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Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the MR CLEAN Registry

Stroke & Vascular Neurology 2023年第1期8卷 17-25页

作者： Sabine L Collette Reinoud P H Bokkers Aryan Mazuri geert j lycklamaànijeholt Robert j van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L M Majoie jan Cees de Groot Gert jan R Luijckx Maarten Uyttenboogaart 无 Department of Radiology Medical Imaging CentreUniversity Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands Department of Radiology Haaglanden Medical CentreThe Haguethe Netherlands Department of Neurology Cardiovascular Research Institute Maastricht(CARIM)Maastricht University Medical CentreMaastrichtthe Netherlands Department of Neurology Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Radiology Maastricht University Medical CentreMaastrichtthe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Neurology University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands On behalf of the MR CLEAN Registry investigators

Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is *** analysed how often IA thrombolytics were administered in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA *** In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the MR CLEAN Registry(March 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 *** endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were *** Of the 2263 included patients,95(4.2%)received IA thrombolytics during *** IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA *** primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal *** outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation *** Local IA thrombolytics were rarely used in the MR CLEAN *** the relatively small st

关键词： arterial throm acute

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Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2021年第4期6卷 572-580,I0037-I0048页

作者： Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart j Emmer Ivo G H jansen Maxim j H L Mulder Robin Lemmens Robert-jan B Goldhoorn Marieke j H Wermer jelis Boiten geert j lycklamaànijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W j Dippel Wim H van Zwam Robert j van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators Neurology Leiden University Medical CentreLeidenThe Netherlands Neurology Erasmus MCRotterdamThe Netherlands Public Health Erasmus MCRotterdamThe Netherlands Neurology Maastricht University Medical Centre+MaastrichtThe Netherlands Radiology and Nuclear Medicine Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Neurology University Hospitals LeuvenLeuvenBelgium Neurosciences Experimental Neurology and Leuven Brain InstituteUniversity of LeuvenLeuvenBelgium VIB Center for Brain&Disease ResearchLaboratory of NeurobiologyLeuvenBelgium Neurology Haaglanden Medical CentreDen HaagThe Netherlands Radiology Haaglanden Medical CentreDen HaagThe Netherlands Neurology Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Radiology Leiden University Medical CentreLeidenThe Netherlands Radiology Maastricht University Medical Centre+MaastrichtThe Netherlands

Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen ***,outcomes after EVT in these late window patients without perfusion imaging are largely *** assessed their characteristics and outcomes in routine clinical *** The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and *** perfusion was no standard imaging *** used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous *** included 3-month mRS score,functional independence(defined as mRS 0-2),and *** Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke *** perfusion was not performed in 87/106(80.2%)late window *** window patients were younger(mean 67 vs 70 years,pjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/C

关键词： treatment beyond Registry

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A hillslope version of the revised Morgan,Morgan and Finney water erosion model

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International Soil and Water Conservation Research 2021年第3期9卷 319-332页

作者： geert Sterk Department of Physical Geography Utrecht UniversityPO Box 80.115NL-3508 TCUtrechtthe Netherlands

The revised Morgan,Morgan and Finney(rMMF)water erosion model calculates annual surface runoff and soil loss from field-sized *** original version of the rMMF is neither suited to calculate water erosion along irregular hillslopes,nor capable to allow infiltration of once generated surface runoff at places where the runoff speed slows down,and infiltration could occur under natural *** aim of this article is to describe a new hillslope version of the rMMF model that allows infiltration of surface runoff,and to show examples of soil erosion modelling along real and hypothetical *** new hillslope version(hMMF)splits the entire hillslope into a number of sections that have individual properties,such as slope angle,slope length,soil properties and vegetation *** surface runoff along the slope is calculated by summing the volume of surface runoff generated in a particular section with the surface runoff coming from the immediate upsiope *** related sediment transport is calculated for each section using the calculated detachment for the section,the sediment coming from the upsiope section and the transport capacity.A new variable is introduced to account for infiltration of surface runoff and allows simulating the effects of soil and water conservation structures on water *** model was tested using measured data from plots in Africa,Asia,the US and Europe,as well as for a surveyed hillslope in Tunisia(Barbara watershed).Overall,the performance of the hMMF was reasonable for surface runoff and poor for soil loss when recommended input variable values are *** of the model resulted in a good performance,which shows the capability of the hMMF model to reproduce measured surface runoff and erosion *** addition,realistic water erosion patterns on hillslopes with soil and water conservation can be simulated.

