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Effect of spinal cord extracts after spinal cord injury on proliferation of rat embryonic neural stem cells and Notch signal pathway in vitro

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 562-567页

作者： Qing-Zhong Zhou ge Zhang Hai-Bo Long fei lei fei Ye Xu-Feng Jia Yun-Long Zhou Jian-Ping Kang Da-Xiong Feng Department of Spine Surgery Affiliated Hospital of Luzhou Medical College Department of Spine Surgery Popele's Hospital of Luzhou Department of Spine Surgery Affiliated TCM Hospital of Luzhou Medical College

Objective:To investigate the effect of the spinal cord extracts(SCE)after spinal cord injuries(SCIs)on the proliferation of rat embryonic neural stem cells(NSCs)and the expressions of mRNA of Notch1 as well as of Hes1 in this process in ***:The experiment was conducted in 4 different mediums:NSCs+PBS(Group A-blank control group),NSCs+SCE with healthy SD rats(Croup B-normal control group),NSCs+SCE with SD rats receiving sham-operation treatment(Croup C-sham-operation group)and NSCs+SCE with SCIs rats(Group D-paraplegic group).Proliferative abilities of 4 different groups were analyzed by MTT chromatometry after co-culture for 1,2,3,4 and 5 d,*** expressions of Notch 1 and Hes1 mRNA were also detected with RT-PCR after co-culture for 24 and 48 h,***:After co-culture for 1,2,3,4 and 5 d respectively,the MTT values of group D were significantly higher than those of group A,group B and group C(P0.05).Both the expressions of Notch1 and Hes1 mRNA of group D were significantly higher than those of other 3 groups after co-culture for 24 h and 48 h as well(P0.05).There was no difference in expressions of Notch1and Hes1 mRNA between 24 h and 48 h treatment in group ***:SCE could promote the proliferation of *** is demonstrated that the microenvironment of SCI may promote the proliferation of ***,SCE could increase the expression of Notch1 and Hes1 mRNA of *** can be concluded that the Notch signaling pathway activation is one of the mechanisms that locally injured microenvironment contributes to the proliferation of ENSC after *** process may be performed by up-regulating the expressions of Notch1 and

关键词： Neural stem cell Cell culture Spinal cord extract Notch signal pathway

Data-driven Transient Stability Assessment Model Considering Network Topology Changes via Mahalanobis Kernel Regression and Ensemble Learning

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1080-1091页

作者： Xianzhuang Liu Xiaohua Zhang lei Chen fei Xu Changyou Feng State Grid Corporation of China State Grid Jibei Electric Power Company the State Key Laboratory of Control and Simulation of Power System and generation Equipment Department of Electrical EngineeringTsinghua University

Transient stability assessment(TSA)is of great importance in power system operation and *** of the usual tasks in TSA is to estimate the critical clearing time(CCT)of a given fault under the given network topology and pre-fault power ***-driven methods try to obtain models describing the mapping between these factors and the CCT from a large number of ***,the influence of network topology on CCT is hard to be analyzed and is often ignored,which makes the models inaccurate and *** this paper,a novel data-driven TSA model combining Mahalanobis kernel regression and ensemble learning is proposed to deal with the *** model is a weighted sum of several *** sub-model only uses the data of one topology to construct a kernel *** weights are determined by both the topological similarity and numerical similarity between the *** similarities are decided by the parameters in Mahalanobis distance,and the parameters are to be *** reduce the model complexity,sub-models within the same topology category share the same *** estimating CCT,the model uses not only the sub-model which the sample topology belongs to,but also other ***,it avoids the problem that there may be too few data under some *** also efficiently utilizes information of data under all the ***,its decision-making process is clear and understandable,and an effective training algorithm is also *** results on both the IEEE 10-machine 39-bus and a real system verify the effectiveness of the proposed model.

关键词： Transient stability assessment critical clearing time network topology change Mahalanobis kernel regression ensemble learning data-driven

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CNN Based Classification of Rigid Targets in Space Using Radar Micro-Doppler Signatures

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Chinese Journal of Electronics 2019年第4期28卷 856-862页

作者： WANG Jun ZHU He lei Peng ZHENG Tong GAO fei School of Electronic and Information Engineering Beihang University

Micro-motion characteristics play an important role in some applications of radar target classification. In this paper, a classification method of rigid targets in space using radar micro-Doppler signatures is proposed. Based on the attitude kinematics of rigid targets,we analyze feasibility of classification using micro-Doppler signatures by the relationship among inertial properties of typical rigid targets, their micro-motion characteristics,and corresponding modulation to radar echoes. According to the micro-Doppler time-frequency distribution of echoes and the scale of training sample set, Convolutional neural network(CNN) based feature extraction method and softmax Classifier are designed. Simulations are carried out to validate its effectiveness and discuss the impact of observation duration, composition of training data and size of convolutional kernels on its classification robustness and computational cost.

