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Development and validation of a rapid chromatographic method for the analysis of flunarizine and its main production impurities

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Journal of Pharmaceutical Analysis 2013年第3期3卷 211-214页

作者： Niamh O'Connor Michael geary Mary Wharton Paul Sweetman Department of Applied Science Limerick Institute of TechnologyMoylish ParkIreland Janssen Pharmaceutical Limited Little IslandCorkIreland

A rapid selective method for the analysis of flunarizine and its associated impurities was developed and validated according to ICH guidelines. The separation was carried out using a Thermo Scientific Hypersil Gold C18 column （50 mm × 4.6 mm i.d., 1.9 μm particle size） with a gradient mobile phase of acetonitrile-ammonium acetate-tetrabutylammoniumhydrogen sulfate buffer, at a flow rate of 1,8 mL/min and UV detection at 230 nm. Naturally aged samples were also tested to determine sample stability. A profile of sample and impurity breakdown was also presented.

关键词： Flunarizine Sub 2 gm column Active pharmaceuticalingredient HPLC

人类大脑、认知与行为进化的整合模型(英文)

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心理学报 2007年第3期39卷 383-397页

作者： David C. geary University of Missouri at Columbia USA

物种进化的历史进程中,大脑、认知与行为系统的进化机能利于有机体控制社会、生物与自然资源,而有机体所控制的各种资源又会影响自身的生存与繁衍。社会、生物与自然资源可以相对稳定,也可以变化不定。资源的稳定变化所传递的信息会引... 详细信息

物种进化的历史进程中,大脑、认知与行为系统的进化机能利于有机体控制社会、生物与自然资源,而有机体所控制的各种资源又会影响自身的生存与繁衍。社会、生物与自然资源可以相对稳定,也可以变化不定。资源的稳定变化所传递的信息会引起大脑、认知以及行为系统做出模块化的自主反应。资源的稳定变化利于人类整合朴素心理学、朴素生物学与朴素物理学,而资源的变化不定所传达出的信息会引起认知与行为系统有意识地进行自上而下的外显行为反应。人类外显行为反应系统的进化导致人类出现自我意识,并具有探索性解决问题的能力。朴素心理能力、意识与问题解决能力可以整合为动机-控制理论。

关键词：进化历史朴素心理学朴素生物学朴素物理学

The Future of Psychology： Evolutionary Approach to Scientific Psychology

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心理学报 2007年第3期39卷 381-382页

作者： Lei Chang David C. geary Department of Educational Psychlogy The Chinese University of Hong Kong University of Missouri at Columbia USA

"Evolutionary psychology is an approach to psychology, in which knowledge and principles from evolutionary biology are put to use in research on the structure of the human mind" (Cosmides & Tooby, 2001, p。1)。The approach can be used to study and to provide broad theoretical framing of nearly all of the issues and topics within the traditionally defined fields of psychology。The 19 papers included in this special issue on evolutionary psychology are written by leading scholars in the field and address topics that can be organized by the familiar divisions of cognitive, developmental, and social psychology。

关键词：心理学发展进化心理学社会心理学认知心理学

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作为药物作用靶的蠕虫神经系统

国外医学（寄生虫病分册） 1993年第1期20卷 20-23页

作者： geary TG 任岚

本文就蠕虫神经肌肉的生物学、生理学及作为药物作用靶的蠕虫神经肌肉系统作了较详尽的综述,为发展作用于蠕虫神经肌肉系统的新药提供了信息。

关键词：药物作用靶蠕虫神经系统

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Editorial

Family Medicine and Community Health 2015年第4期3卷 2-4页

作者： Chaojie Liu Demos Krouskos Michael geary La Trobe University MelbourneAustralia North Richmond Community Health MelbourneAustralia Banyule Community Health MelbourneAustralia

The editorial group is pleased to release this special issue of Family Medicine and Community Health-a Sino-Australian *** are grateful to the contributing authors from China and *** contents of this issue cover a wid... 详细信息

关键词： behaviour Editorial Australia

比较研究——影响中美儿童计算能力差异的认知因素

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心理科学 1993年第1期16卷 22-27页

作者：刘凡 David C.geary Christine Bow-Thomas 徐芬中央教育科学研究所密苏里大学心理系杭州大学心理系

本研究要确定中美儿童基本计算技能的差异是否与他们使用的解题策略和基本加工过程的速度有关。为此,对中美两国的一年级儿童进行了书面计算能力测验,以及一组计算机呈现的加法作业。中国儿童在计算能力测验上表现出3:1的操作优势。中... 详细信息

本研究要确定中美儿童基本计算技能的差异是否与他们使用的解题策略和基本加工过程的速度有关。为此,对中美两国的一年级儿童进行了书面计算能力测验,以及一组计算机呈现的加法作业。中国儿童在计算能力测验上表现出3:1的操作优势。中美儿童使用的解题策略种类一样,但是,中国儿童在策略综合运用的发展程度上超过美国儿童,检索策略的加工速度也超过美国儿童。显然,策略运用和加工速度的差异促成了中国儿童在计算能力测验上的优势.

