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Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

World Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad Khan Mukesh Kumar yadav Dong-Woo Lim Hojun Kim Jing-Hua Wang AbuZar Ansari Biohealth Products Research Center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

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Pharmacological adjuvants for diabetic vitrectomy surgery

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World Journal of Methodology 2024年第4期14卷 84-90页

作者： Ramesh Venkatesh Chaitra Jayadev Vishma Prabhu Priyanka Gandhi Rupal Kathare Naresh K yadav Ayushi Choudhary Jay Chhablani Department of Ophthalmology Narayana NethralayaBangalore 560010India Department of Retina Narayana Nethralaya Eye InstituteBangalore 560010India Department of Vitreo Retina Narayana NethralayaRetina ServSuper Specialty Eye Hospital and Post Graduate Institute of OphthalmologyBangalore 560010India Department of Retina University of Pittsburg School of MedicinePittsburgPA 15213United States

Diabetic vitrectomy is a highly intricate surgical procedure performed during the advanced stages of diabetic retinopathy(DR).It is used to treat conditions such as tractional or combined retinal detachment,vitreous hemorrhage,and subhyaloid hemorrhage,which are all severe manifestations of proliferative *** results of the surgery are uncertain and *** surgery has made significant progress since the early stages of *** the past ten years,advancements in intravitreal pharmacotherapy have emerged,offering new possibilities to improve the surgical results for our *** the realm of medical terminology,an"adjunct"refers to a pharmaceutical or substance employed to aid or expedite the primary therapeutic intervention for a particular *** introduction has broadened the range of therapeutic choices that are accessible prior to,during,and following surgical *** review article will specifically analyze the pharmacological adjuncts used in diabetic vitrectomy surgery,with a focus on their role in facilitating or aiding specific steps of the *** implementation of this system of categorization offers benefits to the surgeon by allowing them to foresee potential difficulties that may occur during the surgical procedure and to choose the appropriate pharmacological agent to effectively tackle these challenges,thus enhancing surgical success rates.

关键词： Diabetic retinopathy Vitrectomy Intravitreal injections Anti-vascular endothelial growth factor Adjuvants Outcomes

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Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation

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Engineering 2024年第7期38卷 175-183页

作者： Guibing Zhu Bangrui Lan Shuci Liu Cameron M.Callbeck Shanyun Wang Liping Jiang Asheesh Kumar yadav Jan Vymazal Mike S.M.Jetten Ganlin Zhang Yongguan Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Department of Environment and Science Queensland GovernmentBrisbaneQLD 4102Australia Department of Environmental Sciences University of BaselBasel 4056Switzerland CSIR-Institute of Minerals and Materials Technology Bhubaneswar 751013India Faculty of Environmental Sciences Czech University of Life Sciences PraguePraha 16521Czech Republic Department of Microbiology Radboud UniversityNijmegen 6525 XZThe Netherlands Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

The availability of nitrogen(N)is crucial for both the productivity of terrestrial and aquatic ecosystems ***,the overuse of artificial fertilizers and the energy required to fix nitrogen have pushed the global nitrogen cycle(N-cycle)past its safe operating limits,leading to severe nitrogen pollution and the production of significant amounts of greenhouse gas nitrous oxide(N2O).The anaerobic ammonium oxidation(anammox)mechanism can counteract the release of ammonium and N2O in many oxygenlimited situations,assisting in the restoration of the homeostasis of the Earth’s N *** this work,we looked into the characteristics of the anammox hotspots’distribution across various types of ecosystems *** hotspots are present at diverse oxic-anoxic interfaces in terrestrial systems,and they are most prevalent at the oxic-anoxic transition zone in aquatic *** on the discovery of an anammox hotspot capable of oxidizing ammonium anoxically into N2 without N2O by-product,we then designed an innovative concept and technical routes of nature-based anammox hotspot geoengineering for climate change,biodiversity loss,and efficient utilization of water *** 15 years of actual use,anammox hotspot geoengineering has proven to be effective in ensuring clean drinking water,regulating the climate,fostering plant and animal diversity,and enhancing longterm environmental *** sustainable biogeoengineering of anammox could be a workable natural remedy to resolve the conflicts between environmental pollution and food security connected to N management.