关键词： Water erosion modelling Morgan-morgan-finney model Hillslope Surface runoff Sediment transport Soil loss Soil and water conservation

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Does feeding more phases reduce ammonia concentrations from broiler litter?

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Animal Nutrition 2022年第4期11卷 152-159页

作者： Madri Brink geert P.j.janssens Evelyne Delezie Flanders Research Institute for Agriculture Fisheries and Food(ILVO)Animal Sciences UnitScheldeweg 689090 MelleBelgium Department of Veterinary and Biosciences Ghent UniversityHeidestraat 199820 MerelbekeBelgium

We compared a 3-and 5-phase feeding program in terms of ammonia concentrations measured at litter level,litter composition and quality,nitrogen(N)utilization,performance,welfare,and meat deposition in broilers.A total of 744 Ross 308 male broilers was divided into 2 treatments,each with 6 *** 3-phase diets were formulated to CP and digestible lysine contents of 205 and 11.5 g/kg(0 to 9 d),195 and 10.8 g/kg(9 to 24 d),and 183.3 and 10.15 g/kg(24 to 39 d),*** 5-phase diets had additional phases from 17 to 24 d and 32 to 39 d with CP and digestible lysine contents of 188 and 10.4 g/kg and 177 and 9.8 g/kg,*** 5 phases reduced the NH3concentrations at litter level by37.95%and 20.81%at 23(P<0.05)and 37 d of age(P<0.05),*** was a tendency for a lower litter total ammoniacal nitrogen concentration for the 5-phase treatment than the 3-phase treatment at 24 and 39 d of age(P<0.1 for both).Total N concentration of the litter also tended to be lower for the 5-phase treatment at 39 d of age(P<0.1).The lower NH3coincided with a lower average litter pH at 24 and 32 d of age(P<0.05 for both).Birds fed the 5-phase treatments had a lower incidence of foot lesions at 24 d of age(P<0.001).Performance as well as carcass yield could be maintained,except for FCR,which was higher for the 5-phase treatment between 17 and 24 d of age and the overall period(P<0.05 and<0.001,respectively).The impact of the 5-phase treatment regarding the utilization of N(digestibility,excretion,and retention)was less clear,however the NH3volatilized from the litter was significantly *** 5 phases may therefore potentially reduce the NH3emitted from broiler houses which has several environmental and health *** the 5-phase treatment resulted in a significant decrease in feed efficiency,growth performance and meat deposition were maintained.

关键词： Broiler Ammonia Phase feeding Crude protein Performance

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Reduction of dietary crude protein and feed form:Impact on broiler litter quality,ammonia concentrations,excreta composition,performance,welfare,and meat quality

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Animal Nutrition 2022年第2期9卷 291-303页

作者： Madri Brink geert P.j.janssens Peter Demeyer Ozer Bagci Evelyne Delezie Flanders Research Institute for Agriculture Fisheries and Food(ILVO)Animal Sciences UnitScheldeweg 689090 MelleBelgium Department of Nutrition Genetics and EthologyGhent UniversityHeidestraat 199820 MerelbekeBelgium Flanders Research Institute for Agriculture Fisheries and Food(ILVO)Agricultural Engineering UnitBurg.Van Gansberghelaan 1159820 MerelbekeBelgium Department of Mechanical Engineering Eindhoven University of Technology5600 MB-EindhovenNetherlands.

