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Advances in magnesium-containing bioceramics for bone repair

Biomaterials Translational 2024年第1期5卷 3-20页

作者： Qi L. Zhao T. Yan J. ge w. Jiang w. w.ng J. Gholipourmalekabadi M. Lin K. w.ng X. Zhang L. Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Department’s Education Deputy Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Institute of Translational Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconstruction of bone defects or fractures caused by ageing, trauma and tumour resection is still a great challenge in clinical treatment. Although autologous bone graft is considered as gold standard, the source of natural bone is limited. In recent years, regenerative therapy based on bioactive materials has been proposed for bone reconstruction. Specially, numerous studies have indicated that bioactive ceramics including silicate and phosphate bioceramics exhibit excellent osteoinductivity and osteoconductivity, further promote bone regeneration. In addition, magnesium (Mg) element, as an indispensable mineral element, plays a vital role in promoting bone mineralisation and formation. In this review. different types of Mg-containing bioceramics including Mg-containing calcium phosphate-based bioceramics (such as Mg-hydroxyapatite, Mg-biphasic calcium phosphate), Mg-containing calcium silicate-based bioceramics (such as Mg2SiO4, Ca2MgSi2O7and Mg-doped bioglass), Mg-based biocements, Mg-containing metal/polymer-bioceramic composites w.re systematacially summarised. Additionally, the fabrication technologies and their materiobiological effects w.re deeply discussed, Clinical applications and perspectives of magnesium-containing bioceramics for bone repair are highlighted. Overall, Mg-containing bioceramics are regarded as regenerative therapy w.th their optimised performance. Furthermore, more in-depth tw.-w.y researches on their performance and structure are essential to satisfy their clinical needs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： bioactive ions bioceramics bone repair magnesium osteoconductivity

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Controllability of Semilinear Integrodifferential Degenerate Sobolev Equations

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Journal of Systems Science & Complexity 2024年第5期37卷 1923-1936页

作者： ge Zhaoqiang School of Mathematics and Statistics Xi’an Jiaotong University

In this paper, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations w.th nonlocal conditions is investigated in the sense of integral solution in Hilbert spaces. Some sufficient and necessary conditions are obtained. Firstly, the existence and uniqueness of integral solutions of semilinear integrodifferential degenerate Sobolev equations w.th nonlocal conditions are considered by ge-evolution operator theory and Sadovskii's fixed point theorem, the existence and uniqueness theorem of solutions is given. Secondly, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations w.th nonlocal conditions is studied in the sense of integral solution. The criterion for approximate controllability is provided. The obtained results have important theoretical and practical value for the study of controllability of semilinear integrodifferential degenerate Sobolev equations w.th nonlocal conditions.

关键词： Approximate controllability ge-evolution operator integral solution Sadovskii’s fixed point theorem semilinear integrodifferential degenerate Sobolev equations

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Polymeric piezoelectric accelerometers w.th high sensitivity,broad bandw.dth,and low.noise density for organic electronics and w.arable microsystems

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Microsystems & Nanoengineering 2024年第3期10卷 63-74页

作者： Chang ge Edmond Cretu The Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBCCanada

Piezoelectric accelerometers excel in vibration *** the emerging trend of fully organic electronic microsystems,polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals,such as vocal vibrations in w.arable speaking assistants for those w.th speaking ***,high-performance polymeric piezoelectric accelerometers suitable for such applications are *** organic compounds such as PVDF have inferior properties to their inorganic counterparts such as ***,most existing polymeric piezoelectric accelerometers have very unbalanced performance *** often sacrifice resonance frequency and bandw.dth for a flat-band sensitivity comparable to those of PZT-based accelerometers,leading to increased noise density and limited application *** this study,a new.polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is *** new.design aims to simultaneously achieve high sensitivity,broad bandw.dth,and low.*** samples w.re manufactured and characterized,demonstrating an average sensitivity of 29.45 pC/g w.thin a±10 g input range,a 5%flat band of 160 Hz,and an in-band noise density of 1.4μg/√*** results surpass those of many PZT-based piezoelectric accelerometers,show.ng the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.

关键词： piezoelectric polymeric overcome

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Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： ge CHEN Xiaoyan CHEN Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view.on meridional deflection of eddy propagation is polew.rd for cyclones and equatorw.rd for anticyclones. This w.dely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, w. approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow.dragging, yielding the follow.ng main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks w.ich are spatially asymmetric(though azimuthally symmetric) betw.en the tw. signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent polew.rd(equatorw.rd) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. w.stw.rd propagating eddies are substantially affected by thermal fading, w.ile opposite ones by flow.dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation geostrophic adjustment

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Solid Desiccant Heat Pump Fresh Air Unit using Composite Silica gel

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Journal of Thermal Science 2024年第4期33卷 1286-1300页

作者： YANG Tianyu GUO Defang ge Tianshu Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityKey Laboratory of Power Mechanical EngineeringMOE ChinaShanghai200240China Qingdao Haier A/C Electronic Co. LtdQingdao266101China

The introduction of fresh air into the indoor space leads to a significant increase in cooling or heating *** desiccant heat pump fresh air unit w.ich can handle the latent and sensible load of fresh air efficiently have been proposed *** improve the performance of the solid desiccant heat pump fresh air unit in the fresh air handling process,in this paper,the application of composite silica gel in a heat pump fresh air unit w.s *** comparison betw.en silica gel coating(SGC)and composite silica gel coating(CSGC)show. that the adsorption rate and w.ter uptake capacity of CSGC are more than tw. times higher than those of *** experimental setup for the solid desiccant heat pump fresh air unit w.s *** performance of SGC and CSGC w.s tested in the setup *** show.that under summer conditions,compared w.th the solid desiccant heat pump fresh air unit using silica gel(SGFU),the average moisture removal and COP of the one using composite silica gel(CSGFU)increased by 15%and 30%,*** w.nter conditions,compared w.th SGFU,the average humidification and COP of CSGFU increased by 42%and 17%.w.th optimal operation conditions of 3 min sw.tchover time and 40 r/s compressor frequency,the COP of CSGFU under summer conditions can reach *** also show.that the CSGFU and SGFU have higher COP and dehumidification rate under higher outdoor temperature and humidity ratio.

