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Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies

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Pharmacology & Pharmacy 2011年第3期2卷 212-225页

作者： Renu Chadha Sushma Gupta Natasha Pathak geeta shukla D.V.S. Jain Raghuvir R S Pissurlenkar Evans C Coutinho 不详

The purpose of the present work is to improve the antimalarial activity of arteether through enhancing its solubility subsequently bioavailability by incorporating the drug into the cyclodextrins cavity. The effect of hydrophilic polyvinyl propylene (PVP) polymer on the complexation and solubilizing efficiencies of cyclodextrins (CDs) is also elucidated. Inclusion of arteether molecule in solid state was evidenced by Differential scanning calorimeter (DSC), Powder X-ray diffractometery (PXRD), and in solution state by NMR and solution calorimetry. A 1:1 stoichiometry was proposed by the phase solubility studies both in presence and absence of PVP. The most plausibe mode of inclusion of arteether into the CD cavity is revealed by molecular modeling studies utalizing Fast Rigid Exhaustive Docking acronym. Solution calorimetry was used further to confirm 1:1 stiochiometry in presence or absence of PVP by determining the enthalpy of interaction between the drug and cyclodextrins. The inclusion of drug was found to be exothermic process accompanied by small positive value of entropy (ΔSo). The methylated-β-CD showed the best ability to solublize arteether which is approximately at par with β-CD in the presence of PVP. Better complexation efficiency of β-CD in presence of PVP is also reflected by the higher numerical values of stability constant (K). Compelete eradication of the parasite from the blood and highest anti-malarial pharmacological activity was observed in the complexes of arteether with M-?-CD while 83.7% was observed for ternary complexes of β-CD in presence of PVP.

关键词： Arteether cyclodextrins ternary complexes complexation efficiency in vivo studies

Role of Moringa oleifera in regulation of diabetes-induced oxidative stress

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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 426-432页

作者： Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair geeta Watal Alternative Therapeutics Unit Drug Development DivisionMedicinal Research Lab.Department of ChemistryUniversity of Allahabad Christopher Bond Life Sciences Center Department of Molecular Microbiology & ImmunologyUniversity of Missouri School of Medicine Department of NMR All India Institude of Medical Sciences Department of Biochemistry.University of Allahabad National Medicinal Plants Boord Alternative Therapeutics Unit Drug Development DivisionMedicinal Research Lab.Department of ChemistryUniversity of Allahahad

Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta ***) young leaves by in vivo as well as in vitro ***:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic *** effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were ***:Significant increase in activities of ***, GST while,a decrease in LPO content was ***,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,*** the other *** assay results of *** leaves was(85.00±5.00)μM of Fe^+/g of extract ***:The significant antioxidant activities of *** leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage.

关键词： Moringa oleifera leaves Diabetes Free radical Oxidative damage Scavenging Antioxidant

Polymer Nanocomposites in Sensor Applications: A Review on Present Trends and Future Scope

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Chinese Journal of Polymer Science 2021年第6期39卷 665-691,I0005页

作者： Prashant shukla Pooja Saxena Amity Institute for Advanced Research and Studies(Materials&Devices) Amity UniversitySector-125Noida 201303India G L Bajaj Institute of Technology and Management Greater Noida-201306Uttar PradeshIndia

Polymers are crucial constituents of modern electronic *** can be used in their pristine,composite or nanocomposite forms for several domestic and industrial applications with innumerable unique *** nanocomposites have gained wide theoretical interest and numerous practical applications in diverse fields of science and technology as they bestow the materials not only with virtuous processability but also with exceptional *** is evidenced that the electrical conductance of polymer nanocomposite is governed by the conductive filler networks within the polymer ***,insignificant variation in the conductive networks can result in noteworthy variations in the output electric signal of polymer *** this stimuli-responsive performance of conductive networks to the physical parameters,polymer nanocomposites can be harnessed to fabricate novel sensitive sensors to detect vital physical parameters ***/stress,pressure,temperature,solvent or *** and phenomenological studies on polymer nanocomposites are still *** explanations are being sought but the mechanisms governing the formation of several polymer nanocomposites are still topics of debate in the material science *** in-depth investigation requires copious scientific *** review analytically sketches the synthesis,microstructures,physiochemical properties and the underlying mechanisms for stimuli-responsiveness to the physical parameters of the polymer nanocomposites as well as their applications in various sensitive sensors and ***,it became evocative for this review to focus on their processing methodologies,physiochemical physiognomies,classification and probable potentials of polymer *** review primarily presents the current literature survey on polymer composites and the gap areas in the study encourages the objective of the present review ***,the status,perspec

关键词： Polymers Polymer nanocomposites Sensors CNT Graphene

Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit shukla Archana SHARMA Pulsed Power and Electromagnetics Division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

Acclimation and Tolerance Strategies of Rice under Drought Stress

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Rice science 2015年第4期22卷 147-161页