Nitrogen(N)excreted by poultry is converted to ammonia(NH3),presenting an environmental risk and a health risk to the farmer and animals.A study was performed to investigate the effect of reduced CP and feed form on broiler performance and welfare,meat and litter quality,N utilization,and NH3 concentrations at litter level.A total of 2,232 Ross 308 male broilers was divided into 6 treatments and 6 replicates,which was fed diets in both pellet and mash forms with different CP levels of 205.0 g/kg(H,high),187.5 g/kg(M,intermediate)and 175.0 g/kg(L,low)in the grower phase and 195.0 g/kg(H),180.0 g/kg(M)and 165.6 g/kg(L)in the finisher *** amino acids(AA)were supplemented to maintain digestible AA-to-digestible lysine *** dietary CP content to 187.5 g/kg in the grower phase and 180.0 g/kg in the finisher phase reduced NH3 concentrations at litter level(P<0.001),but a further reduction in dietary CP had no additional *** treatments had better litter qualities and lower incidences of foot and hock lesions than pellet treatments at d 38(P<0.001).In addition,treatments with reduced CP had lower incidence of foot lesions at d 38(P<0.001).Broilers fed pelleted diets had higher ADFI,ADG,and final BW,improved feed conversion ratio(FCR),and heavier carcasses(P<0.001)than those fed mash diets over a production period of 39 *** could not be maintained when birds were fed L CP pelleted *** study demonstrated that,with the supplementation of AA to meet requirements,the concentration of dietary CP can be reduced to 187.5 and 180.0 g/kg in the grower and finisher phases respectively,without impairing broiler performance,meat yield and *** diets were favorable when considering the overall litter quality and welfare of the ***,they could not maintain the same broiler performance and slaughter yield as pelleted *** from the present study may assist the poultry sector towards a socially acceptable lowemission

关键词： Broiler Ammonia Crude protein Feed form Performance

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Direct Load Control of Thermostatically Controlled Loads Based on Sparse Observations Using Deep Reinforcement Learning

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CSEE journal of Power and Energy Systems 2019年第4期5卷 423-432页

作者： Frederik Ruelens Bert j.Claessens Peter Vrancx Fred Spiessens geert Deconinck Department of Electrical Engineering KU Leuven/EnergyVille3001 LeuvenBelgium REstore Centrica2600 AntwerpBelgium AI-lab Vrije Universiteit Brussel1050 BrusselsBelgium Vito/EnergyVille 2600 MolBelgium

This paper considers a demand response agent that must find a near-optimal sequence of decisions based on sparse observations of its *** a relevant set of features from these observations is a challenging task and may require substantial domain *** way to tackle this problem is to store sequences of past observations and actions in the state vector,making it high dimensional,and apply techniques from deep *** paper investigates the capabilities of different deep learning techniques,such as convolutional neural networks and recurrent neural networks,to extract relevant features for finding near-optimal policies for a residential heating system and electric water heater that are hindered by sparse *** simulation results indicate that in this specific scenario,feeding sequences of time-series to an Long Short-Term Memory(LSTM)network,which is a specific type of recurrent neural network,achieved a higher performance than stacking these time-series in the input of a convolutional neural network or deep neural network.

关键词： Convolutional networks deep reinforcement learning long short-term memory residential demand response

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Cytomegalovirus in inflammatory bowel disease： Asystematic review

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World journal of Gastroenterology 2016年第3期22卷 1321-1330页

作者： Tessa EH Römkens geert j Bulte Loes HC Nissen joost PH Drenth Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre6500 HB NijmegenThe Netherlands Department of Gastroenterology and Hepatology Jeroen Bosch Hospital5200 ME HertogenboschThe Netherlands

AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these ***: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used "cytomegalovirus" OR "CMV" OR "cytomegalo virus" AND "inflammatory bowel disease" OR "IBD" OR "ulcerative colitis" OR "colitis ulcerosa" OR "Crohn's disease". Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in ***: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East ***: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials.

关键词： Inflammatory bowel disease Cytomegalovirus Ulcerative colitis Crohn's disease Systematicreview

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Reproduction,Development,and Growth Response to Captive Diets in the Shangcheng Stout Salamander,Pachyhynobius shangchengensis(Amphibia,Urodela,Hynobiidae)

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Asian Herpetological Research 2012年第3期3卷 192-197页

作者： Frank PASMANS geert P.j.jANSSENS Max SPARREBOOM3 jianping jIANG Kanto NISHIKAWA Department of Pathology Bacteriology and Avian DiseasesFaculty of Veterinary MedicineGhent University Salisburylaan 1339820 MerelbekeBelgium Animal Nutrition Laboratory Faculty of Veterinary MedicineGhent University Salisburylaan 1339820 MerelbekeBelgium Netherlands Centre for Biodiversity Naturalis P.O.Box 9517 NL-2300 RA LeidenThe Netherlands Chengdu Institute of Biology Chinese Academy of Sciences Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-nihonmatsu-cho Sakyo606-8501 KyotoJapan

