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Prevalence of Gestational Malaria in Kisangani,Democratic Republic of Congo

Open Journal of Obstetrics and Gynecology 2018年第10期8卷 854-866页

作者： Noel Labama Otuli Jean-Didier Bosenge Nguma Maindo A.Mike-Antoine Antoine Modia O’yandjo gedeon katenga bosunga Joris Losimba Likwela Jean-Pascal Manga Okenge Department of Gynecology and Obstetrics Faculty of Medicine and PharmacyUniversity of KisanganiKisanganiDemocratic Republic of the Congo Department of Public Health Faculty of Medicine and PharmacyUniversity of KisanganiKisanganiDemocratic Republic of the Congo

Introduction: Gestational malaria is a major public health problem because it is a threat to pregnant women and their children. As Kisangani is a stable malaria transmission area and there is a paucity of data on the status of gestational malaria in our settings, we have found it appropriate to determine the prevalence of gestational malaria and its determinants in Kisangani City. Methods: We conducted a cross-sectional analytical study in Kisangani from January 1 to September 30, 2017. Our population study consisted of 1248 parturients recruited at delivery. We made the thick drop in peripheral blood from parturients at the admission and at the level of placental impressions after delivery. Results: The average age of the respondents was 25.3971 ± 6.2452 years;the overall prevalence of gestational malaria was 27.56% including 12.66% peripheral parasitaemia, 12.34% placental parasitaemia and 2.56% parasitaemia level and placental and peripheral blood impressions. Youngest age ≤ 18 years [OR (95% CI) = 2.44 (1.75 - 3.41), p 0.001], primiparity [OR (95% CI) = 2.94 (2.00 - 4.32), p 0.001] and positive HIV serology [OR (95% CI) = 3.01 (1.23 - 7.43), p = 0.008] increased the risk of gestational malaria;the use of mosquito net impregnated with insecticide [OR (95% CI) = 0.29 (0.14 - 0.61), p 0.001] reduced this risk. Conclusion: The prevalence of gestational malaria is 27.56% in Kisangani. The youngest age ≤ 18 years, the primiparity and positive HIV serology of pregnant women were the most associated risk factors.

关键词： Gestational Malaria Thick Drop Placental Imprint Parasitaemia Kisangani

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Anti-Sperm Antibodies: Prevalence of Ig A and Ig G Positive Serology among Infertile Patients in Kisangani, Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2019年第5期9卷 707-714页

作者： Mike-Antoine Maindo Alongo Juakali Sihalikyolo Salomon Batina Agasa Antoine Modia O’yandjo Bernard Mbutu Gédéon katenga bosunga Jean-Pascal Manga Okenge Department of Obstetrics and Gynecology Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Intitut Superieur des Techniques Médicales de Kisangani Ema Esu Laboratory Kisangani Democratic Republic of Congo

Introduction: Infertility in a couple is a stressful situation. Among the causes is the presence of antisperm antibodies that play a harmful role in reducing fertility and negatively influencing in vitro fertilization. The aim of this study is to determine their prevalence among infertile patients in Kisangani. Patients and methods: We conducted an analytical cross-sectional study in health facilities in the city of Kisangani. Of the 1379 patients who consulted for conception, 311 were tested for antisperm antibodies by ELISA. Results: Of the 311 patients, 121 tested positive (38.91%). Women were significantly more likely to be positive (p-value = 0.013). Ig G was positive in 32.48% of patients and Ig A in 10.93%. Age was a significant predictor of the number of positive patients (p-value < 0.001). Compared to patients of ≤30 years of age, having 31 to 40 years of age or 41 years of age and older increased respectively 2 and 3 times the risk of being positive. In secondary infertility, women are twice as likely to be positive. Conclusion: The prevalence of antisperm antibodies is very high among infertile patients in Kisangani with predominance among women. Older age increases the risk of positivity. This test should therefore be integrated into infertility investigations as often as possible.

