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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progre.sion of periodontitis

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International Journal of Oral science 2024年第2期16卷 265-279页

作者： Alfredo Torres m.Angélica michea Ákos Végvári marion Arce Valentina Pérez marcela Alcota Alicia morales Rolando Vernal mauricio Budini Roman A.Zubarev Fermín e.González Laboratory of experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory dise.ses,yet its association with progre.sive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progre.sion,we asse.sed sixteen periodontitis-diagnosed *** progre.sion was clinically monitored over twelve wee.s via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progre.sion and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RnA sequencing(scRnA-seq)dataset(Gse164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progre.sion was identified as occurring at a faster rate than traditionally *** samples from progre.sing and non-progre.sing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological proce.ses and molecular functions during progre.sive periodontitis were revealed and a set of hub proteins,including snCA,CA1,HBB,sLC4A1,and AnK1 was strongly associated with the clinical progre.sion status of ***,we found specific proteins-drive.s or suppre.sors-associated with ferroptosis(snCA,FTH1,HsPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progre.sion of ***,the integration of quantitative proteomic data with scRnA-seq analysis suggested the.susceptibility of fibroblasts to *** analyses reveal proteins and proce.ses linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progre.sive periodontal *** findings may le

关键词： finding progre.sion faster

exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of sport and Health science 2024年第2期13卷 160-171页

作者： Yue Dai Yi Cheng Renkai ge Ke Chen Liming Yang Key Lab of Adolescent Health Asse.sment and exercise Intervention of ministry of education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China shanghai Key Laboratory of multidime.sional Information Proce.sing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China school of Physical education and Health Care East China Jiaotong UniversityNanchang 330013China Key Laboratory of High Confidence.software Technologies of ministry of education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expre.sion and protein *** hope is to update the community with a cellular and molecular unde.standing of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity excitability exercise Ion channel modulation neuron adaptation

Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the Quality of soursop (Annona muricata L.) Fruit

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Phyton-International Journal of experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo Ángel elpidio Díaz-Jasso Rosendo Balois-morales Verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico estancias Posdoctorales-Consejo nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening proce.s of soursop involves complex changes in gene expre.sion and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been exte.sively explored in ***,in this paper,we present a comprehe.sive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the.starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprote.se FTsH8(FTsH8_ORYsJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYsJ),mitogen-activated protein kinase YODA(YODA_ARATH),R-man-delonitrile lyase-like(mGL_ARATH),26s prote.se regulatory subunit 6A homolog(PRs6_sOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(meT2-ORYsJ)were correlated and differentially accumulated and expre.sed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

Coupling WO_(3-x) dots-encapsulated metal-organic frameworks and template-free branche. polymerization for dual signal-amplified electrochemiluminescence biose.sing

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Chinese Chemical Lette.s 2024年第4期35卷 469-474页

作者： Fei Yin erli Yang Xue ge Qian sun Fan mo Guoqiu Wu Yanfei shen medical school Southeast UniversityNanjing 210009China Center of Clinical Laboratory medicine Zhongda HospitalSoutheast UniversityNanjing 210009China Jiangsu Provincial Key Laboratory of Critical Care medicine Southeast UniversityNanjing 210009China

Developing accurate and se.sitive DnA methyltransferase(mTase) analysis methods is e.sential for early clinical diagnosis and development of antimicrobial drug targe.s. In this work, by coupling WO_(3-x) dotsencapsulated metal-organic frameworks(mOFs) as co-reactants and terminal deoxynucleotidyl transferase(Td T)-mediated template-free branche. polymerization, a dual signal-amplified electrochemiluminescent(eCL) biose.sor was constructed to detect DnA adenine methylation(Dam) mTase. The employment of WO_(3-x) dots-encapsulated mOFs(i.e., nH_(2)-UIO66@WO_(3-x) ) was not only beneficial for biomolecule conjugation because of the abundant amino groups but also led to a 7-fold enhanced eCL response due to the incre.sed loading of WO_(3-x). moreover, Td T-mediated template-free branche. polymerization promoted the capture of eCL emitte.s on the electrode.surface, achieving 20-fold enhanced signal amplification. The presented eCL biose.sor demonstrated a low detection limit of 2.4 × 10^(-4)U/m L, and displayed high reliability for the detection of Dam mTase in both spiked human serum and e. coli cell samples, and for the.screening of potential inhibitors. This study ope.s a new avenue for designing a dual signal amplificationbased eCL bioassay for Dam mTase and screening inhibitors in the fields of clinical diagnosis and drug development.

