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Frontiers of Structural and Civil Engineering 2024年第1期18卷 66-79页

作者： Yaxin TAO Xiaodi DAI geert de SCHUTTER Kim Van TITTELBOOM Department of Structural Engineering and Building Materials Ghent UniversityGhent 9052Belgium

Robotic-based technologies such as automated spraying or extrusion-based 3-dimensional(3D)concrete printing can be used to build tunnel linings,aiming at reducing labor and mitigating the associated safety issues,especially in the high-geothermal ***-based 3D concrete printing(3DCP)has additional advantages over automated sprayings,such as improved surface quality and no ***,the effect of different temperatures on the adhesion performance of 3D-printed materials for tunnel linings has not been *** study developed several alkali-activated slag mixtures with different activator modulus ratios to avoid the excessive use of Portland cement and enhance sustainability of 3D printable *** thermal responses of the mixtures at different temperatures of 20 and 40℃ were *** adhesion strength of the alkali-activated material was evaluated for both early and later ***,the structural evolution of the material exposed to different temperatures was *** was followed by microstructure *** indicate that elevated temperatures accelerate material reactions,resulting in improved early-age adhesion ***,higher temperatures contribute to the development of a denser microstructure and enhanced mechanical strength in the hardened stage,particularly in mixtures with higher silicate content.

关键词： alkali-activated material 3DCP tunnel lining high-geothermal environment adhesion

Combined peakreductionandself-consumptionusingproximalpolicy optimisation

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Energy and AI 2024年第2期16卷 24-31页

作者： Thijs Peirelinck Chris Hermans Fred Spiessens geert Deconinck ESAT KU LeuvenKasteelpark Arenberg 10 bus 24453001 LeuvenBelgium AMO Flemish Institute for Technological Research(VITO)Boeretang 2002400 Mol Belgium AMO EnergyVilleThor Park 83103600 GenkBelgium

Residential demand response programs aim to activate demand flexibility at the household *** recent years,reinforcement learning(RL)has gained significant attention for these type of applications.A major challenge of RL algorithms is data *** RL algorithms,such as proximal policy optimisation(PPO),have tried to increase data *** tionally,combining RL with transfer learning has been proposed in an effort to mitigate this *** this work,we further improve upon state-of-the-art transfer learning performance by incorporating demand response domain knowledge into the learning *** evaluate our approach on a demand response use case where peak shaving and self-consumption is incentivised by means of a capacity *** show our adapted version of PPO,combined with transfer learming,reduces cost by 14.51%compared to a regular hysteresis controller and by 6.68%compared to traditional PPO.

关键词： Demand response Reinforcement learning Electric water heater Peak shaving Transfer learning

Phase I Dose Escalation Study with the Lewis Y Carbohydrate Specific Humanized Antibody IGN311

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Journal of Cancer Therapy 2011年第5期2卷 760-771页

作者： Daniel Oruzio Gunter Waxenecker Christoph Aulmann Bruno Markl Theodor Wagner geert mudde Manfred Schuster Norbert Eller Andrea Mayer Stefan Stranner Gottfried Himmler Hans Loibner Günter Schlimok Ralf Kircheis Andreas Nechansky Zentralklinikum AugsburgGermany Igeneon ViennaAustria AGES Pharmed ViennaAustria S-TARget ViennaAustria Apeiron ViennaAustria CDMS ViennaAustria Immatics TubingenGermany f-Star ViennaAustria ViroLogik ErlangenGermany Meridian Biopharmaceuticals ViennaAustria.

Purpose: Investigation of safety, tolerability, pharmacokinetics, and anti-tumor activity of the Lewis Y-specific, fully humanized monoclonal antibody (mAb) IGN311 in patients with Lewis Y positive tumors in a Phase I clinical trial. Experimental Design: Twelve patients (pts) were enrolled in an open-label, uncontrolled, dose escalating Phase I study. Three pts received 50 mg, three pts 100 mg and six pts 200 mg IGN311 by i.v. infusion on days 1 and 15. Blood samples were taken immediately before infusion, and 0.5, 4, 8, 24 hours post infusion, as well as on days 3, 5 and 8 after the first and second infusion, respectively, and day 29. A final visit was scheduled for day 43. Results: No drug related adverse events were observed in the 50 mg and 100 mg dose groups. Three out of six patients in the 200 mg dose group showed drug related adverse reactions with nausea, vomiting and hypotension in one patient (NCI CTC grade 3) being the dose limiting toxicities. t1/2 of IGN311 was ~20 days after second infusion of IGN311. Sera of patients receiving IGN311 were capable of lysing Lewis Y positive tumor cells in vitro by both, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Circulating tumor cells found in the peripheral blood in two out of twelve pts prior to treatment were reduced after treatment to below the quantification limit of the detection method. None of the patients showed an increase in the number of disseminated tumor cells during treatment period. Conclusions: The good safety and PK profile, the biological activity regarding CDC and ADCC mediated tumor cell lysis, and the elimination of circulating tumor cells warrant further clinical investigation of IGN311.