关键词： Antisperm Antibody Immune Infertility Unexplained Infertility Democratic Republic of Congo

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Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2019年第8期9卷 1130-1141页

作者： Maindo Alongo Mike-Antoine Juakali Sihalikyolo Salomon Batina Agasa Antoine Modia O’yandjo Bernard Mbutu Gédéon katenga bosunga Jean-Pascal Manga Okenge Department of Obstetrics and Gynecology Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Intitut Superieur des Techniques Médicales de Kisangani Ema Esu Laboratory Kisangani Democratic Republic of Congo

Introduction: Antisperm antibodies (ASA) prevalence is high in Kisangani. ASA are one of the male factors of infertility that can reduce spermatozoa motility and cervical penetration or prevent acrosomal reaction and even alter embryo development. This study aims to determine the risk factors of ASA positivity among infertile men in Kisangani. Patient and Method: We conducted a case-control study during a period of 2 years in Kisangani on 111 men who consulted for conception and tested for ASA by ELISA. We did a simple pairing that concerned only the type of infertility. For a better balance between the number of cases and controls per stratum to provide better accuracy in the adjusted OR estimate, we performed a 1:1 match. Results: This study showed that businessmen [ORa = 5.0000(1.2452 - 20.0767)] and jobless [ORa = 5.8125(1.1477 - 29.4367)] were at risk of being positive for ASA. Violent blow to testicles [ORa = 6.7391(1.3455 - 33.7545)], cure of hernia [ORa = 4.3478(1.0722 - 17.6299)], Chlamydia infection [ORa = 4.7125(1.3405 - 16.5665)], leucospermia [ORa = 4.1429(1.0406 - 19.7155)] and presence of Staphylococcus aureus [ORa = 3.4444(0.6410 - 18.5082)] were associated to positive ASA. Conclusion: This study shows that factors that may lead to risky sexual behavior and physical or infectious trauma are important risk factors for ASA positivity. It is therefore necessary to search for them systematically during male infertility in order to guide the search for ASA.

关键词： Antisperm Antibody Chlamydia Trachomatis Men Infertility Immune Infertility Infertility Democratic Republic of Congo

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Hysterosalpingographic Findings among Patients Undergoing Infertility Work-Up in Kisangani, Democratic Republic of the Congo

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 267-277页

作者： Jean-Didier Bosenge Nguma Antoine Modia O’yandjo Jeanot Juakali Sialikyolo Gaston Litalema Liogo Antoine Molua Aundu Roger Amisi Kitoko Gédeon katenga bosunga Department of Gynecology-Obstetrics Faculty of Medicine and Pharmacy University of Kisangani Kisangani DRC Department of Medical Imaging Radiology Unit Kisangani University Hospital Kisangani DRC Department of Medical Imaging Unit of Imaging of Women University of Kinshasa Kinshasa DRC Department of Surgery Faculty of Medicine and Pharmacy University of Kisangani Kisangani DRC

Introduction: Hysterosalpingography is an important tool in the investigation of the causes of female infertility. In developing countries such as the Democratic Republic of Congo, the HSG is the basic tool for performing first-line anatomical (pelvic) assessment. The aim of this study is to determine the prevalence of the different lesions observed in hysterosalpingography carried out during the assessment of infertile women monitored in Kisangani. The study set also out to look for differences in these lesions according to the type of infertility. Methods: This cross-sectional study was conducted in Kisangani from June 2016 to December 2018. The 130 cases of hysterosalpingography performed for female infertility assessment during the study period were included, of which 33.07% for primary infertility and 66.93% for secondary infertility. Results: The mean age of the patients was 33.52 ± 6.01 years;the history of pelvic inflammatory disease was noted with a predominance for secondary infertility (11% vs. 4.65%). Using hysterosalpingography, 7 (5.38%) patients had a normal result;94 (72.31%) had tubal obstruction;25 (19.23%) had hydrosalpinx;11 (8.46%) had uterine fibroids;pelvic adhesions were suspected in 12.64% of cases. There was no obvious association between all these lesions and the type of infertility. Conclusion: We found that tubal obstructions were the most prevalent lesions in this study, regardless of the type of infertility. These lesions would reflect the high prevalence of septic abortions and sexually transmitted infections in developing countries such as the Democratic Republic of the Congo.

关键词： Hysterosalpingography Female Infertility Tubal Obstruction Hydrosalpinx Pelvic Adhesion Uterine Fibroids

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Performance of Sickle SCAN<sup>®</sup>in the Screening of Sickle Cell Disease in Kisangani Pregnant Women and Attitude towards Results

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Open Journal of Blood Diseases 2020年第2期10卷 23-36页

作者： Yvette Neema-Ufoy Mungu Jean Jeannot Juakali-Sihalikyolo Roland Djang’eing’a Marini Gédéon katenga-bosunga Hermane Avohou-Tonakpon Stéphane Leduc Franç ois Boemer Salomon Batina-Agasa Department of Obstetrics and Gynecology Kisangani University Clinics University of Kisangani Kisangani The Democratic Republic of the Congo Department of Pharmaceutical Sciences Faculty of Medicine and of Pharmacy Kisangani The Democratic Republic of the Congo Laboratory of Pharmaceutical and Analytical Chemistry Department of Pharmacy CIRM University of Liege Liege Belgium Laboratory of Biochemistry and Human Genetics University Hospital of Liege Liege Belgium Department of Internal Medicine Kisangani University Clinics Kisangani The Democratic Republic of the Congo