The Shangcheng stout salamander(Pachyhynobius shangchengensis) is a poorly known stream dwelling hynobiid salamander from China. We studied the reproduction, development and growth response of the salamander to different diets in captivity. Two females each produced two unique, striated egg sacs, with each containing 18 and 20, and 22 and 32 white eggs with an average diameter of 3.3 mm. Hatchlings(n = 27) had front- and hind-limb buds with interdigit membranes and a large yolk sac, and developed cornified finger and toe tips during further development. Metamorphosis occurred between d 441 and d 454 after hatching at an average total length of 94.8 mm(n = 21). These reproductive and developmental traits fit in well with the ancestral state reconstruction in hynobiids. If corrected for dry mass, feed conversion ratios obtained by feeding bloodworms(Chironomidae) to P. shangchengensis larvae and mealworms(Tenebrio molitor) to postmetamorphs, were very low(0.33 and 0.34 respectively), equaling a very high mass conversion efficiency.

关键词： Pachyhynobius shangchengensis husbandry reproduction nutrition development

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Interleukin-6 secretion is limited by self-signaling in endosomes

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journal of Molecular Cell Biology 2019年第2期11卷 144-157页

作者： Danielle R.j.Verboogen Natalia H.Revelo Martin ter Beest geert van den Bogaart Departme nt of Tumor Immuno logy Radboud Institute for Molecular Life Sciences Radboud University Medical Center 6525 GA Nijmegen The Netherlands Department of Molecular Immunology Groningen Biomolecular Sciences and Biotechnology Institute University of Groningen Nijenborgh 7 9747 AG Groningen The Netherlands

Cells producing cytokines often express the receptor for the same cytokine, which makes them prone to autocrine signaling. How cytokine release and signaling are regulated in the same cell is not understood? In this study, we demonstrate that signaling by exogenous and self-synthesized inflammatory cytokine interleukin-6 (IL-6) within endosomal compartments acts as a cellular brake that limits the synthesis of IL-6. Our data show that IL-6 is internalized by dendritic cells and signals from endosomal compartments containing the IL-6 receptor. Newly synthesized IL-6 also traffics via these endosomal compartments and signals in transit to the plasma membrane. This allows activation of STAT3 which in turn limits toll-like receptor 4 stimulant lipopolysaccharide (LPS) triggered transcription of IL-6. Long-term exposure to LPS removes this brake via inhibition of STAT3 by increased expression of suppressor of cytokine signaling 3 and results in fully fledged IL-6 production. This transient regulation could prevent excessive IL-6 production during early infections.

关键词： membrane trafficking cytokine release exocytosis interleukin-6 endosomal signaling

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Combined peak reduction and self-consumption using proximal policy optimisation

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Energy and AI 2024年第2期16卷 24-31页

作者： Thijs Peirelinck Chris Hermans Fred Spiessens geert Deconinck ESAT KU LeuvenKasteelpark Arenberg 10 bus 24453001 LeuvenBelgium AMO Flemish Institute for Technological Research(VITO)Boeretang 2002400 Mol Belgium AMO EnergyVilleThor Park 83103600 GenkBelgium

Residential demand response programs aim to activate demand flexibility at the household *** recent years,reinforcement learning(RL)has gained significant attention for these type of applications.A major challenge of RL algorithms is data *** RL algorithms,such as proximal policy optimisation(PPO),have tried to increase data *** tionally,combining RL with transfer learning has been proposed in an effort to mitigate this *** this work,we further improve upon state-of-the-art transfer learning performance by incorporating demand response domain knowledge into the learning *** evaluate our approach on a demand response use case where peak shaving and self-consumption is incentivised by means of a capacity *** show our adapted version of PPO,combined with transfer learming,reduces cost by 14.51%compared to a regular hysteresis controller and by 6.68%compared to traditional PPO.

关键词： Demand response Reinforcement learning Electric water heater Peak shaving Transfer learning

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