关键词：计算技能解题策略认知儿童

Review Study of Detection of Diabetes Models through Delay Differential Equations

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Applied Mathematics 2016年第10期7卷 1087-1102页

作者： Dimplekumar Chalishajar David H. geary Geoffrey Cox Department of Applied Mathematics Virginia Military Institute Lexington VA USA

Mathematical models based on advanced differential equations are utilized to analyze the glucose-insulin regulatory system, and how it affects the detection of Type I and Type II diabetes. In this paper, we have incorporated several models of prominent mathematicians in this field of work. Three of these models are single time delays, where either there is a time delay of how long it takes insulin produced by the pancreas to take effect, or a delay in the glucose production after the insulin has taken effect on the body. Three other models are two-time delay models, and based on the specific models, the time delay takes place in some sort of insulin production delay or glucose production delay. The intent of this paper is to use these multiple delays to analyze the glucose-insulin regulatory system, and how if it is not properly working at any point, the high risk of diabetes becomes a reality.

关键词： Delay Differential Equations MATLAB Diabetes Insulin-Glucose Model

Effects of Reduced <i>in Utero</i>and Post-Weaning Nutrition on Glucose Clearance Measures and Serum Metabolites

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Agricultural Sciences 2018年第8期9卷 947-957页

作者： Richard Waterman Mark Petersen Thomas geary Lance Vermeire USDA-ARS Fort Keogh Livestock and Range Research Laboratory Miles City MT USA

Lowering production costs while maintaining an optimal level of production is important to producers in extensive environments. Efforts that strive to match the environment to the nutritional requirements of the grazing animal will substantially improve economic returns to the producer. Therefore, a 3-yr study was implemented that evaluated glucose clearance and serum metabolites in primiparous beef heifers (n = 48;16/yr) from two different feeding regimes. Serum metabolites and glucose clearance measures were analyzed by fitting a repeated measure mixed model using the MIXED procedure of SAS 9.4 (SAS Inst., Inc., Cary, NC). Heifers dams received adequate 1.8 (ADEQ) or marginal 1.2 (MARG) kg/d winter supplementation for approximately 80 d prior to parturition and their heifer calves were then randomly assigned to heifer development treatments that provided ad-libitum (AL) or 80% of ad-libitum (LAL) feed post weaning. Heifers that received the AL treatment during the developmental period were then assigned the 1.8 kg/d winter supplementation for life, whereas heifers that received the LAL treatment during development were assigned the 1.2 kg/d winter supplementation for life. Peak glucose concentrations in response to a bolus dose of glucose changed in magnitude between ADEQ and MARG in utero treatments and decreased further removed from parturition (P = 0.05). However, these changes did not manifest along with other glucose clearance measures (P > 0.17) indicating that regardless of in utero treatment or heifer development treatment the reduction in feed input did not greatly influence glucose clearance measures or baseline serum metabolites throughout postpartum, first parity period.

关键词： Heifer Development Glucose Primiparous Beef Cow

The anti-scarring effect of corneal stromal stem cell therapy is mediated by transforming growth factorβ3

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Eye and Vision 2020年第1期7卷 512-525页

作者： Lin Weng James L.Funderburgh Irona Khandaker Moira L.geary Tianbing Yang Rohan Basu Martha L.Funderburgh Yiqin Du Gary Hin-Fai Yam Department of Ophthalmology University of Pittsburgh School of medicine203 Lothrop StreetPittsburghPA 15213USA Shanghai Lanhe Optometry and Ophthalmology Clinic Shanghai 200032People’s Republic of China

Background:Corneal stromal stem cells(CSSC)reduce corneal inflammation,prevent fibrotic scarring,and regenerate transparent stromal tissue in injured *** effects rely on factors produced by CSSC to block the fibrotic gene *** study investigated the mechanism of the scar-free regeneration ***:Primary human CSSC(hCSSC)from donor corneal rims were cultivated to passage 3 and co-cultured with mouse macrophage RAW264.7 cells induced to M1 pro-inflammatory phenotype by treatment with interferonγand lipopolysaccharides,or to M2 anti-inflammatory phenotype by interleukin-4,in a Transwell *** timecourse expression of human transforming growth factorβ3(hTGFβ3)and hTGFβ1 were examined by immunofluorescence and ***β3 knockdown for>70%in hCSSC[hCSSC-TGFβ3(si)]was achieved by small interfering RNA ***ïve CSSC and hCSSC-TGFβ3(si)were transplanted in a fibrin gel to mouse corneas,respectively,after wounding by stromal *** clarity and the expression of mouse inflammatory and fibrosis genes were ***:hTGFβ3 was upregulated by hCSSC when co-cultured with RAW cells under M1 *** of hCSSC to wounded mouse corneas showed significant upregulation of hTGFβ3 at days 1 and 3 post-injury,along with the reduced expression of mouse inflammatory genes(CD80,C-X-C motif chemokine ligand 5,lipocalin 2,plasminogen activator urokinase receptor,pro-platelet basic protein,and secreted phosphoprotein 1).By day 14,hCSSC treatment significantly reduced the expression of fibrotic and scar tissue genes(fibronectin,hyaluronan synthase 2,Secreted protein acidic and cysteine rich,tenascin C,collagen 3a1 andα-smooth muscle actin),and the injured corneas remained ***,hCSSC-TGFβ3(si)lost these anti-inflammatory and anti-scarring functions,and the wounded corneas showed intense ***:This study has demonstrated that the corneal regenerative effect of hCSSC is mediated by TGFβ3,inducing a s

关键词： Cornea wound healing Corneal stromal stem cells TGFβ3 Inflammation Fibrosis