In the Democratic Republic of the Congo, the sickle cell trait carriage is estimated at 25%. Routine neonatal screening is not a common practice, leading to a very late diagnosis. In this study, the screening of pregnant women was assessed as well as their attitudes. This is an analytical cross-sectional study conducted in 245 pregnant women, sampled by convenience in four hospitals in Kisangani city (Democratic Republic of Congo) and screened using the sickle SCAN® test, from February 1 to July 31, 2019. The sensitivity and specificity of the latter were determined using liquid chromatography coupled with mass spectrometry as the gold standard. The attitudes of 240 pregnant women without previous screening history were assessed upon the announcement of the results. The sensitivity of screening for hemoglobin (Hb) AA and Hb AS was 96.69% and 98.39%, respectively;while the specificities were 99.43% and 96.32%, respectively. The Kappa coefficient (κ) was excellent. Concerning attitudes, Hb SS pregnant women and 55.17% of AS pregnant women worried when the results relating to their hemoglobin status were announced. The sickle SCAN® test was found reliable for sickle cell disease screening in Kisangani. The announcement of the results, mainly positive, raises worry among pregnant woman. Therefore, we recommend the involvement of a clinician psychologist for pre-screening counselling and for results announcement, as well as early newborns and unmarried teenage girls screening.

关键词： Sickle SCAN® Liquid Chromatography Pregnant Women Attitudes Kisangani

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Labor Induction with Oral Misoprostol in Term Pregnancy: A Clinical Trial

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Journal of Biosciences and Medicines 2021年第10期9卷 74-88页

作者： Teddy Habiragi Matega Mike-Antoine Alongo Maindo Jean-Didier Nguma Bosenge Albert Okolongo Wembakoy Noël Otuli Labama Jean-Jeannot Syhalikyolo Juakali Antoine O’Yandjo Modia Jean-Pascal Okenge Manga Gédéon bosunga katenga Department of Gynecology and Obstrics Faculty of Medecine and Pharmacy University of Kisangani Kisangani Democratic Republic of Congo Congolaise National Police Provincial Hospital of Tshopo Kisangani Democratic Republic of Congo Higher Institute of Medical Techniques of Haut Uélé Isiro Democratic Republic of Congo

Introduction: Induction of labor has become an increasingly utilized obstetric intervention in developed countries. It contributes to reduce the maternal and perinatal morbidity and mortality. Dinoprostone derivatives are often used under cardiotocography. In poor countries, health structures have neither fetal monitoring, nor means of preserving Dinoprostone derivatives. Misoprostol therefore constitutes an alternative. This study seeks to establish the efficacy and safety of oral Misoprostol and to assess maternal and perinatal prognosis in an area with limited resource. Methods: This is a multi-center clinical trial, conducted in 3 hospitals centers in Kisangani, Tshopo Province/Democratic Republic of Congo from December 1, 2020 to May 31, 2021. Our sample was constituted with 68 pregnant women with term pregnancy. Fifty micrograms of Misoprostol was administered orally. The data were collected prospectively, their encoding was carried out on an Excel sheet 2013 and their analysis carried out using the EPI INFO software. Results: The average age of the pregnant women was 23.17 ± 5.76 years. The average parity was 1.02 ± 1.2. The average body mass index (BMI) was 24.98 ± 2.55 Kg/m2. 66 (97.1%) patients had received a maximum of 3 doses of Misoprostol. Out of the 16 parturients who received 3 doses or more, 11 (68.8%) had a BMI ≥ 25. The average duration of labor was 16.03 ± 7.99 hours. 66 (97.1%) pregnant women had delivered vaginally. 57 (83.8%) patients delivered within 24 hours. Out of the 11 patients who delivered after 24 hours, 7 (63.6%) had a BMI ≥ 25. The induction failure rate was 2.9% (2 patients). 2 (2.9%) fetuses had presented pathological modification of fetal heart rate (FHR). 2 (2.9%) patients had undergone cesarean section. Conclusion: Labor induction with oral Misoprostol is effective and associated with low maternal and perinatal morbidity. A BMI ≥ 25 kg/m2

关键词： Misoprostol Efficacy Labor BMI Kisangani

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