关键词： Biogeochemical N-cycle Oxic-anoxic interface Nature-based solution Biogeoengineering Nitrogen sustainable development

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竞争激烈的防护涂料市场

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中国涂料 2024年第6期39卷 75-76页

作者： Chirag Tripathi Atul yadav Surabhi Patankar Markets and Markets公司

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建... 详细信息

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建筑和基础设施、海洋和发电行业的发展,以及消费品和家电、建筑业和家具等各行各业的进步。将生产设施转移至亚太地区的主要好处在于生产成本低、可获得熟练且廉价的劳动力,并能够更好地服务于当地的新兴市场。

关键词：防护涂料复合年增长率基础设施新兴市场发电行业消费品经济发展水平竞争激烈

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Axisymmetric free vibrations of infinite micropolar thermoelastic plate

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Applied Mathematics and Mechanics(English Edition) 2007年第3期28卷 369-383页

作者： Rajneesh Kumar geeta Partap Department of Mathematics Kurukshetra UniversityKurukshetra 136119HaryanaIndia Department of Applied Mathematics Dr.B.R.Ambedkar National Institute of TechnologyJalandhar 144011PunjabIndia

The propagation of axisymmetric free vibrations in an infinite homogeneous isotropic micropolar thermoelastic plate without energy dissipation subjected to stress free and rigidly fixed boundary conditions is investigated. The secular equations for homogeneous isotropic micropolar thermoelastic plate without energy dissipation in closed form for symmetric and skew symmetric wave modes of propagation are derived. The different regions of secular equations are obtained. At short wavelength limits, the secular equations for symmetric and skew symmetric modes of wave propagation in a stress free insulated and isothermal plate reduce to Rayleigh surface wave frequency equation. The results for thermoelastic, micropolar elastic and elastic materials are obtained as particular cases from the derived secular equations. The amplitudes of displacement components, microrotation and temperature distribution are also computed during the symmetric and skew symmetric motion of the plate. The dispersion curves for symmetric and skew symmetric modes and amplitudes of displacement components, microrotation and temperature distribution in case of fundamental symmetric and skew symmetric modes are presented graphically. The analytical and numerical results are found to be in close agreement.

关键词： micropolar thermoelastic plate thermoelasticity without energy dissipation circular crested waves symmetric and skew symmetric amplitudes

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CURING KINETICS AND THERMAL STABILITY OF EPOXY BLENDS CONTAINING PHOSPHOROUS-OXIRANE WITH AROMATIC AMIDE-AMINE AS CURING AGENTS

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Chinese Journal of Polymer Science 2012年第5期30卷 694-704页

作者： geeta Durga A.K.Narula School of Basic and Applied Sciences Guru Gobind Singh Indraprastha University

This article describes the synthesis of a series of aromatic amide-amines and their potential use as epoxy hardeners. These amines were synthesized by the reaction of L-phenylalanine （PA） with diamines of different structures i.e. 1,4- phenylene diamine （PD）, 1,5-diamino naphthalene （N）, 4,4＇-（9-fluorenyllidene）-dianiline （F）, 4,4＇-diaminodiphenyl sulphide （DS） and 3,4＇-oxydianiline （O） in a stoichiometric ratio （I ：1）. Structural characterization of synthesized amide-amines was done with the help of elemental analysis and spectroscopic techniques viz. FT-IR, 1H-NMR and 13C-NMR. An epoxy blend was prepared by mixing tris（glycidyloxy） phosphine oxide （TGPO） with conventional epoxy i.e. diglycidyl ether of bisphenol-A （DGEBA） in an equivalent ratio of 2：3 to incorporate phosphorous into the main chain. The curing kinetics of the epoxy blend with synthesized aromatic amide-amines was investigated by non-isothermal DSC technique using multiple heating rate method （5, 10, 15 and 20 K/min.）. The activation energies were determined by fitting the experimental data into Kissinger and Ozawa kinetic models. The activation energies obtained through Ozawa method were slightly higher than those of Kissinger method but were comparable. However, both the energies were found to be dependent on the structure of amines. The thermal stability and weight loss behavior of isothermally cured thermosets were also investigated using thermogravimetric analysis （TGA） in nitrogen atmosphere. All the samples showed improved thermal stability in terms of char yield than using only amines as hardeners.

关键词： Phosphorylated epoxy Amide-Amines Curing kinetics Char yield Thermal stability.