关键词： Dual signal-amplified electrochemiluminescence WO_(3-x)dots mOFs Template-free branche. polymerization DnA methyltransferase

A novel clinical artificial intelligence model for dise.se detection via retinal imaging

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The Innovation 2024年第2期5卷 11-12页

作者： Yidian Fu Liang ma sheng Wan shengfang ge Zhi Yang Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China shanghai Key Laboratory of Orbital Dise.ses and Ocular Oncology Shanghai 200011China PCA Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of EducationNanjing 210000China Jiangsu Key Lab of Image and Video Unde.standing for social security School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210000China

Artificial intelligence(AI)is an emerging field in which computerized syste.s are used to carry out complex tasks in place of *** AI algorithms have been developed for dise.se diagnosis and prediction and treatment recommendation across various clinical data types,e.g.,chest X-rays,electrocardiograms,and other radiological images.1 In ophthalmology,particularly,great progre.s has been made in AI syste.s over the past *** fundus photography(CFP)and optical coherence tomography(OCT),which are readily available in routine clinical practice,are both mainstream and useful retinal imaging modalities in *** september 2023,the 2023 Lasker-Debakey Clinical medical Research Award was awarded to three.scientists for their work on OCT for accurate retinal dise.se detection.

关键词： clinical routine diagnosis

selective oxygen electroreduction to hydrogen peroxide in acidic media:The.superiority of single-atom catalysts

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nano Research 2024年第6期17卷 4668-4681页

作者： ergui Luo Tongtong Yang Jingyi Liang Yuhong Chang Junming Zhang Tianjun Hu Junjie ge Jianfeng Jia Key Laboratory of magnetic molecules and magnetic Information materials of ministry of education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China school of Chemistry and materials science University of Science and Technology of ChinaHefei 230026China state Key Laboratory of electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Two-electron oxygen reduction reaction(2e-ORR)provides an environmentally friendly direction for the on-site production of hydrogen peroxide(H_(2)O_(2)).Central to this technology is the exploitation of efficient,economical,and safe 2e-ORR *** overview starts with the fundamental chemistry of ORR to highlight the decisive role of adsorbing intermediates on the reaction pathway and activity,followed by a comprehe.sive.survey of the tuning strategies to favor 2e-ORR on traditional precious *** latest achievements in designing efficient and selective precious-metal-based single-atom catalysts(sACs)and metal-nitrogen-carbon(m-nx/C)catalysts,from the aspects of material synthesis,theoretical calculations,and mass transport promotion,are.systematically *** introductions on the evaluation metrics for 2e-ORR catalysts and the primary reactor designs for cathodic H_(2)O_(2)synthesis are also *** conclude this review with an outlook on the challenges and direction of efforts to advance electrocatalytic 2e-ORR into realistic H_(2)O_(2)production.

关键词： oxygen reduction reaction H_(2)O_(2)production single-atom catalysts selectivity

A novel videogrammetry-based full-field dynamic deformation monitoring method for variable.sweep wings

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Acta mechanica sinica 2024年第8期40卷 120-132页

作者： Liqiang Gao Yan Liu Bin Jiang Zhendong ge Haoyang Li Xiang Guo Tao suo Qifeng Yu school of Civil Aviation Northwestern Polytechnical UniversityXi’an710072China shaanxi Key Laboratory of Impact Dynamics and engineering Application Northwestern Polytechnical UniversityXi’an710072China College of Physics and Optoelectronic engineering Shenzhen UniversityShenzhen518060China Institute of Intelligent Optical me.surement and Detection Shenzhen UniversityShenzhen518060China

