检索结果-南通市图书馆

SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan Gupta Manisha yadav Subhash yadav Bidhan Chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New insights into nitric oxide biosynthesis underpin lateral root development

引用

Molecular Plant 2024年第5期17卷 691-693页

作者： Kapuganti Jagadis Gupta Nidhi yadav Aprajita Kumari Gary J.Loake National Institute for Plant Genome Research Aruna Asaf Ali MargNew Delhi 110070India Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK Centre for Engineering Biology School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK

In recent years,nitric oxide(NO)has emerged as a key redox signaling molecule in plants functioning in the regulation of key developmental programs and the orchestration of responses to a plethora of environmental cues(Kolbert et al.,2019).The predominant route for the transfer of NO bioactivity is through S-nitrosylation,the addition of an NO moiety to a protein cysteine thiol to form an S-nitrosothiol(Yun et al.,2011).Specificity for this process is established by the structural constraints imposed by tertiary protein structure in gating access to given cysteine redox switches and associated proteins that can either facilitate the addition or removal of the NO moiety at these residues(Umbreen et al.,2018).

关键词： moiety addition redox

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Direction of Slant and Horizontal Stroke as Potential Suggestive Markers for the Determination of Handedness

引用

Journal of Forensic Science and Medicine 2024年第3期10卷 165-170页

作者： Pawan Gupta Anu Singla Baljeet yadav Vartika Khare Dr.APJ Abdul Kalam Institute of Forensic Science and Criminology Bundelkhand UniversityJhansiUttar PradeshIndia Department of Forensic Science Medi-Cap UniversityIndoreMadhya PradeshIndia

Background:The task of document examiners is very challenging,as they need to gather all the relevant facts to make an informed decision regarding the questioned *** the present study,a total of 300 handwriting samples from 100 different writers(involving 50 right-handed and 50 left-handed)were collected at Bundelkhand University,*** and stroke,as characteristic features of handwriting,were visually examined under a stereomicroscope to ascertain the ***:Slants and Strokes as characteristic features were analyzed in a total of 300 handwriting samples collected from 50 left-handed and 50 right-handed writers of age 17–22 years.A reference text comprising three pangram sentences printed on A4 paper and a blue ball point pen was used for ***:The data collected during the study were analyzed using a statistical method(Chi-square test)and revealed that the left-handed writers(LHWs)had a significantly(P<0.05)different writing style than the right-handed *** indicated that LHWs are more likely to make strokes in the right-to-left direction and slant of letters in the backward direction,while right-handed writers make strokes in the left-to-right direction and slant of letters in the forward ***:The findings of the study showed valuable insight and highlighted the significance of the direction of slant and horizontal stroke as potential indicators for the determination of handedness.

关键词： Forensic science handedness handwriting stroke questioned document slant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The circuitry landscape of perovskite solar cells:An in-depth analysis

引用

Journal of Energy Chemistry 2024年第7期94卷 393-413页

作者： Siddhi Vinayak Pandey Daniel Prochowicz Apurba Mahapatra Saravanan Pandiaraj Abdullah N.Alodhayb Seckin Akin Pankaj yadav Department of Solar Energy School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Self-Development Skills King Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Metallurgical and Materials Engineering Necmettin Erbakan University42060 KonyaTurkey Department of Physics School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

The extensive research and development in perovskite solar cells (PSCs) have rekindled the hopes of converting solar energy into *** elusive understanding of underlying mechanisms is required for the development of efficient *** the years,Impedance Spectroscopy (IS) characterization,along with complementary techniques,has proven to be an effective way to understand and analyze the charge transport and recombination at interface and bulk of *** IS of PSCs have been analyzed,interpreted,and improvised continuously,revealing intricate details about the ***,there is a lack of centralized source of these details,which make it tougher to account for the generalized approach to understand the device *** present work is focused on compiling the research done on various PSC device architectures via IS to construct a comprehensive foundation of information on impedance plots,equivalent circuits,and associated processes.

关键词： Impedance Spectroscopy Perovskite solar cells Equivalent Circuits

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Layer chicken microbiota:a comprehensive analysis of spatial and temporal dynamics across all major gut sections

引用

Journal of Animal Science and Biotechnology 2024年第3期15卷 1056-1070页

作者： yadav Sharma Bajagai Thi Thu Hao Van Nitish Joat Kapil Chousalkar Robert J.Moore Dragana Stanley Institute for Future Farming Systems Central Queensland UniversityRockhamptonQLD 4701Australia School of Science RMIT UniversityBundooraVIC 3083Australia School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background The gut microbiota influences chicken health,welfare,and productivity.A diverse and balanced microbiota has been associated with improved growth,efficient feed utilisation,a well-developed immune system,disease resistance,and stress tolerance in *** studies on chicken gut microbiota have predominantly focused on broiler chickens and have usually been limited to one or two sections of the digestive system,under con-trolled research environments,and often sampled at a single time *** extend these studies,this investigation examined the microbiota of commercially raised layer chickens across all major gut sections of the digestive system and with regular sampling from rearing to the end of production at 80 *** aim was to build a detailed picture of microbiota development across the entire digestive system of layer chickens and study spatial and temporal *** The taxonomic composition of gut microbiota differed significantly between birds in the rearing and pro-duction stages,indicating a shift after laying *** microbiota compositions were observed between proven-triculus and gizzard,as well as between jejunum and ileum,likely due to their anatomical ***-lus dominated the upper gut in pullets and the lower gut in older *** oesophagus had a high proportion of Proteobacteria,including opportunistic pathogens such as *** abundance of Gallibacterium increased after peak production in multiple gut *** was enriched in the late-lay phase compared to younger birds in multiple gut *** influenced microbial richness and diversity in different *** upper gut showed decreased diversity over time,possibly influenced by dietary changes,while the lower gut,specifi-cally cecum and colon,displayed increased richness as birds ***,age-related changes were inconsist-ent across all organs,suggesting the influence of organ-specific factors in micro