关键词： fresh air system desiccant coated heat exchanger humidification dehumidification experimental comparison

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Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： Sheng Mi Chaofeng Hou w.i ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid w.s investigated theoretically and the critical bubble size w.s derived from macroscale thermodynamic equations,below.w.ich the system destabilizes w.th sharp drop in *** critical size w.s quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,w.ere stronger attraction betw.en the molecules at low.r density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems w.ere reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size

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Flocking Effects of the Stochastic Cucker-Smale System w.th Noise

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Journal of Systems Science & Complexity 2024年第5期37卷 1978-1994页

作者： HAN Ning ge Bin LI Lin School of Mathematical Sciences Harbin Engineering University

In this paper, the flocking behavior of a Cucker-Smale model w.th a leader and noise is studied in a finite time. The authors present a Cucker-Smale system w.th tw. nonlinear controls for a complex netw.rk w.th stochastic synchronization in probability. Based on the finite-time stability theory of stochastic differential equations, the sufficient conditions for the flocking of stochastic systems in a finite time are obtained by using the Lyapunov function method. Finally, the numerical simulation of the particle system is carried out for the leader and noise, and the correctness of the results is verified.

关键词： Cucker-Smale model flocking behavior leader noise

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Soft coarse-grained particle model for particle-fluid systems

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Particuology 2024年第1期84卷 178-193页

作者： Yanhao Ye Ji Xu w.i ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China

By modeling a group of neighboring real particles as a single coarse-grained particle(CGP),discrete particle method(DPM)is now.capable of simulating industrial-scale particle-fluid ***,a systematic approach to determine the CGP properties and develop their interaction models is still lacking,w.ich casts uncertainty on the predictivity of the *** this study,collisions betw.en predefined particle groups are analyzed to construct kernel functions for modeling the CGPs and then the model parameters are determined by equating the statistical properties of the CGPs and the real particles in the physical process *** approach is implemented for homogeneous cooling of granular gas,then demonstrated effective in simulating experimental fluidized beds.

关键词： Coarse-grain(CG) Discrete particle method(DPM) Fluidized bed Multi-scale simulation

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Activity regulation and applications of metal-organic framew.rk-based nanozymes

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Rare Metals 2024年第3期43卷 900-914页

作者： ge Fang Shou-Xin Bao gen-Xiu Zhou Cui-Cui ge State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China Suzhou Nanomicro Technology Co. LtdSuzhou 215000China

As a new.generation of artificial enzymes,nanozymes show.outstanding advantages such as high stability,low.cost,and facile synthesis,w.ich endow.them w.th promising applications in biomedical and environmental *** the various reported nanozymes,metal-organic framew.rks(MOFs)could mimic the active center of natural enzymes and provide a hydrophobic environment,w.ich makes MOFs attractive alternatives to natural *** to the highly structural diversity and tailorability of MOFs,rational design w.ll contribute to improve the activity of MOF-based nanozymes and promote their potential applications in both biomedical and environmental ***,a comprehensiye suminary of activity regulatory strategies of MOF-based nanozymes is urgently ***,w. summarized the activity regulatory strategies of MOFs w.th intrinsic enzyme-like activities via modulation of metal nodes,ligands,structures and *** the applications of MOF-based nanozymes in biosensing,hazardous degradation,antibacterial,and cancer therapy w.re also ***,the current challenges and future perspectives w.re discussed in *** is highly expected that this review.w.ll provide a better understanding on the rational design of novel high-performance MOF-based nanozymes.

关键词： Metal-organic framew.rks(MOF)-based nanozymes Activity regulation Biosensing Cancer therapy Hazardous degradation Antibacterial

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Carbonic anhydrase-like enzymes in the formation of Lycopodium alkaloid

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Chinese Journal of Natural Medicines 2024年第3期22卷 193-194页

作者： DONG Huiw.n ge Huiming State key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China

Plant alkaloids,renow.ed for their structural diversity and bioactivity,are prominent in both modern and traditional medicine[1].Unraveling the intricacies of plant alkaloid biosynthesis could pave the w.y for the discovery of new.natural products and *** may also shed light on the roles of existing pathw.ys in host biology and provide valuable tools for metabolic engineering in plants and microbes[2].Unlike other major classes of plant natural products,such as terpenoids and polyketides,the formation of alkaloid scaffolds does not conform to a uniform chemical theme or depend on a singular enzyme class[3].A case in point is the Lycopodium alkaloids in the Lycopodiaceae family,w.ere the enzymes responsible for their core scaffold construction remain unidentified[4].

关键词： Lycopodium alkaloid Carbonic anhydrase-like enzymes Biosynthesis

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