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Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Age.t

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Chinese journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu Bing Wen-Yu Ma Ming-Hui Wu Peng Gao Xiao Zhou Hai-Bin Luo Long Wang Wen-ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating age.t(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).this enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.these findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating age.t Microcellular injection molding Heat-resistance toughness

Effect of V on high-temperature mechanical properties of Al-5Cu-1.5Ni alloy

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journal of Iron and Steel Research International 2024年第7期31卷 1792-1810页

作者： jun-ge Cui Yong-bin Chen Xiang-zhou Fu Hai-long Yang Han-zhang Wang An-min Li Li-wen Pan School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004GuangxiChina Guangxi Higher Education Key Laboratory of Advanced Materials Nanning 530004GuangxiChina

the effects of V on microstructure,room temperature,and high-temperature(350℃)mechanical properties of Al-5Cu-1.5Ni alloy were *** results show that Al-5Cu-1.5Ni-xV alloys mainly compriseα-Al,Al_(2)Cu,Al_(3)(Ni,Cu)_(2),Al_(3)Ni,Al7Cu4Ni,and Al_(10)V *** addition of V can signally refineα-Al dendritic structure,which improves the mechanical properties of the as-cast alloys at room and high *** t6 heat treatment(540℃/12 h/WC+170℃/8 h/AC),α-Al,network skeleton structure Al_(3)(Ni,Cu)_(2),and Al_(10)V phases all show coarsening,while the fine nano-θ'-Al_(2)Cu precipitated from the matrix and dispersed *** introduction of V promotes the quantity of precipitatedθ'-Al_(2)Cu *** ultimate tensile strength of the heat-treated alloys at room and high temperatures is greatly improved compared to that of the as-cast *** highest high-temperature ultimate tensile strength of the alloys with V is 111.8 MPa,21.5%higher than that of the base *** analysis shows that the improvement of high-temperature mechanical properties after heat treatment is mainly due to the introduction of V,increasing the precipitated quantity of nano-θ'-Al_(2)Cu particles and improving its thermal *** dispersion strengthening effect ofθ'-Al_(2)Cu particles exceeds the weakening effect of other adverse microstructures on the mechanical properties.

关键词： Al-Cu-Ni-V alloy θ'-Al_(2)Cu phase Heat treatment Microstructure Mechanical property

EHMt2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1187-1203页

作者： Yongyun Li tianyu Zhu jie Yang Qianqian Zhang Shiqiong Xu Shengfang ge Renbing jia jianming Zhang Xianqun Fan department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200001China National Research Center for translational Medicine(Shanghai) State Key Laboratory of Medical GenomicsShanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of translational Medicine Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 200240China

Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma(UM).Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular *** search of genetic vulnerability for UM,we found that inhibition of euchromatic histone lysine methyltransferase 2(EHMt2)expression or activity significantly reduced the proliferation and migration capacity of cancer ***,elevated expression of EHMt2 had been validated in UM ***,Kaplan-Meier survival analysis indicated high EHMt2 protein level was related to poor recurrence-free survival and a more advanced t *** immunoprecipitation sequencing analysis and the following mechanistic investigation showed that ARHGAP29 was a downstream target of *** transcription was suppressed by EHMt2 in a methyltransferasedependent pattern in GNAQ/11-mutant UM cells,leading to elevated RhoA *** constitutively active RhoA in UM cells lacking EHMt2 restored oncogenic *** blocking EHMt2 and GNAQ/11 signaling in vitro and in vivo showed a synergistic effect on UM growth,sugge.ting the driver role of these two key *** summary,our study shows evidence for an epigenetic program of EHMt2 regulation that influences UM progression and indicates inhibiting EHMt2 and MEK/ERK simultaneously as a therapeutic strategy in GNAQ/11-mutant UM.

关键词： Uveal melanoma EHMt2 RhoA pathway ARHGAP29 G protein GNAQ GNA11

CD4^(+)t cells produce IFN-I to license cDC1s for induction of cytotoxic t-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij j.P.Welters tom de Wit Ellen Schrama Hans van Eenennaam Saskia j.Santegoets timo Oosenbrug Annemarthe van der Veen joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz jacobs Sjoerd H.van der Burg jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)t cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic t lymphocyte(CtL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)t-cell help,specifically in t-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)t cells in *** CD4^(+)t cells produce IFNβvia the StING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CtL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CtL response ***-I-producing CD4^(+)t cells are present in diverse t-cell-infiltrated cancers and likely deliver“help”signals to CtLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)t *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)t cells in the tME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)t-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CtL priming tumor control

Highly efficient ternary organic solar cells with excellent open-circuit voltage and fill factor via precisely tuning molecular stacking and morphology

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Science China Chemistry 2024年第3期67卷 963-972页

作者： Dinghong Sun Zhenyu Chen jianfeng Zhang Wei Song jingyu Shi jintao Zhu Yuanyuan Meng Fei jin Shuncheng Yang Ziyi ge Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China Faculty of Material Science and Chemical Engineering Ningbo UniversityNingbo 315211China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and devices Ningbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049China department of Chemical and Environmental Engineering University of Nottingham NingboNingbo 315100China

the micro-morphology and molecular stacking play a key role in determining the charge.transport process and nonradiative energy loss, thus impacting the performances of organic solar cells(OSCs). to address this issue, a non-fullerene acceptor PhC6-IC-F with alkylbenzene side-chain, possessing optimized molecular stacking, complementary absorption spectra and forming a cascade energy level alignment in the PM6:BtP-eC9 blend, is introduced as guest acceptor to improve efficiency of ternary OSCs. the bulky phenyl in the side-chain can regulate crystallinity and optimizing phase separation between receptors in ternary blend films, resulting in the optimal phase separations in the ternary films. As a result, high efficiencies of 18.33% as photovoltaic layer are obtained for PhC6-IC-F-based ternary devices with excellent fill factor(FF) of 78.92%. Impressively, the ternary system produces a significantly improved open circuit voltage(V_(oc)) of 0.857 V compared with the binary device,contributing to the reduced density of trap states and suppressed non-radiative recombination result in lower energy loss. this work demonstrates an effective approach for adjusting the aggregation, molecular packing and fine phase separation morphology to increase V_(oc) and FF, paving the way toward high-efficiency OSCs.

