enhanced using a chimp optimization algorithm(ChOA).Extracting the users’emotions toward an event is beneficial for prediction,but when coupled with visualizations,it becomes more ***-chart and wordcloud are generated to visualize the emotional analysis results.

关键词： Twitter apache Hadoop emotional analysis OSVNN ChoA timeline graph ﬂume hive

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Comparison of TiAlN, AlCrN, and AlCrN/TiAlN coatings for cutting-tool applications

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International Journal of Minerals,Metallurgy and Materials 2014年第8期21卷 796-805页

作者： T.Sampath kumar S.Balasivanandha Prabu geetha Manivasagam K.A.Padmanabhan Department of Mechanical Engineering C.Abdul Hakeem College of Engineering and Technology Hakeem Nagar Melvisharam 632509 India Department of Mechanical Engineering College of Engineering Guindy Anna University Chennai 600025 India School of Mechanical and Building Sciences VIT University Vellore 632014 India School of Engineering Sciences & Technology University of Hyderabad Hyderabad 500046 India

Monolayer and bilayer coatings of TiAlN, AlCrN, and AlCrN/TiAlN were deposited onto tungsten carbide inserts using the plasma enhanced physical vapor deposition process. The microstructures of the coatings were characterized using scanning electron microscopy （SEM） and atomic force microscopy （AFM）. The SEM micrographs revealed that the AlrN and AlCrN/TiAlN coatings were uniform and highly dense and contained only a limited number of microvoids. The TiAIN coating was non-uniform and highly porous and contained more micro droplets. The hardness and scratch resistance of the specimens were measured using a nanoindentation tester and scratch tester, respectively. Different phases formed in the coatings were analyzed by X-ray diffraction （XRD）. The AlCrN/TiAlN coating exhibited a higher hardness （32.75 GPa）, a higher Young＇s modulus （561.97 GPa）, and superior scratch resistance （LcN = 46 N） compared to conventional coatings such as TiAlN, A1CrN, and TiN.

关键词： cutting tools coatings physical vapor deposition characterization nanoindentation

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Extraction and Characterization of Myofibrillar Proteins from Different Meat Sources:A Comparative Study

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Journal of Bioresources and Bioproducts 2021年第4期6卷 367-378页

作者： Pavan kumar Dara Anjana geetha Upasana Mohanty Mahadevan Raghavankutty Suseela Mathew Ravishankar Chandragiri Nagarajarao Anandan Rangasamy Biochemistry and Nutrition Division ICAR-Central Institute of Fisheries TechnologyCochin 682029KeralaIndia Department of Food and Nutrition Mody UniversityLakshmangarh 332311RajasthanIndia College of fisheries Central Agricultural UniversityTripura 799210India

In the present study,myofibrillar proteins were extracted from the meat proteins of beef,lamb,chicken,tuna and emperor fish using non-denaturation method,and their physico-chemical and rheological properties were *** myofibrillar proteins of beef,emperor and lamb samples had higher percentage of protein extractability than tuna and chicken *** tuna sample showed significantly higher bound bromophenol blue(BPB)value while lamb samples showed lower value(P<0.05).The myofibrillar protein of chicken sample was found to have more ionic and hydrogen bonds than all other myofibrillar *** disulphide bonds in tuna and lamb myofibrillar protein samples were significantly higher than other three samples(P<0.05).The myofibrillar protein samples showed major bands myosin heavy chain,α-actinin,desimin,actin,troponin,tropomyosin and myosin light chain with wider molecular weight distribution in the range of 20-200 *** myofibrillar proteins exhibited Newtonian and shear thickening nature behaviour at lower protein concentration(1 mg/mL)as revealed by flow profile and visco-elastic analysis using rheometer.

关键词： Myofibrillar proteins Sodium dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE) Rheological and surface-active property

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Maxillofacial trauma in a pregnant patient:Contemporary management principles with a case report&review of literature

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Chinese Journal of Traumatology 2020年第2期23卷 78-83页

作者： geetha Sridharan Elavenil Panneerselvam Keerthana Ponvel Swetha Tarun V.B.Krishna kumar Raja Department of Oral and Maxillofacial Surgery SRM Dental College and HospitalRamapuram CampusRamapuramChennai 600089Tamil NaduIndia

Trauma during pregnancy deserves special attention because of its management objectives,***-being of both pregnant woman and *** trauma directly affects the nutrition of foetus by interfering with the normal functions in a pregnant woman such as mouth *** and breathing,Hence early restitution of form and function of maxillofacial skeleton is ***,the gravid status is associated with numerous anatomical and physiological changes which present with clinical dilemma related to imaging and treatment.A careful scrutiny of the patient's systermic and gestational status is absolutely essential before,during and after instituting any interventional *** present a case of bilateral condyle fracture in a 30-year-old pregnant woman in the third trimester(32 weeks).She was treated with inter maxillary fixation using orthodontic brackets&*** successful restitution of occlusion,the patient was advised aggressive physiotherapy which ensured normal mouth *** weeks later,the patient delivered *** patient was followed up at one month and 3 month and demonstrated restitution of normal occlusion,mouth opening and lower|acial *** article aims at analyzing the contermporary principles in management of maxillfacial trauma in a pregnant woman and clarifying the common misconceptions.

关键词： Trauma Pregnancy Foetus Condyle fracture

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材料模型对高温Ti-6Al-4V合金理论成形极限图预测的影响（英文）

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Transactions of Nonferrous Metals Society of China 2016年第3期26卷 736-746页

作者： Nitin KOTKUNDE Sashank SRINIVASAN geetha KRISHNA Amit kumar GUPTA Swadesh kumar SINGH Department of Mechanical Engineering Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad 500078TelanganaIndia Department of Mechanical Engineering Gokaraju Rangaraju Institute of Engineering and TechnologyHyderabad 500072TelanganaIndia

成形极限图是一种用来描述使板材不发生局部颈缩所需最大主应变的重要图形。它是一种预测板材变形过程中变形极限的方便、有效的工具。本研究中,在400°C和不同样品宽度的条件,通过Nakazima实验得到了Ti-6Al-4V合金的成形极限图。此外,... 详细信息

成形极限图是一种用来描述使板材不发生局部颈缩所需最大主应变的重要图形。它是一种预测板材变形过程中变形极限的方便、有效的工具。本研究中,在400°C和不同样品宽度的条件,通过Nakazima实验得到了Ti-6Al-4V合金的成形极限图。此外,为了使用成形极限图对材料参数进行理论预测,提出了不同的各向异性屈服准则(Barlat 1989,Barlat 1996,Hill 1993)和不同的硬化模型(Hollomon幂定律、Johnson-Cook(JC)模型、改进的Zerilli-Armstrong(m-ZA)和Arrhenius(m-Arr)模型)。结合所提出的屈服准则和本构模型,通过Marciniak和Kuczynski(M-K)理论确定了Ti-6Al-4V合金的成形极限图。结果表明:屈服模型对材料成形极限图的影响大于本构模型的影响。然而,材料的厚度缺陷系数(f_0)与其硬化模型密切相关。Hill(1993)屈服准则最适合于成形极限图右边区域的预测,而Barlat(1989)屈服准最适合于成形极限图左边区域的预测。由于所得到的混合理论成形极限图兼具Barlat(1989)和Hill(1993)屈服模型和m-Arr硬化模型的优点,因此,它与实验得到的成形极限图吻合很好。

关键词： Ti-6Al-4V合金屈服准则硬化模型 Marciniak-Kuczynsk理论成形极限图

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