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Artificial intelligence in breast ultrasound

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World Journal of Radiology 2019年第2期11卷 19-26页

作者： ge-ge wu Li-Qiang Zhou Jian-Wei Xu Jia-Yu Wang Qi Wei You-Bin Deng Xin-wu Cui Christoph F Dietrich Sino-german Tongji-Caritas Research Center of Ultrasound in Medicine Department of Medical Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Ultrasound The First Affiliated Hospital of Zhengzhou University Medical Clinic 2 Caritas-Krankenhaus Bad Mergentheim Academic Teaching Hospital of the University of Würzburg

Artificial intelligence(AI) is gaining extensive attention for its excellent performance in image-recognition tasks and increasingly applied in breast ultrasound. AI can conduct a quantitative assessment by recognizing imaging information automatically and make more accurate and reproductive imaging diagnosis. Breast cancer is the most commonly diagnosed cancer in women,severely threatening women's health, the early screening of which is closely related to the prognosis of patients. Therefore, utilization of AI in breast cancer screening and detection is of great significance, which can not only save time for radiologists, but also make up for experience and skill deficiency on some beginners. This article illustrates the basic technical knowledge regarding AI in breast ultrasound, including early machine learning algorithms and deep learning algorithms, and their application in the differential diagnosis of benign and malignant masses. At last, we talk about the future perspectives of AI in breast ultrasound.

关键词： Breast Ultrasound Artificial intelligence Machine learning Deep learning

Posttraumatic stress symptoms among Chinese university students during the COVID-19 pandemic:Prevalence,correlates,and mental health help-seeking

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World Journal of Psychiatry 2025年第1期15卷 145-152页

作者： Rui-Yao wu Lin-Feng ge Bao-Liang Zhong Department of Psychiatry The Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430012Hubei ProvinceChina Department of Psychiatry Wuhan Mental Health CenterWuhan 430012Hubei ProvinceChina

BACKGROUND Revisiting the epidemiology of posttraumatic stress symptoms(PTSSs)among university students during the coronavirus disease 2019(COVID-19)pandemic as well as understanding the mental health help-seeking behavior of individuals with PTSSs has critical implications for public mental health strategies in future medical *** To investigate the prevalence and correlates of PTSSs among university students during the first wave of the COVID-19 pandemic in China and to examine mental health help-seeking behaviors among these *** A total of 2507 Chinese university students were recruited via snowball *** students completed the Seven-item Screening Scale for Post-traumatic Stress Disorder during the first wave of the COVID-19 pandemic in ***-graphic characteristics,pandemic-related characteristics,and mental health help-seeking behaviors of students with PTSSs were also *** The prevalence of PTSSs among the participants was 28.0%.Seven significant correlates of PTSSs were identified(odds ratio=1.23-3.65,P≤0.024):Female sex,being 19 years old or older,living with others or alone,a low level of family economic status,fair or poor interpersonal relationships,severe or very severe local pandemic,and having family members diagnosed with ***,only 3.28%of the students with PTSSs reported seeking help from mental health *** the 23 students who sought help from mental health specialists,13 opted for online or telephone-based psychological *** Our data suggest that there was a high risk of PTSSs among university students and a high level of unmet mental health needs during the COVID-19 *** delivery of mental health services online or via telephone is a promising approach to address these unmet needs.

关键词： Posttraumatic stress symptoms University students COVID-19 Mental health help-seeking China

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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基于离散指数趋近律的开关电源模糊滑模控制

测控技术 2017年第7期36卷 52-55,59页

作者：王红旗万各各吴海波河南理工大学电气工程与自动化学院河南焦作454000

对于Buck/Boost变换器,传统的控制器如PID控制器、Ⅲ型误差放大器等存在超调量过大、响应时间过长、鲁棒性不强等问题,为克服这些缺点,提出基于离散指数趋近律的开关电源模糊滑模控制方案。首先,针对工作在电感电流连续模式(CCM)的Buck/... 详细信息

对于Buck/Boost变换器,传统的控制器如PID控制器、Ⅲ型误差放大器等存在超调量过大、响应时间过长、鲁棒性不强等问题,为克服这些缺点,提出基于离散指数趋近律的开关电源模糊滑模控制方案。首先,针对工作在电感电流连续模式(CCM)的Buck/Boost变换器采用状态空间平均法建立平均线性模型;然后设计离散指数趋近律的滑模控制器,并分析了切换参数对系统的影响;最后,为改善控制效果,设计了模糊控制器。仿真结果表明,相对于传统的控制器,指数趋近律的模糊滑模控制器有效地降低了超调量,提高了系统的响应时间,并且对外部干扰的鲁棒性较好。利用所设计的控制算法实现了对50 W高频开关电源样机的良好控制,进一步证明了所提方法的有效性。

关键词： Buck/Boost拓扑平均线性模型指数趋近律模糊滑模控制

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun wu Shengbo ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

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我国汽车工业的技术水平分析

工业工程与管理 2002年第5期7卷 53-55页

作者：郭戈吴先华华北电力大学经济管理系河北保定071003 武汉理工大学管理学院湖北武汉430070

介绍了道格拉斯生产函数测定技术水平的方法 ,用统计软件SPSS1 0 .0对我国汽车工业1 979～ 2 0 0 0年的有关数据进行了回归分析 ,测算出了汽车工业的技术水平 ,得出了我国汽车工业的规模尚且不够 ,技术进步的贡献较低。

关键词：汽车工业技术水平 Solow模型中国道格拉斯生产函数测算方法

Energy estimation and coupling synchronization between biophysical neurons

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Science China(Technological Sciences) 2020年第4期63卷 625-636页