作者： Veena PANDEY Alok shukla Department of Plant Physiology College of Basic Sciences and HumanitiesGovind Ballabh Pant University of Agriculture & Technology

Rice （Oryza sativa L.） is an important food crop and requires larger amount of water throughout its life cycle as compared to other crops. Hence, water related stress cause severe threat to rice production. Drought is a major challenge limiting rice production. It affects rice at morphological （reduced germination, plant height, plant biomass, number of tillers, various root and leaf traits）, physiological （reduced photosynthesis, transpiration, stomatal conductance, water use efficiency, relative water content, chlorophyll content, photosystem II activity, membrane stability, carbon isotope discrimination and abscisic acid content）, biochemical （accumulation of osmoprotectant like proline, sugars, polyamines and antioxidants） and molecular （altered expression of genes which encode transcription factors and defence related proteins） levels and thereby affects its yield. To facilitate the selection or development of drought tolerant rice varieties, a thorough understanding of the various mechanisms that govern the yield of rice under water stress condition is a prerequisite. Thus, this review is focused mainly on recent information about the effects of drought on rice, rice responses as well as adaptation mechanisms to drought stress.

关键词： rice water drought stress yield attribute morphological characteristic physiological characteristic biochemical characteristic molecular level

Dynamic scheduling of market price-based combined heat–power-constrained renewable microgrid

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Clean Energy 2023年第4期7卷 859-872页

作者： Sunita shukla Manjaree Pandit Department of Electrical Engineering Madhav Institute of Technology&ScienceGwalior 474005India

In this paper,a market price-based combined heat–power dynamic dispatch model for a microgrid is *** microgrid comprises cogeneration units and wind and solar power-generation units.A battery and a heat storage tank are incorporated to optimally balance variations in heat-and-power load *** proposed model explores the impact of market prices of electricity,heat supply and load variability on the optimal schedule such that profit maximizes and emission,loss and waste heat are *** Weibull probability distribution function is applied to characterize the uncertain renewable power variable in the model and to find the over-and under-scheduling *** problem is solved using an improved differential evolution algorithm in which a fuzzy membership module is appended to obtain a solution having the highest attainment for the selected multiple *** results show that the proposed model can handle uncertain heat–power demand and price scenarios to produce feasible and optimal schedules with owner profits,heat utilization and renewable share varying between 10.55–115.97%,72.51–90.39%and 26.82–38.05%,respectively.

关键词： renewable energy combined heat power(CHP) microgrid(MG) economic dispatch MG profit

Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

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Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez Surabhi shukla Department of Pharmaceutical Sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGylation targeted delivery tau

Molecules against COVID-19:An in Silico Approach for Drug Development

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Journal of Electronic Science and Technology 2021年第1期19卷 14-24页

作者： Rhythm Bharti Sandeep Kumar shukla the Sri Venkateswara College University of DelhiNew Delhi 110021. The Institute of Nuclear Medicine and Allied Sciences Defence Research and Development OrganizationDelhi 110054

A large number of deaths have been caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)worldwide,turning it into a serious and momentous threat to public *** study tends to contribute to the development of effective treatment strategies through a computational approach,investigating the mechanisms in relation to the binding and subsequent inhibition of SARS-CoV-2 ribonucleic acid(RNA)-dependent RNA polymerase(RdRp).Molecular docking was performed to screen six naturally occurring molecules with antineoplastic properties(Ellipticine,Ecteinascidin,Homoharringtonine,Dolastatin 10,Halichondrin,and Plicamycin).Absorption,distribution,metabolism,and excretion(ADME)investigation was also conducted to analyze the druglike properties of these *** docked results have clearly shown binding of ligands to the SARS-CoV-2 RdRp ***,all ligands were found to obey Lipinski’s rule of *** results provide a basis for repurposing and using molecules,derived from plants and animals,as a potential treatment for the coronavirus disease 2019(COVID-19)infection as they could be effective therapeutics for the same.

关键词： Coronavirus disease 2019(COVID-19) drug repurposing,molecular docking natural therapeutics RNA-dependent RNA polymerase(RdRp) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

Electron Paramagnetic Resonance and Optical Absorption of VO2+Doped Ammonium Selenate Single Crystals

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Chinese Physics Letters 2011年第3期28卷 203-206页

作者： Ram Kripal Ashutosh Kumar shukla Department of Physics University of AllahabadAllahabad 211002India Department of Physics Ewing Christian CollegeAllahabad 211003India

An electron paramagnetic resonance study of vanadyl ions doped in ammonium selenate single crystals is carried out at room *** is found that the VO^(2+)ion takes up an interstitial *** spin Hamiltonian parameters obtained from the crystal rotations are g‖=1.9576±0.0002,g⊥=1.9889±0.0002,A‖=203±2 G,A⊥=78±2 *** optical absorption study is also carried out to evaluate various bonding *** the basis of these parameters the nature of bonding in the complex is discussed.

关键词： temperature parameters bonding