关键词： Inertial model Micro-motion Radar micro-Doppler Convolutional neural network

Effects of graphene oxides on transport and deposition behaviors of bacteria in saturated porous media

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Science China(Technological Sciences) 2019年第2期62卷 276-286页

作者： ge Zhi WU Dan HE lei LIU XianWei TONG MeiPing The Key Laboratory of Water and Sediment Sciences Ministry of Education College of Environmental Sciences and EngineeringPeking University

The effects of graphene oxides on the transport and deposition behaviors of bacteria(Gram-negative Escherichia coli and Grampositive Bacillus subtilis) in quartz sand were investigated in both NaCl and CaCl_2 solutions at pH 6.5. Both breakthrough curves and retained profiles of bacteria in the absence and presence of GO under all examined solution conditions were obtained. The results demonstrated that for both types of bacteria, the presence of GO increased the transport and decreased the deposition of bacteria at both low(10 mM) and high ionic strengths(50 mM) in NaCl solutions. However, opposite observations were achieved at different ionic strengths in CaCl_2 solutions. Particularly, GO facilitated the transport and inhibited the deposition of bacteria in 1 m M CaCl_2 solutions, while they suppressed the transport of bacteria in 2.5 m M CaCl_2 solutions. Clearly, the cell transport and deposition behaviors in porous media would be greatly influenced by the GO copresent in suspensions. Furthermore, we found that with GO copresent in suspensions, the transport and deposition behaviors of bacteria were highly associated with those of GO. The heteroaggregation of bacteria and GO also contributed to the decreased cell transport in 2.5 mM CaCl_2 solutions. This study showed that GO copresent in suspensions could act as mobile carriers for bacteria transport in porous media, leading to the alteration of cell transport and deposition behaviors.

关键词： bacteria transport graphene oxide interaction cotransport porous media

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PCDH-based nonlinear H∞control of VSC-HVDC with wind power integrated

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Journal of Control and Decision 2021年第1期8卷 41-49页

作者： Xingyu Lv Bangjun lei Shumin fei Foreign language Teaching Center Guizhou Institute of TechnologyGuiyangPeople’s Republic of China Key Laboratory of Power Dig Data of Guizhou Province School of Electrical and Information EngineeringGuizhou Institute of TechnologyGuiyang 550003People’s Republic of China Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationSchool of AutomationSoutheast UniversityNanjingPeople’s Republic of China

Based on the port-controlled dissipative Hamiltonian(PCDH)system,a novel nonlinear(NN)H∞control is designed for the wind farm side(WFS)voltage source converter(VSC)of VSC-based high-voltage direct current(VSC-HVDC)transmission system connected large wind ***,the uncertain nonlinear dynamical model of WFS VSC in the VSC-HVDC is established by taking external disturbances and parameter variations into ***,the dissipative Hamiltonian structure of the WFS VSC system is constructed by means of variable ***,on the basis of the obtained dissipative Hamiltonian structure,a NN H∞control is put ***,the simulation results show that the proposed NN H∞control gains the advantage over the interconnection and damping assignment passivity-based(IDA-PB)control.

关键词： VSC-HVDC large wind farm Hamiltonian function method nonlinear H∞control

Visual dual chemodynamic/photothermal therapeutic nanoplatform based on superoxide dismutase plus Prussian blue

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Nano Research 2019年第5期12卷 1071-1082页

作者： Shan lei Jinxing Chen Kun Zeng Mozhen Wang Xuewu ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Enzyme-based anticancer therapy is more attractive for the less side effect than conventional ***,the poor stability and low membrane permeability of enzymes during the intracellular delivery are constraints for its practical *** this work,we synthesized novel near-infrared (NIR)-responsive core-shell-structured Prussian blue@fibrous SiO2 (PBFS) nanoparticles as the carrier of superoxide dismutase (SOD) and a glutathione (GSH)-activated Fenton reagent (DiFe).The PBFS nanoparticles are further modified with aGSH-responsive cationic polymer (poly(2-(acryloyloxy)-N,N-dimethyl-N-(4-(((2-((2-(((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)oxy)ethyl)disulfaneyl)ethoxy)carbonyl)amino)benzyl)ethan-1-aminium,PSS) containing disulfide bonds and *** SOD and DiFe are loaded on the PBFS-PSS nanoparticles,dual chemodynamic/photothermal therapeutic nanoparticulate systems (PBFS-PSS/DiFe/SOD) are *** vitro experiments show that PBFS-PSS/DiFe/SOD nanoparticles have good biocompatibility and can be tracked under fluorescence microscope during the intracellular delivery process in MCF-7 tumor cells due to the GSH-activated release of *** also exhibit high efficiency in NIR photothermal conversion and GSH-activated Fenton reaction in tumor cells,thus achieving high-efficient killing effect of tumor cells based on the combination of photothermal and chemodynamic therapeutic performance (PTT and CDT).This work offers a novel pathway to construct a visual multifunctional nanomedicine platform for future cancer therapy.

关键词： copper-zinc superoxide dismutase Fenton reagent Prussian blue near-infrared (NIR) photothermal therapy fluorescence

Power Matching and Energy Efficiency Improvement of Hydraulic Excavator Driven with Speed and Displacement Variable Power Source

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Chinese Journal of Mechanical Engineering 2019年第6期32卷 142-153页

作者： lei ge Long Quan Xiaogang Zhang Zhixin Dong Jing Yang Key Lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology

Mobile machinery energy efficiency and emission pollution are the national and worldwide issues. This paper contributes in solving these problems by applying a speed variable power source. Unfortunately, almost all of the speed variable systems have the dynamic response problem when the motor starts with full load or heavy load. To address this problem, a hydraulic accumulator is used to balance the load of the power source for assisting starting of the motor and a matching method combined with speed and displacement control of the pump is proposed to improve the energy efficiency and dynamic performance simultaneously under different working conditions. Also, the power source/valve combined control strategy of an independent metering system is designed to realize flow matching of the whole system. Firstly, a test system is established to study the dynamic performance and energy efficiency of the speed variable power source with an auxiliary accumulator. Working performance and energy consumption of the power source under different rotating speeds and different loads are studied. And then, the hydraulic excavator test rig with the proposed system is constructed. Furthermore, the working performance of the excavator with the speed-fixed and speed-variable strategy are studied comparatively. Results show that, compared with fixed-speed strategy, the electric power consumption during the idle period and partial load condition can be reduced about 2.05 kW and 1.37 kW. The energy efficiency of speed variable power source is about 40%-71%, which is higher than that of the fixed-speed power source by 3%–10%.

关键词： Hydraulic excavator Power matching Speed variable Energy efficiency

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STIL enhances the development of lung adenocarcinoma by regulating the glycolysis pathway

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Oncology research 2025年第1期33卷 123-132页

作者： lei Wang Xianjin Xie Department of Respiratory Medicine Jen Ching Memorial Hospital Suzhou 215300 China. Department of Respiratory Medicine Shandong Provincial Third Hospital Jinan 250010 China.

Background:To investigate SCL/TAL 1 interrupting locus ()'s role and prognostic significance in lung adenocarcinoma (LUAD) progression, we examined and E2 promoter binding factor 1 (E2F1) expression and their impacts on LUAD prognosis using gene Expression Profiling Interactive Analysis (gePIA).Methods:Functional assays including CCK-8, wound-healing, 5-ethynyl-2-deoxyuridine (EdU), Transwell assays, and flow cytometry, elucidated and E2F1's effects on cell viability, proliferation, apoptosis, and migration. gene set enrichment analysis (GSEA) identified potential pathways, while metabolic assays assessed glucose metabolism.Results:Our findings reveal that and E2F1 are overexpressed in LUAD, correlating with adverse outcomes. It enhances cell proliferation, migration, and invasion, and suppresses apoptosis, activating downstream of E2F1. Silencing E2F1 reversed the promotion effect of the overexpression on cell viability and invasiveness. Importantly, modulates glycolysis, influencing glucose consumption, lactate production, and energy balance in LUAD cells.Conclusion:Our model, incorporating , age, and disease stage, robustly predicts patient prognosis, underscored 's pivotal role in LUAD pathogenesis through metabolic reprogramming. This comprehensive approach not only confirms 's prognostic value but also highlights its potential as a therapeutic target in LUAD.

关键词： E2 promoter binding factor 1 Glycolysis Lung adenocarcinoma SCL/TAL1 interrupting locus (STIL)

Upgrade design and prototype implementation of cryogenic control system in BEPCII

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Radiation Detection Technology and Methods 2021年第3期5卷 404-408页

作者： Gang Li ge lei Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Science Beijing 100049China

Background The cryogenic control system of BEPCII has been in stable operation for more than 10 years,providing techni-cal support for the generation of cryogenic *** core hardware of the cryogenic control system is composed of PLC and VME controller,and the operating software includes PLC commercial software and ***,some hardware and software are *** An upgrade prototype of the cryogenic control system is designed and built to study the compatibility contradiction between software and hardware,and ensure the long-term stable operation of cryogenic *** Keep the hardware architecture,upgrade the software and hardware modules of PLC and VME respectively,and test the system *** The upgrading prototype of the cryogenic control system solves the problem of software and hardware compat-ibility,and makes it possible to achieve a seamless and smooth upgrade of the cryogenic control system in the future.

关键词： EPICS PLC Cryogenic control Upgrade