作者： wu FuQiang MA Jun ZHANG ge Department of Physics Lanzhou University of TechnologyLanzhou 730050China NAAM-Research Group King Abdulaziz UniversityJeddah 21589Saudi Arabia

Static charges can induce spatial electric field while moving charges can induce magnetic *** a result,continuous pumping and exchange of intercellular and extracellular Calcium,potassium and sodium of cells will generate time-varying magnetic field in the ***,the physical effect of electromagnetic induction in neural activities should be included in building biological *** the other hand,the occurrence of action potential and propagation of ions require energy consumption and supply,so the estimation of physical energy becomes *** on our memristive biophysical neuron model,the Hamilton energy function is obtained by using the Helmholtz’s theorem,and this energy is contributed by the electric field and magnetic field described by magnetic *** is found that this improved neuron model can present the main dynamical properties in neural activities,and it characterizes the lower threshold behavior and subthreshold oscillation during refractory *** external forcing current on an isolate is adjusted to calculate the firing patterns,energy function and mode transition,which shows the dependence of energy on electrical ***,magnetic coupling is triggered to modulate the phase synchronization between two identical neurons connected by electric synapse,respectively.

关键词： memristor energy magnetic field phase synchronization

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核因子I-C调控人根尖牙乳头干细胞的分化

中国组织工程研究 2025年第31期29卷 6667-6673页

作者：吴越朱永娜葛翔刘樊何泽禹刘茜蚌埠医科大学口腔医学院蚌埠医科大学第二附属医院口腔科安徽省蚌埠市233000

背景:体外过表达核因子I-C基因可促进人根尖牙乳头干细胞的分化,Wnt/β-catenin信号通路的激活也可促进人根尖牙乳头干细胞的分化,而且核因子I-C对间充质干细胞中Wnt/β-catenin通路具有调节作用。然而,核因子I-C能否通过激活人根尖牙... 详细信息

背景:体外过表达核因子I-C基因可促进人根尖牙乳头干细胞的分化,Wnt/β-catenin信号通路的激活也可促进人根尖牙乳头干细胞的分化,而且核因子I-C对间充质干细胞中Wnt/β-catenin通路具有调节作用。然而,核因子I-C能否通过激活人根尖牙乳头干细胞中Wnt/β-catenin通路进而影响细胞分化,目前尚未见报道。目的:探讨核因子I-C通过Wnt/β-Catenin信号通路调控人根尖牙乳头干细胞分化的作用。方法:玻片覆盖组织块法培养人根尖牙乳头干细胞,慢病毒转染过表达核因子I-C基因。①设置对照组、空载体组和过表达核因子I-C组,Western blot检测β-Catenin、LRP5和TCF7L2的表达。②设置对照组、空载体组、过表达核因子I-C组和过表达核因子I-C+DKK-1(Wnt通路抑制剂)组,细胞成骨诱导7 d后进行碱性磷酸酶染色及活性定量,细胞成骨诱导14 d后qPCR和Western blot检测Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白的表达,茜素红染色观察矿化结节形成情况。结果与结论:①与对照组、空载体组相比,过表达核因子I-C组人根尖牙乳头干细胞中Wnt/β-Catenin通路相关蛋白β-Catenin、LRP5、TCF7L2表达显著升高(P<0.01);②与对照组、空载体组相比,过表达核因子I-C组人根尖牙乳头干细胞中碱性磷酸酶活性显著升高(P<0.01),Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白表达均显著升高(P<0.01),矿化结节数量显著增加(P<0.01);③与过表达核因子I-C组相比,过表达核因子I-C+DKK-1组人根尖牙乳头干细胞中碱性磷酸酶活性、Runt相关转录因子2、牙本质涎磷蛋白、骨钙素mRNA及蛋白表达显著下降(P<0.05),矿化结节数量显著减少(P<0.05)。结果表明:核因子I-C能够激活人根尖牙乳头干细胞中Wnt/β-catenin信号通路,介导人根尖牙乳头干细胞的成骨/成牙分化。

关键词：人根尖牙乳头干细胞核因子I-C Wnt 信号通路分化成骨 DKK-1 工程化干细胞

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Biodegradation of oil wastewater by free and immobilized Yarrowia lipolytica W29

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Journal of Environmental Sciences 2009年第2期21卷 237-242页

作者： wu Lan ge Gang WAN Jinbao College of Life Science Nanchang University Nanchang 330031 China College of Environmental Science and Engineering Nanchang University Nanchang 330031 China

The ability of Yarrowia lipolytica W29 immobilized by calcium alginate to degrade oil and chemical oxygen demand （COD） was examined. The degradation rules of oil and COD by immobilized cells with the cell density of 6.65 × 10^6 CFU/mL degraded 2000 mg/L oil and 2000 mg/L COD within 50 h at 30℃ （pH 7.0, 150 r/min）, similarly to those of free cells, and the degradation efficiencies of oil and COD by immobilized cells were above 80%, respectively. The factors affecting oil and COD degradation by immobilized cells were investigated, the results showed that immobilized cells had high thermostability compared to that of free cells, and substrate concentration significantly affected degrading ability of immobilized cells. Storage stability and reusability tests revealed that the oil degradation ability of immobilized cells was stable after storing at 4~C for 30 d and reuse for 12 times, respectively, the COD degradation rate of immobilized cells was also maintained 82% at the sixth cycle. These results suggested that immobilized Y lipolytica might be applicable to a wastewater treatment system for the removal of oil and COD.

关键词： Yarrowia lipolytica biodegradation oil wastewater calcium alginate