关键词： Passive Immunotherapy Therapeutic Monoclonal Antibody Disseminated Tumor Cells Phase I Study Lewis Y Carbohydrate HAHA (Human Anti-Human Antibodies)

The shear strength of the interface between artificial rock and printed concrete at super-early ages

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 51-65页

作者： Yong Yuan Xiaoyun Wang Jiao-Long Zhang Yaxin Tao Kim Van Tittelboom Luc Taerwe geert De Schutter College of Civil Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China Belgium-China Joint Laboratory for Industrialized Construction Tongji UniversityShanghai 200092China Magnel-Vandepitte Laboratory for Structural Engineering and Building Materials Ghent UniversityGhent 9052Belgium

3D concrete printing has the potential to replace shotcrete for construction of linings of tunnels in hard *** shear strength of the interface between rock and printed concrete is vital,especially at super-early ***,traditional methods for testing the shear strength of the interface,e.g.,the direct shear test,are time-consuming and result in a high variability for fast-hardening printed *** this paper,a new fast bond shear test is *** test can be completed in 1 min,with another 2 min for preparing the next *** influence of the matrix composition,the age of the printed matrices,and the interface roughness of the artificial rock substrate on the shear strength of the interface was experimentally *** tests were conducted at the age of the matrices at the 1st,the 4th,the 8th,the 16th,the 32nd,and the 64th min after its final setting.A dimensionless formula was established to calculate the shear strength,accounting for the age of the printed matrices,the interface roughness,and the shear failure *** was validated by comparing the calculated results and the experimental results of one group of samples.

关键词： rock tunnel printed concrete interface fast bond shear test shear strength

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443,I0009页

作者： Lucas Hanssens Maarten Houlleberghs C.Vinod Chandran geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.M.Denayer Christine E.A.Kirschhock Johan A.Martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team(COK-KAT) 3001 LeuvenBelgium NMR/X-Ray Platform for Convergence Research(NMRCoRe) 3001 LeuvenBelgium Centre for Ordered Materials Organometallics and Catalysis(COMOC)Department of ChemistryGhent University9000 GhentBelgium Department of Chemical Engineering Vrije Universiteit Brussel1050 BrusselBelgium

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH_(4)/CO_(2) exchange Direct gas exchange

A hillslope version of the revised Morgan,Morgan and Finney water erosion model

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International Soil and Water Conservation Research 2021年第3期9卷 319-332页

作者： geert Sterk Department of Physical Geography Utrecht UniversityPO Box 80.115NL-3508 TCUtrechtthe Netherlands

The revised Morgan,Morgan and Finney(rMMF)water erosion model calculates annual surface runoff and soil loss from field-sized *** original version of the rMMF is neither suited to calculate water erosion along irregular hillslopes,nor capable to allow infiltration of once generated surface runoff at places where the runoff speed slows down,and infiltration could occur under natural *** aim of this article is to describe a new hillslope version of the rMMF model that allows infiltration of surface runoff,and to show examples of soil erosion modelling along real and hypothetical *** new hillslope version(hMMF)splits the entire hillslope into a number of sections that have individual properties,such as slope angle,slope length,soil properties and vegetation *** surface runoff along the slope is calculated by summing the volume of surface runoff generated in a particular section with the surface runoff coming from the immediate upsiope *** related sediment transport is calculated for each section using the calculated detachment for the section,the sediment coming from the upsiope section and the transport capacity.A new variable is introduced to account for infiltration of surface runoff and allows simulating the effects of soil and water conservation structures on water *** model was tested using measured data from plots in Africa,Asia,the US and Europe,as well as for a surveyed hillslope in Tunisia(Barbara watershed).Overall,the performance of the hMMF was reasonable for surface runoff and poor for soil loss when recommended input variable values are *** of the model resulted in a good performance,which shows the capability of the hMMF model to reproduce measured surface runoff and erosion *** addition,realistic water erosion patterns on hillslopes with soil and water conservation can be simulated.

关键词： Water erosion modelling Morgan-morgan-finney model Hillslope Surface runoff Sediment transport Soil loss Soil and water conservation

Experimental and numerical prediction of railway induced vibration

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第11期13卷 802-813页

作者： Hans VERBRAKEN geert LOMBAERT geert DEGRANDE Department of Civil Engineering KU LeuvenKasteelpark Arenberg 40 B24483001 HeverleeBelgium

In this paper,both measurements and numerical simulations of railway induced vibration are discussed.A measurement campaign has been carried out along the high-speed railway track in Lincent,*** experimental determination of transfer functions and vibration velocity during train passages are discussed.A numerical model is introduced to predict the transfer functions and the vibration velocity during train *** comparison of experimental and numerical results demonstrates the importance of accurate numerical models and input *** results are obtained in the framework of the development of a hybrid prediction method,where numerical and experimental data can be combined to improve the prediction accuracy for railway induced vibration.

关键词： Component Railway induced vibration Experimental prediction Numerical prediction

Prediction of vibrations induced by trains on line 8 of Beijing metro

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第4期11卷 280-293页

作者： De-yun DING Shashank GUPTA Wei-ning LIU geert LOMBAERT geert DEGRANDE Sehool of Civil Engineering Beijing Jiaotong University Beijing 100044 China Department of Civil Engineering K. U Leuven B3001 Heverlee Belgium

This paper mainly discusses the problem of ground-borne vibrations due to the planned line 8 of Beijing metro which passes under the National Measurement Laboratory.A lot of vibration sensitive equipments are placed in the *** is therefore necessary to study the impact of vibrations induced by metro trains on sensitive equipments and important to propound a feasible vibration mitigation *** on the coupled periodic finite element-boundary element (FE-BE) method,a 3D dynamic track-tunnel-soil interaction model for metro line 8 has been used to predict vibrations in the free field induced by trains running at variable speeds between 30 km/h and 80 km/*** types of track structures commonly used on the Beijing metro network have been considered:(1) high resilience direct fixation fasteners,(2) Vanguard fasteners,(3) a floating slab track and (4) a floating ladder *** each of these track types,the vibration isolation efficiency has been *** results of the numerical study can be used to predict vibrations in nearby buildings and to decide upon effective vibration countermeasures.

关键词： Ground-borne vibrations Coupled periodic finite element-boundary element (FE-BE) method Track structure Vibration isolation efficiency

Non-steady State Chloride Migration and Binding in Cracked Self-compacting Concrete

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Journal of Wuhan University of Technology(Materials Science) 2013年第5期28卷 921-926页

作者：马保国穆松 De Schutter geert School of Materials Science and Engineering Wuhan University of Technology Magnel Laboratory for Concrete Research Department of Structural EngineeringGhent University

We adopted a notch method to study the influence of crack width （macro level） on chloride transport and binding of cracked concrete under a non-steady state migration test. The results show that migration coefficient of cracked concrete increases with increasing crack width up to a critical value （0.43 mm）, for the whole concrete or the area close to crack; the increase of migration coefficient could be independent from crack parameter when a critical crack width is reached. For chloride binding, Langmuir isotherms of cracked concrete samples exhibit the similar decreasing trend as crack width increases from 0.27 to 1.96 mm. The increased current value could be responsible for the trend based on the hypothesis of electric force.

关键词： crack chloride diffusion migration test chloride binding crack width

Counting the SNAREs needed for membrane fusion

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分子细胞生物学报:英文版 2011年第4期3卷 204-205页

作者： geert van den Bogaart Reinhard Jahn Department of Neurobiology Max-Planck Institute for Biophysical ChemistryAm Fassberg 1137077 GottingenGermany

SNARE proteins mediate most membrane fusion reactions in eukaryotic cells,and are thereby vital for many functions,including synaptic transmission,cell growth,and ***,until recently it was still unclear how many of these proteins are required to catalyze membrane fusion in *** a recent Science paper,Mohrmann et al.(2010)elegantly show that in chromaffin cells,three SNARE complexes are required for the synchronous release of granules,whereas only a single SNARE complex is sufficient for overall release.

关键词： release thereby complexes