关键词： Chicken microbiota Gut microbiota Layers Spatial variation Temporal variation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in metal oxide-based electrocatalysts for sustainable water splitting

引用

Materials Reports(Energy) 2024年第3期4卷 19-34页

作者： Aasiya S.Jamadar Rohit Sutar Susmita Patil Reshma Khandekar Jyotiprakash B.yadav Vacuum Techniques and Thin Film Laboratory USICShivaji UniversityKolhapur416004MaharashtraIndia

Metal oxide-based electrocatalysts are promising alternatives to platinum group metals for water splitting due to their low cost,abundant raw materials,and impressive *** review covers recent progress in various metal oxides tailored for hydrogen and oxygen evolution reactions,discussing their crystal structure,composition,and surface modification influence on *** like surface engineering,doping,and nanostructuring are evaluated for enhancing catalytic activity and *** key considerations for commercialization are highlighted,emphasizing ongoing research,innovation,and future scope to drive widespread adoption of water-splitting technology for a cleaner and sustainable future.

关键词： Metal oxide HER OER Electrocatalyst Overall water spilling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

引用

Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu Vinod Kumar Kajal Kamboj Ashok Kumar Pannu Ashok Kumar yadav Mandip Bhatia Atul Saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of Experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue Cytokine Doxycycline Serum ferritin C reactive protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defect mediated losses and degradation of perovskite solar cells:Origin impacts and reliable characterization techniques

引用

Journal of Energy Chemistry 2024年第7期94卷 217-253页

作者： Himangshu Baishy Ramkrishna Das Adhikari Mayur Jagdishbhai Patel Deepak yadav Tapashi Sarmah Mizanur Alam Manab Kalita Parameswar Krishnan lyer Centre for Nanotechnology Indian Institute of Technology GuwahatiGuwahati 781039AssamIndia Department of Chemistry Indian Institute ofTechnology GuwahatGuwahati739AssamIndi

The rapid advancement of halide-based hybrid perovskite materials has garnered significant research attention,particularly in the domain of photovoltaic *** to their exceptional optoelec-tronic properties,they demonstrated power conversion efficiency(PcE)of over 25%in single junction solar *** the notable progress in PCE over the past decade,the inherent high defect density pre-senting in perovskite materials gives rise to several loss mechanisms and associated ion migration in per-ovskite solar cells(PsCs)during operational *** factors collectively contribute to a significant stability challenge in PsCs,placing their longevity far behind for *** numerous reports have explored defects,ion migration,and their impacts on device performance,a com-prehensive correlation between the types of defects and the degradation kinetics of perovskite materials and PsCs has been *** this context,this review aims to provide a comprehensive overview of the origins of defects and ion migration,emphasizing their correlation with the degradation kinetics of per-ovskite materials and PsCs,leveraging reliable characterization ***,these charac-terization techniques are intended to comprehend loss mechanisms by different passivation approaches to enhance the durability and PCE of PSCs.

关键词： Perovskite solar cells Defects lon migration Degradation Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rational management of the plant microbiome for the Second Green Revolution

引用

Plant Communications 2024年第4期5卷 1-15页

作者： Xiaofang Li Xin Zheng Nikita yadav Shouvik Saha El-Sayed Salama Xiangkai Li Likun Wang Byong-Hun Jeon Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763South Korea Natural Resources Research Institute University of Minnesota DuluthHermantownMN 55811USA Department of Biotechnology Brainware UniversityBarasatKolkata 700125West BengalIndia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhouGansu 730000China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life ScienceLanzhou UniversityLanzhouGansu 730000China

The Green Revolution of the mid-20th century transformed agriculture worldwide and has resulted in envi-ronmental challenges.A new approach,the Second Green Revolution,seeks to enhance agricultural pro-ductivity while minimizing negative environmental *** microbiomes play critical roles in plant growth and stress responses,and understanding plant–microbiome interactions is essential for developing sustainable agricultural practices that meet food security and safety challenges,which are among the United Nations Sustainable Development *** review provides a comprehensive exploration of key deterministic processes crucial for developing microbiome management strategies,including the host effect,the facilitator effect,and microbe–microbe interactions.A hierarchical framework for plant mi-crobiome modulation is proposed to bridge the gap between basic research and agricultural *** framework emphasizes three levels of modulation:single-strain,synthetic community,and in situ mi-crobiome ***,rational management of plant microbiomes has wide-ranging applications in agriculture and can potentially be a core technology for the Second Green Revolution.

关键词： Second Green Revolution plant microbiome rational management host effect microbiome heritability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advancements in nanotechnology for the delivery of phytochemicals

引用

Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan K.yadav Nazneen Sultana Arun Agarwal Saurabh Verma Manish K.Chourasia Jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：