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Aqueous Leaf Extract of Moringa oleifera (Moringaceae) Effectively Treats Induced Hemolytic Anemia in Wistar Rats

Journal of Biosciences and Medicines 2023年第8期11卷 154-168页

作者： Semado Franck Médard Tchogou Atchadé Pascal Medoatinsa Seinde Espérance Agbogba Félicienne Abissi Yollande Kassa Roxane Lokonon Jacques Ezéchiel Houngbeme Alban Agbonon Amegnon gbénou joachim djimon Baba-Moussa Lamine Senou Maximin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin National Pharmacognosy Laboratory (LNP) Institute for Research and Experimentation in Traditional Medicine and Pharmacopoeia (IREMPT) Porto Novo Benin Laboratory of Physiology/Pharmacology Faculty of Sciences University of Lome Lome Togo Doctoral School (ED-STIM) National University of Sciences Technologies Engineering and Mathematics (UNSTIM) Abomey Benin Laboratory of Biology and Molecular Typing in Microbiology University of Abomey-Calavi Cotonou Benin

Introduction: Moringa oleifera was a medicinal plant generally used by populations in the food and therapeutic fields. It’s used to treat anemia has been observed in the Djougou Zone in northern Benin. To our knowledge, there were no scientific data available that have evaluated its efficacy in the treatment of haemolytic anemia. This was what justifies this research work in which the phytochemical analysis, extraction and evaluation of the anti-anemic effect were carried out. Methods: Five groups of five Wistar rats each were formed. All the rats were rendered anemic by injection of phenylhydrazine hydrochloride on the first two days D0 and D1 except those in the negative control group. From the second day, the anemic groups were force-fed either with the aqueous extract of Moringa oleifera leaves at 200 or 300 mg/kg body weight/day, or with vitafer, the reference drug against anemia. The positive control group (anemia) was not treated. Blood samples were taken from all the rats on different days: D0, D2, D7, D10 and D15 to evaluate the data of the hemogram and the osmotic resistance of the red blood cells. Results: Phytochemical analysis revealed the presence of tannins, flavonoids, leucoanthocyanins, saponosides, triterpenes and mucilages. A good yield was obtained at the extraction. Both the extract and the reference drug vitafer completely corrected anemia within two weeks after stimulating hemoglobin synthesis and early release of immature red blood cells into the bloodstream. Its effect seemed dose-dependent and specific. Conclusion: Moringa oleifera leaves showed good therapeutic efficacy and can be considered and exploited for transformation into improved traditional medicines (ITM) in the treatment of anemia.

关键词： Moringa oleifera Hemolytic Anemia Red Blood Cells Wistar Rats

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Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon C.Werthmann joachim Herz Department of Molecular Genetics and Center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern Medical Center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

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Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie C.joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

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The whole and its parts: Visualizing Gaussian mixture models

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Visual Informatics 2024年第2期8卷 67-79页

作者： joachim Giesen Philipp Lucas Linda Pfeiffer Laines Schmalwasser Kai Lawonn Friedrich-Schiller-University Jena Germany German Aerospace Center DLR-Institute of Data Science Jena Germany

Gaussian mixture models are classical but still popular machine learning *** appealing feature of Gaussian mixture models is their tractability,that is,they can be learned efficiently and exactly from data,and also support efficient exact inference queries like soft clustering data *** seemingly simple,Gaussian mixture models can be hard to *** are at least four aspects to understanding Gaussian mixture models,namely,understanding the whole distribution,its individual parts(mixture components),the relationships between the parts,and the interplay of the whole and its *** a structured literature review of applications of Gaussian mixture models,we found the need for supporting all four *** identify candidate visualizations that effectively aid the user needs,we structure the available design space along three different representations of Gaussian mixture models,namely as functions,sets of parameters,and sampling *** the design space,we implemented three design concepts that visualize the overall distribution together with its ***,we assessed the practical usefulness of the design concepts with respect to the different user needs in expert interviews and an insight-based user study.

关键词： Gaussian mixture models

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Prevalence and intensity of urinary schistosomiasis and soil-transmitted helminths among women of reproductive age in Mwaluphamba,Kwale

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 71-83页

作者： Samuel M.Ngui Joseph M.Mwangangi joachim Richter Josephine W.Ngunjiri Department of Biological Sciences University of EmbuKenya Medical Entomology Kenya Medical Research Institute(KEMRI)Center for Geographic Medicine Research Coast KilifiKenya Institute of International Health Global Health CenterCharitéUniversity MedicineBerlinCorporate Member of Free University and Humboldt University and Berlin Institute of HealthBerlinGermany Swiss Tropical and Public Health Institute BaselSwitzerland Tropical and Infectious Diseases Department of Biological sciencesUniversity of EmbuKenya

Objective:To assess the epidemiology of urinary schistosomiasis and soil-transmitted helminthiasis among women of reproductive age in Mwaluphamba,Kwale County,***:A community-based cross-sectional study design was employed to randomly sample 422 women of reproductive age(15-<50 years)from four villages in Mwaluphamba *** specimens were collected and examined using the Kato-Katz method,while filtration technique was used to analyze urine ***’sociodemographic details were obtained using a standardized ***:Urinary schistosomiasis prevalence was at 4.7%(20/422,95%CI 2.8%-6.9%)while the prevalence of soil-transmitted helminthiasis infection was 4.5%(19/422,95%CI 2.6%-6.7%).The infection intensities of urinary schistosomiasis among the study participants ranged from 1 to 120 eggs/10 mL of urine with median egg count of 18.45 eggs/10 *** patients were diagnosed with light infection,of 56.16 egg/gram and 48.48 egg/gram for Trichuris trichiura and hookworms,*** without latrines had 15.7 times higher risk of having urinary schistosomiasis compared to those with a ***,use of surface water(aOR=1.0,95%CI 0.2-1.4,P=0.010)and crossing the river to go to a place(aOR=1.1,95%CI 0.3-1.6,P=0.009)were statistically significant risk factors for getting urinary *** bivariable regression analysis,defecating around the water source(OR=4.3,95%CI 1.5-12.9)had a statistically significant association with the prevalence of soil-transmitted helminthiasis(P=0.008).Conclusions:This study has given an insight on the prevalence and intensity of urinary schistosomiasis and soil-transmitted helminthiasis in Mwaluphamba location that form a basis for strengthening the control and elimination programmes for these neglected tropical diseases.

关键词： Urinary schistosomiasis Prevalence Soiltransmitted helminths Mwaluphamba

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Building Blocks of Nature

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1226-1303页

作者： Hans joachim Dudek Retired Auf dem Komp Germany

By means of a representation of the elementary objects by the Lagrange density and by the commutators of the communication relations, correlations can be formed using the Fourier transform, which under the conditions of the Hamilton principle, describes correlation structures of the elementary objects with oscillator properties. The correlation structures obtained in this way are characterized by physical information, the essential component of which is the action. The correlation structures describe the physical properties and their interactions under the sole condition of the Hamilton’s principle. The structure, the properties and the interactions of elementary objects can be led back in this way to a fundamental four dimensional structure, which is therefore in their different modifications the building block of nature. With the presented method, an alternative interpretation of elementary physical effects to quantum mechanics is obtained. This report provides an overview of the fundamentals and statements of physical information theory and its consequences for understanding the nature of elementary objects.

关键词： Hamilton Principle as Global Law in Physics Physical Information Generated by Action Correlation Space Mass and Charge Formation Interpretation of Physical Effects

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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa and Justicia secunda

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American Journal of Plant Sciences 2022年第12期13卷 1460-1477页

作者： Louis Fagbohoun gbènagnon C. Nonvidé Aziz Sina Orou Alban Houngbèmè Amoussatou Sakirigui Felix Gunin joachim djimon gbénou Kaba Research Laboratory in Chemistry and Applications (LaKReCA) National University of Sciences Technologies Engineering and Mathematics Abomey Benin Laboratory of Biologie and Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Univessity of Abomey-Calavi Abomey-Calavi Benin Laboratory of Pharmacognosy and Essential Oils Department of Chemistry University of Abomey-Calavi Abomey-Calavi Benin

Justicia secunda, Sorghum bicolor, Gossypiun barbadense and Hibiscus sabdariffa are dye plants traditionally used in Benin for the treatment of anemia. This work is part of the therapeutic valorization of dyes from these plants. Its objective is to characterize their composition in chemical groups and evaluate their harmlessness and their anti-anaemic property in laboratory rats. Anemia was induced in Wistar rats by phenylhydrazine hydrochloride followed by treatment by gavage with hydroethanolic extracts of the plants studied. Phytochemical screening of these extracts made it possible to characterize the major chemical groups, in particular alkaloids, polyphenols including tannins, flavonoids and leucoanthocyanins, as well as reducing compounds and saponosides in the plants studied. Cytotoxic analysis of these extracts on Artemia salina shrimp larvae revealed globally high LC50 values of between 3.14 and 4.64 mg/mL, which testify a priori to the harmlessness of these extracts. The administration of the hydroethanolic extract of each plant to anaemic rats at doses of 2000 mg/kg/d promoted, after 15 days, an increase in hemoglobin levels, the number of red blood cells and hematocrit, going to more than 90% recovery of the hematological parameters involved. The highest rate, 99.06% being that of the species Justicia secunda followed closely by Sorghum bicolor (96.80%) compared to 93.93% obtained by treatment with the Ranferon-12 positive control used. Indeed, these results confirm the therapeutic indication of these plants in the resorption of anemia in traditional medicine.

关键词： Anemia Resorption Tinctorial Plants Phytochemistry Benin

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矩形边界限定形式的感应电机低开关频率预测控制研究

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中国电机工程学报 2024年第8期44卷 3278-3286,I0029页

作者：齐昕张家宁 HOLTZ joachim 田柏轩任佳仕王辰宇周珂北京科技大学机械工程学院北京市海淀区100083 伍珀塔尔大学电机与驱动实验室德国伍伯塔尔42119 北京科技大学顺德研究生院广东省佛山市528399 北京科技大学高等工程师学院北京市海淀区100083

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以... 详细信息

圆形边界限定形式预测控制对电流畸变的限定在各方向均相同,无法通过增大边界圆半径进一步降低开关频率。因此,该文提出一种矩形边界限定形式的预测控制方法。首先,深入分析感应电机数学模型,发现感应电机转子子系统的低通物理特性,以及励磁电流波动对电磁转矩的影响不显著;其次,利用该特性,将限定边界改为矩形,对转矩电流与励磁电流进行独立约束,适度增加励磁电流畸变允许限值,扩大电流轨迹运动范围,延长开关状态切换时长;再次,探究电流矢量梯度同边界约束间的数学关系,提出该方法下电压矢量筛选与寻优准则,筛选出最优矢量;最终,进行实验对比。实验结果证明,在相同系统动态特性和转矩波动下,相较于圆形边界限定策略,矩形边界限定策略可以进一步降低开关频率。

关键词：矩形边界低开关频率预测控制感应电机

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The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu Joshua Spille Marta Lipińska-Chwałek joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEM Magnesium Corrosion Passive layer

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Effect of the Implementation of Emonc in the Reduction of Maternal Deaths in the Department of Collines from 2018 to 2022

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 259-266页

作者： joachim Aifa Florence Abraham Roger Klikpezo Edgard-Marius Ouendo Badirou Aguemon Faculty of Health Sciences of Cotonou Department of Public Health Cotonou Benin Nursing and Midwifery Training Institute University of Parakou Parakou Benin Assistant in Gynecology-Obstetrics FM-University of Parakou Parakou Benin Full Professor of Public Health and Epidemiology Ouidah Regional Institute of Public Health Ouidah Benin Full Professor of Public Health Faculty of Health Sciences of Cotonou Cotonou Benin

Background: Maternal and neonatal mortality remains a public health problem in Benin. Each year, approximately 1500 maternal deaths and more than 12,000 newborn deaths are recorded there. In order to correct the situation, strategies such as the implementation of Emergency Obstetric and Neonatal Care (EmONC) were initiated. Objective: Determine the rates of maternal deaths in EmONC centers in the Collines department from 2018 to 2022. Framework and Methods: The study took place in Benin precisely in the Collines department. This was a descriptive cross-sectional study. Data collection was carried out during the first two weeks of January 2023 and covered data from the 09 Basic Emergency Obstetric and Neonatal Care centers (BEMONC) and the Obstetric and Neonatal Care centers of Complete Emergency (CEmONC) of the Collines department from 2018 to 2022. An estimate of the ratios of maternal deaths occurring at the level of the EmONC centers of the Collines department from 2018-2022 was carried out followed by constructive suggestions. Results: During the five years (2018 to 2022), the Collines department recorded 42,582 live births with 148 maternal deaths, i.e. a ratio of 348 maternal deaths per 100,000 live births. Between 2018 and 2022, the highest maternal death ratio was recorded in 2019, i.e. 425 maternal deaths per 100,000 live births for all EmONC centers and 607 maternal deaths per 100,000 live births in EmONC centers. The highest maternal death ratio at the BEmONC center level was recorded in 2020, i.e. 129 maternal deaths per 100,000 births. Conclusion: These results suggest that despite the implementation of EmONC in the Collines department, maternal deaths have not decreased. To improve these outcomes for a reduction in maternal deaths, urgent action must be taken.

关键词： Effect BEmONC CEmONC Maternal deaths Department of Collines

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