关键词： alkylbenzene side-chain morphology regulation ternary blends organic solar cells

Inflow and outflow permeability tests in a very soft clay under low stresses

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journal of Rock Mechanics and ge.technical Engineering 2024年第8期16卷 3270-3283页

作者： j.W.S.Vargas F.A.B.Danziger F.R.Lopes t.Lunne Federal University of Rio de janeiro Rio de JaneiroBrazil Norwegian ge.technical Institute OsloNorway

In situ inflow and outflow permeability tests with the BAt probe at SarapuíII soft clay test site are presented.A description of the BAt permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low *** pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the *** role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe *** show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early *** inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading *** sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests *** are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases.

关键词： Permeability test Soft clay BAt probe Inflow and outflow tests

Life under tension: the relevance of force on biological polymers

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Biophysics Reports 2024年第1期10卷 48-56页

作者： Matthew t.j.Halma Longfu Xu department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.V.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： tension Optical tweezers Molecular force

Structure and thermoelectric properties of half-Heusler-like tiFeCu_(x)Sb alloys

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journal of Materiomics 2024年第3期10卷 523-530页

作者： Siyuanyang Yin Qizhu Li Shaoqin Wang jiajun Chen Zirui Dong Yubo Zhang Binghui ge jiye Zhang jun Luo School of Materials Science and Engineering Shanghai University99 Shangda RoadShanghai200444China Institutes of Physical Science and Information technology Anhui University111 Jiulong RoadHefei230601China Minjiang Collaborative Center for theoretical Physics College of Physics and Electronic Information EngineeringMinjiang University200 Xiyuangong RoadFuzhou350108China Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji University4800 Caoan RoadShanghai201804China

Previous research on the ternary ti-Fe-Sb system has revealed that stoichiometric tiFeSb cannot exist as a stable compound,whereas a single-phase tiFe_(1.33)Sb alloy with the half-Heusler-like structure has been synthesized by adding excessive *** this work,we report that tiFeSb can also be stabilized by filling additional Cu to the vacant 4d site of the half-Heusler *** experiments indicate that the tiFe-Cu_(x)Sb(x=0-0.25)samples exhibit a p-type conduction with extremely high carrier concentration((0.5-2.5)×10^(22)cm^(-3)),while these samples attain very large Seebeck coefficients,over 100 mV/K in the whole measured temperature range for the samples with x=*** addition,a logarithmic divergence of the temperature-dependent specific heat capacity(CP/t)is observed at low temperatures,implying the strange-metal behavior of tiFeCu_(x)Sb *** partial filling of the vacant 4d site results in significantly reduced lattice thermal conductivity,leading to the low total thermal conductivity of 2.8 W·m^(-1)·K^(-1)at 823 K for the tiFeCu_(0.20)Sb ***,a dimensionless figure of merit zt of 0.54 at 923 K is realized for tiFeCu_(0.20)Sb,demonstrating that promising thermoelectric materials with intriguing physical properties can be discovered in the composition gap of half-and full-Heusler alloys.

关键词： tiFeSb thermoelectric materials Heusler alloys Vacancy-filled

Spent graphite regeneration:Exploring diverse repairing manners with impurities-catalyzing effect towards high performance and low energy consumption

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journal of Energy Chemistry 2024年第4期91卷 656-669页

作者： Yu Dong Zihao Zeng Zhengqiao Yuan Bing Wang Hai Lei Wenqing Zhao Wuyun Ai Lingchao Kong Yue Yang Peng ge School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Henan Institute of Advanced technology Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Xinmao New Energy technology Co. LTDShenzhen 518100GuangdongChina

Spent battery recycling has received considerable attention because of its economic and environmental potential.A large amount of retired graphite has been produced as the main electrode material,accompanied by a detailed exploration of the repair ***,they still suffer from unclear repair mechanisms and physicochemical *** this study,spent graphite was repaired employing three methodologies:pickling-sintering,pyrogenic-recovery,and high-temperature *** to the catalytic effect of the metal-based impurities and temperature control,the as-obtained samples displayed an ordered transformation,including the interlayer distance,crystalline degree,and grain *** anodes of lithium ions batteries,the capacity of repaired samples reached up to 310 mA h g^(-1)above after 300loops at 1.0 C,similar to that of commercial ***,benefitting from the effective assembly of carbon atoms in internal structure of graphite at>1400℃,their initial coulombic efficiency were>87%.Even at 2.0 C,the capacity of samples remained approximately 244 mA h g^(-1)after 500 *** electrochemical and kinetic analyses revealed that a low temperature enhanced the isotropy,thereby enhancing the rate ***,economic and environmental analyses revealed that the revenue obtained through suitable pyrogenic-recovering manners was approximately the large.t value(5500$t^(-1)).thus,this study is expected to clarify the in-depth effect of different repair methods on the traits of graphite,while offering all-round evaluations of repaired graphite.

关键词： Spent graphite regeneration Repair temperature treatment