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RAYLEIGH LAMB WAVES IN MICROPOLAR ISOTROPIC ELASTIC PLATE

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Applied Mathematics and Mechanics(English Edition) 2006年第8期27卷 1049-1059页

The propagation of waves in a homogeneous isotropic micropolar elastic cylindrical plate subjected to stress free conditions is investigated. The secular equations for symmetric and skew symmetric wave mode propagation are derived. At short wave limit, the secular equations for symmetric and skew symmetric waves in a stress free circular plate reduces to Rayleigh surface wave frequency equation. Thin plate results are also obtained. The amplitudes of displacements and microrotation components are obtained and depicted graphically. Some special cases are also deduced from the present investigations. The secular equations for symmetric and skew symmetric modes are also presented graphically.

关键词： micropolar elastic plate circular crested waves secular equations phasevelocity amplitudes

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Structural and Spectroscopic Characterizations of ZnO Quantum Dots Annealed at Different Temperatures

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Journal of Materials Science & Technology 2013年第11期29卷 1035-1039页

作者： geeta Rani P.D.Sahare Department of Physics and Astrophysics University of Delhi

Here, we report the synthesis and characterizations of sol-gel derived zinc oxide （ZnO） quantum dots （QDs） using zinc acetate dihydrate （Zn（CH3COO）2.2H20） and lithium hydroxide monohydrate （LiOH.H20） as raw material. The as-prepared ZnO QDs was annealed at different temperature （400, 700, and 900 ℃） and the structural, optical properties were investigated by X-ray diffraction （XRD）, high resolution transmission electron microscopy （HRTEM）, UV-Vis and photoluminescence （PL） spectroscopy. The powder XRD patterns of the obtained samples showed the formation of single-phase wurtzite structure and the morphological changes have been observed with increasing annealing temperature. In the absorption spectra, the optical band gap of nanocrystalline ZnO QDs decreased from 3.18 to 3.11 eV and the particle size increased with increasing temperature. In the PL spectra, a broad green emission peak related to defect levels in the visible range of the spectra have been recorded.

关键词： ZnO quantum dots Photoluminescence UV-Vis spectroscopy

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Fusion of Medical Images in Wavelet Domain:A Hybrid Implementation

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Computer Modeling in Engineering & Sciences 2020年第1期122卷 303-321页

作者： Satya Prakash yadav Sachin yadav Department of Information Technology ABES Institute of Technology(ABESIT)GhaziabadIndia Department of Computer Science and Engineering G.L.Bajaj Institute of Technology and Management(GLBITM)Greater NoidaIndia

This paper presents a low intricate,profoundly energy effective MRI Images combination intended for remote visual sensor frameworks which leads to improved understanding and implementation of treatment;especially for *** is done by combining the original picture which leads to a significant reduction in the computation time and *** proposed technique conquers the calculation and energy impediment of low power tools and is examined as far as picture quality and energy is *** are performed utilizing MATLAB 2018a,to quantify the resultant vitality investment funds and the reproduction results show that the proposed calculation is very quick and devours just around 1%of vitality decomposition by the hybrid combination ***,the effortlessness of our proposed strategy makes it increasingly suitable for continuous applications.

关键词： Medical image fusion wavelet transform DWT DCT ICA fusion techniques multimodal fusion

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Stock values predictions using deep learning based hybrid models

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CAAI Transactions on Intelligence Technology 2022年第1期7卷 107-116页

作者： Konark yadav Milind yadav Sandeep Saini Department of Electronics and Communication Engineering The LNM Institute of Information TechnologyJaipurIndia Department of Computer Science and Engineering Rajasthan Technical UniversityKotaRajasthanIndia

Predicting the correct values of stock prices in fast fluctuating high-frequency financial data is always a challenging task.A deep learning-based model for live predictions of stock values is aimed to be developed *** authors'have proposed two models for different *** first one is based on Fast Recurrent Neural Networks(Fast RNNs).This model is used for stock price predictions for the first time in this *** second model is a hybrid deep learning model developed by utilising the best features of FastRNNs,Convolutional Neural Networks,and Bi-Directional Long Short Term Memory models to predict abrupt changes in the stock prices of a *** 1-min time interval stock data of four companies for a period of one and three days is *** with the lower Root Mean Squared Error(RMSE),the proposed models have low computational complexity as well,so that they can also be used for live *** models'performance is measured by the RMSE along with computation *** model outperforms Auto Regressive Integrated Moving Average,FBProphet,LSTM,and other proposed hybrid models on both RMSE and computation time for live predictions of stock values.

关键词： companies price stock

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