检索结果-南通市图书馆

Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine

引用

Pharmacology & Pharmacy 2023年第10期14卷 428-440页

作者： Kouakou Etienne Effo Yacouba Adebo Adehouni gbongué eric tia Amenan Geneviève Irié-N’Guessan N’Doua Gisèle Kouakou Siransy Department of Pharmacology Clinical and Therapeutic Pharmacy Faculty of Pharmaceutical and Biological Sciences University of Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire

Background: “Diarra”, a traditional herbal remedy made from five (5) medicinal plants, might be endowed with anti-diarrhoeal properties according to its owner. However, scientific evidence of its safety, tolerability and activity has not been established. Objective: This study aimed to assess the safety, tolerability and anti-diarrhoeal activity of “Diarra” in experimental rats. Materials and Methods: Safety was assessed by acute (OECD 423) and sub-acute (OECD 407) toxicity studies at doses of 5, 10 and 20 mg/kg. Clinical tolerability was assessed for 28 days. On day 29, a blood sample was taken to evaluate biological tolerability. The anti-diarrhoeal activity was investigated in a castor oil-induced diarrhoea model. Rats were given the remedy at doses of 5, 10 and 20 mg/kg and then castor oil 1 hour later. They were observed for 4 hours and diarrhoeal stools were collected. The Percentage of diarrhoeal inhibition was calculated. Results: A single dose of “Diarra” at a dose of 2000 mg/kg did not induce any lethality, behavioural or weight change in rats for 14 days. When administered once daily for 28 days, “Diarra” did not cause lethality or significant behavioural disorders or significant weight loss in rats. No biological disorders were observed. The treatment of rats with “Diarra” at doses of 5 mg/kg, 10 mg/kg and 20 mg/kg in a single administration inhibited the occurrence of diarrhoeal stools. The respective percentages of inhibition were 60%, 50% and 62%, similar to those of loperamide at a dose of 2 mg/kg (68%). Conclusion: “Diarra” has an anti-diarrheal activity in rats. It is also safe to use this remedy as such.

关键词： Safety Tolerability Antidiarrheal Diarra Traditional Medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine

引用

Pharmacology & Pharmacy（药理与制药） 2023年第10期

作者： Kouakou Etienne Effo Yacouba Adebo Adehouni gbongué eric tia Amenan Geneviève Irié-N’Guessan N’Doua Gisèle Kouakou Siransy

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score

引用

Stroke & Vascular Neurology 2021年第2期6卷 314-318页

作者： Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan eric Peterson Janet Prvu Bettger Department of Neurology Duke University School of MedicineDurhamNorth CarolinaUSA Duke Clinical Research Institute DurhamNorth CarolinaUSA AstraZeneca UK Ltd CambridgeUK Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Division of Cardiology Brigham and Women's HospitalBostonMassachusettsUSA Division of Cardiology Ronald Reagan UCLA Medical CenterLos AngelesCaliforniaUSA

Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(tia)and role of ABCD^(2) score in identifying high-risk individuals are not *** We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a tia to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital *** Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index tia was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to *** with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs *** contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) *** This study validates the use of ABCD^(2) score for long-term risk assessment after tia in patients aged 65 years and *** efforts for community-based follow-up care after tia are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for tia.

关键词： admitted score prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

颈动脉内膜切除治疗暂时性脑缺血

引用

中华外科杂志 1989年第12期27卷 743-745页

作者：周定标 eric.,DL 解放军总医院神经外科美国明尼苏达大学医学院神经外科美国Mayo医学中心神经外科

本文报告颈动脉内膜切除治疗tia 45例的治疗体会。所有患者均经血管造影证实颈动脉颅外段狭窄。无手术死亡。除2例术后1周内各有1次tia,2例对侧肢体肌力减退(分别在2天和5天后恢复),1例轻度声嘶外,余均顺利恢复。作者讨论了颈动脉内膜... 详细信息

本文报告颈动脉内膜切除治疗tia 45例的治疗体会。所有患者均经血管造影证实颈动脉颅外段狭窄。无手术死亡。除2例术后1周内各有1次tia,2例对侧肢体肌力减退(分别在2天和5天后恢复),1例轻度声嘶外,余均顺利恢复。作者讨论了颈动脉内膜切除在tia防治中的作用、tia患者颈动脉内膜切除的指征和手术有关问题。

关键词：暂时性脑缺血动脉内膜切除 tia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：