The me.surement of wing dynamic deformation in morphing aircraft is crucial for achieving closed-loop control and evaluating structural *** variable.sweep wings with active large deformation,this paper proposes a novel videogrammetric method for full-field dynamic deformation me.surement.A stereo matching method based on epipolar ge.metry constraint and topological constraint is presented to find the corresponding targe.s between stereo *** addition,a new method based on affine transformation combined with adjacent closest point matching is developed,aiming to achieve fast and automatic tracking of targe.s in time.series images with large deformation.A calculation model for dynamic deformation paramete.s is established to obtain the displacement,sweep variable angle,and span *** verify the proposed method,a dynamic deformation me.surement experiment is conducted on a variable.sweep wing *** results indicate that the actual accuracy of the proposed method is approximately 0.02%of the me.sured area(e.g.,0.32 mm in a 1.6 m scale).During one morphing course,the.sweep variable angle,the.span variation and the displacement incre.se gradually,and then *** maximum sweep variable angle is 36.6°,and the.span variation is up to 101.13 *** overall configuration of the wing surface is effectively reconstructed under different morphing states.

关键词： morphing aircraft Variable.sweep wing Videogrammetry Large dynamic deformation Target matching and tracking

RnA barcode.segments for sARs-CoV-2 identification from HCoVs and sARsr-CoV-2 lineages

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Virologica sinica 2024年第1期39卷 156-168页

作者： Changqiao You shuai Jiang Yunyun Ding shunxing Ye Xiaoxiao Zou Hongming Zhang Zeqi Li Fenglin Chen Yongliang Li Xingyi ge Xinhong Guo College of Biology Hunan UniversityChangsha410082China College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha410128China

severe acute respiratory syndrome coronavirus 2(sARs-CoV-2),the pathogen responsible for coronavirus dise.se 2019(COVID-19),continues to evolve,giving rise to more variants and global *** research has demonstrated that barcode.segments can effectively and cost-efficiently identify specific species within closely related *** this study,we designed and tested RnA barcode.segments based on genetic evolutionary relationships to facilitate the efficient and accurate identification of sARs-CoV-2 from exte.sive virus samples,including human coronaviruses(HCoVs)and sARsr-CoV-2 *** sequences sourced from nCBI and GIsAID were meticulously selected and curated to construct training se.s,encompassing 1733 complete genome.sequences of HCoVs and sARsr-CoV-2 *** genetic-level species testing,we validated the accuracy and reliability of the barcode.segments for identifying ***,75 main and subordinate.species-specific barcode.segments for sARs-CoV-2,located in ORF1ab,s,e,ORF7a,and n coding sequences,were intercepted and screened based on single-nucleotide polymorphism sites and weighted ***-testing,these.segments exhibited high recall rates(nearly 100%),specificity(almost 30%at the nucleotide level),and precision(100%)performance on *** were eventually visualized using one and two-dime.sional combined barcodes and deposited in an online database(http://***/).The.succe.sful integration of barcoding technology in sARs-CoV-2 identification provides valuable insights for future.studies involving complete genome.sequence polymorphism ***,this cost-effective and efficient identification approach also provides valuable reference for future research endeavors related to virus surveillance.

关键词： RnA barcode.segments sARs-CoV-2 variants and related lineages HCoVs genetic tests Complete genome.sequences

Long-term prognosis and its associated predictive factors in patients with e.sinophilic gastroenteritis

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World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li ge-Chong Ruan shuang Liu Tian-ming Xu Ye ma Wei-Xun Zhou Wei Liu Peng-Yu Zhao Zhi-Rong Du Ji Li Jing-nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUnD e.sinophilic gastroenteritis(ege)is a chronic recurrent dise.se with abnormal e.sinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,dise.se relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of ege and risk factors for dise.se *** To describe the clinical characteristics of ege and possible predictive factors for dise.se relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with ege admitted to one medical center between 2013 and *** records were collected and ***-meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free.survival(RFs).ResULTs eGe.showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),diste.sion(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin e(Ige)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at le.st one *** variables at baseline might have been associated with the overall RFs rate,including age at diagnosisears[hazard ratio(HR)2.0408,95%confidence interval(CI):1.0082–4.1312,P=0.044],body mass index(BmI)>24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),dise.se duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum Ige>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).COnCLUsIOn In patients with ege,younger onset age,longer dise.se c

关键词： e.sinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence